Article
Pharmacology & Pharmacy
Guangxia Yang, Kai Wang, Hua Song, Rujie Zhu, Shuai Ding, Hui Yang, Jian Sun, Xin Wen, Lingyun Sun
Summary: This study investigated the effect of celastrol on osteoarthritis (OA) and identified the mechanisms involved. The results showed that celastrol delayed cartilage damage, reduced osteophyte formation and bone resorption in an OA rat model. In vitro experiments also demonstrated that celastrol suppressed the production of inflammatory factors and inhibited matrix degradation. Furthermore, celastrol inhibited the TLR2/NF-kappa B signaling pathway. These findings suggest that celastrol could be a potential therapy for OA by targeting this signaling pathway.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Pharmacology & Pharmacy
Hongbo You, Rui Zhang, Lingying Wang, Qiyong Pan, Zekai Mao, Xiaojian Huang
Summary: Osteoarthritis (OA) is a major cause of cartilage pain and limited mobility in middle-aged and elderly individuals, with inflammation-induced cartilage degeneration playing a key role. Shikimic acid (SA) has been found to have significant anti-inflammatory effects and potential therapeutic effects for OA by suppressing IL-1 beta-induced pathways.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
Linglong Liu, Limei Xu, Shengjie Wang, Lili Wang, Xiaoning Wang, Huifeng Xu, Xihai Li, Hongzhi Ye
Summary: This study identified and confirmed the essential role of the TLR4/MyD88/NF-kappa B signalling pathway in DHJSD treatment for osteoarthritis. The study also found that miRNA plays a synergistic role in regulating gene pathways related to this signaling pathway. These findings provide a basis for further investigation into the mechanisms of DHJSD in treating osteoarthritis.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Pharmacology & Pharmacy
Xiuhui Chen, Yanhong Chen, Yitao Ou, Wenjie Min, Shuli Liang, Lei Hua, Yinghua Zhou, Cheng Zhang, Peifeng Chen, Zhongjin Yang, Wenhui Hu, Ping Sun
Summary: The abnormal activation of NLRP3 inflammasome is important in the pathogenesis of psoriasis. Bortezomib, a marketed drug for treating multiple myeloma, specifically inhibits NLRP3 inflammasome activation and may be a potential therapeutic drug for psoriasis.
BIOCHEMICAL PHARMACOLOGY
(2022)
Article
Medicine, General & Internal
Yumei Cao, Su'an Tang, Xiaoyu Nie, Zuoqing Zhou, Guangfeng Ruan, Weiyu Han, Zhaohua Zhu, Changhai Ding
Summary: The study identified miR-214-3p as a key regulator in osteoarthritis, impacting ECM metabolism and cell apoptosis in cartilage by modulating the NF-kappa B signaling pathway. Targeting IKKP, decreased miR-214-3p exacerbates OA development, suggesting it as a potential novel therapeutic target for OA.
Article
Immunology
Huangming Zhuang, Bin Li, Ting Xie, Changgeng Xu, Xunshan Ren, Fuze Jiang, Tianrun Lei, Panghu Zhou
Summary: 3-IAld reduces inflammation in osteoarthritis through the AhR-NF-Kappa B signaling pathway.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Cell Biology
Jiansen Lu, Hong Guan, Dan Wu, Zhiqiang Hu, Hongbo Zhang, Huaji Jiang, Jingyao Yu, Ke Zeng, Hongyu Li, Haiyan Zhang, Chenglong Pan, Daozhang Cai, Xiao Yu
Summary: The study shows that pseudolaric acid B (PAB) can alleviate articular cartilage degeneration and synovitis during osteoarthritis (OA) by inhibiting NE-kappa B signalling and reducing the production of pro-inflammatory cytokines. Through stabilizing PPAR gamma, PAB regulates NE-kappa B signalling and suggests targeting synovial inflammation or inhibiting vessel formation at early stage could be an effective preventive strategy for OA.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2021)
Article
Pharmacology & Pharmacy
Minjun Yao, Caihua Zhang, Lingzhi Ni, Xiaoxiao Ji, Jianqiao Hong, Yazhou Chen, Jie Wang, Congsun Li, Jiyan Lin, Tingting Lu, Yihao Sheng, Menghao Sun, Mingmin Shi, Chenhe Zhou, Xunzi Cai
Summary: This study demonstrated for the first time the protective medicinal efficacy of cepharanthine (CEP) in osteoarthritis. CEP suppressed inflammation and increased protein expression in joint tissues while restoring cellular autophagy. The mouse model confirmed the therapeutic potential of CEP in osteoarthritis treatment.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Food Science & Technology
Haiyan Wen, Siqi Zhou, Jianping Li, Fei Peng, Xiaotao Han, Haohuan Li
Summary: The study highlights the protective effect of Nuciferine (Nuf) against osteoarthritis (OA) by reducing extracellular matrix degradation and inhibiting the production of inflammatory cytokines. Nuf attenuates OA progression by targeting the PI3K/Akt/NF-kappa B signaling pathway.
JOURNAL OF FUNCTIONAL FOODS
(2021)
Article
Pharmacology & Pharmacy
Zengxin Jiang, Guobin Qi, Wei Lu, Hao Wang, Defang Li, Weibin Chen, Lei Ding, Xiuying Yang, Hengfeng Yuan, Qingmin Zeng
Summary: This study found that omaveloxolone exerts antioxidative, anti-inflammatory, antiapoptotic and anti-ECM degradation effects via activation of the Nrf2/ARE signaling pathway and inhibition of the NF-kappa B signaling pathway in chondrocytes in vitro and attenuates osteoarthritis progression in vivo, suggesting its potential as a therapeutic agent for OA.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Cell & Tissue Engineering
Z-M Liu, C-C Lu, P-C Shen, S-H Chou, C-L Shih, J-C Chen, Y. C. Tien
Summary: Suramin has been found to effectively inhibit IL-1 beta-induced apoptosis in NP cells, reduce the expression of catabolic proteins, and upregulate anabolic proteins. It also alleviates IL-1 beta-induced inflammation and proteoglycan depletion, representing a potential therapeutic approach for IDD.
BONE & JOINT RESEARCH
(2021)
Review
Endocrinology & Metabolism
Yongjun Ye, Jianguo Zhou
Summary: Osteoarthritis (OA) is a joint disease associated with chronic inflammation. Inhibiting the NF-κB pathway, which plays a role in inflammation, can be a potential strategy for treating OA. Natural flavonoids, a type of polyphenol with anti-inflammatory properties, have shown protective activity against OA by inhibiting the NF-κB signaling pathway.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Orthopedics
Weiyi Xia, Jian Xiao, ChengLin Tong, Jiajie Lu, Yurong Tu, Sunlong Li, Libing Ni, Yifeng Shi, Peng Luo, Xiaolei Zhang, Xiangyang Wang
Summary: The effects of Orientin on murine chondrocytes treated with IL-1 beta were evaluated in vitro, and the healing effect of Orientin was assessed in a standard OA model in mice. Results showed that Orientin suppressed pro-inflammatory mediators and cartilage degradation, and downregulated activation of NF-kappa B by activating Nrf2/HO-1 axis and SIRT6 signaling pathway, suggesting its potential as a treatment for OA.
JOURNAL OF ORTHOPAEDIC RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Haijun Zhao, Weijie Zhu, Wude Mao, Chengkai Shen
Summary: The study demonstrates that PRP can protect chondrocytes from doxorubicin-induced damage, inhibiting apoptosis and inflammation, and improving cartilage destruction. This research provides a new theoretical basis for the clinical treatment of osteoarthritis caused by doxorubicin.
MOLECULAR MEDICINE
(2021)
Article
Dentistry, Oral Surgery & Medicine
Yineng Han, Yiping Huang, Qiaolin Yang, Lingfei Jia, Yunfei Zheng, Weiran Li
Summary: This study revealed that SNHG5 mediates periodontal inflammation through the NF-kappa B signaling pathway, providing a potential therapeutic target for periodontitis treatment.
JOURNAL OF CLINICAL PERIODONTOLOGY
(2022)