Article
Nutrition & Dietetics
Sergej M. Ostojic, Tonje Holte Stea, Dagrun Engeset
Summary: Male fertility decline is a global public health problem, and finding efficient biomarkers and interventions to enhance fertility is of utmost importance. Creatine, due to its role in sperm energy metabolism, has been recognized as a potential candidate for promoting male fertility.
Article
Multidisciplinary Sciences
Sergey V. V. Stovbun, Dmitry V. V. Zlenko, Alexander A. A. Bukhvostov, Alexander S. S. Vedenkin, Alexey A. A. Skoblin, Dmitry A. A. Kuznetsov, Anatoly L. L. Buchachenko
Summary: The rate of a chemical reaction can be influenced by the isotope composition of the reactants, resulting in sensitivity to the external magnetic field. This study demonstrates the impact of the external magnetic field on enzymatic DNA synthesis, as well as the effect of spin-bearing magnesium ions. The rate of DNA synthesis decreases steadily with increasing magnetic field induction in the presence of zero-spin magnesium ions. However, in the presence of spin-bearing magnesium ions, the dependence of the reaction rate on magnetic field induction is non-monotonic with a distinct minimum at 80-100 mT. A proposed chemical scheme and biophysical mechanism explain this observed effect by considering the competition between Zeeman and Fermi interactions in the external magnetic field.
SCIENTIFIC REPORTS
(2023)
Article
Environmental Sciences
Yi Zhang, Pai Zheng, Jiaqi Shi, Ying Ma, Zhangjian Chen, Tiancheng Wang, Guang Jia
Summary: This study aimed to investigate the association of ambient temperature with creatine kinase MB (CK-MB) and creatine kinase (CK). The results showed a V-shaped relationship between CK-MB and ambient temperature, and a linear relationship between CK and ambient temperature. Cold exposure was associated with increased levels of CK-MB and CK, while no heat-related elevation was observed. These findings suggest a possible adverse effect of cold exposure on myocardial injury.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Critical Care Medicine
Stefano Guerra, Julie G. Ledford, Erik Melen, Iris Lavi, Anne-Elie Carsin, Debra A. Stern, Jing Zhai, Marta Vidal, Mariona Bustamante, Kenneth J. Addison, Renata G. Vallecillo, Dean Billheimer, Gerard H. Koppelman, Judith Garcia-Aymerich, Nathanael Lemonnier, Montserrat Fito, Carlota Dobano, Simon Kebede Merid, Inger Kull, Rosemary R. C. McEachan, John Wright, Leda Chatzi, Manolis Kogevinas, Daniela Porta, Silvia Narduzzi, Ferran Ballester, Ana Esplugues, Carlos Zabaleta, Amaia Irizar, Jordi Sunyer, Marilyn Halonen, Jean Bousquet, Fernando D. Martinez, Josep M. Anto
Summary: A study was conducted to screen circulating proteins in childhood asthma and investigate their association with the disease in a mouse model. It was found that creatine kinase (CK) was consistently associated with asthma, and this association was further supported by gene expression analysis and a mouse model experiment.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Jelena Branovets, Niina Karro, Karina Barsunova, Martin Laasmaa, Craig A. Lygate, Marko Vendelin, Rikke Birkedal
Summary: In mice with creatine deficiency, the hexokinase and adenylate kinase did not change, but in AGAT KO mice, increased expression and activity of hexokinase I were found, which could affect mitochondrial regulation and reactive oxygen species production.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Manoj Kumar Tembhre, Mukesh Kumar Sriwastva, Milind Padmakar Hote, Shikha Srivastava, Priyanka Solanki, Shafaque Imran, Ramakrishnan Lakshmy, Alpana Sharma, Kailash Jaiswal, Ashish Datt Upadhyay
Summary: Interleukin-33 (IL-33) may play a pathogenic role in advanced atherosclerosis (aAT) by exacerbating neutrophil extracellular trap (NET) formation and promoting macrophage necroptosis, leading to the release of inflammatory factors and the instability/rupture of atherosclerotic plaques.
Article
Agriculture, Dairy & Animal Science
Kayla C. Mowry, Timber L. Thomson-Parker, Cruz Morales, Kalley K. Fikes, Kyle J. Stutts, Jessica L. Leatherwood, Mark J. Anderson, Rachelle X. Smith, Jessica K. Suagee-Bedore
Summary: This study demonstrates that consuming crude rice bran oil or a flaxseed oil blend for 60 days may benefit lightly worked, young horses by reducing training-program-related increases in interleukin-1 beta, while a flaxseed oil blend may reduce exercise-induced increases in creatine kinase. Additionally, the flaxseed oil blend has the potential to increase plasma omega-3 and omega-6 fatty acids.
Article
Nutrition & Dietetics
Chutimon Khemtong, Antonio Tessitore, Salvador J. Jaime, Giuliana Gobbi, Jorgen Jensen, Ai-Lun Yang, Chia-Hua Kuo, Giancarlo Condello
Summary: The results of this study suggest that BCAAs supplementation does not provide any benefits for basketball players in mitigating muscle damage and soreness, improving neuromuscular performance, and maintaining arterial stiffness after COD exercises.
Article
Radiology, Nuclear Medicine & Medical Imaging
Dushyant Kumar, Ravi Prakash Reddy Nanga, Deepa Thakuri, Neil Wilson, Abigail Cember, Melissa Lynne Martin, Dan Zhu, Russell T. Shinohara, Qin Qin, Hari Hariharan, Ravinder Reddy
Summary: This study demonstrated the feasibility and repeatability of the 3D-CrCEST method in calf muscle, along with proposing an improved B1+ correction approach for measuring creatine-recovery kinetics within a large 3D volume of calf muscle.
MAGNETIC RESONANCE IN MEDICINE
(2021)
Article
Biology
Li Li, Zhujun Li, Conghua Lu, Jianghua Li, Kejun Zhang, Caiyu Lin, Xiaolin Tang, Zhulin Liu, Yimin Zhang, Rui Han, Yubo Wang, Mingxia Feng, Yuan Zhuang, Chen Hu, Yong He
Summary: The mechanism of acquired resistance to osimertinib, a third-generation EGFR-TKI, is mediated by IL-6 and Laminin alpha 5/FAK signaling. Combining ibrutinib with osimertinib is proposed as a strategy to overcome osimertinib acquired resistance.
COMMUNICATIONS BIOLOGY
(2022)
Review
Nutrition & Dietetics
Sergej M. Ostojic
Summary: Post-viral fatigue syndrome (PVFS) is a chronic neurological disease with no definite etiological factor(s) or diagnostic test. Research suggests that irregularities in creatine metabolism may be a feature of PVFS, and supplementing creatine and related compounds could potentially improve fatigue symptoms in patients.
Article
Pharmacology & Pharmacy
Yi Lu, Peng Zhang, Hongdan Chen, Qingyi Tong, Jia Wang, Qing Li, Cheng Tian, Jian Yang, Senlin Li, Zijun Zhang, Huimin Yuan, Ming Xiang
Summary: Targeting microfilaments with cytochalasins, such as cytochalasin Q (CQ), is considered a promising anticancer strategy. CQ was found to inhibit creatine metabolism and cytosolic glycolysis in melanoma cells by directly binding to and inactivating creatine kinase B (CKB). Furthermore, CQ and CKB depletion both suppressed the PI3K/AKT/FoxO1 pathway.
TOXICOLOGY AND APPLIED PHARMACOLOGY
(2022)
Review
Clinical Neurology
Jiali Gao, Thanuja Dharmadasa, Andrea Malaspina, Pamela J. Shaw, Kevin Talbot, Martin R. Turner, Alexander G. Thompson
Summary: While elevated CK levels in ALS largely reflect lower motor neuron denervation, they are not independently associated with survival when measured during the symptomatic phase of the disease.
JOURNAL OF NEUROLOGY
(2022)
Article
Clinical Neurology
L. Pitscheider, M. Karolyi, F. R. Burkert, R. Helbok, J. V. Wanschitz, C. Horlings, E. Pawelka, S. Omid, M. Traugott, T. Seitz, A. Zoufaly, E. Lindeck-Pozza, E. Woll, R. Beer, S. Seiwald, R. Bellmann-Weiler, H. Hegen, W. N. Loscher
Summary: COVID-19 patients exhibit similar frequency of hyperCKemia as influenza patients, but lower CK levels overall. The severity of disease and inflammation markers strongly correlate with CK levels, but it remains unclear whether this is due to a virus-triggered inflammatory response or direct muscle toxicity.
EUROPEAN JOURNAL OF NEUROLOGY
(2021)
Article
Medicine, General & Internal
Peng Gu, Shengjin Han, Zhengwu Zhou, Jianzhong Ma
Summary: The objective of this study was to investigate the changes to the myocardial enzyme profile and its clinical value in patients with different degrees of spleen injury. The results showed that the increase in myocardial enzyme spectrum was positively correlated with the severity of spleen injury, suggesting that patients may have myocardial damage in the early stage of traumatic spleen injury and should be treated as soon as possible.
Article
Biotechnology & Applied Microbiology
Kirankumar B. Gudagudi, Niccolo Passerin d'Entreves, Nicholas J. Woudberg, Paul J. Steyn, Kathryn H. Myburgh
Article
Endocrinology & Metabolism
Kiara Boodhoo, Mare Vlok, David L. Tabb, Kathryn H. Myburgh, Mari van de Vyver
Summary: This study showed that chronic wounds in obese diabetic individuals have delayed healing processes and dysregulated protein expression compared to acute wounds. Early intervention in the healing process may be crucial for effective outcomes.
JOURNAL OF MOLECULAR ENDOCRINOLOGY
(2021)
Article
Cell & Tissue Engineering
Candice de Boer, Bridget Calder, Dee Blackhurst, David Marais, Jonathan Blackburn, Martina Steinmaurer, Nicholas J. Woudberg, Sandrine Lecour, Jason Lovett, Kathy Myburgh, Deon Bezuidenhout, Paul Human, Neil H. Davies
Summary: This study aimed to develop a multi-step purification protocol to isolate serum exosomes and evaluate their regenerative potential. The purification process of UC DG SEC significantly improved the removal of lipoproteins from serum exosomes, leading to enhanced cellular proliferation and potential angiogenic response in vivo. The purified exosomes showed increased levels of exosome-related proteins and reduced amounts of lipoproteins, indicating a more accurate identification of serum exosome functional activity and composition.
JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE
(2021)
Article
Endocrinology & Metabolism
Chane Paulsen, David R. Hall, Deidre Mason, Mari van de Vyver, Ankia Coetzee, Magda Conradie
Summary: This retrospective study analyzed blood sugar fluctuations in pregnant women with diabetes who received antenatal betamethasone, indicating that women receiving insulin therapy may experience hypoglycemic events, but no serious incidents occurred after corrective doses. Enhanced surveillance is recommended for the first 72 hours after betamethasone administration.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Cell & Tissue Engineering
Michelle Maartens, Maria Jacoba Kruger, Mari van de Vyver
Summary: The study demonstrated that NAC/AAP antioxidant supplementation improved the antioxidant status of diabetic animals, reduced lipid peroxidation, and cellular damage, while also enhancing the population doubling time of MSCs and downregulating genes associated with oxidative stress.
STEM CELLS AND DEVELOPMENT
(2021)
Article
Cell & Tissue Engineering
Mari van de Vyver, Kiara Boodhoo, Trivia Frazier, Katie Hamel, Marta Kopcewicz, Benjamin Levi, Michelle Maartens, Sylwia Machcinska, Johanna Nunez, Chase Pagani, Emma Rogers, Katarzyna Walendzik, Joanna Wisniewska, Barbara Gawronska-Kozak, Jeffrey M. Gimble
Summary: This study aims to develop and validate a scoring system based on healing parameters in each phase, which can be easily and accurately assessed using H&E or MT staining. The study compares parameters assessed using different staining methods and reports high sensitivity for each parameter, ranging between 80% and 95%. The validated scoring system defines minimum criteria for assessing wound healing dynamics and is associated with academic and scientific institutions involved in its development.
STEM CELLS AND DEVELOPMENT
(2021)
Correction
Biochemistry & Molecular Biology
M. van de Vyver, P. J. Idensohn, C. U. Niesler
Article
Obstetrics & Gynecology
David R. Hall, Mari van de Vyver
Summary: The study aims to evaluate the pregnancy outcomes and complications of transabdominal cerclage (TAC) procedure. The results indicate that TAC is a safe and effective option in the hands of experienced doctors.
INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS
(2023)
Article
Biochemistry & Molecular Biology
D. S. H. Ramklowan, C. Snyman, M. van de Vyver, C. U. Niesler
Summary: Fibroblasts play a crucial role in wound healing by migrating to the injury site and differentiating into myofibroblasts. Impaired wound healing is associated with a lack of myofibroblasts, resulting in reduced tissue strength and function. Communication between fibroblasts and myofibroblasts, as well as other cellular mediators of repair, influences the outcome of wound repair. However, establishing an in vitro model to investigate this communication is challenging. This study presents a model that allows the retention and culture of fibroblast and myofibroblast phenotypes, and demonstrates the importance of considering paracrine communication during wound healing.
Review
Endocrinology & Metabolism
Mari van de Vyver
Summary: Inflammation is a vital immune response that defends against harmful bacteria and pathogens, and also plays a crucial role in tissue maintenance and repair. However, under pathological conditions, there can be persistent inflammation without infection, known as sterile metabolic inflammation or metainflammation. This disruption of the immune response is associated with disease progression, immune senescence, and should not be overlooked in clinical management.
JOURNAL OF ENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
Ilze Mentoor, Anna-Mart Engelbrecht, Mari van de Vyver, Paul J. van Jaarsveld, Theo Nell
Summary: The study reveals that adipocyte secretory factors in the breast tumor microenvironment may promote treatment resistance to doxorubicin in breast cancer cells, by increasing the utilization of inflammatory mediators and inhibiting the release of fatty acids.
Review
Cell Biology
T. Ollewagen, K. H. Myburgh, M. van de Vyver, C. Smith
Summary: Although rheumatoid arthritis affects 1% of the global population, the role of rheumatoid cachexia – which occurs in up to a third of patients – is often neglected in research, despite its significant impact on patients' quality of life. Understanding the cellular and molecular processes involved in rheumatoid cachexia, as well as its potential treatment, is crucial and requires a focus on the intricate interactions between various cells.
JOURNAL OF BIOMEDICAL SCIENCE
(2021)
Article
Endocrinology & Metabolism
T. van der Made, M. van de Vyver, M. Conradie-Smit, Magda Conradie
Summary: The incidence of thyrotoxicosis is high in women with hyperemesis gravidarum (HG), with the majority being hCG-mediated. About one-third of patients with Graves' disease are asymptomatic and rely on antibody testing for diagnosis. Free T4 levels decrease with clinical stabilization of HG, suggesting dehydration may influence measurements.
JOURNAL OF ENDOCRINOLOGY METABOLISM AND DIABETES OF SOUTH AFRICA
(2021)
Article
Physiology
Colin Venter, Kathryn H. Myburgh, Carola U. Niesler
Summary: This passage discusses the phenotypic changes of myofibroblasts and macrophages under different stimuli, as well as their interactions. Through experimental conditions, it was found that a PI3K-associated mechanism can rescue myofibroblasts.
PHYSIOLOGICAL REPORTS
(2021)
