Article
Pharmacology & Pharmacy
Takeshi Suginohara, Megumi Kawaguchi, Seiwa Michihara, Nina Fujita, Li-Kun Han, Ryuji Takahashi
Summary: Ninjin'yoeito (NYT), a traditional Japanese medicine, may have therapeutic effects on symptoms, muscle atrophy, and increase in plasma IL-6 level caused by rheumatoid arthritis. It can inhibit the increases in arthritis scores, reduce pain threshold, and prevent muscle atrophy in the Collagen-induced arthritis (CIA) model.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Clinical Neurology
Han Gengyu, Dai Jinyue, Gong Chunjie, Zhang Bo, Jiang Yu, Li Jiaming, Li Weishi
Summary: The study found an association between preoperative paraspinal muscle degeneration and multiple postoperative complications after lumbar surgery, but caution should be exercised in interpreting these findings due to the limited quantity of available literature and high heterogeneity among studies.
EUROPEAN SPINE JOURNAL
(2022)
Article
Immunology
Iris Paola Guzman-Guzman, Claudia Isabel Ramirez-Velez, Ramces Falfan-Valencia, Jose Eduardo Navarro-Zarza, Ilse Adriana Gutierrez-Perez, Oscar Zaragoza-Garcia, Monica Ramirez, Natividad Castro-Alarcon, Isela Parra-Rojas
Summary: The SNP of the PADI2 gene plays a crucial role in the pathogenesis and severity of rheumatoid arthritis (RA), with specific genotypes in women from southern Mexico being associated with early disease onset, positive autoantibodies, and radiographic joint damage.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Susana Aidee Gonzalez-Chavez, Salma Marcela Lopez-Loeza, Samara Acosta-Jimenez, Ruben Cuevas-Martinez, Cesar Pacheco-Silva, Eduardo Chaparro-Barrera, Cesar Pacheco-Tena
Summary: Lifestyle modifications in preclinical Rheumatoid Arthritis (RA) have the potential to delay the onset of the disease. Physical exercise (PE) has been shown to benefit RA patients, but its impact in reducing the risk of developing RA has not been extensively studied. This study investigated the effects of low-intensity PE on the joints of mice with pre-arthritic CIA. The results showed that PE reduced joint inflammation and damage, as well as down-regulated the expression of proinflammatory genes and proteins. Further research is needed to understand the underlying mechanisms of PE in preclinical arthritis and its role in reducing the risk of developing RA.
Review
Chemistry, Medicinal
Mohammad Beba, Hamed Mohammadi, Cain C. T. Clark, Kurosh Djafarian
Summary: The study aimed to assess the effects of curcumin supplementation on exercise-induced muscle damage, muscle soreness, inflammation, muscle strength, and joint flexibility. The meta-analysis showed that curcumin supplementation significantly reduced creatine kinase activity, muscle soreness, and TNF-alpha concentration, and improved muscle strength and range of motion. However, no significant changes were found in IL-6 and IL-8 levels. Further high-quality studies are needed to evaluate the long-term effects and safety of curcumin supplementation.
PHYTOTHERAPY RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Yoichiro Kamada, Yuji Arai, Shogo Toyama, Atsuo Inoue, Shuji Nakagawa, Yuta Fujii, Kenta Kaihara, Ryota Cha, Osam Mazda, Kenji Takahashi
Summary: This study investigated the effects of treadmill running under hypoxic conditions on the joints and muscles of collagen-induced arthritis (CIA) rats. The results showed that exercise under hypoxia can alleviate joint destruction and prevent slow-twitch muscle atrophy and fibrosis. Furthermore, the combination of hypoxia with treadmill running further enhanced the preventive effects on slow-twitch muscle atrophy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Dumitru Constantin-Teodosiu, Despina Constantin
Summary: Muscle fatigue can decrease the capacity of muscles to complete tasks over time, with short-lasting fatigue often caused by overtraining, undertraining, or physical injury, while persistent and severe fatigue may be associated with pathological states or chronic exposure to certain substances.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Pharmacology & Pharmacy
Yan Yan, Ming Li, Jie Lin, Yanan Ji, Kexin Wang, Dajun Yan, Yuntian Shen, Wei Wang, Zhongwei Huang, Haiyan Jiang, Hualin Sun, Lei Qi
Summary: This review summarizes the role of AMPK in regulating mitochondrial function and its impact on skeletal muscle metabolism and health.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Francesca Bosco, Lorenza Guarnieri, Saverio Nucera, Miriam Scicchitano, Stefano Ruga, Antonio Cardamone, Samantha Maurotti, Cristina Russo, Anna Rita Coppoletta, Roberta Macri, Irene Bava, Federica Scarano, Fabio Castagna, Maria Serra, Rosamaria Caminiti, Jessica Maiuolo, Francesca Oppedisano, Sara Ilari, Filomena Lauro, Luigi Giancotti, Carolina Muscoli, Cristina Carresi, Ernesto Palma, Micaela Gliozzi, Vincenzo Musolino, Vincenzo Mollace
Summary: The aim of this study was to evaluate if chronic constriction injury (CCI) of the sciatic nerve in rats can be a valid model to study muscle atrophy and consequent osteoporosis. The results showed that CCI can cause significant decreases in muscle mass and bone mass and alterations in the expression of molecular markers of muscle atrophy and osteoporosis. This study suggests that CCI may serve as a valid approach to study muscle-bone crosstalk and to identify new strategies to prevent osteosarcopenia.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Physiology
Joseph J. Bass, Edward J. O. Hardy, Thomas B. Inns, Daniel J. Wilkinson, Mathew Piasecki, Robert H. Morris, Abi Spicer, Craig Sale, Ken Smith, Philip J. Atherton, Bethan E. Phillips
Summary: This study aimed to develop an experimental paradigm to investigate muscles with different susceptibility to atrophy, with the hope of uncovering central mechanisms. Results showed that after immobilization, there were differences in muscle volume and thickness between the tibialis anterior (TA) and medial gastrocnemius (MG) muscles, providing valuable insights into mechanisms of disuse atrophy.
FRONTIERS IN PHYSIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Elisa Duranti, Chiara Villa
Summary: ALS is a fatal disease characterized by the loss of motor neurons, leading to muscle damage and paralysis. Muscle research plays a crucial role in understanding the molecular mechanisms and developing treatments for this disease.
Article
Plant Sciences
Xiao-Li Li, Liang Wang, Ming-Chao He, Wen-Xiong Li, Jia-Li Zhang, Yong-Fang Fu, Yan Zhang
Summary: This study found that Gu-Shu-Kang protected male mice against dexamethasone-induced disturbance in the musculoskeletal system by enhancing muscle strength and improving bone density and osteogenesis. These findings suggest that Gu-Shu-Kang may have potential applications in the treatment of muscle atrophy and osteoporosis triggered by glucocorticoids.
PHARMACEUTICAL BIOLOGY
(2022)
Article
Multidisciplinary Sciences
Lin Liu, Hiroyuki Koike, Takehito Ono, Shinichiro Hayashi, Fujimi Kudo, Atsushi Kaneda, Hiroyuki Kagechika, Ichiro Manabe, Tomoki Nakashima, Yumiko Oishi
Summary: KLF5 is identified as a key mediator of early muscle atrophy program, regulating atrophy-related programs such as metabolic changes and proteolysis. Pharmacological intervention with Am80 can suppress muscle atrophy and its expression increases in age and sarcopenia conditions, suggesting a potential preventive treatment.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Geriatrics & Gerontology
Xiaoyan Chen, Gongxiang Liu, Siyuan Li, Xiufang Lin, Zhenli Han, Xiaoyi Hu, Jinhui Wu, Ming Yang
Summary: The different measurement protocols for handgrip strength recommended by the AWGS 2019 update significantly affect the measurement values and identification of handgrip strength asymmetry, but not handgrip strength weakness.
JOURNAL OF THE AMERICAN MEDICAL DIRECTORS ASSOCIATION
(2023)
Article
Chemistry, Multidisciplinary
Huan Liu, Dengke Pan, Pu Li, Dandan Wang, Bo Xia, Ruixin Zhang, Junfeng Lu, Xiangyang Xing, Jiaxiang Du, Xiao Zhang, Long Jin, Lin Jiang, Linong Yao, Mingzhou Li, Jiangwei Wu
Summary: A novel sepsis pig model is created by modifying the surgical strategy of cecal ligation and puncture (CLP), which for the first time recapitulates the whole course of sepsis in humans. Increased levels of ZBED6 in skeletal muscle are shown in this model and sepsis patients, and protection against sepsis-induced muscle wasting is demonstrated in ZBED6-deficient pigs. The direct target of ZBED6 is revealed to be DOCK3, and septic ZBED6-deficient pigs show increased DOCK3 expression in skeletal muscle and myocytes, activating the RAC1/PI3K/AKT pathway and protecting against sepsis-induced muscle wasting.
