Article
Nutrition & Dietetics
Mariah Kay Jackson, Laura D. Bilek, Nancy L. Waltman, Jihyun Ma, James R. Hebert, Sherry Price, Laura Graeff-Armas, Jill A. Poole, Lynn R. Mack, Didier Hans, Elizabeth R. Lyden, Corrine Hanson
Summary: Little is known about the relationship between diet and inflammation and its impact on bone health. This cross-sectional study examined the association between diet's inflammatory potential and bone-related outcomes in midwestern post-menopausal women. The results showed that there was no significant association between the inflammatory potential of diet and bone density or structure in this cohort.
Article
Nutrition & Dietetics
Sabrina Paolino, Elvis Hysa, Sabrina Atena Stoian, Emanuele Gotelli, Andrea Casabella, Paolo Vittoriano Clini, Greta Pacini, Carmen Pizzorni, Alberto Sulli, Elena Nikiphorou, Vanessa Smith, Maurizio Cutolo
Summary: Bone quantity and quality do not significantly differ between MetS+ and MetS- RA patients. However, MetS+ RA patients show higher disease activity and lower vitamin D levels. Furthermore, metabolic parameter alterations are correlated with bone quality changes, suggesting potential bone microarchitecture impairments despite unchanged BMD values.
Article
Nutrition & Dietetics
Addolorata Corrado, Cinzia Rotondo, Daniela Cici, Stefano Berardi, Francesco Paolo Cantatore
Summary: This study demonstrated that supplementation with calcifediol is more effective and faster than cholecalciferol in increasing 25(OH)D serum levels and improving muscular function in post-menopausal women. Weekly administration of cholecalciferol showed the best results in this regard.
Article
Biochemistry & Molecular Biology
Mohammed. G. A. Ansari, Abdul Khader Mohammed, Kaiser A. Wani, Syed D. Hussain, Abdullah M. Alnaami, Saba Abdi, Naji J. Aljohani, Nasser M. Al-Daghri
Summary: The study found that VDR gene variants were significantly associated with increased risk of osteoporosis in Saudi postmenopausal women, suggesting a close relationship between specific gene variations and decreased bone density leading to osteoporosis.
CURRENT ISSUES IN MOLECULAR BIOLOGY
(2021)
Article
Endocrinology & Metabolism
Gregory A. Kline, Suzanne N. Morin, Lisa M. Lix, William D. Leslie
Summary: Bone mineral density (BMD) loss shows greater variability at shorter testing intervals, but this variability diminishes over longer intervals. Using reports of rapid BMD loss as an indication for antifracture medication initiation may not be accurate.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Sport Sciences
Gersiel Nascimento de Oliveira Junior, Jairo de Freitas Rodrigues de Sousa, Marcelo Augusto da Silva Carneiro, Fernanda Maria Martins, Samarita Beraldo Santagnello, Fabio Lera Orsatti
Summary: The study indicates that resistance training in postmenopausal women can promote muscle hypertrophy and strength gains, but high-volume resistance training does not significantly improve W '. Only strength (MIVC) is a predictor of W ' improvement.
EUROPEAN JOURNAL OF SPORT SCIENCE
(2021)
Review
Physiology
Santosh Thapa, Ananya Nandy, Elizabeth Rendina-Ruedy
Summary: Osteoporosis is a common endocrinologic disorder characterized by chronic bone loss, with post-menopausal women being most affected. Gonadal sex hormones, particularly estrogen, play a crucial role in regulating bone mass, impacting bone formation and resorption, and potentially contributing to osteoporosis through alterations in bone cell metabolism potential.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Endocrinology & Metabolism
Wolfgang Kemmler, Michael Hettchen, Matthias Kohl, Marie Murphy, Laura Bragonzoni, Mikko Julin, Tapani Risto, Simon von Stengel
Summary: This study found that a 3-month interruption of supervised group exercise in adults led to significant detraining effects, especially in muscle mass and hip/leg strength. Self-reported individual outdoor activities and exercise significantly increased during the lockdown period, indicating that people have the ability to engage in physical activity at home spontaneously.
CALCIFIED TISSUE INTERNATIONAL
(2021)
Article
Dentistry, Oral Surgery & Medicine
Ronak Bhatt, Sunit Kumar Jurel, Pooran Chand, Neeti Solanki, Kaushal Kishor Agrawal, Shyam Pyari Jaiswar, Amit Arya
Summary: This study compared satisfaction levels and occlusal force with complete dentures between premenopausal and postmenopausal Indian women, showing significantly higher satisfaction and occlusal force in the premenopausal group.
JOURNAL OF PROSTHETIC DENTISTRY
(2022)
Article
Endocrinology & Metabolism
Samuel R. R. Buchanan, Ryan M. M. Miller, Michelle Nguyen, Christopher D. D. Black, J. Mikhail Kellawan, Michael G. G. Bemben, Debra A. A. Bemben
Summary: Evaluating alterations in circulating microRNA expression and its relationship with musculoskeletal health in postmenopausal women, this study found that whole-body vibration is an effective mechanical stimulus for altering c-miR-21-5p expression.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Computer Science, Interdisciplinary Applications
Firat Matur, Yekta Ulgen
Summary: This study found that a PhA measuring device could be considered as a complementary tool for osteoporosis screening in post-menopausal women, but it was not correlated with bone mineral density in obese individuals.
MEDICAL & BIOLOGICAL ENGINEERING & COMPUTING
(2023)
Article
Biochemistry & Molecular Biology
Yen-Huai Lin, Yu-Tai Shih, Michael Mu Huo Teng
Summary: The study found a significant association between osteosarcopenia and fragility fractures, especially when considering high-fracture-risk osteopenia and osteoporosis. Women with osteosarcopenia were more likely to have previously sustained a fracture compared to those without osteosarcopenia, with sarcopenia alone, and with osteoporosis alone.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Sport Sciences
Alexios Batrakoulis, Panagiotis Tsimeas, Chariklia K. Deli, Dimitrios Vlachopoulos, Esther Ubago-Guisado, Athanasios Poulios, Athanasios Chatzinikolaou, Dimitrios Draganidis, Konstantinos Papanikolaou, Kalliopi Georgakouli, Dimitrios Batsilas, Luis Gracia-Marco, Athanasios Z. Jamurtas, Ioannis Fatouros
Summary: This study found that a 10-month high-intensity interval-type neuromuscular training programme significantly improved musculoskeletal fitness in overweight and obese women, leading to changes in muscular strength, endurance, flexibility, and balance. After five months of detraining, the improvements were reduced but not completely abolished.
JOURNAL OF SPORTS SCIENCES
(2021)
Article
Endocrinology & Metabolism
Ayse Zengin, Bharati Kulkarni, Anuradha V. Khadilkar, Neha Kajale, Veena Ekbote, Nikhil Tandon, Santosh K. Bhargava, Harshpal Singh Sachdev, Shikha Sinha, David Scott, Sanjay Kinra, Caroline H. D. Fall, Peter R. Ebeling
Summary: This study aimed to determine the prevalence of sarcopenia in adults from India and explore muscle-bone relationships. The results showed that Indian-specific cut-points were lower than existing definitions, emphasizing the necessity of appropriate cut-points for accurate sarcopenia assessment in ethnic populations. Sex differences in associations between muscle variables and areal bone mineral density were also observed, with greater positive associations in women than in men.
CALCIFIED TISSUE INTERNATIONAL
(2021)
Article
Geriatrics & Gerontology
Geise Ferreira da Cruz, Tatiana Mion Lunz, Tatielle Rocha de Jesus, Mariana Braga Costa, Camila Vilarinho Vidigal, Ben-Hur Albergaria, Jose Luiz Marques-Rocha, Valdete Regina Guandalini
Summary: This study verified the association between appendicular skeletal muscle mass index (ASMI) and various variables in postmenopausal women. The results showed that ASMI was associated with BMI and muscle mass reserve indicators such as calf circumference and adductor pollicis muscle thickness (APMT). These findings suggest that simple and low-cost measures can be used to predict and track the risk of skeletal muscle mass depletion and sarcopenia.
Article
Medicine, General & Internal
M. Katsoulis, V. Benetou, T. Karapetyan, D. Feskanich, F. Grodstein, U. Pettersson-Kymmer, S. Eriksson, T. Wilsgaard, L. Jorgensen, L. A. Ahmed, B. Schoettker, H. Brenner, A. Bellavia, A. Wolk, R. Kubinova, B. Stegeman, M. Bobak, P. Boffetta, A. Trichopoulou
JOURNAL OF INTERNAL MEDICINE
(2017)
Article
Endocrinology & Metabolism
V. Benetou, P. Orfanos, D. Feskanich, K. Michaelsson, U. Pettersson-Kymmer, L. Byberg, S. Eriksson, F. Grodstein, A. Wolk, N. Jankovic, L. C. P. G. M. de Groot, P. Boffetta, A. Trichopoulou
OSTEOPOROSIS INTERNATIONAL
(2018)
Correction
Genetics & Heredity
Paul J. Leo, Margaret M. Madeleine, Sophia Wang, Stephen M. Schwartz, Felicity Newell, Ulrika Pettersson-Kymmer, Kari Hemminki, Goran Hallmans, Sven Tiews, Winfried Steinberg, Janet S. Rader, Felipe Castro, Mahboobeh Safaeian, Eduardo L. Franco, Francois Coutlee, Claes Ohlsson, Adrian Cortes, Mhairi Marshall, Pamela Mukhopadhyay, Katie Cremin, Lisa G. Johnson, Cornelia L. Trimble, Suzanne Garland, Sepehr N. Tabrizi, Nicolas Wentzensen, Freddy Sitas, Julian Little, Maggie Cruickshank, Ian H. Frazer, Allan Hildesheim, Matthew A. Brown
Article
Immunology
Xiao Bao, Aimee L. Hanson, Margaret M. Madeleine, Sophia S. Wang, Stephen M. Schwartz, Felicity Newell, Ulrika Pettersson-Kymmer, Kari Hemminki, Sven Tiews, Winfried Steinberg, Janet S. Rader, Felipe Castro, Mahboobeh Safaeian, Eduardo L. Franco, Francois Coutlee, Claes Ohlsson, Adrian Cortes, Mhairi Marshall, Pamela Mukhopadhyay, Katie Cremin, Lisa G. Johnson, Suzanne M. Garland, Sepehr N. Tabrizi, Nicolas Wentzensen, Freddy Sitas, Cornelia Trimble, Julian Little, Maggie Cruickshank, Ian H. Frazer, Allan Hildesheim, Matthew A. Brown, Emma L. Duncan, YingPu Sun, Paul J. Leo
JOURNAL OF INFECTIOUS DISEASES
(2018)
Article
Medicine, General & Internal
Katerina Trajanoska, John A. Morris, Ling Oei, Hou-Feng Zheng, David M. Evans, Douglas P. Kiel, Claes Ohlsson, J. Brent Richards, Fernando Rivadeneira
BMJ-BRITISH MEDICAL JOURNAL
(2018)
Article
Endocrinology & Metabolism
Denis A. Baird, Daniel S. Evans, Frederick K. Kamanu, Jennifer S. Gregory, Fiona R. Saunders, Claudiu V. Giuraniuc, Rebecca J. Barr, Richard M. Aspden, Deborah Jenkins, Douglas P. Kiel, Eric S. Orwoll, Steven R. Cummings, Nancy E. Lane, Benjamin H. Mullin, Frances M. K. Williams, J. Brent Richards, Scott G. Wilson, Tim D. Spector, Benjamin G. Faber, Deborah A. Lawlor, Elin Grundberg, Claes Ohlsson, Ulrika Pettersson-Kymmer, Terence D. Capellini, Daniel Richard, Thomas J. Beck, David M. Evans, Lavinia Paternoster, David Karasik, Jonathan H. Tobias
JOURNAL OF BONE AND MINERAL RESEARCH
(2019)
Letter
Oncology
Hauke Thomsen, Subhayan Chattopadhyay, Niels Weinhold, Pavel Vodicka, Ludmila Vodickova, Per Hoffmann, Markus M. Noethen, Karl-Heinz Joeckel, Christian Langer, Roman Hajek, Goeran Hallmans, Ulrika Pettersson-Kymmer, Claes Ohlsson, Florentin Spaeth, Richard Houlston, Hartmut Goldschmidt, Kari Hemminki, Asta Foersti
Letter
Oncology
Subhayan Chattopadhyay, Hauke Thomsen, Niels Weinhold, Iman Meziane, Stefanie Huhn, Miguel Inacio da Silva Filho, Pavel Vodicka, Ludmila Vodickova, Per Hoffmann, Markus M. Noethen, Karl-Heinz Joeckel, Boerge Schmidt, Stefano Landi, Roman Hajek, Goeran Hallmans, Ulrika Pettersson-Kymmer, Claes Ohlsson, Paolo Milani, Giampaolo Merlini, Dorota Rowcieno, Philip Hawkins, Ute Hegenbart, Giovanni Palladini, Ashutosh Wechalekar, Stefan O. Schoenland, Richard Houlston, Hartmut Goldschmidt, Kari Hemminki, Asta Foersti
Article
Endocrinology & Metabolism
Maria Nethander, Ulrika Pettersson-Kymmer, Liesbeth Vandenput, Mattias Lorentzon, Magnus Karlsson, Dan Mellstrom, Claes Ohlsson
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2020)
Article
Endocrinology & Metabolism
Monika Frysz, Denis Baird, Jenny S. Gregory, Richard M. Aspden, Nancy E. Lane, Claes Ohlsson, Ulrika Pettersson-Kymmer, David Karasik, Jonathan H. Tobias, Lavinia Paternoster
Summary: The study found that genetic variants associated with adolescent hip shape are also related to adult hip shape, involving endochondral bone formation, and may influence the risk of hip osteoarthritis and hip fracture.
Letter
Oncology
Alyssa Clay-Gilmour, Subhayan Chattopadhyay, Michelle A. T. Hildebrandt, Hauke Thomsen, Niels Weinhold, Pavel Vodicka, Ludmila Vodickova, Per Hoffmann, Markus M. Nothen, Karl-Heinz Jockel, Borge Schmidt, Christian Langer, Roman Hajek, Goran Hallmans, Ulrika Pettersson-Kymmer, Claes Ohlsson, Florentin Spath, Richard Houlston, Hartmut Goldschmidt, Elisabet E. Manasanch, Aaron Norman, Shaji Kumar, S. Vincent Rajkumar, Susan Slager, Asta Forsti, Celine M. Vachon, Kari Hemminki
BLOOD CANCER JOURNAL
(2022)
Article
Genetics & Heredity
Yiheng Chen, Tianyuan Lu, Ulrika Pettersson-Kymmer, Isobel D. Stewart, Guillaume Butler-Laporte, Tomoko Nakanishi, Agustin Cerani, Kevin Y. H. Liang, Satoshi Yoshiji, Julian Daniel Sunday Willett, Chen-Yang Su, Parminder Raina, Celia M. T. Greenwood, Yossi Farjoun, Vincenzo Forgetta, Claudia Langenberg, Sirui Zhou, Claes Ohlsson, J. Brent Richards
Summary: Through genome-wide association studies, this study identified associations between 690 metabolites and 248 loci, as well as associations between 143 metabolite ratios and 69 loci. The integration of metabolite-gene and gene expression information revealed 94 effector genes for 109 metabolites and 48 metabolite ratios. The use of Mendelian randomization identified 22 metabolites and 20 metabolite ratios with estimated causal effects on 12 traits and diseases.
Article
Endocrinology & Metabolism
Louise Grahnemo, Anna L. Eriksson, Maria Nethander, Robert Johansson, Mattias Lorentzon, Dan Mellstroem, Ulrika Pettersson-Kymmer, Claes Ohlsson
Summary: This study found a robust association between circulating valine and hip fractures, which was confirmed in a replication study. Further analysis showed that high circulating valine levels were associated with increased cortical bone area and trabecular thickness. Therefore, circulating valine may be an important marker for predicting hip fractures.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Cell Biology
Maria Nethander, Eivind Coward, Ene Reimann, Louise Grahnemo, Maiken E. Gabrielsen, Carl Wibom, Reedik Magi, Thomas Funck-Brentano, Mari Hoff, Arnulf Langhammer, Ulrika Pettersson-Kymmer, Kristian Hveem, Claes Ohlsson
Summary: A large-scale study using five European biobank cohorts identified five genetic signals associated with hip fractures, with one signal related to falls and four signals involved in bone biology. Mendelian randomization analyses showed that decreased femoral neck bone mineral density (BMD), Alzheimer's disease, and regular smoking had causal effects on the risk of hip fractures. The strong causal effect of decreased femoral neck BMD on hip fractures supports its use as a surrogate outcome in clinical trials.
CELL REPORTS MEDICINE
(2022)
Article
Public, Environmental & Occupational Health
Nikos Papadimitriou, Konstantinos K. Tsilidis, Philippos Orfanos, Vassiliki Benetou, Evangelia E. Ntzani, Isabelle Soerjomataram, Annemarie Kuenn-Nelen, Ulrika Pettersson-Kymmer, Sture Eriksson, Hermann Brenner, Ben Schoettker, Kai-Uwe Saum, Bernd Holleczek, Francine D. Grodstein, Diane Feskanich, Nicola Orsini, Alicja Wolk, Andrea Bellavia, Tom Wilsgaard, Lone Jorgensen, Paolo Boffetta, Dimitrios Trichopoulos, Antonia Trichopoulou
LANCET PUBLIC HEALTH
(2017)