Review
Biology
Wenwen Zeng, Fan Yang, Wei L. Shen, Cheng Zhan, Peng Zheng, Ji Hu
Summary: According to Descartes, minds and bodies cannot interact causally, but in neuroscience, there is growing evidence of the bidirectional interaction between the brain and peripheral organs. This interaction plays a crucial role in regulating various bodily functions and is associated with disorders like anxiety and neurodegenerative diseases.
SCIENCE CHINA-LIFE SCIENCES
(2022)
Review
Neurosciences
Jessica L. Mueller, Rhian Stavely, Ryo Hotta, Allan M. Goldstein
Summary: With the increasing prevalence of neurological disorders in an aging population, there is a critical need to better understand exogenous strategies for nervous system repair. Stem cell therapy offers a promising approach, but is limited by various factors. Researchers propose the use of autologous cells derived from the peripheral nervous system as an alternative source for CNS repair, which has shown neurogenic potential and eliminates concerns around tumorigenic risk, ethical considerations, and immune-mediated rejection.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Clinical Neurology
Simon Rinaldi, Alexander Davies, Janev Fehmi, Heidi N. Beadnall, Justine Wang, Todd A. Hardy, Michael H. Barnett, Simon A. Broadley, Patrick Waters, Stephen W. Reddel, Sarosh R. Irani, Fabienne Brilot, Russell C. Dale, Sudarshini Ramanathan
Summary: Antibodies to myelin oligodendrocyte glycoprotein (MOG) are associated with CNS demyelination including optic neuritis and transverse myelitis. The study of an Australasian MOGAD cohort revealed a subgroup possibly mediated by coexistent autoantibodies, presenting with myeloradiculitis, combined central and peripheral demyelination syndromes, and inflammatory neuropathies, being responsive to immunotherapy.
NEUROLOGY-NEUROIMMUNOLOGY & NEUROINFLAMMATION
(2021)
Article
Multidisciplinary Sciences
Han Su, Ning Liu, Yalin Zhang, Juan Kong
Summary: This study demonstrates that vitamin D may impact energy homeostasis in the central nervous system by modulating the renin-angiotensin system activity. In Cyp27b1(-/-) mice, enhanced RAS activity led to increased metabolic rate, while in the VD-treated group, there was a slightly inhibited metabolic rate due to reduced RAS and sympathetic nerve activities.
JOURNAL OF ADVANCED RESEARCH
(2021)
Review
Medicine, Research & Experimental
Yueshan Pang, Juan Xiong, You Wu, Weijun Ding
Summary: Nobiletin, a compound with high fat solubility, high bioavailability, and low toxicity, has been extensively studied for its various biological functions in the nervous system. It has shown positive effects in inhibiting inflammatory factor expression, promoting nerve cell survival and axon growth. Additionally, nobiletin has been found to protect the enteric nervous system, spinal cord, and sciatic nerve.
EUROPEAN JOURNAL OF MEDICAL RESEARCH
(2023)
Article
Neurosciences
Rita Moretti, Mauro Giuffre, Nicola Merli, Paola Caruso, Stefano Di Bella, Claudio Tiribelli, Lory Saveria Croce
Summary: HCV, known for its hepatotropic effects, is also associated with systemic disorders affecting the neurological and psychiatric systems. The direct or indirect effects of HCV on the brain, possibly mediated by alterations in the blood-brain barrier, require further study for a better understanding.
Article
Developmental Biology
Aliia Murtazina, Igor Adameyko
Summary: The peripheral nervous system is a heterogeneous system with diverse functions, including communication between the brain and the body, control of development and regeneration. It can be divided into sensory, motor, autonomic and enteric domains. Recent advances in single-cell transcriptomics have revealed new neuronal subtypes and improved cell-type classifications. This article discusses the roles, origin and heterogeneity of the peripheral nervous system, highlighting recent discoveries and future perspectives.
Article
Immunology
Zhiguang Lin, Jingjing Ma, Yan Ma, Qing Li, Hui Kang, Mengxue Zhang, Bobin Chen, Rong Xia
Summary: Circulating NK cells have a prognostic impact on primary central nervous system lymphoma (PCNSL). Patients with higher counts and proportions of NK cells have better prognosis, and the changes in NK cell counts before and after chemotherapy are also associated with prognosis. Higher NK cell counts are associated with longer overall survival, while higher fold changes in NK cell proportions and counts are associated with longer progression-free survival.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Cardiac & Cardiovascular Systems
Guido Grassi, Giuseppe Mancia, Murray Esler
Summary: The overdrive of the sympathetic nervous system in heart failure has been reported for over half a century. Recent advancements in methodological approaches have provided a better understanding of various aspects of neuroadrenergic alterations, including regional differences, the role of the central nervous system, and the involvement of reflex mechanisms. Additionally, the impact of sympathetic activation on cardiovascular organs and potential therapeutic interventions have been highlighted.
CARDIOVASCULAR RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
In K. Cho, Faye Clever, Gordon Hong, Anthony W. S. Chan
Summary: Huntington's Disease (HD) is an incurable autosomal dominant disease characterized by severe neurodegeneration. The expansion of CAG trinucleotide repeat on the Huntingtin gene (HTT) is responsible for the disease. Our study focused on tissue-specific CAG repeat instability in transgenic nonhuman primate models of HD, and found a correlation between CAG repeat expansion and symptom severity and tissue susceptibility. Additionally, we observed a correlation between CAG repeat expansion and the expression profile of certain genes.
Article
Environmental Sciences
Marina Bellot, Helena Bartolome, Melissa Faria, Cristian Gomez-Canela, Demetrio Raldua
Summary: The study found significant changes in the levels of ten monoaminergic neurotransmitters in the head, trunk, and whole body of zebrafish larvae after treatment with 5 M deprenyl. While most monoaminergic neurochemicals were higher in the head than in the trunk in control larvae, deprenyl treatment resulted in changes with serotonin and norepinephrine increasing in both the head and trunk, and dopamine, L-DOPA, and homovanillic acid levels being modulated only in the head. Notably, the highly significant increase in dopamine levels observed in the head after deprenyl treatment was not detected in the whole-body analysis, indicating that the analysis of neurotransmitters in the whole body of zebrafish larvae should not be used as a general surrogate of the brain.
Review
Biochemistry & Molecular Biology
Jae-Min Lee, You Jung Choi, Myung Chul Yoo, Seung Geun Yeo
Summary: Peripheral facial nerve injury causes changes in neuroactive substances that affect nerve cell damage, survival, growth, and regeneration. This review explores the biomolecules involved in peripheral facial nerve damage and their impact on the central nervous system (CNS), aiming to identify potential strategies for treating facial nerve injury and functional recovery. By identifying the biomolecules in the CNS that change after peripheral nerve damage, this review could contribute to the development of effective treatment strategies for peripheral facial palsy.
Review
Agriculture, Dairy & Animal Science
Niccolo Fonti, Francesca Parisi, Cagla Aytas, Sara Degl'Innocenti, Carlo Cantile
Summary: This study retrospectively analyzed 92 cases of NSL in dogs and cats, summarizing their characteristics and comparing the results with previous studies. The occurrence of NSL was similar in both species, and nine pathological patterns were identified. Additionally, this study described for the first time the occurrence of lymphomatosis cerebri in a dog.
Review
Clinical Neurology
Gelsomina Mansueto, Giuseppe Lanza, Francesco Fisicaro, Danielle Alaouieh, Emily Hong, Sara Girolami, Marco Montella, Alessandro Feola, Mario Di Napoli
Summary: This review provides a comprehensive update on the clinical assessment, diagnosis, complications, and treatment of PCNSV. Recent developments and advances in technology have improved diagnostic accuracy and provided new insights for preventing misdiagnosis. However, treatment for PCNSV remains largely empirical.
CURRENT NEUROLOGY AND NEUROSCIENCE REPORTS
(2022)
Review
Chemistry, Inorganic & Nuclear
Ke Chen, Si Sun, Junying Wang, Xiao-Dong Zhang
Summary: The central nervous system is crucial for human health, and the treatment of CNS diseases is essential. Artificial enzymes offer high stability and catalytic activity, showing great potential for treating neuroinflammation and other disorders.
COORDINATION CHEMISTRY REVIEWS
(2021)
Article
Public, Environmental & Occupational Health
A. Justine Dowd, Liam Kronlund, Cassandra Warbeck, Candice Parmar, Julia T. Daun, Kathryn Wytsma-Fisher, Raylene A. Reimer, Guillaume Millet, Tak Fung, S. Nicole Culos-Reed
Summary: The pilot MOVE-C study showed that a 12-week HIIT plus lifestyle education program can significantly improve quality of life, exercise behavior, gastrointestinal symptoms, and self-compassion among inactive adults with coeliac disease. This intervention also resulted in significant improvements in adherence to a gluten-free diet for all participants.
PSYCHOLOGY & HEALTH
(2022)
Article
Physiology
Rafael de Almeida Azevedo, Daniel A. Keir, Jonas Forot, Danilo Iannetta, Guillaume Y. Millet, Juan M. Murias
Summary: This study investigates the relationship between the development of slow component of oxygen uptake and muscle fatigue, finding that they are correlated in a time- and intensity-dependent manner. The results suggest that the slow component of oxygen uptake may depend on muscle fatigue, even if the mechanisms of reduced contractile function differ among intensities.
Article
Sport Sciences
Arash Khassetarash, Michael Baggaley, Gianluca Vernillo, Guillaume Y. Millet, W. Brent Edwards
Summary: The repeated bout effect influences lower-extremity biomechanics during downhill running, possibly related to strength loss and muscle pain.
EUROPEAN JOURNAL OF SPORT SCIENCE
(2023)
Article
Sport Sciences
Robin Trama, Yoann Blache, Frederique Hintzy, Jeremy Rossi, Guillaume Y. Millet, Christophe Hautier
Summary: The purpose of this study was to assess the impact of mountain ultramarathons on foot-ground impact and soft tissue vibrations. The results showed that only the soft tissue vibrations of the vastus lateralis muscle were affected after mountain trail running races, regardless of the running distance.
EUROPEAN JOURNAL OF SPORT SCIENCE
(2023)
Review
Sport Sciences
Marie-Caroline Play, Robin Trama, Guillaume Y. Millet, Christophe Hautier, Marlene Giandolini, Jeremy Rossi
Summary: This narrative review provides an overview of soft tissue vibrations (STV) during running, including their characteristics, quantification methods, and influencing factors. The literature employs various parameters to characterize STV, but time-frequency approaches should be used to better assess neuromuscular adaptations. Compression apparels appear to effectively reduce STV, while the effects of footwear are varied and individual. Fatigue increases vibration amplitude, but further studies are needed to examine prolonged running and neuromuscular fatigue.
SPORTS MEDICINE-OPEN
(2022)
Article
Physiology
Titouan P. Perrin, Jeremy Rossi, Hugo A. Kerherve, Guillaume Y. Millet
Summary: The study aimed to investigate the effect of longitudinal bending stiffness (LBS) on energy cost of uphill running. Twenty well-trained male runners participated in the study and it was found that LBS did not have a significant effect on the energy cost of uphill running. However, there was a large interindividual variability in response to LBS changes, suggesting that increasing shoe LBS may be beneficial for certain runners.
INTERNATIONAL JOURNAL OF SPORTS PHYSIOLOGY AND PERFORMANCE
(2023)
Article
Neurosciences
Giorgio Varesco, Thomas Lapole, Nicolas Royer, Benjamin Singh, Audrey Parent, Leonard Feasson, Guillaume Y. Millet, Vianney Rozand
Summary: In this study, the researchers aimed to compare the fatigability of knee extensors following isometric and concentric tasks. They found that despite greater torque-time integral and duration for isometric contraction, both isometric and concentric tasks induced a similar performance fatigability at exhaustion. However, contractile function was more altered in the concentric task. Additionally, the study found that sex-related differences in fatigability depended on the contraction mode used during testing.
JOURNAL OF ELECTROMYOGRAPHY AND KINESIOLOGY
(2022)
Article
Physiology
Loic Espeit, Thomas Lapole, Guillaume Y. Millet, Vianney Rozand, Nicola A. Maffiuletti
Summary: The study compared the maximal evocable torque (MET) between conventional and wide-pulse neuromuscular electrical stimulation (NMES) at two different frequencies. The results showed that wide-pulse protocols led to greater MET and lower maximal tolerable current intensity compared to conventional NMES.
EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY
(2023)
Article
Physiology
Frederic Sabater-Pastor, Katja Tomazin, Gregoire P. Millet, Julien Verney, Leonard Feasson, Guillaume Y. Millet
Summary: This study aimed to determine the physiological predictors of performance in a 166-km trail-running race. The results showed that VO(2)max and velocity at VO(2)max are significant predictors of performance in this race, suggesting that ultratrail runners should focus on developing these qualities to optimize their performance.
INTERNATIONAL JOURNAL OF SPORTS PHYSIOLOGY AND PERFORMANCE
(2023)
Article
Sport Sciences
Loic Espeit, Eric Luneau, Callum G. Brownstein, Julien Gondin, Guillaume Y. Millet, Vianney Rozand, Nicola A. Maffiuletti, Thomas Lapole
Summary: Comparing conventional and wide-pulse NMES, the study found no significant difference in evoked torque. All NMES protocols induced objective fatigability and peripheral alterations, but had no effect on CNS excitability. The results suggest that the chronic effects and treatment effectiveness of conventional and wide-pulse NMES may be comparable.
SCANDINAVIAN JOURNAL OF MEDICINE & SCIENCE IN SPORTS
(2023)
Article
Sport Sciences
Franck Le Mat, Mathias Gery, Thibault Besson, Cyril Ferdynus, Nicolas Bouscaren, Guillaume Y. Millet
Summary: By analyzing a large dataset of trail running races, this study shows that the gap in endurance performance between men and women decreases as the distance increases. It also reveals that the difference in endurance between sexes is smaller among top performers.
Article
Physiology
Rafael de Almeida Azevedo, Pablo R. Fleitas-Paniagua, Mackenzie Trpcic, Danilo Iannetta, Guillaume Y. Millet, Juan M. Murias
Summary: The aim of this study is to investigate the effects of different ramp-incremental (RI) slopes on fatigability and recovery in females and males. The results showed that gender had no significant effect on performance fatigability and recovery, and different RI slopes did not alter the level of performance fatigability at task failure.
JOURNAL OF APPLIED PHYSIOLOGY
(2023)
Review
Sport Sciences
Nicolas J. A. Berger, Russ Best, Andrew W. Best, Andrew M. Lane, Guillaume Y. Millet, Martin Barwood, Samuele Marcora, Patrick Wilson, Shawn Bearden
Summary: This paper reviews the major limitations in ultra-endurance running (UER) and discusses factors such as thermoregulation, oxygen delivery and utilization, running economy and biomechanics, fatigue, digestive system, and psychology. It provides guidance and suggestions for practitioners and future research in these areas.
Article
Sport Sciences
Thibault Besson, Frederic Sabater Pastor, Giorgio Varesco, Marilyne Berthet, Djahid Kennouche, Pierre-Eddy Dandrieux, Jeremy Rossi, Guillaume Y. Millet
Summary: This study aimed to compare the differences in running economy, biomechanics, strength, and power between elite and experienced trail runners. The results showed that elite runners had better running economy and enhanced lower-limb muscle strength and velocity. These findings suggest that strength training can improve trail running performance.
JOURNAL OF STRENGTH AND CONDITIONING RESEARCH
(2023)
Article
Physiology
Frederic Sabater-Pastor, Katja Tomazin, Gregoire P. Millet, Julien Verney, Leonard Feasson, Guillaume Y. Millet
Summary: This study found that VO(2)max and velocity at VO(2)max are significant predictors of performance in a 166-km trail-running race. Therefore, ultratrail runners should focus on developing these two qualities to optimize their race performance.
INTERNATIONAL JOURNAL OF SPORTS PHYSIOLOGY AND PERFORMANCE
(2023)
