Article
Pediatrics
Ryan M. Hanson, Amy J. Wagner
Summary: Severe, complicated Clostridium difficile colitis is rare in pediatric patients and little is known about its medical and surgical management in this population. A case report of a 15-year-old female patient with severe, complicated C difficile colitis successfully treated with diverting loop ileostomy and colonic lavage is presented. This approach, instead of subtotal colectomy and end ileostomy, should be considered as an alternative for pediatric patients with severe, complicated C difficile colitis.
Article
Immunology
Yuan-Pin Hung, Jen-Chieh Lee, Bo-Yang Tsai, Jia-Ling Wu, Hsiao-Chieh Liu, Hsiu-Chuan Liu, Hsiao-Ju Lin, Pei-Jane Tsai, Wen-Chien Ko
Summary: The risk factors of Clostridium difficile-associated diarrhea (CDAD) vary among hospitalized patients with different lengths of hospital stay. Malignancy, prior cephalosporin, and proton pump inhibitor therapy are independent risk factors for CDAD. Intervention strategies for preventing CDAD may need to be tailored based on the duration of hospital stay.
JOURNAL OF MICROBIOLOGY IMMUNOLOGY AND INFECTION
(2021)
Article
Pathology
Sicilia Perumalsamy, Su Chen Lim, Thomas Riley
Summary: Less is known about Clostridioides difficile infection (CDI) in children compared to adults, and the rising incidence of CDI in hospitalized pediatric patients, emergence of hypervirulent strains and community-associated CDI (CA-CDI) in the past decade pose a potential threat. This study in a tertiary hospital in Perth, Western Australia, characterized C. difficile isolates from pediatric patients and found various ribotypes and toxin gene profiles. The study provides a baseline for future surveillance of pediatric CDI in Australia.
Article
Microbiology
Jessica M. Chisholm, Papanin Putsathit, Thomas V. Riley, Su-Chen Lim
Summary: This study reveals the common presence of toxigenic Clostridium difficile in wastewater treatment plants (WWTPs) in Western Australia, which are being released into the environment and becoming a potential source/reservoir for community-associated C. difficile infection (CA-CDI).
MICROBIOLOGY SPECTRUM
(2023)
Article
Food Science & Technology
Parvin Ghorbani Filabadi, Ebrahim Rahimi, Amir Shakerian, Zahra Esfandiari
Summary: This study identified the prevalence and genetic diversities of Clostridium difficile contamination in meat nuggets in Isfahan, Iran. Out of 600 food samples, 7 C. difficile strains were found, with a prevalence of 1.17%. The isolated strains were found to be toxigenic and resistant to antibiotics, except for vancomycin. The absence of the tcdC gene in the genome of all isolates may be due to a mutation.
JOURNAL OF FOOD QUALITY
(2022)
Review
Microbiology
Wiep Klaas Smits, Anna Maria Roseboom, Jeroen Corver
Summary: Plasmids are common in the enteropathogen Clostridioides difficile and may encode functions relevant to pathogenesis, such as antimicrobial resistance and toxin production.
CURRENT OPINION IN MICROBIOLOGY
(2022)
Review
Multidisciplinary Sciences
Tebelay Dilnessa, Alem Getaneh, Workagegnehu Hailu, Feleke Moges, Baye Gelaw
Summary: A high prevalence of C. difficile was observed among hospitalized patients, emphasizing the need for attention and prevention. The resistance of C. difficile to metronidazole and vancomycin was lower compared to other antibiotics.
Article
Biotechnology & Applied Microbiology
Jianfeng Wang, Chu Yang, Chao Zhang, Xiaoyan Mao, An Lizhe
Summary: In this study, the genome of Clostridium difficile was studied using metagenomic technology, revealing its gene sequence information and potential toxicological genes. Through gene function analysis and pathogenicity analysis, the metabolism activity, catalytic activity, carbohydrate-active enzyme genes and other aspects of the bacterium were understood, and an assessment was made on its virulence genes.
Article
Critical Care Medicine
Christian A. Gonzalez, Noelle L. Van Rysselberghe, Clayton Maschhoff, Michael J. Gardner
Summary: This study utilized a large national database to investigate the incidence and risk factors of Clostridium difficile (C. diff) infection in patients with lower extremity fractures. The results showed that C. diff infection was associated with increased mortality, readmission, and length of hospital stay compared to patients without C. diff infection.
INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED
(2022)
Article
Urology & Nephrology
Anna Giuliani, Silvia Lerco, Sabrina Milan Manani, Matteo Marcello, Ilaria Tantillo, Roberto Nicolin, Claudio Ronco, Monica Zanella
Summary: Peritoneal dialysis (PD) associated peritonitis is a common complication leading to discontinuation of PD. Clostridium difficile colitis is a frequent healthcare-associated infection in patients with end-stage kidney disease. PD patients with Clostridium difficile infection (CDI) present a challenging scenario for antibiotic treatment strategy as broad-spectrum antibiotics may worsen CDI-related colitis, while discontinuation of antibiotic therapy may worsen peritonitis.
PERITONEAL DIALYSIS INTERNATIONAL
(2023)
Review
Microbiology
Marta Mattana, Riccardo Tomasello, Claudia Cammarata, Paola Di Carlo, Teresa Fasciana, Giulio Giordano, Alessandro Lucchesi, Sergio Siragusa, Mariasanta Napolitano
Summary: This review analyzed the correlation between coagulation complications related to C. difficile infection and inflammasome activation, particularly the pyrin-dependent one. The evidence suggests that inflammasome activation increases the risk of venous thromboembolism, and inhibition of molecules involved in coagulation activation could block this process. It may be possible to reduce complications and mortality associated with C. difficile infection by reducing inflammatory activity and preventing thromboembolic complications.
Review
Medicine, General & Internal
Ibrahim A. Al-Zahrani
Summary: Clostridioides difficile (C. difficile) infection is a global threat to many healthcare settings. Excessive use of antimicrobials, lack of optimal antibiotic policies, and suboptimal infection control practices have fueled the development of this health issue. Prudent use of antimicrobials and simple infection control measures can significantly reduce infection rates.
SAUDI MEDICAL JOURNAL
(2023)
Article
Multidisciplinary Sciences
Srijita Basak, Debashrito Deb, Utkarsh Narsaria, Tamalika Kar, Filippo Castiglione, Indraneel Sanyal, Pratap D. Bade, Anurag P. Srivastava
Summary: Clostridium difficile infection is a major health-associated infection with high incidence and mortality rates. A chimeric vaccine candidate was designed using immunoinformatics, which showed stability and reliability in silico and molecular dynamics simulations. Docking studies demonstrated stable interactions with immune receptors, and in silico modeling indicated competent expression in E. coli system for potential immune response.
SCIENTIFIC REPORTS
(2021)
Article
Biotechnology & Applied Microbiology
Peng An Khun, Long Duc Phi, Huong Thi Thu Bui, Nguyen Thi Bui, Quyen Thi Huyen Vu, Luong Duy Trinh, Deirdre A. Collins, Thomas Riley
Summary: This study investigated the prevalence, molecular type, and antimicrobial susceptibility of Clostridioides difficile in the environment in Vietnam. It found that the overall contamination rate of C. difficile was 24.5%, with the highest prevalence in pig farm and hospital soils. C. difficile was also found in pig feces and potato surfaces. These findings highlight the importance of environmental sources in the epidemiology of C. difficile infection in Vietnam.
JOURNAL OF APPLIED MICROBIOLOGY
(2023)
Article
Nanoscience & Nanotechnology
Jiuxing Li, Jimmy Gu, Hongfen Zhang, Rudi Liu, Wenqing Zhang, Mostafa Mohammed-Elsabagh, Jianrun Xia, Devon Morrison, Sandy Zakaria, Dingran Chang, Amjad Arrabi, Yingfu Li
Summary: A highly specific DNA aptamer for RNase H2 from Clostridium difficile was developed through SELEX, demonstrating its potential for diagnostic tests and drug development.
ACS APPLIED MATERIALS & INTERFACES
(2021)