Article
Biotechnology & Applied Microbiology
Yue Ke, Yu Ye, Jintao Wu, Yanxia Ma, Yuxin Fang, Fei Jiang, Jinhua Yu
Summary: A phosphoserine-loaded chitosan membrane was synthesized to improve the osteogenic effect of chitosan membranes. The incorporation of phosphoserine into chitosan membranes was confirmed and the phosphoserine-chitosan membranes significantly stimulated bone regeneration.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Review
Cell Biology
Dimitrios Agas, Maria Giovanna Sabbieti
Summary: The bone marrow landscape is comprised of specialized and stem/progenitor cells that coordinate tissue-related and physiological features. Understanding the intramural relationships between different cell populations within specific anatomical niches is crucial for orchestrating cell behavior and hierarchies in bone marrow populations. Autophagy plays a key role in maintaining bone marrow homeostasis through coordinating the activity of stem and mature cells.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Article
Cell & Tissue Engineering
Juanli Dang, Jizhong Yang, Zhou Yu, Lin Chen, Zhaoxiang Zhang, Kai Wang, Jiezhang Tang, Chenggang Yi
Summary: In this study, it was found that bone marrow mesenchymal stem cells (BM-MSC) improved fat graft retention by enhancing angiogenesis and regulating macrophage polarization. These results help elucidate the role of BM-MSC in fat grafting.
STEM CELL RESEARCH & THERAPY
(2022)
Article
Biochemistry & Molecular Biology
Zhongliu Cao, Yanfeng Wu, Lingling Yu, Lingfeng Zou, Liu Yang, Sijian Lin, Jue Wang, Zhen Yuan, Jianghua Dai
Summary: This study demonstrates that mDC-Exo promotes osteogenic differentiation of BM-MSCs and enhances BM-MSCs-mediated bone regeneration through the transfer of miR-335.
MOLECULAR MEDICINE
(2021)
Article
Engineering, Biomedical
Jiang-Shan Gong, Guo-Qiang Zhu, Yu Zhang, Bei Chen, Yi-Wei Liu, Hong-Ming Li, Ze-Hui He, Jing-Tao Zou, Yu-Xuan Qian, Sheng Zhu, Xin-Yue Hu, Shan-Shan Rao, Jia Cao, Hui Xie, Zhen-Xing Wang, Wei Du
Summary: This study developed a novel BMSC-aptamer functionalized hydrogel and demonstrated its effectiveness in recruiting BMSCs and promoting bone regeneration.
MATERIALS TODAY BIO
(2023)
Article
Biochemistry & Molecular Biology
Hui Hu, Xiaowei Hu, Lin Li, Yan Fang, Yan Yang, Jingjing Gu, Jiadong Xu, Lisheng Chu
Summary: Exosomes derived from bone mesenchymal stem cells (BMSC-Exos) can promote angiogenesis and improve neurological functions in ischemic stroke mice via upregulation of miR-21-5p. In vitro experiments show that BMSC-Exos also enhance the functions of human umbilical vein endothelial cells (HUVECs).
Article
Cell Biology
Lili Chang, He Gao, Li Wang, Ning Wang, Shumei Zhang, Xiaona Zhou, Huijun Yang
Summary: The study found that miR-1228 is highly expressed in serum exosomes of gastric cancer patients, and up-regulation of miR-1228 can down-regulate MMP-14 expression, effectively hindering the development of gastric cancer.
Article
Biochemistry & Molecular Biology
Malini Rethnam, Darren Qiancheng Tan, Toshio Suda
Summary: Multiple myeloma (MM) has been shown to modulate mesenchymal stem cells (MSCs) and tissue inhibitor of matrix metalloproteinase 1 (TIMP-1) plays a role in preventing MM cell migration. The study highlights the previously unreported role of the TAB1-TIMP-1 axis in the context of the MM bone marrow niche.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Cell & Tissue Engineering
Xinxin Zhang, Xiaorui Jiang, Shan Jiang, Xiyu Cai, Shengji Yu, Guoxian Pei
Summary: This study demonstrated that sensory nerve fibers can promote osteogenesis of tissue-engineered bone grafts (TEBGs) by influencing vascularization and provided cytological evidence for the neurotization of TEBGs.
STEM CELL RESEARCH & THERAPY
(2021)
Article
Biotechnology & Applied Microbiology
Yuxin Zhang, Tianchang Wang, Dahe Zhang, Jiayi Li, Xiaokun Yue, Weiqing Kong, Xiaoding Gu, Zixian Jiao, Chi Yang
Summary: This study investigates the effects of CGFs-loaded hydrogel on BMSCs and the reconstruction of critical-size bone defects. The results show that the hydrogel promotes the proliferation and osteogenic differentiation of BMSCs in vitro, and induces bone healing and reconstruction of medullary cavity structure in vivo.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Review
Pharmacology & Pharmacy
Katerina E. E. Miari, Mark T. S. Williams
Summary: The bone marrow plays a vital role in adult hematopoiesis, but abnormalities in stromal elements such as fibroblasts and MSCs can lead to blood malignancies like AML. This review emphasizes the significance of bone marrow fibroblasts and MSCs in both health and AML, and their impact on patient prognosis. The review also discusses how stromal elements contribute to therapy resistance by creating an immunosuppressive microenvironment, making it challenging to target the bone marrow stroma for improved AML outcomes.
BRITISH JOURNAL OF PHARMACOLOGY
(2023)
Article
Immunology
Rene Reitermaier, Thomas Krausgruber, Nikolaus Fortelny, Tanya Ayub, Pablo Augusto Vieyra-Garcia, Philip Kienzl, Peter Wolf, Anke Scharrer, Christian Fiala, Marita Kolz, Manuela Hiess, Martin Vierhapper, Christopher Schuster, Andreas Spittler, Christof Worda, Wolfgang Weninger, Christoph Bock, Rene Reitermaier, Adelheid Elbe-Buerger
Summary: Single-cell analyses identified a naive T cell population expressing specific T cell receptors enriched in fetal skin and intestine. These cells may contribute to early skin development and fetal immune defense, showing fundamental differences in immune surveillance between fetal and adult human skin.
JOURNAL OF EXPERIMENTAL MEDICINE
(2021)
Article
Engineering, Biomedical
Xuzheng Liu, Wanli Chen, Bo Shao, Xinchi Zhang, Yinggang Wang, Siqian Zhang, Wei Wu
Summary: The study showed that by rational designing hierarchically porous membranes with 3D microstructure, it can facilitate early and durable influx of M2 macrophages, promoting recruitment of BMSCs and osteogenesis. Additionally, the 4D morphing of the membrane can fully regenerate calvarial bone and arcshape bone.
Article
Polymer Science
Ci Li, Meng Zhang, Song-Yang Liu, Feng-Shi Zhang, Teng Wan, Zhen-Tao Ding, Pei-Xun Zhang
Summary: This study demonstrated the effectiveness of constructing peripheral nerve conduits based on chitosan acetylation, showing good biocompatibility and mechanical properties. Culturing bone marrow mesenchymal stem cells (BMSCs) as spheroids improves therapeutic potential, with BMSCs spheroids exhibiting better results in the PNI rat model with small gap tubulization. Chitin nerve conduits with BMSCs spheroids provide a promising therapy option for peripheral nerve regeneration.
Article
Endocrinology & Metabolism
Liwei Yuan, Jia Cao, Mingyue Hu, Dabao Xu, Yan Li, Shiyun Zhao, Juanjuan Yuan, Huixing Zhang, Yani Huang, He Jin, Meixia Chen, Dan Liu
Summary: The combination of BMSCs and estrogen can promote the regeneration of damaged endometrium, inhibit EMT, and activate the Wnt/beta-catenin signaling pathway. These findings provide a new therapeutic strategy and mechanistic explanation for the treatment of IUA.
REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY
(2022)
Article
Immunology
Hilal Uensal, Canan Caka, Hacer Neslihan Bildik, Saliha Esenboga, Alphan Kupesiz, Baris Kuskonmaz, Duygu Uckan Cetinkaya, Mirjam van Der Burg, Ilhan Tezcan, Deniz Cagdas
Summary: The study investigated the demographic, clinical, laboratory, follow-up, and treatment characteristics of 21 patients with Major Histocompatibility Complex Class II (MHC-II) deficiency. It was found that patients with Bare Lymphocyte Syndrome (BLS) exhibited clinical findings similar to severe combined immunodeficiency (SCID), and the flow cytometric MHC-II expression study played a crucial role in the diagnosis, differential diagnosis, early hematopoietic stem cell transplantation (HSCT), and post-HSCT follow-up.
SCANDINAVIAN JOURNAL OF IMMUNOLOGY
(2024)
Article
Immunology
Axel Rosell, Cecilia Karlstrom, Joakim S. Dahlin, Daryl Boey, Monika Klimkowska, Kajsa Ax, Charlotte Thalin, Johanna Ungerstedt
Summary: There is no evidence of global increase in neutrophil extracellular trap release in patients with systemic mastocytosis.
SCANDINAVIAN JOURNAL OF IMMUNOLOGY
(2024)
Article
Immunology
Charles W. Armitage, Connor P. O'Meara, Emily R. Bryan, Avinash Kollipara, Logan K. Trim, Danica Hickey, Alison J. Carey, Wilhelmina M. Huston, Gavin Donnelly, Anusch Yazdani, Richard S. Blumberg, Kenneth W. Beagley
Summary: This study demonstrates that IgG seroconversion during male infection can amplify female immunopathology and infertility. IgG transcytosis through the FcRn receptor allows Chlamydia to cross the epithelial barrier and be phagocytosed by antigen-presenting cells. This leads to increased pro-inflammatory signaling and T cell proliferation, resulting in more severe pathology and infertility in female mice.
SCANDINAVIAN JOURNAL OF IMMUNOLOGY
(2024)
Article
Immunology
Fatma Gonca Kocanci, Azize Yasemin Goksu Erol, Fatma Yildiz, Hamiyet Eciroglu
Summary: Calcineurin inhibitors, such as pimecrolimus, have been found to have preventive effects against neuroinflammation and apoptotic pathways, which are underlying mechanisms in neurodegenerative diseases. This study demonstrated that pimecrolimus exerts neuroprotective effects by inhibiting inflammation and oxidative stress, making it a potential treatment option for neurodegenerative diseases.
SCANDINAVIAN JOURNAL OF IMMUNOLOGY
(2024)