Review
Immunology
Jose Inciarte-Mundo, Beatriz Frade-Sosa, Raimon Sanmarti
Summary: S100A9/S100A8 (calprotectin), a member of the S100 protein family, plays a crucial role in innate immunity activation and is essential in the pathogenesis of rheumatoid arthritis (RA). Calprotectin levels in serum or plasma have been found to correlate better with composite inflammatory disease activity indexes compared to conventional markers like C-reactive protein (CRP) or erythrocyte sedimentation rate (ESR). It independently predicts radiographic progression and shows strong correlations with other sensitive techniques to detect inflammation.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Dongyan Ding, Rumei Luan, Qianfei Xue, Junling Yang
Summary: S100A12, S100A8, and S100A9 are inflammatory disease biomarkers with significant functional significance in idiopathic pulmonary fibrosis (IPF). Elevated levels of these biomarkers are associated with poor outcomes in IPF patients and can serve as predictors of prognosis.
Review
Biochemistry & Molecular Biology
Ourania S. Kotsiou, Dimitrios Papagiannis, Rodanthi Papadopoulou, Konstantinos I. Gourgoulianis
Summary: This review provides insights into the potential role of Calprotectin in the pathophysiology of lung diseases, highlighting its multifunctionality in cellular processes and emphasizing its potential as a biomarker.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Rheumatology
Michael Gernert, Marc Schmalzing, Hans-Peter Tony, Patrick-Pascal Strunz, Eva Christina Schwaneck, Matthias Froehlich
Summary: Calprotectin in the serum can be a useful inflammation parameter in tocilizumab-treated rheumatoid arthritis patients, with good sensitivity and specificity for detecting disease activity.
ARTHRITIS RESEARCH & THERAPY
(2022)
Article
Multidisciplinary Sciences
Ruisheng Song, Kevin Struhl
Summary: The study reveals that the calcium-dependent cytokines S100A8 and S100A9 can act as transcriptional coactivators in breast cellular transformation, enhancing oncogenic transcription and promoting the transformation phenotype.
Review
Biochemistry & Molecular Biology
Yu Chen, Yuzhen Ouyang, Zhixin Li, Xiufang Wang, Jian Ma
Summary: S100A8 and S100A9, as Ca2+ binding proteins in the S100 family, have crucial roles in modulating inflammatory responses and inflammation-associated diseases. They participate in multiple signaling pathways in tumor cells and contribute to tumor development, growth, and metastasis. Moreover, they have shown potential as diagnostic or prognostic biomarkers in cancer and have become therapeutic targets. This review focuses on the characteristics of S100A8/A9, S100A9, and S100A8, their interactions with tumor cells and microenvironments, and their clinical applications as biomarkers and therapeutic targets.
BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER
(2023)
Article
Gastroenterology & Hepatology
Cem Ercalik, Mehmet Cetin Baskaya, Sebahat Ozdem, Bulent Butun
Summary: The study found that subclinical intestinal inflammation was higher in early stages of ankylosing spondylitis (AS) and fecal calprotectin levels were not correlated with disease activity in AS. Patients with AS who did not use nonsteroidal anti-inflammatory drugs (NSAIDs) may have lower FC levels. The AS group had a significantly higher FC test positivity rate than the rheumatoid arthritis (RA) group.
ARAB JOURNAL OF GASTROENTEROLOGY
(2021)
Review
Immunology
Pengpeng Xia, Xingduo Ji, Li Yan, Siqi Lian, Ziyue Chen, Yi Luo
Summary: S100 proteins are small proteins that are only expressed in vertebrates and play a crucial role in various biological processes. Among them, S100A8, S100A9, and S100A12 are important in resisting microbial infection and maintaining immune homeostasis. They can chelate metal nutrients of pathogens, inhibit pathogen growth, initiate inflammatory signal transduction, induce cytokine expression, and participate in immune regulation. They can also serve as disease markers for screening and detecting related diseases.
Article
Multidisciplinary Sciences
Jacqueline Chaparro-Olaya, Liliana Morales, Moises David Leon Falla, Paula C. C. Hernandez, Wilson Bautista-Molano, Alejandro Ramos-Casallas, Juliette de Avila, Juan Manuel Bello-Gualtero, Fabian Cortes Munoz, Consuelo Romero-Sanchez
Summary: This study evaluated intestinal parasitic infection in 51 SpA patients and found no significant differences in parasite frequency between SpA patients and healthy controls. However, significantly higher levels of fecal calprotectin were found in the SpA patients compared to controls. When comparing Blastocystis spp. colonized and Blastocystis spp. free SpA patients, FCP levels were significantly higher in the Blastocystis spp. free group. The findings suggest a potential relationship between Blastocystis spp. and intestinal inflammation in SpA patients.
SCIENTIFIC REPORTS
(2022)
Article
Immunology
Fataneh Tavasolian, Robert D. Inman
Summary: Ankylosing spondylitis (AS) is a chronic autoimmune inflammatory disability with a complex etiology involving genetic susceptibility, epigenetic modifications, and environmental factors. MicroRNAs and the gut microbiome play critical roles in the immunopathogenesis of AS, suggesting a co-evolutionary symbiotic link between host immunity and the gut microbiome. Significant advances have been made in understanding the immunological mechanisms underlying AS.
AUTOIMMUNITY REVIEWS
(2021)
Article
Medicine, Research & Experimental
Anca Cardoneanu, Sebastian Cozma, Ciprian Rezus, Florin Petrariu, Alexandra Maria Burlui, Elena Rezus
Summary: The study reveals that the gut microbiome in patients with ankylosing spondylitis (AS) is associated with an inflammatory state and dysbiosis. The results show a decrease in gut bacterial diversity in the AS group, with significantly lower levels of Clostridium leptum and higher levels of Escherichia coli.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2021)
Article
Immunology
Duygu Eryavuz Onmaz, Abdullah Sivrikaya, Kevser Isik, Sedat Abusoglu, Ilknur Albayrak Gezer, Fatma Humeyra Yerlikaya, Gulsum Abusoglu, Ali Unlu, Dilek Tezcan
Summary: The study found altered kynurenine pathway metabolism in AS patients. Conventional therapy and anti-TNF-alpha therapy are effective in reducing the Kynurenine/Tryptophan ratio and CRP levels.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Rheumatology
Marie Vallier, Beatrice Segurens, Elise Larsonneur, Vincent Meyer, Stephanie Ferreira, Christophe Caloustian, Jean-Francois Deleuze, Maxime Dougados, Mathias Chamaillard, Corinne Miceli-Richard
Summary: This study aimed to evaluate the association between gut microbiota composition and patient characteristics, as well as the predictive value on the response to TNF inhibitor treatment in AxSpA patients. The results showed that HLA-B27 status and smoking had a significant influence on gut microbiota composition. In addition, analysis of seven bacterial operational taxonomic units (OTUs) could predict the response to TNFi treatment.
Article
Biochemistry & Molecular Biology
Woosol Chris Hong, Da Eun Lee, Hyeon Woong Kang, Myeong Jin Kim, Minsoo Kim, Ju Hyun Kim, Sungsoon Fang, Hyo Jung Kim, Joon Seong Park
Summary: Pancreatic ductal adenocarcinoma (PDAC) is a deadly form of pancreatic cancer and the role of CD74 in PDAC is not well understood. Silencing CD74 in the pancreatic cancer cell line Capan-1 led to reduced cell proliferation, migration, invasion, increased apoptosis, and decreased expression and secretion of S100A8 and S100A9. The study suggests that CD74 may serve as a potential diagnostic biomarker and therapeutic target for pancreatic cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Immunology
Zena Chen, Xuqi Zheng, Xinyu Wu, Jialing Wu, Xiaomin Li, Qiujing Wei, Xi Zhang, Linkai Fang, Ou Jin, Jieruo Gu
Summary: The study found that the gut microbiome was significantly restored in AS patients after adalimumab therapy, with a higher abundance of Comamonas in non-responders compared to responders, although no statistical difference was observed. These results suggest the potential of gut microbiome as biomarkers for therapeutic evaluation.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Rheumatology
J. K. Wallman, G-M Alenius, E. Klingberg, V Sigurdardottir, S. Wedren, S. Exarchou, U. Lindstrom, D. Di Giuseppe, J. Askling, L. T. H. Jacobsson
Summary: The validity of clinical ICD-10 diagnoses for PsA in the Swedish NPR is good, with positive predictive values (PPVs) of 69-82% for CASPAR fulfilment and 86% for meeting any established PsA classification criteria.
SCANDINAVIAN JOURNAL OF RHEUMATOLOGY
(2023)
Article
Immunology
Kristina Lejon, Urban Hellman, Anjani Kumar, Helena Forsblad-d'Elia
Summary: The purpose of this study was to investigate the changes in different cell types and disease-related factors in patients with ankylosing spondylitis (AS) from northern Sweden. The study found a significant reduction in the number of TFH cells, plasmablasts, and B memory cells in AS patients, which may be related to an aberrant humoral immune response associated with inflammation. Some cell types in female patients were negatively correlated with inflammation markers.
SCANDINAVIAN JOURNAL OF IMMUNOLOGY
(2023)
Article
Rheumatology
A. J. Landgren, E. Klingberg, L. T. H. Jacobsson, U. Bergsten, M. Dehlin
Summary: This study compared health-related quality of life (HRQoL) among patients with gout, psoriatic arthritis (PsA), rheumatoid arthritis (RA), and ankylosing spondylitis (AS). HRQoL was assessed using the RAND36-Item Health Survey, and results were stratified by sex and age-matched.
SCANDINAVIAN JOURNAL OF RHEUMATOLOGY
(2023)
Article
Rheumatology
Thomas Frisell, Hannah Bower, Matilda Morin, Eva Baecklund, Daniela Di Giuseppe, Benedicte Delcoigne, Nils Feltelius, Helena Forsblad-d'Elia, Elisabet Lindqvist, Ulf Lindstroem, Johan Askling
Summary: The objective of this study was to assess and compare the incidence rates of key safety outcomes for individual targeted synthetic or biological disease-modifying antirheumatic drugs (b/ts DMARDs) in rheumatoid arthritis (RA). The study found that the b/tsDMARDs currently used to treat RA have acceptable and largely similar safety profiles, but differences exist in particular concerning tolerability and specific infection risks.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Article
Orthopedics
Ulrika Bergsten, Mats Dehlin, Eva Klingberg, Anton J. Landgren, Lennart T. H. Jacobsson
Summary: This study aimed to explore gender differences in patients with gout regarding self-reported gout severity, illness perceptions, impact on daily activities and quality of life, advice from healthcare professionals, and changes in dietary or alcohol habits. The findings showed that women with gout experienced more severe symptoms, worse illness perceptions, and greater impact on daily activities and quality of life compared to men. However, they received less advice from healthcare professionals. Therefore, these gender differences should be addressed in clinical care.
BMC MUSCULOSKELETAL DISORDERS
(2023)
Article
Rheumatology
Sofia Exarchou, Johan K. Wallman, Daniela Di Giuseppe, Eva Klingberg, Valgerdur Sigurdardottir, Sara Wedren, Ulf Lindstrom, Carl Turesson, Lennart T. H. Jacobsson, Johan Askling
Summary: This study aimed to estimate the prevalence of clinically diagnosed Psoriatic Arthritis (PsA) in Sweden in 2017 and assess the use of disease-modifying antirheumatic drugs (DMARDs) among PsA patients in contact with specialized rheumatology care. The prevalence of PsA in Sweden was approximately 0.35% among adults aged 18 to 79 years in 2017, and nearly three-fourths of PsA patients in recent contact with specialized rheumatology care received DMARD therapy in 2017.
JOURNAL OF RHEUMATOLOGY
(2023)
Article
Immunology
Martina Frodlund, Per Nived, Aikaterini Chatzidionysiou, Anna Sodergren, Eva Klingberg, Anders Bengtsson, Monika Hansson, Sophie Olsson, Elisa Pin, Lars Klareskog, Meliha C. Kapetanovic
Summary: This study aimed to investigate antibody responses in patients with inflammatory rheumatic diseases (IRD) treated with biologic/targeted disease modifying anti-rheumatic drugs (b/ts DMARDs) after the second and third dose of COVID-19 vaccine. The results showed that the percentage of patients with positive antibody response was significantly lower after two doses in patients receiving rituximab or abatacept treatment. However, the antibody response improved after the third dose.
Article
Rheumatology
Ulf Lindstrom, Daniela di Giuseppe, Sofia Exarchou, Gerd-Marie Alenius, Tor Olofsson, Eva Klingberg, Lennart Jacobsson, Johan Askling, Johan K. Wallman
Summary: This study aimed to compare the treatment outcomes of patients with newly diagnosed psoriatic arthritis (PsA) and rheumatoid arthritis (RA) using methotrexate (MTX) monotherapy. The results showed that PsA patients were less likely to continue the use of MTX compared to RA patients, and the effectiveness of MTX was also lower in PsA.
Article
Rheumatology
Karin Bengtsson, Johan Askling, Mattias Lorentzon, Bjoern Rosengren, Anna Deminger, Eva Klingberg, Lennart Jacobsson, Helena Forsblad-d'Elia
Summary: Both men and women with AS have a slightly higher risk of non-vertebral fractures than the general population, with men having a particularly higher risk of fractures of the proximal humerus, distal forearm or hip.
Article
Rheumatology
C. Feldthusen, M. Hallstrom, A. d'Elia, A. Deminger, U. Kiltz, H. Forsblad-d'Elia
Summary: The objective of this study was to translate the ASAS HI EFIS into Swedish and culturally adapt it for a Swedish context, and to assess the construct validity of the Swedish version of ASAS HI and test-retest reliability in ASAS HI and EFIS in Swedish patients with AS. The results showed that the Swedish version of ASAS HI is valid and reliable, and recommended for assessing the impact of AS on global functioning and health.
SCANDINAVIAN JOURNAL OF RHEUMATOLOGY
(2023)
Article
Rheumatology
Aj Landgren, Lth Jacobsson, E. Klingberg, R. Mirzaev, M. Dehlin
Summary: By comparing gout severity and health-related quality of life (HRQoL), this study found that higher gout severity was associated with lower HRQoL.
SCANDINAVIAN JOURNAL OF RHEUMATOLOGY
(2023)
Article
Rheumatology
A. J. Landgren, C. A. Jonsson, A. Bilberg, B. Eliasson, L. Torres, M. Dehlin, L. T. H. Jacobsson, I. Gjertsson, I. Larsson, E. Klingberg
Summary: Weight loss in patients with psoriatic arthritis is associated with decreased levels of leptin and cytokines, especially interleukin-23. These findings partly explain the anti-inflammatory effect of weight reduction in psoriatic arthritis.
ARTHRITIS RESEARCH & THERAPY
(2023)
Article
Rheumatology
Erik Hulander, Tatiana Zverkova Sandstrom, Jeannette Beckman Rehnman, Lucy Law, Stefan Soderberg, Helena Forsblad-d'Elia
Summary: This study assessed the dietary nutrient intake in patients with r-axSpA and compared it to persons without r-axSpA. The results showed that the patients had impaired dietary intake, particularly in nutrients with anti-inflammatory properties. Therefore, it is suggested to incorporate nutrition screening into the management of r-axSpA patients.
ARTHRITIS RESEARCH & THERAPY
(2023)
Article
Rheumatology
Magnus Hallstrom, Eva Klingberg, Anna Deminger, Jeannette Beckman Rehnman, Mats Geijer, Helena Forsblad-d'Elia
Summary: This study examined the factors that influence BASFI scores in r-axSpA patients, both overall and stratified by sex. The results showed that age, body mass index, disease activity, fatigue, and tenderness were independently associated with BASFI. There were no significant differences in BASFI scores between males and females, but certain individual questions showed gender differences, such as worse ability to look over shoulder in males and worse ability to climb stairs in females.
ARTHRITIS RESEARCH & THERAPY
(2023)