Article
Biochemistry & Molecular Biology
Yasmina Rodriguez-Sillke, Michael Schumann, Donata Lissner, Federica Branchi, Fabian Proft, Ulrich Steinhoff, Britta Siegmund, Rainer Glauben
Summary: By analyzing patients with celiac disease and inflammatory bowel disease, it was found that antigen-specific effector T-cells can respond to barrier disruption and antigen translocation in the peripheral blood. Using antigen-reactive T-cell enrichment technique, it was observed that the frequency and phenotype of nutritional antigen-specific T-cells correlated to the presence of intestinal inflammation in patients with Celiac disease and Crohn's disease. These findings suggest that active small intestinal inflammation is crucial for the development of a peripheral food antigen-specific T-cell response in Crohn's disease and celiac disease.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Medicine, General & Internal
Monica Gros, Belen Gros, Jose Emilio Mesonero, Eva Latorre
Summary: Irritable bowel syndrome (IBS) is a functional gastrointestinal disorder with unknown etiology, potentially related to neurotransmitter dysfunctions. Research has shown that IBS patients often have abnormal neurotransmitter levels, leading to exploration of novel pharmacological approaches such as 5-HT3 receptor antagonists, 5-HT4 receptor agonists, and GABA-analogous medications.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Psychology, Biological
Andre Schulz, Sina-Katharina Welsch, Sarah Etringer, Greta Hansen, Lea Milbert, Jochen Schneider, Gennaro Taddei, Raquel Gomez Bravo, Charilaos Lygidakis, Zoe van Dyck, Annika Lutz, Paul Wilmes, Claus Vogele
Summary: This study investigates whether IBD and IBS patients have altered perception of 'natural' gastric distensions. The results show that IBD patients drink significantly more water until satiation than IBS patients, suggesting relative gastric hypersensitivity in IBS and relative hyposensitivity in IBD patients.
PHYSIOLOGY & BEHAVIOR
(2023)
Article
Microbiology
Enfu Tao, Yuhao Wu, Chenmin Hu, Zhenya Zhu, Diya Ye, Gao Long, Bo Chen, Rui Guo, Xiaoli Shu, Wei Zheng, Ting Zhang, Xinyi Jia, Xiao Du, Marong Fang, Mizu Jiang
Summary: The study demonstrates that maternal separation induces irritable bowel syndrome (IBS) from early life to adulthood in mice. The disrupted intestinal mitochondrial structure and significant dysbiosis of intestinal microbiota in early life may contribute to the initiation and progression of IBS.
FRONTIERS IN MICROBIOLOGY
(2023)
Review
Gastroenterology & Hepatology
Rebecca Kuang, David J. Levinthal, Amir A. Ghaffari, Claudia Ramos del Aguila de Rivers, Aylin Tansel, David G. Binion
Summary: The Solanaceae family of plants, commonly known as Nightshade vegetables, have significant culinary, economic, and cultural importance. However, some compounds derived from Nightshades may have adverse effects on human health, including intestinal damage and activation of mast cells. Edible Nightshades are gaining attention as potential triggers for gut symptoms in gastrointestinal disorders.
DIGESTIVE DISEASES AND SCIENCES
(2023)
Article
Multidisciplinary Sciences
Isabelle A. M. van Thiel, Aimilia A. Stavrou, Auke de Jong, Bart Theelen, Mark Davids, Theodorus B. M. Hakvoort, Iris Admiraal-van den Berg, Isabelle C. M. Weert, Martine A. M. Hesselink-van de Kruijs, Duong Vu, Christine Moissl-Eichinger, Sigrid E. M. Heinsbroek, Daisy M. A. E. Jonkers, Ferry Hagen, Teun Boekhout, Wouter J. de Jonge, Rene M. van den Wijngaard
Summary: Irritable bowel syndrome (IBS) is a common disorder characterized by chronic abdominal pain and changes in bowel movements. Visceral hypersensitivity may be caused by intestinal fungi, but the diversity of fungal communities does not differ between IBS subgroups. The study highlights the importance of conducting strain-specific cause-and-effect studies in IBS research.
SCIENTIFIC REPORTS
(2022)
Review
Gastroenterology & Hepatology
Mariana Brizuela, Joel Castro, Andrea M. Harrington, Stuart M. Brierley
Summary: This review discusses the underlying causes of chronic visceral pain in patients with IBS, highlighting the role of mediators and receptors that induce itch in the skin acting as gut irritants. Activation of these receptors triggers changes in neuronal excitability, leading to visceral hypersensitivity and pain, suggesting potential therapeutic targets for more effective treatment options.
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
(2021)
Review
Medicine, General & Internal
Mihaela Fadgyas Stanculete, Abdulrahman Ismaiel, Stefan-Lucian Popa, Octavia Oana Capatina
Summary: Irritable bowel syndrome (IBS) is a disorder characterized by altered gut-brain interaction and dysfunction of the brain-gut-microbiota axis. Prior studies have shown significant impairments in the health-related quality of life of patients with IBS. Resilience, as a psychosocial ability, plays a crucial role in promoting health and enhancing stress response.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Pharmacology & Pharmacy
Siyu Tian, Hang Zhang, Siqi Chen, Pengning Wu, Min Chen
Summary: This bibliometric study provides a comprehensive summary of the research trend and developments in visceral hypersensitivity in Irritable Bowel Syndrome (IBS). The study reveals that China, the United States, and Belgium are the main contributors in this field, focusing on exploring the disease mechanisms and sensitizing factors. Additionally, the study highlights the potential relationship between gut microbiota and visceral hypersensitivity, suggesting probiotics as a promising direction for future research in this area.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Gastroenterology & Hepatology
Brian E. Lacy, Mark Pimentel, Darren M. Brenner, William D. Chey, Laurie A. Keefer, Millie D. Long, Baha Moshiree
Summary: Irritable bowel syndrome (IBS) is a chronic disorder that significantly impacts patients' quality of life. The American College of Gastroenterology has developed a clinical guideline using GRADE methodology for the management of IBS, recommending a positive diagnostic approach, specific tests, treatments, and gut-directed psychotherapy to improve symptoms for patients with IBS.
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2021)
Article
Psychiatry
Thomas Jan Konturek, Cristina Martinez, Beate Niesler, Ivo van der Voort, Hubert Moennikes, Andreas Stengel, Miriam Goebel-Stengel
Summary: Several studies have suggested a potential role of BDNF in modulating abdominal pain in IBS. This study aimed to investigate BDNF expression in human colonic biopsies and its correlation with IBS symptom severity. While there was no significant difference in BDNF protein levels between IBS patients and controls, subgroup analysis revealed differences in BDNF mRNA levels between female and male IBS patients. Further research is needed to explore the implications of these findings for different subgroups of IBS patients.
FRONTIERS IN PSYCHIATRY
(2021)
Article
Biochemistry & Molecular Biology
Zijuan Bi, Shisheng Zhang, Yangyang Meng, Ya Feng, Yinshu Wang, Enkang Wang, Xiangxue Pan, Ruixin Zhu, Haiting Fan, Shuhua Pang, Lixin Zhu, Jianye Yuan
Summary: The knockout of the SERT gene may lead to changes in the serotonin system, causing VH and accelerated gastrointestinal motility in female rats, which can be used as an animal model of IBS.
Review
Gastroenterology & Hepatology
Brennan Spiegel
Summary: This article proposes a hypothesis, known as the gravity hypothesis, that seeks to explain the pathogenesis of irritable bowel syndrome (IBS) by relating it to the influence of gravity on human evolution. It suggests that ineffective gravity management systems may lead to the development of IBS. The article reviews the impact of gravity on human evolution, discusses the imperfect adaptation of Homo sapiens to gravity, and explores the consequences of gravity intolerance in relation to IBS. It also considers the diagnostic and therapeutic implications of this hypothesis and suggests further experiments to support or reject it.
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2022)
Article
Immunology
Wu Enqi, Song Jingzhu, Pei Lingpeng, Ling Yaqin
Summary: The study identified significant differences in microbial composition and function between two irritable bowel syndrome rat models, with potential implications for visceral hypersensitivity induced by early adversity. The findings suggest the importance of evaluating gut microbiota characteristics in IBS research and considering potential differences in modeling procedures.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Article
Medicine, General & Internal
Merve Ceren Akgor, Doga Vuralli, Damla Hazal Sucu, Saliha Gokce, Bahar Tasdelen, Fatih Gultekin, Hayrunnisa Bolay
Summary: The frequency of irritable bowel syndrome (IBS) is higher in medication overuse headache (MOH) patients compared to migraine patients. The coexistence of IBS may confound cognitive functions. The specific food triggers for MOH patients are mainly dopaminergic foods, while migraine patients are mostly triggered by histaminergic and processed foods. Personalized diets focusing on food triggers and interference with leaky gut should be integrated into MOH and migraine treatment for sustainable management of these disorders.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Gastroenterology & Hepatology
Gaetano Bergamaschi, Fabiana Castiglione, Renata D'Inca, Marco Astegiano, Walter Fries, Monica Milla, Carolina Ciacci, Fernando Rizzello, Simone Saibeni, Rachele Ciccocioppo, Ambrogio Orlando, Fabrizio Bossa, Mariabeatrice Principi, Piero Vernia, Chiara Ricci, Maria L. Scribano, Giorgia Bodini, Dario Mazzucco, Gabrio Bassotti, Gabriele Riegler, Andrea Buda, Matteo Neri, Flavio Caprioli, Fabio Monica, Aldo Manca, Erica Villa, Gionata Fiorino, Michele Comberlato, Nicola Aronico, Cristina Della Corte, Roberta Caccaro, Paolo Gionchetti, Paolo Giuffrida, Paola Iovino, Marco Lenti, Caterina Mengoli, Lucienne Pellegrini, Alberto Pieraccini, Davide Ribaldone, Anna Testa, Cristina Ubezio, Anna Viola, Maurizio Vecchi, Catherine Klersy, Antonio Di Sabatino
Summary: The prevalence of anemia in Italian IBD patients is lower than previously reported, with the majority being caused by iron deficiency and leading to fatigue and decreased quality of life. However, a large proportion of patients with iron and/or vitamin deficiencies remain untreated.
INFLAMMATORY BOWEL DISEASES
(2023)
Article
Gastroenterology & Hepatology
Jostein H. Ibsen, Adity Chopra, Eline Benno Vaage, John T. Vaage, Fridtjof Lund-Johansen, Knut E. A. Lundin
Summary: This study investigated the humoral response to SARS-CoV-2 vaccines in patients with celiac disease (CeD) and compared it with healthy controls. The results showed that the humoral response in CeD patients is similar to that observed in healthy controls.
SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY
(2023)
Article
Multidisciplinary Sciences
Marketa Chlubnova, Asbjorn O. Christophersen, Geir Kjetil F. Sandve, Knut E. A. Lundin, Jorgen Jahnsen, Shiva Dahal-Koirala, Ludvig M. Sollid
Summary: 42 wheat gluten-reactive T cell clones with different phenotypes and no reactivity to known epitopes were screened. Synthetic peptides were identified bioinformatically from a wheat gluten protein database and tested against the T cell clones. Reactivity of 10 T cell clones was assigned, and 5 previously uncharacterized gliadin/glutenin epitopes with a 9-nucleotide oligomer core region were identified. This work represents an advance in identifying CeD-driving gluten epitopes.
Article
Nutrition & Dietetics
Frida van Megen, Maria Fossli, Gry I. Skodje, Monica H. Carlsen, Lene F. Andersen, Marit B. Veierod, Knut E. A. Lundin, Christine Henriksen
Summary: A study on women with celiac disease and ongoing symptoms revealed that their dietary intake was unbalanced, with higher intake of fat and lower intake of protein and dietary fiber. This highlights the importance of nutritional follow-up for celiac patients and the development of nutrient-dense gluten-free products.
CLINICAL NUTRITION ESPEN
(2023)
Article
Nutrition & Dietetics
Anne Mari Herfindal, Frida van Megen, Mari K. O. Gilde, Jorgen Valeur, Knut Rudi, Gry I. I. Skodje, Knut E. A. Lundin, Christine Henriksen, Siv Kjolsrud Bohn
Summary: Individuals with CeD often experience gastrointestinal symptoms despite adherence to a GFD. The LFD may lead to changes in the faecal microbiota profile, but does not significantly affect gut integrity and inflammation markers in GFD-treated CeD patients.
BRITISH JOURNAL OF NUTRITION
(2023)
Letter
Gastroenterology & Hepatology
Carolina Ciacci, Francesco Valitutti
DIGESTIVE AND LIVER DISEASE
(2023)
Article
Nutrition & Dietetics
Najla Hajji, Ilaria Russo, Jessica Bianco, Ornella Piazza, Paola Iovino, Antonella Santonicola, Carolina Ciacci
Summary: This study aims to investigate the effects of Globularia alypum L. in patients with ulcerative colitis and normal controls. The results showed that this plant has significant effects on most studied markers and enzymes in both UC patients and normal controls.
Review
Medicine, General & Internal
Herbert Wieser, Massimo Amato, Mario Caggiano, Carolina Ciacci
Summary: This review summarizes recent investigations on dental manifestations in celiac disease, including delayed dental eruption and maturity, dental enamel defects, molar incisor hypomineralization, dental caries, dental plaque, and periodontitis. Studies have shown a higher frequency of delayed dental eruption and maturation in children, and dental enamel defects in individuals with celiac disease compared to healthy individuals. Malabsorption of micronutrients and impaired immunity are considered the main causes. Early diagnosis and a gluten-free diet can prevent the development of these conditions. Dentists can play a significant role in identifying unrecognized celiac disease and preventing long-term complications. Research on dental caries, plaque, and periodontitis in celiac disease is lacking and inconsistent, requiring further examination.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Nutrition & Dietetics
Fabiana Zingone, Luisa Bertin, Daria Maniero, Michela Palo, Greta Lorenzon, Brigida Barberio, Carolina Ciacci, Edoardo Vincenzo Savarino
Summary: Most adverse reactions to food are self-reported by patients and not validated by tests. Our study aims to clarify the myths and reality of common food intolerances, providing clinicians with guidance for diagnosis and treatment. The review finds that many food intolerances lack sufficient evidence and lead to unnecessary dietary restrictions for patients.
Review
Medicine, General & Internal
Herbert Wieser, Carolina Ciacci, Carolina Gizzi, Antonella Santonicola
Summary: Celiac disease is a chronic gluten-sensitive immune-mediated enteropathy that is characterized by various signs and symptoms. While otorhinolaryngological complaints in Celiac disease are relatively rare, recent studies have shown an increased prevalence of certain mouth and throat conditions in Celiac patients. The association between Celiac disease and other oral manifestations and esophageal disorders requires further investigation.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Food Science & Technology
Lisa Garnweidner-Holme, Monica Hellmann, Christine Henriksen, Elisabeth Austad, Solveig Ivara Watters, Line Gaundal, Knut E. A. Lundin, Mari C. W. Myhrstad, Vibeke H. Telle-Hansen, Jana Pexova Kalinova
Summary: This study investigated the experiences of people with coeliac disease (CeD) with gluten-free bread, and found that they preferred fibre-rich gluten-free bread that is satiating and has a good texture.
Meeting Abstract
Gastroenterology & Hepatology
Antonio Rispo, Oriana Olmo, Benedetta Toro, Nicola Mattia Cantisani, Nicola Imperatore, Simona Ricciolino, Alessia Dalila Guarino, Roberto de Sire, Giulio Calabrese, Carolina Ciacci
Meeting Abstract
Gastroenterology & Hepatology
A. Rispo, O. Olmo, B. Toro, N. M. Cantisani, N. Imperatore, S. Ricciolino, L. Limansky, R. Caso, M. Giaquinto, C. Ciacci
DIGESTIVE AND LIVER DISEASE
(2023)
Meeting Abstract
Gastroenterology & Hepatology
C. Guerini, P. Bianchi, L. Libera, A. Vanoli, G. Arpa, N. Aronico, D. Furlan, F. Grillo, G. Nesi, G. Sampietro, S. Ardizzone, P. Fociani, R. Fiocca, G. Latella, F. Sessa, A. D'Errico, D. Malvi, C. Mescoli, M. Rugge, S. Ferrero, G. Poggioli, F. Rizzello, M. C. Macciomei, D. Santini, U. Volta, R. De Giorgio, G. Caio, A. Calabro, C. Ciacci, M. D'Armiento, A. Rizzo, G. Solina, F. Tonelli, V. Villanacci, R. Cannizzaro, V Canzonieri, A. M. Florena, L. Biancone, G. Monteleone, R. Caronna, A. Ciardi, L. Elli, F. Caprioli, M. Vecchi, R. D'Inca, F. Zingone, A. D'Odorico, B. Oreggia, Reggiani Bonetti, M. Astegiano, L. Cantoro, C. Papi, G. Sandri, M. Silano, P. Usai, V Perfetti, E. Quaquarini, A. G. Giannone, A. Orlandi, V Barresi, R. Ciccocioppo, G. Amodeo, E. Biletta, A. Di Sabatino
DIGESTIVE AND LIVER DISEASE
(2023)
Meeting Abstract
Gastroenterology & Hepatology
M. A. Latorre, P. I. Bianchi, M. V. Lenti, Aronico N., C. Petrucci, C. C. D'Agate, M. Neri, U. Volta, M. G. Mumolo, M. Astegiano, A. S. Calabro, F. Zingone, G. Latella, A. Di Sario, A. Carroccio, C. Ciacci, F. Luzza, C. Bagnato, M. C. Fantini, L. Elli, G. Cammarota, A. Gasbarrini, P. Portincasa, C. Quatraccioni, C. Iannelli, N. Vecchione, G. Broglio, G. Ianiro, I. Marsilio, S. Bibbo, B. Marinoni, D. Tomaselli, L. Abenavoli, R. Pilia, G. Santacroce, E. Lynch, A. Carrieri, P. Mansueto, M. Gabba, G. Alunno, C. Rossi, F. Onnis, K. Efthymakis, N. Cesaro, M. Vernero, Baiano F. Svizzero, M. Silano, C. Klersy, G. R. Corazza, A. Di Sabatino
DIGESTIVE AND LIVER DISEASE
(2023)