期刊
SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY
卷 47, 期 11, 页码 1274-1282出版社
TAYLOR & FRANCIS LTD
DOI: 10.3109/00365521.2012.688215
关键词
comorbidity; helicobacter pylori; irritable bowel syndrome; population
资金
- North Norway Regional Health Authority [SFP-32-04]
- Norwegian Foundation for Health and Rehabilitation
- National Association for Digestive Diseases
- University of Tromso
Objective. To assess the occurrence of functional bowel (FB) symptoms in Northern Norway, and to describe gender differences, comorbidity, and association to risk factors, including Helicobacter pylori infection. Materials and methods. Adult subjects (18-85 years) from the communities Bodo and Sorreisa were invited to complete a questionnaire on gastrointestinal symptoms, and to provide stool samples for assessment of H. pylori. Results. Of 3927 invited subjects, 1731(44.1%) responded to the questionnaire and 1416 (36.0%) provided stool samples. Functional bowel symptoms were found in 25%, somewhat more frequent in females (28.6%). Symptom pattern differed between genders only with regard to constipation. Presence of FB symptoms was significantly associated with gastroesophageal reflux symptoms, headache, dizziness, palpitations, sleep disturbances, and musculoskeletal symptoms. Psychometric traits were also more prevalent: feeling of low coping ability, feeling depressed, feeling of time pressure, and a low self-evaluation of health. In a multivariate regression model, factors that influenced the reporting FB symptoms were male gender (OR 0.71, 95% CI (0.52; 0.96)), age 50-69 years or >= 70 years (OR 0.49 (0.30; 0.80) and 0.40 (0.21; 0.79)), obesity (OR 1.61 (1.05; 2.47)), NSAID use (OR 2.50 (1.63; 3.83)), and previous abdominal surgery (OR 1.54 (1.05; 2.26)). The presence of H. pylori was not associated with FB symptoms. Conclusions. Functional bowel symptoms are prevalent, but our findings may be prone to self-selection bias. FB symptoms carry a significant burden of comorbidity. Female gender and low age are known risk factors for FB symptoms, whereas NSAID use as a risk factor deserves further clarification.
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