Article
Biochemistry & Molecular Biology
Tsz Cheung Chong, Iris L. K. Wong, Jiahua Cui, Man Chun Law, Xuezhen Zhu, Xuesen Hu, Jason W. Y. Kan, Clare S. W. Yan, Tak Hang Chan, Larry M. C. Chow
Summary: This study identified Ac15(Az8)(2) as a potent and non-toxic BCRP inhibitor that can reverse BCRP-mediated drug resistance and inhibit tumor growth.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Pharmacology & Pharmacy
Asahi Adachi, Tomoki Yamashita, Shigehiko Kanaya, Yohei Kosugi
Summary: Multiple machine learning approaches, including molecular descriptors and graph convolutional networks (GCNs), were used to predict the efflux activity of MDR1 and BCRP. The predictive performance of these approaches was evaluated using in-house and external datasets, and the ensemble approach of descriptor-based machine learning and GCN achieved the highest predictive performance.
Review
Immunology
Neda Gholamian Dehkordi, Seyed Abbas Mirzaei, Fatemeh Elahian
Summary: Drug resistance in cancer treatment is associated with inflammation, and glucocorticoids and NSAIDs are effective in regulating inflammatory response. These anti-inflammatory agents act by modulating inflammatory genes and DNA transcription factors. Genetic variations in ABC transporter promoters impact transporter expression and function, affecting systemic drug exposure and toxicity.
INFLAMMOPHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Chao-Yun Cai, Qiu-Xu Teng, Megumi Murakami, Suresh V. Ambudkar, Zhe-Sheng Chen, Vijaya L. Korlipara
Summary: A series of 22 quinazolinamine derivatives with potent inhibitory activities on BCRP and P-gp were synthesized. Compound 22 was identified as a dual BCRP and P-gp inhibitor, while compound 33 showed BCRP inhibitory activity. These compounds changed the localization of BCRP and P-gp, inhibiting the efflux of anticancer drugs by the two ABC transporters. Compounds 22 and 33 also stimulated ATP hydrolysis, increasing the accumulation of mitoxantrone in BCRP-overexpressing cells.
Review
Pharmacology & Pharmacy
Sonali Mehendale-Munj, Shivangi Sawant
Summary: Breast Cancer Resistance Protein (BCRP) is an efflux transporter responsible for causing multidrug resistance. BCRP expels potent antineoplastic drugs, leading to resistance and failure in cancer treatment. The regulation and expression of BCRP play important roles in maintaining the balance of xenobiotics and nutrients, impacting cancer therapies.
CURRENT DRUG TARGETS
(2021)
Article
Chemistry, Medicinal
Wei Shi, Ping Zhang, Feng Zou, Jiaqi Zhou, Ziyu Yin, Zilong Cai, Hesham Ghaleb, Yuxuan Jiang, Wenlong Huang, Yan Liu, Qianqian Qiu, Hai Qian
Summary: Chemotherapy is a crucial treatment for cancer, but resistance can occur. Researchers developed and synthesized compounds with dual inhibition to overcome resistance and improve the bioavailability of oral chemotherapy drugs.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Article
Pharmacology & Pharmacy
Tatyana A. Grigoreva, Aleksandra V. Sagaidak, Daria S. Novikova, Vyacheslav G. Tribulovich
Summary: ABC transporters play a crucial role in multidrug resistance and maintaining overall viability. Modulating the activity of these transporters holds promise in overcoming drug delivery challenges and treating diseases caused by genetic polymorphisms.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Article
Oncology
Dawei Sun, Juan Liu, Yunfang Wang, Jiahong Dong
Summary: This study investigates the mechanism and novel treatments of lenvatinib resistance in hepatocellular carcinoma (HCC). It shows that inhibiting MDR1 and BCRP transporters or targeting the EGFR/PI3K pathway can overcome lenvatinib resistance in HCC. Additionally, lenvatinib plays an important role in inhibiting tumor growth and angiogenesis.
FRONTIERS IN ONCOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Nahlah Makki Almansour, Alaa H. M. Abdelrahman, Ekram Ismail Fagiree, Mahmoud A. A. Ibrahim
Summary: Multidrug resistance (MDR) is a major cause of treatment failure in cancer chemotherapy. This study identifies potential drug candidates with anti-MDR effects through virtual screening and molecular simulations, providing new avenues for finding better breast cancer treatment approaches.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2023)
Article
Oncology
Danijela Mandic, Lana Nezic, Ljiljana Amdzic, Natasa Vojinovic, Radoslav Gajanin, Miroslav Popovic, Jugoslav Deri, Milena Todorovic Balint, Jelena Dumanovic, Zoran Milovanovic, Jelica Grujic-Milanovic, Ranko Skrbic, Vesna Jacevic
Summary: This study aimed to investigate whether the coexpression of ABC transporters and survivin was associated with the response to R-CHOP treatment in DLBCL patients. The results showed that DLBCL might harbor molecular signatures such as MRP1/ABCC1, survivin, and BCRP/ABCC2 overexpression that can predict resistance to R-CHOP.
Article
Pharmacology & Pharmacy
C. B. V. Andrade, L. V. A. Lopes, T. M. Ortiga-Carvalho, S. G. Matthews, E. Bloise
Summary: This review comprehensively examines the effect of infection on the placental multidrug resistance (MDR) transporters P-glycoprotein (P-gp) and breast cancer resistance protein (BCRP), finding that infection can regulate the expression of P-gp and BCRP in the placenta by altering their mRNA, protein, and function levels. The modulation effect varies according to different infection factors, gestational age, trophoblast type, and species. The expression and localization of Toll-like receptor (TLR) proteins at the maternal-fetal interface are also discussed, aiming to understand how infective agents modulate placental MDR. The alterations in placental MDR induced by infection may impact the distribution of important MDR substrates and adversely affect pregnancy outcome and maternal/neonatal health.
TOXICOLOGY AND APPLIED PHARMACOLOGY
(2023)
Review
Pharmacology & Pharmacy
Zhiran Ju, Menglan Li, Junde Xu, Daniel C. Howell, Zhiyun Li, Fen-Er Chen
Summary: Cyclooxygenases play a vital role in inflammation, but currently used anti-inflammatory drugs have associated adverse effects. Researchers are searching for novel selective COX-2 inhibitors.
ACTA PHARMACEUTICA SINICA B
(2022)
Article
Pharmacology & Pharmacy
Xing Chang, Zi Liu, Simeng Cao, Jiang Bian, Dayong Zheng, Nuo Wang, Qi Guan, Yingliang Wu, Weige Zhang, Zengqiang Li, Daiying Zuo
Summary: In this study, it was found that 2-Methoxy-5 ((3,4,5-trimethosyphenyl)seleninyl) phenol (SQ) could inhibit BCRP function, block cell cycle, and mediate apoptosis through PI3K-Akt-MDM2 pathway inhibition, thus overcoming multidrug resistance in adriamycin-resistant MCF-7 cells.
TOXICOLOGY AND APPLIED PHARMACOLOGY
(2022)
Article
Gastroenterology & Hepatology
Julien Kirchgesner, Rishi J. Desai, Maria C. Schneeweiss, Laurent Beaugerie, Sebastian Schneeweiss, Seoyoung C. Kim
Summary: Combination therapy with vedolizumab and thiopurines is associated with a lower risk of treatment failure compared to vedolizumab monotherapy in patients with CD, but the effect is less pronounced in UC.
Review
Immunology
Reza Yarani, Ali Shojaeian, Oana Palasca, Nadezhda T. Doncheva, Lars Juhl Jensen, Jan Gorodkin, Flemming Pociot
Summary: This review discusses the differential regulation of miRNAs in inflammatory bowel disease (IBD) and their potential diagnostic and therapeutic applications. Through literature curation and computational analysis, a consensus set of differentially expressed miRNAs in mucosal tissues was obtained. The role of these miRNAs and their potential targets in IBD are highlighted.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Gastroenterology & Hepatology
Garazi P. Alzua, Anne F. Pihl, Anna Offersgaard, Rodrigo Velazquez-Moctezuma, Carlos R. Duarte Hernandez, Elias H. Augestad, Ulrik Fahnoe, Christian K. Mathiesen, Henrik Krarup, Mansun Law, Jannick Prentoe, Jens Bukh, Judith M. Gottwein
Summary: This study identified key determinants of HCV infection and found that N-linked glycosylation motifs can trigger changes in the virus's sensitivity to neutralizing antibodies. These findings contribute to the understanding of how HCV evades antibodies and provide a theoretical basis for vaccine design.
Article
Oncology
Julie A. Schmidt, Inge Huybrechts, Kim Overvad, Anne Kirstine Eriksen, Anne Tjonneland, Rudolf Kaaks, Verena Katzke, Matthias B. Schulze, Valeria Pala, Carlotta Sacerdote, Rosario Tumino, Bas Bueno-de-Mesquita, Maria-Jose Sanchez, Jose M. Huerta, Aurelio Barricarte, Pilar Amiano, Antonio Agudo, Anders Bjartell, Tanja Stocks, Elin Thysell, Maria Wennberg, Elisabete Weiderpass, Ruth C. Travis, Timothy J. Key, Aurora Perez-Cornago
Summary: This study investigated the associations between dietary protein intake and prostate cancer risk and mortality. The results suggest that dairy protein and yogurt protein are positively associated with prostate cancer risk, while egg protein may be positively associated with prostate cancer mortality. However, considering the weak associations and many tests conducted, these results should be interpreted with caution.
Article
Cardiac & Cardiovascular Systems
Tanja Charlotte Frederiksen, Morten Krogh Christiansen, Emelia J. Benjamin, Kim Overvad, Anja Olsen, Christina Catherine Dahm, Henrik Kjaerulf Jensen
Summary: Increasing alcohol intake over a 5-year period is associated with a higher risk of atrial fibrillation (AF), while reducing alcohol intake does not significantly affect AF risk.
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2023)
Article
Respiratory System
Hien Thi Thu Nguyen, Vang Le-Quy, Son Van Ho, Jakob Holm Dalsgaard Thomsen, Malene Pontoppidan Stoico, Hoang Van Tong, Nhat-Linh Nguyen, Henrik Bygum Krarup, Son Hong Nguyen, Viet Quoc Tran, Linh Toan Nguyen, Anh Tuan Dinh-Xuan
Summary: This study aims to predict the severity of COVID-19 based on clinical and biological indicators, and identify biomarkers for prognostic assessment. The most important indicators were IL-6, ferritin, and D-dimer. Two different sets of biomarkers can be used for disease severity assessment and prognosis.
Article
Oncology
Elom K. Aglago, Amanda J. Cross, Elio Riboli, Veronika Fedirko, David J. Hughes, Agnes Fournier, Paula Jakszyn, Heinz Freisling, Marc J. Gunter, Christina C. Dahm, Kim Overvad, Anne Tjonneland, Cecilie Kyro, Marie-Christine Boutron-Ruault, Joseph A. Rothwell, Gianluca Severi, Verena Katzke, Bernard Srour, Matthias B. Schulze, Clemens Wittenbecher, Domenico Palli, Sabina Sieri, Fabrizio Pasanisi, Rosario Tumino, Fulvio Ricceri, Bas Bueno-de-Mesquita, Jeroen W. G. Derksen, Guri Skeie, Torill Enget Jensen, Marko Lukic, Maria-Jose Sanchez, Pilar Amiano, Sandra Colorado-Yohar, Aurelio Barricarte, Ulrika Ericson, Bethany van Guelpen, Keren Papier, Anika Knuppel, Corinne Casagrande, Inge Huybrechts, Alicia K. Heath, Konstantinos K. Tsilidis, Mazda Jenab
Summary: This study examined the association between dietary iron intake and colorectal cancer (CRC) risk. The results showed that in men, higher intake of non-heme iron was associated with a lower risk of CRC, while there was no significant association with total or heme iron intake. In women, there was no significant association between iron intake and CRC risk. Substituting heme iron with non-heme iron was associated with a lower risk of CRC in men.
BRITISH JOURNAL OF CANCER
(2023)
Article
Biochemistry & Molecular Biology
Esther Clavero, Jose Manuel Sanchez-Maldonado, Angelica Macauda, Rob Ter Horst, Belem Sampaio-Marques, Artur Jurczyszyn, Alyssa Clay-Gilmour, Angelika Stein, Michelle A. T. Hildebrandt, Niels Weinhold, Gabriele Buda, Ramon Garcia-Sanz, Waldemar Tomczak, Ulla Vogel, Andres Jerez, Daria Zawirska, Marzena Watek, Jonathan N. Hofmann, Stefano Landi, John J. Spinelli, Aleksandra Butrym, Abhishek Kumar, Joaquin Martinez-Lopez, Sara Galimberti, Maria Eugenia Sarasquete, Edyta Subocz, Elzbieta Iskierka-Jazdzewska, Graham G. Giles, Malwina Rybicka-Ramos, Marcin Kruszewski, Niels Abildgaard, Francisco Garcia Verdejo, Pedro Sanchez Rovira, Miguel Inacio da Silva Filho, Katalin Kadar, Malgorzata Razny, Wendy Cozen, Matteo Pelosini, Manuel Jurado, Parveen Bhatti, Marek Dudzinski, Agnieszka Druzd-Sitek, Enrico Orciuolo, Yang Li, Aaron D. Norman, Jan Maciej Zaucha, Rui Manuel Reis, Miroslaw Markiewicz, Juan Jose Rodriguez Sevilla, Vibeke Andersen, Krzysztof Jamroziak, Kari Hemminki, Sonja I. Berndt, Vicent Rajkumar, Grzegorz Mazur, Shaji K. Kumar, Paula Ludovico, Arnon Nagler, Stephen J. Chanock, Charles Dumontet, Mitchell J. Machiela, Judit Varkonyi, Nicola J. Camp, Elad Ziv, Annette Juul Vangsted, Elizabeth E. Brown, Daniele Campa, Celine M. Vachon, Mihai G. Netea, Federico Canzian, Asta Foersti, Juan Sainz
Summary: By conducting a meta-analysis on the germline genetic data of 234 autophagy-related genes from three independent study populations, we investigated the influence of autophagy-related variants on the risk of Multiple Myeloma (MM) and examined the functional mechanisms behind the observed associations. We identified SNPs within the six CD46, IKBKE, PARK2, ULK4, ATG5, and CDKN2A loci associated with MM risk and found that their effect on disease risk was mediated by specific subsets of immune cells, as well as vitamin D3-, MCP-2-, and IL20-dependent mechanisms.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Genetics & Heredity
Zhanju Liu, Ruize Liu, Han Gao, Seulgi Jung, Xiang Gao, Ruicong Sun, Xiaoming Liu, Yongjae Kim, Ho-Su Lee, Yosuke Kawai, Masao Nagasaki, Junji Umeno, Katsushi Tokunaga, Yoshitaka Kinouchi, Atsushi Masamune, Wenzhao Shi, Chengguo Shen, Zhenglin Guo, Kai Yuan, Shu Zhu, Dalin Li, Jianjun Liu, Tian Ge, Judy Cho, Mark J. Daly, Dermot P. B. McGovern, Byong Duk Ye, Kyuyoung Song, Yoichi Kakuta, Mingsong Li, Hailiang Huang, Maria Abreu, Jean-Paul Achkar, Vibeke Andersen, Charles Bernstein, Steven R. Brant, Luis Bujanda, Siew Chien Ng, Judy Cho, Mark J. Daly, Lee A. Denson, Richard H. Duerr, Lynnette R. Ferguson, Denis Franchimont, Andre Franke, Richard Gearry, Hakon Hakonarson, Jonas Halfvarson, Caren Heller, Hailiang Huang, Antonio Julia, Judith Kelsen, Hamed Khalili, Subramaniam Kugathasan, Juozas Kupcinskas, Anna Latiano, Edouard Louis, Reza Malekzadeh, Jacob L. McCauley, Dermot P. B. McGovern, Christopher Moran, David Okou, Tim Orchard, Aarno Palotie, Miles Parkes, Joel Pekow, Uros Potocnik, Graham Radford-Smith, John D. Rioux, Gerhard Rogler, Bruce Sands, Mark Silverberg, Harry Sokol, Severine Vermeire, Rinse K. Weersma, Ramnik J. Xavier, Naizhong Hu, Qian Cao, Yufang Wang, Yinglei Miao, Hongjie Zhang, Xiaoping Lv, Xiang Gao, Hu Zhang, Jingling Su, Baisui Feng, Ye Zhao, Liangru Zhu, Yan Chen, Lanxiang Zhu, Chunxiao Chen, Yali Wang, Yingde Wang, Zhi Pang, Yingxuan Chen, Xiaolan Zhang, Hui Li, Qin Yu, Mei Ye, Sumin Zhang, Wen Tang, Mei Wang, Xiaocang Cao, Ruixin Zhu, Guangxi Zhou, Zhaolian Bian, Xiaofeng Guo, Xiaoli Wu, Jinchun Liu, Wei Xu, Yuqin Li, Qin Guo, Zhiguo Guo, Mingsong Li, Zhanju Liu
Summary: This study provides the largest investigation of inflammatory bowel diseases (IBDs) in individuals of East Asian ancestries, identifying 80 IBD loci, including 81 new loci. The study also discovers new IBD genes, such as ADAP1 and GIT2, and improves the accuracy of predicting IBD risk by incorporating data from both East Asian and European ancestries.
Article
Gastroenterology & Hepatology
Benjamin E. Stubbe, Poul H. Madsen, Anders C. Larsen, Henrik B. Krarup, Inge S. Pedersen, Carsten P. Hansen, Julia S. Johansen, Stine D. Henriksen, Ole Thorlacius-Ussing
Summary: This study examined the promoter hypermethylation of secreted frizzled-related protein 1 (phSFRP1) in cfDNA as a prognostic biomarker and predictor of treatment effect in patients with metastatic FOLFIRINOX-treated PDAC and locally advanced PDAC. The results showed that phSFRP1 is a clinically useful prognostic biomarker in metastatic PDAC and possibly in locally advanced PDAC.
Article
Hematology
Monique J. T. Crobach, Rayna J. S. Anijs, Sigrid K. Braekkan, Marianne T. Severinsen, Jens Hammerstrom, Hanne Skille, Soren R. Kristensen, Benedikte Paulsen, Anne Tjonneland, Henri H. Versteeg, Kim Overvad, John-Bjarne Hansen, Inger A. Naess, Suzanne C. Cannegieter
Summary: Patients with cancer have a higher risk of developing venous thromboembolism (VTE), which leads to poorer survival compared to cancer alone. This study aimed to investigate the impact of VTE on cancer patients' survival in a general population. The findings showed that cancer patients with VTE had a 3.4-fold higher risk of death compared to those without VTE, regardless of cancer type.
Article
Nutrition & Dietetics
Tammy Y. N. Tong, Robert Clarke, Julie A. Schmidt, Inge Huybrechts, Urwah Noor, Nita G. Forouhi, Fumiaki Imamura, Ruth C. Travis, Elisabete Weiderpass, Krasimira Aleksandrova, Christina C. Dahm, Yvonne T. van der Schouw, Kim Overvad, Cecilie Kyro, Anne Tjonneland, Rudolf Kaaks, Verena Katzke, Catarina Schiborn, Matthias B. Schulze, Ana-Lucia Mayen-Chacon, Giovanna Masala, Sabina Sieri, Maria Santucci de Magistris, Rosario Tumino, Carlotta Sacerdote, Jolanda M. A. Boer, W. M. Monique Verschuren, Magritt Brustad, Therese Haugdahl Nost, Marta Crous-Bou, Dafina Petrova, Pilar Amiano, Jose Maria Huerta, Conchi Moreno-Iribas, Gunnar Engstrom, Olle Melander, Kristina Johansson, Kristina Lindvall, Elom K. Aglago, Alicia K. Heath, Adam S. Butterworth, John Danesh, Timothy J. Key
Summary: This study examined the associations between dietary amino acids and the risks of ischaemic and haemorrhagic stroke. The findings suggest that higher intake of proline may be associated with a lower risk of ischaemic stroke.
EUROPEAN JOURNAL OF NUTRITION
(2023)
Article
Biochemistry & Molecular Biology
David J. Hughes, Lutz Schomburg, Mazda Jenab, Carine Biessy, Catherine Meplan, Aurelie Moskal, Qian Sun, Kamil Demircan, Veronika Fedirko, Elisabete Weiderpass, Maryam Mukhtar, Anja Olsen, Anne Tjonneland, Kim Overvad, Matthias Schulze, Therese Haugdahl Nost, Guri Skeie, Karina Standahl Olsen, Fulvio Ricceri, Sara Grioni, Domenico Palli, Giovanna Masala, Rosario Tumino, Fabrizio Pasanisi, Pilar Amiano, Sandra M. Colorado Yohar, Antonio Agudo, Maria-Jose Sanchez, Eva Ardanaz, Malin Sund, Anne Andersson, Aurora Perez-Cornago, Ruth Travis, Alicia K. Heath, Laure Dossus
Summary: The study found no significant association between selenium status and breast cancer risk. However, higher activity of the selenoenzyme GPX3 was associated with a lower risk of premenopausal breast cancer. Several genetic variants were also found to be associated with breast cancer risk.
FREE RADICAL BIOLOGY AND MEDICINE
(2023)
Review
Biochemistry & Molecular Biology
Vibeke Andersen, Tue B. Bennike, Corinna Bang, John D. Rioux, Isabelle Hebert-Milette, Toshiro Sato, Axel K. Hansen, Ole H. Nielsen
Summary: Inflammatory bowel diseases (IBD) are challenging to manage due to the diversity between patients and the lack of reliable biomarkers. Diet, gut microbiota, genetics, and patient factors are all crucial for disease occurrence and progression. Recent research has identified potential biomarkers for IBD management, but further evaluation is needed. This review provides an update on cutting-edge research in IBD to improve disease management and patient quality of life.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Letter
Oncology
Angelica Macauda, Klara Briem, Alyssa Clay-Gilmour, Wendy Cozen, Asta Foersti, Matteo Giaccherini, Chiara Corradi, Juan Sainz, Yasmeen Niazi, Rob ter Horst, Yang Li, Mihai G. Netea, Ulla Vogel, Kari Hemminki, Susan L. Slager, Judit Varkonyi, Vibeke Andersen, Elzbieta Iskierka-Jazdzewska, Joaquin Martinez-Lopez, Jan Zaucha, Nicola J. Camp, S. Vincent Rajkumar, Agnieszka Druzd-Sitek, Parveen Bhatti, Stephen J. Chanock, Shaji K. Kumar, Edyta Subocz, Grzegorz Mazur, Stefano Landi, Mitchell J. Machiela, Andres Jerez, Aaron D. Norman, Michelle A. T. Hildebrandt, Katalin Kadar, Sonja I. Berndt, Elad Ziv, Gabriele Buda, Arnon Nagler, Charles Dumontet, Malgorzata Razny, Marzena Watek, Aleksandra Butrym, Norbert Grzasko, Marek Dudzinski, Malwina Rybicka-Ramos, Eva-Laure Matera, Ramon Garcia-Sanz, Hartmut Goldschmidt, Krzysztof Jamroziak, Artur Jurczyszyn, Esther Clavero, Graham G. Giles, Matteo Pelosini, Daria Zawirska, Marcin Kruszewski, Herlander Marques, Eva Haastrup, Jose Manuel Sanchez-Maldonado, Uta Bertsch, Marcin Rymko, Marc-Steffen Raab, Elizabeth E. Brown, Jonathan N. Hofmann, Celine Vachon, Daniele Campa, Federico Canzian
Article
Gastroenterology & Hepatology
David Straarup, Kare A. Gotschalck, Peter A. Christensen, Henrik Krarup, Soren Lundbye-Christensen, Aase Handberg, Ole Thorlacius-Ussing
Summary: This study aimed to assess intestinal fatty acid binding protein (I-FABP) and endothelin-1 as diagnostic biomarkers for acute intestinal necrosis (AIN). The study found that endothelin-1 alone had a good diagnostic performance, but the diagnostic performance of I-FABP and endothelin-1 combined was only moderate compared to the commonly used biomarker L-lactate.
SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY
(2023)
Article
Immunology
Marcio Luis Acencio, Marek Ostaszewski, Alexander Mazein, Philip Rosenstiel, Konrad Aden, Neha Mishra, Vibeke Andersen, Prodromos Sidiropoulos, Aggelos Banos, Anastasia Filia, Souad Rahmouni, Axel Finckh, Wei Gu, Reinhard Schneider, Venkata Satagopam
Summary: Chronic inflammatory diseases involve complex molecular mechanisms and pose challenges for effective treatments. Using a systemic network model can help understand the interaction of key pathways. The SYSCID map is an interactive causal interaction network that aids in understanding the molecular mechanisms of inflammatory bowel disease, rheumatoid arthritis, and systemic lupus erythematosus, as well as the complexity of omics data.
FRONTIERS IN IMMUNOLOGY
(2023)