Article
Ophthalmology
Rachael C. Heath Jeffery, Syed Aqif Mukhtar, Derrick Lopez, David B. Preen, Ian L. McAllister, David A. Mackey, Nigel Morlet, William H. Morgan, Fred K. Chen
Summary: The study reported the age-standardized annual incidence of blindness due to AMD and the treatment patterns in Australia. The incidence of blindness rose during the PDT era but declined in the IVT era. The age at AMD blindness registration increased over time, with different trends in PDT and IVT usage.
ASIA-PACIFIC JOURNAL OF OPHTHALMOLOGY
(2021)
Review
Cell Biology
Sonali Nashine
Summary: This article discusses the contribution of aging to ocular diseases such as AMD, and introduces potential therapeutic candidates for AMD along with their known mechanisms of cytoprotection.
Article
Multidisciplinary Sciences
Hidetaka Matsumoto, Junki Hoshino, Ryo Mukai, Kosuke Nakamura, Hideo Akiyama
Summary: The use of brolucizumab in the treatment of nAMD shows significant improvements in visual acuity and reductions in retinal thickness and choroidal thickness. It also has the potential to reduce the treatment burden and regress polypoidal lesions.
SCIENTIFIC REPORTS
(2022)
Review
Ophthalmology
Ian Pearce, Winfried Amoaku, Clare Bailey, Louise Downey, Richard Gale, Faruque Ghanchi, Robin Hamilton, Sajjad Mahmood, Geeta Menon, Jenny Nosek, James Talks, Yit Yang
Summary: Untreated neovascular age-related macular degeneration can lead to severe and permanent visual impairment, highlighting the importance of introducing new treatment options. Expert roundtable meetings provide practical guidance to support the introduction of new anti-VEGF therapy in medical retina services to meet the growing demand for care.
Article
Biochemistry & Molecular Biology
Hanan ElShelmani, Ian Brennan, David J. Kelly, David Keegan
Summary: This study discovered differentially regulated miRNAs in the serum of AMD patients, with eight miRNAs showing higher expression in dry AMD patients compared to wet AMD patients and healthy controls. These miRNAs may serve as diagnostic biomarkers for AMD and potential treatment targets in the future. Detection of significant serum miRNA biomarkers in AMD patients could provide an easy screening tool for at-risk populations.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Reem H. ElSheikh, Muhammad Z. Chauhan, Ahmed B. Sallam
Summary: Age-related macular degeneration (AMD) is a leading cause of blindness in the elderly population, with neovascular AMD (nAMD) being the main contributor to visual loss. Currently approved anti-VEGF agents have shown favorable prognosis for nAMD but come with a substantial financial burden for patients and the healthcare system due to their high cost and the need for repeated treatments and visits. Emerging therapies aim to prolong treatment intervals and introduce new modalities for better results.
Article
Ophthalmology
Justus G. Garweg, Christin Gerhardt
Summary: The study assessed disease stability and treatment interval extension in exudative AMD. Results showed varying rates of disease stability and treatment interval extension among different drugs, with most eyes achieving stability at 12 weeks and some extending treatment to over 12 weeks. This highlights the challenges in balancing treatment intensity in AMD management.
GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Karolina Urbanska, Piotr Witold Stepien, Katarzyna Natalia Nowakowska, Martyna Stefaniak, Natalia Osial, Tomasz Choragiewicz, Mario Damiano Toro, Katarzyna Nowomiejska, Robert Rejdak
Summary: This review provides an overview of the influence of miRNA on the pathogenesis, diagnosis, and treatment of age-related macular degeneration (AMD). miRNAs may serve as potential molecular biomarkers for AMD and targeting specific miRNA abnormalities could offer hope for preventing irreversible vision loss.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Ophthalmology
Michael D. Osterman, Yeunjoo E. Song, Muneeswar Nittala, SriniVas R. Sadda, William K. Scott, Dwight Stambolian, Margaret A. Pericak-Vance, Jonathan L. Haines
Summary: This study identified potential novel genetic risk loci for AMD in a midwestern Amish study population and determined a clear link between the genetic risk of AMD and drusen. Further study may improve understanding of the biological risk factors underlying drusen development.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2022)
Review
Ophthalmology
Shenouda Girgis, Lawrence R. Lee
Summary: Age-related macular degeneration is a global disease with a significant social impact, and the treatment of neovascular AMD has been revolutionized by the advent of anti-VEGF therapy. Currently, investigations are being conducted for possible therapeutic options for dry AMD. Various treatments, including complement pathway inhibitors, visual cycle modulators, antioxidative therapy, gene therapy, and stem cell therapy, are undergoing clinical trials. Two intravitreal anti-complement factors have shown promising results in reducing the growth of geographic atrophy.
CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
(2023)
Article
Biology
Thomas H. Julian, Johnathan Cooper-Knock, Stuart MacGregor, Hui Guo, Tariq Aslam, Eleanor Sanderson, Graeme C. M. Black, Panagiotis Sergouniotis, Lois E. H. Smith
Summary: Age-related macular degeneration (AMD) is a leading cause of blindness, and this study aims to identify causal factors and potential therapeutic targets for AMD through a phenome-wide Mendelian randomisation (MR) study. The results of this study support several putative causal factors for AMD and provide avenues for future translational research.
Article
Engineering, Environmental
Meixin Ran, Yaxin Deng, Jiaqi Yan, Anan Zhang, Ying Wei, Xiaowen Li, Haibing He, Jingxin Gou, Tian Yin, Xing Tang, Jun Kong, Han Zhang, Hongbo Zhang, Yu Zhang
Summary: In this study, a bionic nano-eye-drop with enhanced ocular penetrability and lesion recognizability was developed for the photodynamic therapy (PDT) of wet age-related macular degeneration (wAMD), inspired by the neovascular targeting ability of endogenous low-density lipoproteins (LDL). The nano-eye-drop effectively delivered the laser-induced PDT agent, verteporfin (VP), into neovascular that overexpress LDL receptors, leading to neovascular inhibition and inflammation alleviation.
CHEMICAL ENGINEERING JOURNAL
(2022)
Article
Medicine, General & Internal
Agnieszka Budnik, Marta Sabasinska-Grzes, Magdalena Michnowska-Kobylinska, Lukasz Lisowski, Malgorzata Szpakowicz, Magdalena Lapinska, Anna Szpakowicz, Marcin Kondraciuk, Karol Adam Kaminski, Joanna Konopinska
Summary: Research has shown that inflammatory factors play an important role in the development of age-related macular degeneration (AMD) and glucose disturbances (GD), with C1qTNF1 identified as a key mediator in the integration of lipid metabolism and inflammatory responses.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Engineering, Chemical
Yeon-Kyoung Cho, Seung-Min Lee, Yeong-Ji Kang, Yeong-Mo Kang, In-Chul Jeon, Dae-Hun Park
Summary: Age-related macular degeneration (AMD) is a visual disorder that affects the elderly, and the number of cases may increase due to the aging population. Current therapies for AMD include device-based treatments, anti-inflammatory drugs, anti-vascular endothelial growth factor treatments, and natural product treatments. Although AMD is incurable, its symptoms can be suppressed. Some natural products have shown potential in preventing early AMD by inhibiting cell death and activating anti-apoptotic pathways.
Article
Medicine, General & Internal
Zhuang Cui, Wei Zhou, Qinxue Chang, Tiantian Zhang, Hui Wang, Xiangda Meng, Yuanyuan Liu, Hua Yan
Summary: This study evaluated the cost-effectiveness of conbercept and ranibizumab for the treatment of AMD, DME, and PM in China, finding that conbercept was more suitable and cost-effective compared to ranibizumab under the current Chinese healthcare setting.
FRONTIERS IN MEDICINE
(2021)