Article
Medicine, Research & Experimental
Yue Liang, Min Li, Yuan Tang, Jinlong Yang, Jing Wang, Yuqi Zhu, Huitong Liang, Qinru Lin, Yipen Cheng, Xinyi Yang, Huanzhang Zhu
Summary: A thermosensitive composite hydrogel loaded with nicotinamide mononucleotide (NMN) was synthesized, which effectively promoted diabetic wound healing by inhibiting oxidative stress reactions.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Biochemistry & Molecular Biology
Mahla Lashkari, Mahya Rahmani, Yaser Yousefpoor, Meysam Ahmadi-Zeidabadi, Reza Faridi-Majidi, Zahra Ameri, Moein Salary, Shahrzad Azizi, Arman Shahabi, Amid Rahi, Mohamad Javad Mirzaei-Parsa
Summary: In this study, a bilayer scaffold composed of hydrogel and nanofibers was fabricated to improve the regeneration of injured skin. The results showed that re-epithelialization, angiogenesis, and collagen remodeling were enhanced in ADSCs-seeded bilayer scaffolds.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Pharmacology & Pharmacy
Hira Mahmood, Muhammad Asif, Syed Haroon Khalid, Ikram Ullah Khan, Zunera Chauhdary, Fizza Abdul Razzaq, Sajid Asghar
Summary: In this study, a composite functional wound dressing based on kappa-carrageenan and tannic acid was prepared and co-encapsulated with simvastatin and Geranium oil. The prepared films had excellent mechanical strength, high swelling rate, and good water solubility. The dressing showed superior antioxidant, anti-inflammatory, and broader anti-bacterial activity. The CS/G/TA hydrogel film exhibited excellent wound healing effect through improved angiogenesis and down regulation in the expression of inflammatory markers.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Priyadarshani Choudhary, Baskaran Ramalingam, Sujoy K. Das
Summary: Wound dressings with poor antibacterial properties, adhesion to the wound site, weak mechanical strength, and lack of porosity and flexibility lead to blood loss, delayed wound repair, and sometimes death. In this study, a multifunctional graphene-based nanobiocomposite wound dressing was developed, which demonstrated hydrophilic properties, good mechanical strength, antibacterial activity, non-toxicity to cells, and pro-angiogenic potential. In in-vivo studies using a rat model, the nanobiocomposite dressing significantly enhanced wound healing compared to commercially available dressings, achieving complete wound closure in 14 days. Overall, the CGAPL nanobiocomposite dressing offers a novel and efficient solution for faster wound healing.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Nanoscience & Nanotechnology
Yun Zhu, Li Liu, Shaoqing Chen, Dan Han, Cheng Wang
Summary: Wound infection, especially chronic ones, can lead to the emergence of antibiotic-resistant bacteria and cause physical and mental burden on patients. This study developed an agarose-hyaluronic acid hydrogel that could potentially serve as an antibacterial wound dressing, promoting healing while maintaining antibacterial efficacy.
JOURNAL OF BIOMEDICAL NANOTECHNOLOGY
(2022)
Article
Chemistry, Medicinal
Evi Sulastri, Muhammad Sulaiman Zubair, Ronny Lesmana, Ahmed Fouad Abdelwahab Mohammed, Nasrul Wathoni
Summary: The study found that different concentrations of ulvan in the formula affect the characteristics of the hydrogel films. The SEM showed porous structure, and all hydrogel films can inhibit both gram-positive and gram-negative bacteria. The higher the concentration of ulvan, the higher the viscosity, swelling degree, moisture content, and water vapor transmission rate of the hydrogel films.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2021)
Article
Biochemistry & Molecular Biology
Zhengbo Hu, Kai Zhao, Xingcan Chen, Mingyuan Zhou, Yuchi Chen, Xiaoqing Ye, Fangmei Zhou, Zhishan Ding, Bingqi Zhu
Summary: The developed BSP/BER hydrogel exhibited excellent biocompatibility and remarkable antibacterial, anti-inflammatory, and antioxidant properties. Animal experiments demonstrated that the hydrogel significantly accelerated wound healing in diabetic mice.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Pharmacology & Pharmacy
Xiuling Fang, Yadong Liu, Miaomiao Zhang, Shuwen Zhou, Pengfei Cui, Huaanzi Hu, Pengju Jiang, Cheng Wang, Lin Qiu, Jianhao Wang
Summary: Skin infections are a global issue that requires the development of suitable wound dressings. This study proposes a cost-effective and biocompatible thermosensitive hydrogel that effectively inhibits bacteria and promotes wound healing.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Feng Wang, Shuguang Wang, Liping Nan, Jiawei Lu, Ziqi Zhu, Jintao Yang, Dong Zhang, Junjian Liu, Xiao Zhao, Desheng Wu
Summary: Wound injuries can lead to serious consequences, and the use of biomedical hydrogels as wound dressings has shown great potential in accelerating wound healing.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Boda Wu, Jintao Yang, Yan Zu, Junjie Chi, Keqing Shi
Summary: A multi-functional hydrogel fiber film with aligned structure has been developed, which promotes wound healing. The film possesses high-water content, self-degradability, improved bionic characteristics, oriented cell growth, and enhanced cell proliferation and migration. Encapsulated nanozymes and nanoparticles provide the film with superior reactive oxygen species scavenging and antibacterial capability.
JOURNAL OF NANOBIOTECHNOLOGY
(2022)
Article
Engineering, Biomedical
Faezeh Lotfinia, Mohammad-Reza Norouzi, Laleh Ghasemi-Mobarakeh, Mohammadreza Naeimirad
Summary: In this study, an antibiotic/antioxidant hydrogel was fabricated using red cabbage extract and honey-loaded alginate hydrogel. The hydrogel showed good mechanical properties and water absorption capacity, and exhibited antibacterial activity against both Gram-positive and Gram-negative bacteria. Additionally, the hydrogel had excellent biocompatibility with cells.
JOURNAL OF FUNCTIONAL BIOMATERIALS
(2023)
Review
Polymer Science
Pavel Yudaev, Yaroslav Mezhuev, Evgeniy Chistyakov
Summary: This review examines the use of dressings containing nanoparticles for wound repair and evaluates their antimicrobial effects and healing actions. The analysis of 31 sources published between 2021 and 2022 demonstrates a trend towards the development of modern antibacterial wound-healing nanomaterials.
Article
Biochemistry & Molecular Biology
Lanlan Wang, Dawei Li, Ying Shen, Feng Liu, Yuqi Zhou, Huiping Wu, Qingsheng Liu, Bingyao Deng
Summary: A novel wound dressing with antibacterial activity and good biocompatibility was developed in this study, showing promising application prospects in the field of medical care.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Biochemical Research Methods
Fahimeh Kazeminava, Siamak Javanbakht, Mohammad Nouri, Pourya Gholizadeh, Parinaz Nezhad-Mokhtari, Khudaverdi Ganbarov, Asghar Tanomand, Hossein Samadi Kafil
Summary: In this study, novel antibacterial flexible polymeric hydrogel films were successfully designed and synthesized. The films exhibited good biocompatibility and antibacterial activity, making them a promising candidate for effective wound dressing.
JOURNAL OF BIOLOGICAL ENGINEERING
(2022)
Article
Virology
Changchang Li, Raphael Nyaruaba, Xiaowei Zhao, Heng Xue, Yuhong Li, Hang Yang, Hongping Wei
Summary: This study tested the efficacy of a lysin-loaded hydrogel in treating wound infections caused by resistant bacteria. The results showed that the lysin hydrogel effectively inhibited bacterial growth and had no cytotoxic effects on cells.
Article
Engineering, Chemical
Baljit Singh, Abhishek Dhiman
INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
(2016)
Article
Biochemistry & Molecular Biology
Baljit Singh, Abhishek Dhiman, Rajneesh, Ajay Kumar
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2016)
Article
Polymer Science
Baljit Singh, Abhishek Dhiman
POLYMER SCIENCE SERIES A
(2016)
Article
Pharmacology & Pharmacy
Baljit Singh, Abhishek Dhiman
CURRENT DRUG DELIVERY
(2017)
Article
Pharmacology & Pharmacy
Baljit Singh, Sushma Sharma, Abhishek Dhiman
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2013)
Article
Polymer Science
Baljit Singh, Vikrant Sharma, Abhishek Dhiman, Manisha Devi
POLYMER-PLASTICS TECHNOLOGY AND ENGINEERING
(2012)
Article
Environmental Sciences
Baljit Singh, D. K. Sharma, Abhishek Dhiman, Atul Gupta
TOXICOLOGICAL AND ENVIRONMENTAL CHEMISTRY
(2011)
Article
Environmental Sciences
Baljit Singh, D. K. Sharma, Abhishek Dhiman
TOXICOLOGICAL AND ENVIRONMENTAL CHEMISTRY
(2013)
Article
Biochemistry & Molecular Biology
Baljit Singh, Jasvir Singh, A. Dhiman, Man Mohan
Summary: This research report explores the potential of using psyllium, a therapeutic dietary fiber, for the formation of sterile hydrogel as a drug delivery carrier. The hydrogel was characterized and evaluated for its release profile, blood-polymer interaction, mucosal-polymer adhesion, antioxidant and mechanical properties. The results suggest that the hydrogel is a promising candidate for controlled and sustained drug delivery in the gastrointestinal tract.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Chemistry, Applied
Baljit Singh, Sushma Sharma, Abhishek Dhiman
CARBOHYDRATE POLYMERS
(2017)
Article
Polymer Science
Baljit Singh, D. K. Sharma, Sunil Negi, Abhishek Dhiman
INTERNATIONAL JOURNAL OF PLASTICS TECHNOLOGY
(2015)