Article
Chemistry, Multidisciplinary
G. Lesly Jimenez, Binita Shrestha, Tyron Porter, Bartlomiej Starzyk, Magdalena Lesniak, Marta Kuwik, Marcin Kochanowicz, Magdalena Szumera, R. Lisiecki, D. Dorosz
Summary: Up-conversion nanoparticles have attracted attention for their ability to convert low energy light into high-energy light, but their low efficiency poses limitations. By doping fluoroindate glasses with Yb3+ and Er3+, efficient energy transfer and improved biocompatibility can be achieved, making them suitable for biomedical applications.
Article
Engineering, Biomedical
Matthew Blakeley, Prashant K. Sharma, Hans J. Kaper, Nagihan Bostanci, Thomas Crouzier
Summary: Disruption of lubrication between oral surfaces due to salivary gland hypofunction can negatively impact quality of life. Research suggests that functionalizing polyethylene glycol with wheat germ agglutinin and immobilizing it on oral epithelial cells and tissue can mimic the salivary film, providing long-lasting relief from mucosal dryness.
ADVANCED HEALTHCARE MATERIALS
(2022)
Article
Chemistry, Multidisciplinary
Rajib Sarkar, Binoyargha Dam, Lenida Kyndiah, Fillip Kumar Sarkar, Sushmita Gajurel, Amarta Kumar Pal
Summary: Graphite oxide (GO) was developed from cheap and readily available graphite powder and used as a green heterogeneous carbocatalyst towards the synthesis of spirodibenzo[1,4]diazepine derivatives via a one-pot three-component strategy. The reaction conditions were mild and performed in aqueous ethanol medium, leading to diversely functionalized target products. The catalyst showed high catalytic activity and could be reused up to eight consecutive cycles without significant loss. The use of GO as a metal-free catalyst avoids metal impurities in the final products.
Review
Allergy
Krzysztof Rutkowski, Rita Mirakian, Stephen Till, Ryszard Rutkowski, Annette Wagner
Summary: COVID-19 vaccines can reduce severity of infection and prevent deaths, but limited data on triggers and mechanisms of anaphylaxis exist. Therefore, we propose an innovative allergy support model and practical investigation algorithm for anaphylaxis to these vaccines.
CLINICAL AND EXPERIMENTAL ALLERGY
(2021)
Article
Biochemistry & Molecular Biology
Valentina Busic, Maja Molnar, Vice Tomicic, Dalia Bozanovic, Igor Jerkovic, Dajana Gaso-Sokac
Summary: The study aimed to explore eutectic solvents as a greener alternative for conventional solvents in quaternization reactions, in accordance with green chemistry principles. The reactions using substituted phenacyl bromides and isonicotinamide under different synthetic approaches showed that microwave-assisted organic reactions yielded the highest product yields.
Article
Chemistry, Analytical
Ziheng Hu, Ruifeng Zhu, Gabriela Figueroa-Miranda, Lei Zhou, Lingyan Feng, Andreas Offenhaeusser, Dirk Mayer
Summary: This study presents an electrochemical aptasensor for highly sensitive and selective serotonin (ST) detection, based on truncated DNA aptamers and a polyethylene glycol (PEG) molecule-functionalized sensing interface. The aptasensor shows improved sensitivity and enhanced antifouling ability due to the small size and stable structure of the truncated aptamers, as well as the blocking effect of PEG molecules. The sensor exhibits a wide detection range and low limit of detection, and also demonstrates high selectivity and stability in detecting ST in human serum and artificial cerebrospinal fluid (aCSF).
Article
Chemistry, Multidisciplinary
Hoon Hyun, Min Ho Park, Gayoung Jo, Bo Young Lee, Jae Won Choi, Heung Jae Chun, Hyeon Soo Kim, Dae Hyeok Yang
Summary: The study developed a novel drug carrier for breast cancer therapy, with MGC/CDPF-ic-PTX showing promising anti-cancer effects, enhanced cellular uptake, sustained release, and potential therapeutic efficacy against breast cancer.
Article
Chemistry, Multidisciplinary
Han Yin Lim, Anton V. Dolzhenko
Summary: In this study, the hazardous and toxic solvents, methyl and ethyl cellosolves, commonly used in the synthesis of guanamines, were efficiently replaced by a green alternative, PEG 400. Additionally, the reaction efficiency of PEG 400 was improved by using focused microwave irradiation. The method was successfully applied to the synthesis of twenty diverse 1,3,5-triazine-2,4-diamines.
Article
Materials Science, Multidisciplinary
Tejaswini Appidi, Gayathri Ravichandran, Sushma Mudigunda, Aswathi Thomas, Anil B. Jogdand, Saurabh Kishen, Kalaivanan Subramaniyam, Naresh Emani, Ganesan Prabusankar, Aravind Kumar Rengan
Summary: A facile and eco-friendly method was developed to synthesize a potent antimicrobial agent, fluorescent polyethylene glycol-ascorbic acid complex (FL PEG AA), effective against fungus, bacteria, and virus. The FL PEG AA system showed significant inhibition of growth against Candida albicans, Staphylococcus aureus, Escherichia coli, and Bacteriophage lambda, supporting its application as a novel formulation for antimicrobial purposes.
MATERIALS TODAY COMMUNICATIONS
(2021)
Article
Pharmacology & Pharmacy
Roxana Cristina Popescu, Bogdan Stefan Vasile, Diana Iulia Savu, George Dan Mogosanu, Ludovic Everard Bejenaru, Ecaterina Andronescu, Alexandru Mihai Grumezescu, Laurentiu Mogoanta
Summary: Iron oxide nanoparticles (IONPs) have been widely used in biomedical applications due to their biocompatibility and magnetic properties. This study synthesized IONPs using a modified Massart method and evaluated their characteristics. The results showed that the functionalized IONPs had good biocompatibility and the ability to be cleared by the body.
Article
Chemistry, Organic
Rezvan Kardooni, Ali Reza Kiasat
Summary: This method involves a catalyst-free, cost-effective and environmentally friendly protocol for the synthesis of 3-substituted indoles through a multicomponent condensation reaction in polyethylene glycol 400 (PEG-400) as a reaction medium and promoter, with a key feature being the selectivity in forming heterodimer products over homodimer adducts.
POLYCYCLIC AROMATIC COMPOUNDS
(2021)
Editorial Material
Immunology
Kristine Vanijcharoenkarn, Frances Eun-Hyung Lee, Lindsay Martin, Jennifer Shih, Mary Elizabeth Sexton, Merin Elizabeth Kuruvilla
Summary: Addressing immediate adverse events after the first dose of COVID-19 vaccines, especially allergic reactions, is crucial for effective diagnosis and management to combat the pandemic.
CLINICAL INFECTIOUS DISEASES
(2021)
Article
Immunology
David Pesque, Ramon Maria Pujol, Orianna Marcantonio, Ainhoa Vidal-Navarro, Jose Maria Ramada, Alba Arderiu-Formenti, Agusti Albalat-Torres, Consol Serra, Ana Maria Gimenez-Arnau
Summary: This study evaluated the role of skin testing excipients in delayed skin reactions to mRNA COVID-19 vaccines. The results showed that delayed intradermal testing reactions to PEG-2000 were frequently detected in patients with delayed large local reactions, suggesting a possible role of PEG in the development of these reactions.
Article
Chemistry, Physical
Priyanka Patil, Suresh Kadam, Dayanand Patil, Paresh More
Summary: This study successfully synthesized a carboxylic acid functionalized imidazolium-based acidic ionic liquid, which was used as a catalyst for cost effective and sustainable synthesis of polyhydroquinoline and 6-unsustituted dihydropyrimidinone derivatives in green media. The catalyst showed excellent catalytic performance, stability, and could be easily separated and reused up to five cycles. It achieved high yields of the desired compounds in shorter time in an aqueous medium, with purification-free isolation of pure products.
CATALYSIS COMMUNICATIONS
(2022)
Article
Chemistry, Organic
Pratibha Shukla, Deepa Deswal, Anudeep Kumar Narula
Summary: The reaction of TOSMIC with highly functionalized imines and the use of monomeric silica as a catalyst for the reaction have been reported. The main product, bis(tosylmethyl)azetidine, was formed by the sequential attack of two TOSMIC units upon the carbon-nitrogen double bond of highly functionalized imines. The scope and reactivity of the reaction with functionalized imines and TOSMIC were studied.
JOURNAL OF HETEROCYCLIC CHEMISTRY
(2022)
Article
Chemistry, Physical
Syed Imran Hassan, Ashanul Haque, Yassin A. Jeilani, Rashid Ilmi, Md. Serajul Haque Faizi, Imran Khan, Md. Mushtaque
Summary: The development of fluorescent probes for naked eye analyte detection is a promising research area. The reported DA-D type thioxanthone-based luminophore exhibited reversible acid-base sensing ability and aggregation-enhanced emission characteristics. The probe also showed pH dependent emission color and an intramolecular charge transfer process between donor and acceptor units.
JOURNAL OF MOLECULAR STRUCTURE
(2021)
Article
Polymer Science
Prabhas Bhaumick, Asim Jana, Lokman H. Choudhury
Summary: Conjugated fluorescent polymers containing coumarin monomers were synthesized through Suzuki-Miyaura cross-coupling reaction. These polymers exhibit stability over 300 degrees C and show intense fluorescence, with P3 having a quantum yield of 0.73 in DMF. Additionally, P3 was identified as a selective fluorescence chemosensor for detecting Hg(II) and Fe(II)/Fe(III) ions in water.
Article
Chemistry, Organic
Danish Ali, Tasneem Parvin, Lokman H. Choudhury
Summary: In this study, we have developed an efficient method for the synthesis of alkyl, benzyl, and phenyl selenoethers of aminopyrazoles and aminouracils using visible light and Rose Bengal as an organophotocatalyst. The reaction proceeded smoothly, providing the desired compounds in good to very good yields. This method offers several advantages including metal-free conditions, high yields, use of an organic photocatalyst, and broad substrate scope.
JOURNAL OF ORGANIC CHEMISTRY
(2022)
Article
Spectroscopy
Pranjalee Yadav, Rohit Kumar, S. Srikrishna, Anoop Kumar Pandey, Lokman H. Choudhury, Chandan Upadhyay, Vinod P. Singh
Summary: This work presents the synthesis, characterization, crystal structure and spectroscopic investigations of isophthalohydrazide based probe. The probe selectively detects Al3+ and Cu2+ in aqueous ethanol via fluorometric and colorimetric methods. Sensing mechanism is explored with UV-Vis, fluorescence spectroscopy and H-1 NMR titration, and confirmed with computational results.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2022)
Article
Chemistry, Multidisciplinary
Rahul Yadav, Darakshan, Prabhas Bhaumick, Lokman H. Choudhury, Tasneem Parvin
Summary: A new method for the synthesis of pentacyclic pyran fused pyrazolo benzo[h]quinolines was reported in this study, which involved a one-pot reaction in acetic acid medium. The method allowed the formation of new bonds and rings, resulting in the synthesis of bioactive compounds. The method has the advantages of one-pot process, short reaction time, easier purification, and good product yields.
Article
Chemistry, Organic
Asim Jana, Danish Ali, Prabhas Bhaumick, Lokman H. Choudhury
Summary: In this study, we present a simple and efficient method for the preparation of novel thioether-linked coumarin-fused furans through a one-pot three-component reaction of arylglyoxal, 4-hydroxycoumarin, and various aromatic thiols in the presence of Sc(OTf)3 as a catalyst. This method is also applicable to cyclic 1,3-dicarbonyls and provides good to excellent yields of products with multiple pharmaceutically important motifs.
JOURNAL OF ORGANIC CHEMISTRY
(2022)
Article
Polymer Science
Prabhas Bhaumick, Lokman H. Choudhury
Summary: In this study, a one-pot synthesis of novel coumarin-triazole polymers was reported and characterized. The polymers showed high dye removal efficiency and maintained excellent removal performance during multiple cycles.
Article
Chemistry, Multidisciplinary
Swadhin Swaraj Acharya, Prabhas Bhaumick, Rohit Kumar, Lokman H. Choudhury
Summary: A metal-free one-pot three-component reaction for the synthesis of pyrimidine-linked imidazopyridines using aryl methyl ketones, 2-aminopyridines, and barbituric acids was reported. The reaction was catalyzed by a small amount of molecular iodine in DMSO medium and involved C-H oxidation and the formation of one C-C and two C-N bonds. Various aryl methyl ketones and 2-aminopyridines were found to be suitable substrates. The synthesized products exhibited good to excellent UV and fluorescence properties, with compounds 4p and 4q showing the highest fluorescence quantum yield (0.36) in water medium under basic conditions, and compound 4c showing the highest fluorescence quantum yield (0.75) in DMSO medium.
Article
Chemistry, Multidisciplinary
Nasim Khan, Katsunori Itaya, Thomas Wirth
Summary: New iodotriptycenes, including chiral derivatives, have been synthesized and their catalytic potential in oxidative transformations has been investigated. The enantioselectivities of the products using chiral iodotriptycene catalysts are low, likely due to the large distances between the coordinating groups and the iodine moieties in these compounds.
Article
Chemistry, Organic
Prabhas Bhaumick, Rohit Kumar, Swadhin S. Acharya, Tasneem Parvin, Lokman H. Choudhury
Summary: Here, we present an efficient multicomponent reaction for the synthesis of trisubstituted thiazoles from readily available starting materials. The reaction yields good to excellent results and can also be used to synthesize structurally interesting bis-thiazoles. The structures of the products were confirmed through spectroscopic analysis and single-crystal X-ray diffraction. The indole-linked thiazole compounds produced by this method exhibit significant fluorescence properties. Furthermore, the scope of this reaction can be expanded to prepare novel polymers.
JOURNAL OF ORGANIC CHEMISTRY
(2022)
Article
Chemistry, Organic
Rohit Kumar, Swadhin Swaraj Acharya, Prabhas Bhaumick, Tasneem Parvin, Lokman H. Choudhury
Summary: In this study, a metal-free multicomponent reaction was developed for the synthesis of diverse quinoline-fused pyrroles. The reaction utilized 1,1,1,3,3,3-hexafluoro isopropanol (HFIP) as a reaction medium and promoter, and proceeded under reflux conditions. The methodology demonstrated good yields and regioselectivity, and was applicable to a wide range of substrates. The synthesized fused pyrroles exhibited fluorescence properties, with several compounds showing very good fluorescence quantum yields.
Article
Chemistry, Multidisciplinary
Anoop Kumar Panday, Danish Ali, Tasneem Parvin, Lokman H. H. Choudhury
Summary: In this study, acid-mediated two and three-component domino reactions of cyclic enamines with arylglyoxals were reported for the synthesis of diverse fused pyrroles. Different reaction conditions led to the formation of various fused pyrrole structures with different substituents. These reactions provide a convenient and efficient strategy for the synthesis of complex pyrrole-containing compounds.
Article
Crystallography
Malahat Musrat Kurbanova, Md Serajul Haque Faizi, Emine Berrin Cinar, Asif Jamal, Mustafa Cemberci, Arzu Sadigova, Rizvan Askerov, Necmi Dege, Tahera Nabi
Summary: The title compound, C30H34F2N6O2.2.5H(2)O, was synthesized by condensation of 2-[2-(4-fluorophenyl)hydrazono]-5,5-dimethylcyclohexan-1,3-dione with ethylenediamine in ethanol and crystallized as a 1:2.5 hydrate in space group C2/c. The two independent molecules, with distinct conformations and packing environments, play a crucial role in stabilizing the crystal structure. Analysis of the Hirshfeld surface demonstrates that H...H contacts contribute significantly (48-50%) to the crystal packing. Density functional theory (DFT) calculations reveal a LUMO-HOMO energy gap of 0.827 eV for the molecule.
ACTA CRYSTALLOGRAPHICA SECTION E-CRYSTALLOGRAPHIC COMMUNICATIONS
(2023)
Article
Chemistry, Organic
Asim Jana, Danish Ali, Prabhas Bhaumick, Lokman H. Choudhury
Summary: Here, we describe a simple and efficient method for the synthesis of novel thioether-linked coumarin-fused furans. By employing a one-pot three-component reaction using arylglyoxal, 4-hydroxycoumarin, and various aromatic thiols as starting materials and Sc(OTf)(3) as catalyst, we successfully obtained the desired products. This methodology is also applicable to cyclic 1,3-dicarbonyls and allows for the formation of either a three-component thioether-linked coumarin-fused furan or a two-component furocoumarin product, depending on the choice of thiols. The wide substrate scope, high yields, and presence of important pharmaceutically relevant motifs make this methodology highly valuable.
JOURNAL OF ORGANIC CHEMISTRY
(2022)
Article
Crystallography
Rayya A. Al Balushi, Muhammad S. Khan, Md Serajul Haque Faizi, Ashanul Haque, Kieran Molloy, Paul R. Raithby
Summary: The crystal structure of the compound [Cu4Cl6O(C13H9N)4]·CH2Cl2 features a Cu-4 tetrahedron core with copper(II) cations coordinated to central O atom, chlorido ligands, and the 4-phenylethynylpyridine ligand. Intermolecular interactions such as C-H···Cl, C-H···π, and π-π contribute to linking the molecules and forming a three-dimensional network. Hirshfeld surface analysis indicates that packing arrangement is mainly influenced by H···H and C···H/H···C interactions.
ACTA CRYSTALLOGRAPHICA SECTION E-CRYSTALLOGRAPHIC COMMUNICATIONS
(2021)
