Dependence of the solubility of natural flavonoids in water on the concentration of miramistin, polyvinylpyrrolidone, and human serum albumin

In organized media of the cationic surfactant miramistin and the polymers polyvinylpyrrolidone and human serum albumin, the solubility of natural flavonoids quercetin and rutin increased by one or two orders of magnitude. The increase was more significant for hydrophobic quercetin than for hydrophilic rutin. The solubility also depended on the structure and self-organization of molecules in organized media and the site of flavonoids in them. The calculated binding constants increased in the series polyvinylpyrrolidone < miramistin < human serum albumin.