Development of hypoxia-triggered prodrug micelles as doxorubicin carriers for tumor therapy

Hypoxia-Targeted siRNA Delivery

(2014) F. Perche et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

The flavoprotein FOXRED2 reductively activates nitro-chloromethylbenzindolines and other hypoxia-targeting prodrugs

(2014) Francis W. Hunter et al.   BIOCHEMICAL PHARMACOLOGY

SiRNA-phospholipid conjugates for gene and drug delivery in cancer treatment

(2014) Hongmei Liu et al.   BIOMATERIALS

Far-Red Light Activatable, Multifunctional Prodrug for Fluorescence Optical Imaging and Combinational Treatment

(2014) Moses Bio et al.   JOURNAL OF MEDICINAL CHEMISTRY

Poly-cyclodextrin and poly-paclitaxel nano-assembly for anticancer therapy

(2014) Ran Namgung et al.   Nature Communications

Self-assembling doxorubicin-prodrug nanoparticles as siRNA drug delivery system for cancer treatment: in vitro and in vivo

(2014) Hongmei Liu et al.   Journal of Materials Chemistry B

Nitroreductase Detection and Hypoxic Tumor Cell Imaging by a Designed Sensitive and Selective Fluorescent Probe, 7-[(5-Nitrofuran-2-yl)methoxy]-3H-phenoxazin-3-one

(2013) Zhao Li et al.   ANALYTICAL CHEMISTRY

On-Demand Drug Release System for In Vivo Cancer Treatment through Self-Assembled Magnetic Nanoparticles

(2013) Jae-Hyun Lee et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Development of Azo-Based Fluorescent Probes to Detect Different Levels of Hypoxia

(2013) Wen Piao et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Self-Assembling Doxorubicin–Tocopherol Succinate Prodrug as a New Drug Delivery System: Synthesis, Characterization, and in Vitro and in Vivo Anticancer Activity

(2013) Nicolas Duhem et al.   BIOCONJUGATE CHEMISTRY

Hypoxia-responsive polymeric nanoparticles for tumor-targeted drug delivery

(2013) Thavasyappan Thambi et al.   BIOMATERIALS

High selectivity imaging of nitroreductase using a near-infrared fluorescence probe in hypoxic tumor

(2013) Kehua Xu et al.   CHEMICAL COMMUNICATIONS

Hypoxia-Selective O6-Alkylguanine-DNA Alkyltransferase Inhibitors: Design, Synthesis, and Evaluation of 6-(Benzyloxy)-2-(aryldiazenyl)-9H-purines as Prodrugs of O6-Benzylguanine

(2013) Rui Zhu et al.   JOURNAL OF MEDICINAL CHEMISTRY

Site-Specific and Far-Red-Light-Activatable Prodrug of Combretastatin A-4 Using Photo-Unclick Chemistry

(2013) Moses Bio et al.   JOURNAL OF MEDICINAL CHEMISTRY

Effect of surface charge on the colloidal stability and in vitro uptake of carboxymethyl dextran-coated iron oxide nanoparticles

(2013) Vanessa Ayala et al.   JOURNAL OF NANOPARTICLE RESEARCH

Enzyme Sensitive Synthetic Polymer Micelles Based on the Azobenzene Motif

(2013) Jingyi Rao et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Design of polymeric nanoparticles for biomedical delivery applications

(2012) Mahmoud Elsabahy et al.   CHEMICAL SOCIETY REVIEWS

Abstract B76: Cellular metabolism, murine pharmacokinetics and preclinical antitumor activity of SN29966, a novel hypoxia-activated irreversible pan-HER inhibitor

(2012) A. V. Patterson et al.   MOLECULAR CANCER THERAPEUTICS

Targeting hypoxia brings breath of fresh air to cancer therapy

(2012) Melinda Wenner Moyer   NATURE MEDICINE

Vascular Disrupting Agent Drug Classes Differ in Effects on the Cytoskeleton

(2012) Sujeong Kim et al.   PLoS One

Smart Nanocarrier Based on PEGylated Hyaluronic Acid for Cancer Therapy

(2011) Ki Young Choi et al.   ACS Nano

Acid-Activatable Prodrug Nanogels for Efficient Intracellular Doxorubicin Release

(2011) Fuxing Zhan et al.   BIOMACROMOLECULES

Selective Tumor Hypoxia Targeting by Hypoxia-Activated Prodrug TH-302 Inhibits Tumor Growth in Preclinical Models of Cancer

(2011) J. D. Sun et al.   CLINICAL CANCER RESEARCH

3D-QSAR Study of Combretastatin A-4 Analogs Based on Molecular Docking

(2011) Yinghua Jin et al.   MOLECULES

A New Prodrug-Derived Ratiometric Fluorescent Probe for Hypoxia: High Selectivity of Nitroreductase and Imaging in Tumor Cell

(2011) Lei Cui et al.   ORGANIC LETTERS

Targeting the multiple myeloma hypoxic niche with TH-302, a hypoxia-activated prodrug

(2010) J. Hu et al.   BLOOD

Phosphorescent Light–Emitting Iridium Complexes Serve as a Hypoxia-Sensing Probe for Tumor Imaging in Living Animals

(2010) Shaojuan Zhang et al.   CANCER RESEARCH

Materializing sequential killing of tumor vasculature and tumor cells via targeted polymeric micelle system

(2010) Yiguang Wang et al.   JOURNAL OF CONTROLLED RELEASE

Indolequinone-rhodol conjugate as a fluorescent probe for hypoxic cells: enzymatic activation and fluorescence properties

(2010) Hirokazu Komatsu et al.   MedChemComm

Cytotoxicity, intracellular distribution and uptake of doxorubicin and doxorubicin coupled to cell-penetrating peptides in different cell lines: A comparative study

(2009) Sonia Aroui et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Design of a bioreductively-activated fluorescent pH probe for tumor hypoxia imaging

(2009) Eiji Nakata et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Hypoxic Tumor Microenvironment and Cancer Cell Differentiation

(2009) Yuri Kim et al.   CURRENT MOLECULAR MEDICINE

Systematic Study of Absorption Spectra of Donor–Acceptor Azobenzene Mesogenic Structures

(2008) U. A. Hrozhyk et al.   MOLECULAR CRYSTALS AND LIQUID CRYSTALS

Generation of Oxygen Deficiency in Cell Culture Using a Two-Enzyme System to Evaluate Agents Targeting Hypoxic Tumor Cells

(2008) Raymond P. Baumann et al.   RADIATION RESEARCH

Applications of Nitroimidazole In Vivo Hypoxia Imaging in Ischemic Stroke

(2008) Masashi Takasawa et al.   STROKE