Editorial Material
Biochemistry & Molecular Biology
Paul A. M. Michels, Michael L. Ginger
Summary: A recent study found that a protein complex, which is responsible for mitochondrial cristae formation, also drives the formation of intracytoplasmic membranes in alphaproteobacteria, indicating a bacterial origin for the biogenesis of mitochondrial cristae.
Review
Biochemistry & Molecular Biology
Jin-Ho Koh, Jong-Yeon Kim
Summary: Mitochondria are essential for cellular functions, with NAD(+) playing a crucial role in metabolism. PGC-1 alpha is key in orchestrating mitochondrial biogenesis and regulating the NAD(+) pool.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Materials Science, Multidisciplinary
P. Li, Y. Kim, A. C. Bobel, L. G. Hector, A. K. Sachdev, S. Kumar, A. F. Bower
Summary: The study revealed the microstructural origin of anisotropy in the yield stress and ultimate tensile strength of AlSi10Mg tensile specimens, which is attributed to an elongated Al-Si cellular network within individual grains. Micropillar compression tests and numerical simulations confirmed that the anisotropy is caused by the alignment of the cellular network in the build direction.
Article
Evolutionary Biology
Heyu Lin, Edmund R. R. Moody, Tom A. Williams, John W. Moreau
Summary: Using genome-resolved phylogenetic analyses, this study sheds light on the origin of microbial mercury methylation, the evolution of the hgcAB gene, and the distribution of hgc in Bacteria and Archaea. It also suggests that the ability to produce antimicrobial compounds may have conferred a selective advantage in early Earth.
GENOME BIOLOGY AND EVOLUTION
(2023)
Article
Multidisciplinary Sciences
Yongsung Lee, Chung Hyun Cho, Chanyoung Noh, Ji Hyun Yang, Seung In Park, Yu Min Lee, John A. West, Debashish Bhattacharya, Kyubong Jo, Hwan Su Yoon
Summary: We report a multipartite circular mitochondrial genome in the Stylonematophyceae red algae, which encode one or two genes bounded by a specific cassette and a conserved constant region. Visualization using fluorescence microscope and scanning electron microscope confirms the circularity of these minicircles. These highly divergent mitogenomes exhibit reduced gene sets. The newly generated chromosome-level nuclear genome assembly of Rhodosorus marinus reveals the transfer of most mitochondrial ribosomal subunit genes to the nuclear genome. Recombination between minicircles and a unique gene inventory may explain the transition from a typical mitochondrial genome to minicircles. Our findings offer insight into minicircular organelle genome formation and highlight an extreme case of mitochondrial gene inventory reduction.
NATURE COMMUNICATIONS
(2023)
Article
Multidisciplinary Sciences
Ritsuko Morita, Noriko Sanzen, Hiroko Sasaki, Tetsutaro Hayashi, Mana Umeda, Mika Yoshimura, Takaki Yamamoto, Tatsuo Shibata, Takaya Abe, Hiroshi Kiyonari, Yasuhide Furuta, Itoshi Nikaido, Hironobu Fujiwara
Summary: This study utilized marker-independent long-term 3D live imaging and single-cell transcriptomics to investigate the development of epithelial lineage in mouse hair follicles. The findings revealed that precursors of different epithelial lineages align in a 2D concentric manner and extend to form longitudinally aligned, 3D cylindrical compartments. The fate of placode cells is determined by cell position rather than the orientation of cell division.
Article
Multidisciplinary Sciences
Florian A. Schober, David Moore, Ilian Atanassov, Marco F. Moedas, Paula Clemente, Akos Vegvari, Najla El Fissi, Roberta Filograna, Anna-Lena Bucher, Yvonne Hinze, Matthew The, Erik Hedman, Ekaterina Chernogubova, Arjana Begzati, Rolf Wibom, Mohit Jain, Roland Nilsson, Lukas Kall, Anna Wedell, Christoph Freyer, Anna Wredenberg
Summary: The gradual decline in mitochondrial SAM levels leads to defects in mitochondrial function, including loss of metabolites and impaired assembly of the oxidative phosphorylation system. These findings demonstrate the importance of cellular methylation potential for energy metabolism, with direct relevance for pathophysiology, aging, and cancer.
Article
Meteorology & Atmospheric Sciences
Fucheng Yang, Zhaohua Wu
Summary: By utilizing an energy budget model, this study reveals that the semiannual component of surface air temperature over mid-latitude and subpolar oceans is a response to the annually evolving solar irradiance due to the varying heat capacity of the oceanic mixed layer.
Article
Materials Science, Multidisciplinary
Jie Huang, Tao Chen, Daqing Huang, Tengzhou Xu
Summary: In this study, the dynamic behavior characteristics of droplet transition and weld pool in high-speed photography are extracted using an image processing program. The transfer of mass, heat, and momentum due to arc heating and droplet impact influences the dynamic behavior of the weld pool and microstructure in P-GMAW process. The influence of current waveform on arc pressure and droplet impact is quantitatively analyzed with different parameters. Furthermore, the internal relation between current waveform parameters and weld pool behavior and microstructure is investigated. The results show that droplet impact is positively related to pulse peak current, and rectangular wave pulse has a stronger impact than exponential wave with the same waveform parameters. The impact of droplet transition enhances the convective intensity of the weld pool and slows down the cooling rate of the solidified weld microstructure, resulting in increased grain size.
Article
Environmental Sciences
D. A. Novikov, F. F. Dultsev, E. V. Borisov, A. V. Chernykh, E. A. Fursenko
Summary: The studies of gas composition in the hydrocarbon pools of the Arctic regions of West Siberia revealed the specific features of gas composition and the vertical and lateral gas zoning. The highly mature Triassic-Middle Jurassic coaly matter was identified as the source of dry hydrocarbon gases in the Lower and Middle Jurassic complex. The Cretaceous sediments, especially the low-maturity terrestrial organic matter, produced the majority of light-isotope gases in the Aptian-Albian-Cenomanian sediments.
ENVIRONMENTAL EARTH SCIENCES
(2023)
Article
Forestry
Bernd Degen, Yulai Yanbaev, Ruslan Ianbaev, Svetlana Bakhtina, Albina Tagirova
Summary: The study aimed to investigate the genetic variability and differentiation among populations of pedunculate oak at the eastern margin of the species distribution range. Utilizing new DNA sequencing technology, the research found a relatively similar genetic diversity in seven populations, with significant genetic distances and the presence of genetically peculiar populations. Geographic location played a significant role in genetic differentiation among populations.
JOURNAL OF FORESTRY RESEARCH
(2021)
Article
Food Science & Technology
Dhananjay Kumar, Rajiv Ranjan Kumar, Preeti Rana, S. K. Mendiratta, R. K. Agarwal, Praveen Singh, Sarita Kumari, Jyoti Jawla
Summary: The study developed species-specific RPA-LF assays for identifying the origin of food animals, optimized using Twist Amp basic kit components. The assays detected cattle, buffalo, and pig DNA exclusively, showing high diagnostic sensitivity and correlation with PCR assays. This method can detect target species in meat samples at concentrations as low as 1%.
JOURNAL OF FOOD SCIENCE AND TECHNOLOGY-MYSORE
(2021)
Article
Biochemistry & Molecular Biology
Sebastian Carballal, Victor Vitvitsky, Roshan Kumar, David A. Hanna, Marouane Libiad, Aditi Gupta, Jace W. Jones, Ruma Banerjee
Summary: This study demonstrates that H2S increases lipid synthesis in cells by affecting mitochondrial NAD(P)H pools and enabling reductive carboxylation of alpha-ketoglutarate. H2S also leads to time-dependent changes in various lipid classes, upregulating triglycerides while downregulating phosphatidylcholine.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2021)
Article
Biotechnology & Applied Microbiology
Sevahn K. Vorperian, Mira N. Moufarrej, Stephen R. Quake
Summary: Cell types affected by diseases can be identified by analyzing cell-free RNA, allowing the determination of their tissue of origin. By utilizing various databases and transcriptomic cell atlases, cell type signature scores can be used to infer cell types contributing to cell-free RNA in different diseases.
NATURE BIOTECHNOLOGY
(2022)
Article
Biology
Vivek Garg, Junji Suzuki, Ishan Paranjpe, Tiffany Unsulangi, Liron Boyman, Lorin S. Milescu, W. Jonathan Lederer, Yuriy Kirichok
Summary: The study reveals that the MICU subunits do not block the MCUcx pore in the absence or presence of extramitochondrial Ca2+, but instead potentiate MCUcx activity by modifying its gating properties to spend more time in the open state when extramitochondrial Ca2+ is elevated.
Article
Biochemistry & Molecular Biology
Miroslava Derenko, Galina Denisova, Boris Malyarchuk, Anahit Hovhannisyan, Zaruhi Khachatryan, Peter Hrechdakian, Andrey Litvinov, Levon Yepiskoposyan
MOLECULAR GENETICS AND GENOMICS
(2019)
Article
Multidisciplinary Sciences
Martin Sikora, Vladimir V. Pitulko, Vitor C. Sousa, Morten E. Allentoft, Lasse Vinner, Simon Rasmussen, Ashot Margaryan, Peter de Barros Damgaard, Constanza de la Fuente, Gabriel Renaud, Melinda A. Yang, Qiaomei Fu, Isabelle Dupanloup, Konstantinos Giampoudakis, David Nogues-Bravo, Carsten Rahbek, Guus Kroonen, Michael Peyrot, Hugh McColl, Sergey V. Vasilyev, Elizaveta Veselovskaya, Margarita Gerasimova, Elena Y. Pavlova, Vyacheslav G. Chasnyk, Pavel A. Nikolskiy, Andrei V. Gromov, Valeriy I. Khartanovich, Vyacheslav Moiseyev, Pavel S. Grebenyuk, Alexander Yu. Fedorchenko, Alexander I. Lebedintsev, Sergey B. Slobodin, Boris A. Malyarchuk, Rui Martiniano, Morten Meldgaard, Laura Arppe, Jukka U. Palo, Tarja Sundell, Kristiina Mannermaa, Mikko Putkonen, Verner Alexandersen, Charlotte Primeau, Nurbol Baimukhanov, Ripan S. Malhi, Karl-Goran Sjogren, Kristian Kristiansen, Anna Wessman, Antti Sajantila, Marta Mirazon Lahr, Richard Durbin, Rasmus Nielsen, David J. Meltzer, Laurent Excoffier, Eske Willerslev
Article
Medicine, Legal
Slobodan Davidovic, Boris Malyarchuk, Tomasz Grzybowski, Jelena M. Aleksic, Miroslava Derenko, Andrey Litvinov, Urszula Rogalla-Ladniak, Milena Stevanovic, Natasa Kovacevic-Grujicic
INTERNATIONAL JOURNAL OF LEGAL MEDICINE
(2020)
Article
Anthropology
V. G. Moiseyev, A. Zubova, P. S. Grebenyuk, A. Lebedintsev, B. A. Malyarchuk, A. Y. Fedorchenko
Summary: The study reconstructs biological affinities in a cranial sample from a collective burial on Cape Bratyev in Babushkin Bay. Results show that the Old Koryak population was heterogeneous with connections to Epi-Jomon people of Hokkaido, and shared history with Okhotsk culture people. The Okhotsk people are the result of admixture of ancient Chukchi and Eskimo groups, and Tungus-Manchu groups.
ARCHAEOLOGY ETHNOLOGY AND ANTHROPOLOGY OF EURASIA
(2021)
Article
Biochemistry & Molecular Biology
Miroslava Derenko, Galina Denisova, Irina Dambueva, Boris Malyarchuk, Boris Bazarov
Summary: The study found that Mongolic-speaking populations exhibit strong genetic resemblance to East Asian populations like the Chinese, Japanese, and Uyghurs, showing high genetic diversity. The gene pools of these populations contain components from East Asian, Siberian, autochthonous, Europe, and West Asia/Caucasus ancestry. Specific subhaplogroups identified in Mongolic-speaking populations have a coalescence age not exceeding 1.7 kya, indicating retention of genetic structure established during the Mongol empire.
MOLECULAR GENETICS AND GENOMICS
(2022)
Article
Genetics & Heredity
B. A. Malyarchuk, M. Derenko, G. A. Denisova
Summary: The genetic features of the indigenous population in Far East Siberia reflect their long-term adaptation to a diet rich in fats, which results in reduced need for additional synthesis of polyunsaturated fatty acids.
RUSSIAN JOURNAL OF GENETICS
(2021)
Article
Genetics & Heredity
Alexander Morseburg, Luca Pagani, Boris Malyarchuk, Miroslava Derenko, Toomas Kivisild
Summary: This study reexamined the role of the R577X mutation in the ACTN3 gene in muscle metabolism and concluded that the frequency distribution of this mutation is more likely influenced by genetic drift rather than selection in cold climates.
AMERICAN JOURNAL OF HUMAN GENETICS
(2022)
Letter
Genetics & Heredity
Boris Malyarchuk, Katarzyna Skonieczna, Anna Duleba, Miroslava Derenko, Alexandra Malyarchuk, Tomasz Grzybowski
FORENSIC SCIENCE INTERNATIONAL-GENETICS
(2022)
Article
Archaeology
B. A. Malyarchuk, M. Derenko, S. A. Borinskaya, A. B. Malyarchuk, T. Andreeva, E. Rogaev
Summary: This study conducted a comparative analysis of random match probabilities of whole mitochondrial genomes and hypervariable regions in Eurasian populations, finding that the former has significantly higher probabilities than the latter. Therefore, analyzing full-length mitochondrial genome sequences is crucial for the accurate interpretation of genetic identifications in archaeogenetics.
KRATKIE SOOBSHCHENIYA INSTITUTA ARKHEOLOGII
(2021)
Review
Agriculture, Multidisciplinary
B. A. Malyarchuk
VAVILOVSKII ZHURNAL GENETIKI I SELEKTSII
(2020)
Article
Agriculture, Multidisciplinary
B. A. Malyarchuk
VAVILOVSKII ZHURNAL GENETIKI I SELEKTSII
(2019)
Article
Anthropology
P. S. Grebenyuk, A. Yu Fedorchenko, A. Lebedintsev, B. A. Malyarchuk
TOMSKII ZHURNAL LINGVISTICHESKIKH I ANTROPOLOGICHESKIKH ISSLEDOVANII-TOMSK JOURNAL OF LINGUISTICS AND ANTHROPOLOGY
(2019)