期刊
RUSSIAN JOURNAL OF GENERAL CHEMISTRY
卷 88, 期 6, 页码 1325-1330出版社
MAIK NAUKA/INTERPERIODICA/SPRINGER
DOI: 10.1134/S1070363218060439
关键词
cyclodextrins; sulfasalazine; complex formation; thermodynamics; solubility
资金
- Russian Foundation for Basic Research [15-43-03017-r-tscntr-a]
Complex formation of alpha-, beta-, and gamma-cyclodextrins with sulfasalazine in biologically relevant buffer solutions (pH 1.2 and 7.4) was studied. Formation of inclusion complexes of 1 : 1 stoichiometry between the drug and cyclodextrins was revealed. The ionization state of sulfasalazine more strongly affects the complex formation than does the structure of cyclodextrins. Compared with a neutral molecule, sulfasalazine anionic species forms with cyclodextrins more stable complexes, which are essentially stabilized by possible surface interactions.
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