期刊
RSC ADVANCES
卷 5, 期 75, 页码 61309-61317出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c5ra09075j
关键词
-
资金
- Research Fund for the Doctoral Program of Higher Education of China [20120201130004]
- Science and Technology Developing Project of Shaanxi Province [2015KW-001]
- Natural Science Basic Research Plan in Shaanxi Province of China [2015JQ5165]
- Fundamental Research Funds for the Central Universities [XJJ2014090]
- National Natural Science Foundation of China Major Research Plan on Nanomanufacturing [91323303]
- National Natural Science Foundation of China [61078058]
- 111 Project of China [B14040]
In this study, polydimethylsiloxane-bioactive glass-poly(caprolactone) (PDMS-BG-PCL) hybrid monoliths with various PDMS-BG contents were successfully fabricated via a typical sol-gel route. As a reinforcement, the PDMS-BG was used to improve the biomineralization activity, mechanical properties and osteoblasts biocompatibility of PCL polymer. The incorporation of PCL significantly decreased the formation time and increased the toughness of crack-free PDMS-BG-PCL hybrid monoliths. The mechanical properties of PDMS-BG-PCL hybrid monoliths were significantly affected by the content of PDMS-BG and PDMS-BG-PCL (30 wt%) showed a much higher elastic modulus (328.87 +/- 18.82 MPa). The hydrophilicity of PDMS-BG-PCL hybrids was also increased as the PDMS-BG increased. Additionally, the biomineralization activity of PDMS-BG-PCL hybrid monoliths could be tailored by the PDMS-BG content. All PDMS-BG-PCL hybrids could induce fast deposition of a crystalline apatite layer on their surface in SBF for 7 days. The in vitro cellular studies also showed that PDMS-BG-PCL hybrids can enhance osteoblasts attachment and cell viability compared with PCL. The crack-free monolith structure, biomimetic hybrid composition and high apatite-forming bioactivity make PDMS-BG-PCL hybrid a promising candidate as scaffolds and implants for drug delivery and bone regeneration applications.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据