Article
Biophysics
Jeehae Shin, Sheng Li
Summary: This study investigates the interaction between DNA-conjugated molecules and lipid molecules, revealing that the morphology and amount of lipid layers formed are influenced by liposome concentration and recruiter molecule type. Surface chemistry plays a crucial role in determining the lipid layers formed, leading to multilayers on hydrophilic surfaces and monolayers on hydrophobic surfaces. The overall charge and fluidity of liposomes further modulate the total amount of lipid layers formed, providing a new approach to fine-tune lipid layer formation behavior.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2021)
Article
Biochemistry & Molecular Biology
Mohamed Hamdi, Enas Elmowafy, Hend Mohamed Abdel-Bar, Akram M. ElKashlan, Khuloud T. Al-Jamal, Gehanne A. S. Awad
Summary: Drug covalently bound to polymers has formed a promising drug delivery platform with targeting ability, boosting drug loading and controlled release. This study demonstrated that entecavir conjugated to hyaluronic acid in lipid nanohybrids can target Kupffer cells and hepatocytes.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Chemistry, Physical
Tingyu Lei, Xingchen Liu, Amar Deep Pathak, Sharan Shetty, Qingya Liu, Xiaodong Wen
Summary: This study examined the mechanism of carbon deposition and hydrogenation on Fe clusters using the DFTB-NMD method, revealing the formation of carbon chains, rings, and fused rings during deposition. Hydrogenation of activated carbon occurs via direct C-H coupling, while hydrogenation of graphitic carbon involves various reactions. The Fe catalyst primarily provides active sites for hydrogen dissociation and spillover, with limited activity in C-C bond breaking.
JOURNAL OF PHYSICAL CHEMISTRY LETTERS
(2021)
Article
Chemistry, Applied
Qing Zhang, Yuanyuan Zhang, Haibo Chen, Lei Zhang, Peng Li, Huining Xiao, Weibing Wu
Summary: This article describes the controllable and uniform loading of gold nanospheres on cellulose nanocrystals by electrostatic adsorption self-assembly. The particle spacing of gold nanospheres on cellulose nanocrystal surface was successfully regulated by adjusting size, Zeta potential, and loading ratio. This method provides an easy and efficient approach to constructing one-dimensional hot spots, which is crucial for enhancing the performance of surface enhanced Raman scattering spectroscopy. The resulting nanohybrid shows improved reproducibility and sensitivity for SERS detection, making it potentially valuable for sensing applications.
CARBOHYDRATE POLYMERS
(2022)
Article
Polymer Science
Thi-Thanh-Tam Nguyen, Daniel Grande, Clemence Le Coeur, Alicia Contreras, Alina Vashchuk, Alexander Fainleib, Encarnacion Torralba, Stephane Bastide
Summary: A novel approach has been developed to elaborate nanoporous polymers using nanoporous gold as a template, allowing for the replication of any polymeric material based on the solubility behavior. The resulting nanoporous polymers exhibit well-defined nanostructures with a homogeneous size distribution, showing promise for versatile polymer diversity and precise tuning of nanostructure size.
EUROPEAN POLYMER JOURNAL
(2021)
Article
Polymer Science
Jun Ho Kwon, Jiwon Kim, Kyoung Taek Kim
Summary: Polymer cubosomes are mesoporous structures formed by the self-assembly of block copolymers with a highly asymmetric block ratio, providing a large surface area and internal volume for catalyst accommodation. Functionalized BCPs self-assembled into nanoreactors can catalyze reactions efficiently in organic solvents, demonstrating enhanced catalytic performance compared to molecular catalysts even after multiple recycling.
Article
Polymer Science
Ke Zheng, Shenggui Chen, Haochun Zhan, Junpeng Situ, Ziying Chen, Xiaxia Wang, Dongdong Zhang, Lei Zhang
Summary: In this study, a strategy for efficient synthesis of phenolic polymers was established by enzymatic polymerization in a nanoreactor. The results indicated that this method could efficiently synthesize phenolic polymers in water and allow for easy separation of the products through temperature control, while the catalyst could be reused.
Review
Biochemistry & Molecular Biology
Aiswarya Chaudhuri, Dulla Naveen Kumar, Rasheed A. Shaik, Basma G. Eid, Ashraf B. Abdel-Naim, Shadab Md, Aftab Ahmad, Ashish Kumar Agrawal
Summary: Lipid-based nanoparticles (LNPs) are a promising treatment option for triple-negative breast cancer (TNBC) with advantages such as increased drug loading capacity, enhanced stability, reduced toxicity, and limited drug resistance compared to conventional therapy and other nanoparticles. However, issues such as high cost, scaling up formulation production, and targeted delivery still need to be addressed.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Medicine, Research & Experimental
Zih-Chan Lin, Tsong-Long Hwang, Tse-Hung Huang, Kohei Tahara, Jiri Trousil, Jia-You Fang
Summary: The actively targeted nanocarriers loaded with the phosphodiesterase 4 inhibitor AN2728 showed promising results in treating psoriasiform inflammation. The nanohybrids demonstrated efficient targeting properties and inhibited cytokine/chemokine overexpression in keratinocytes, as well as reducing neutrophil migration. In a psoriasis-like skin mouse model, the targeted nanoparticles were superior to free drug and non-targeted nanoparticles in mitigating skin inflammation, showing potential for therapeutic applications in cutaneous inflammation.
Article
Chemistry, Physical
Qingzhao Chu, Chenguang Wang, Dongping Chen
Summary: We propose a neural network-based model to construct the potential energy surface of soot formation and investigate the critical process of PAH radical inception through molecular dynamics simulations. The results show that physical interaction enhances chemical inception and this enhancement is observed in clusters of pi- and sigma-radicals.
Article
Biochemical Research Methods
Andre Q. Figueiredo, Carolina F. Rodrigues, Natanael Fernandes, Ilidio J. Correia, Andre F. Moreira
Summary: This study developed a novel and simpler methodology for producing gold-polymer hybrid structures for cancer photothermal therapy applications. The Au-Alg-NH nanohybrids were synthesized through a straightforward and faster process, using ascorbic acid to promote the in situ reduction and nucleation of gold on a crosslinked alginic acid polymeric matrix. This synthesis process avoids the use of toxic stability agents and the laborious washing and purification steps commonly used in the production of gold-based nanoparticles.
BIOTECHNOLOGY JOURNAL
(2023)
Article
Chemistry, Physical
Marta Rubio-Camacho, Maria Jose Martinez-Tome, Carlos Cuestas-Ayllon, Jesus M. de la Fuente, Rocio Esquembre, C. Reyes Mateo
Summary: A fast and environmentally-friendly method has been developed for the synthesis of gold nanoparticles (AuNPs) on thermosensitive liposomes. The arrangement of the AuNPs can be controlled and tuned by the lipid phase, charge, and synthesis temperature. The resulting nanohybrids show plasmon peaks within the visible/near-infrared region and retain the physical properties of the liposomes, making them excellent candidates for light-mediated therapies with controlled drug delivery capacity.
COLLOID AND INTERFACE SCIENCE COMMUNICATIONS
(2023)
Article
Chemistry, Analytical
Yujun Cheng, Tao Chen, Donglei Fu, Jingquan Liu
Summary: Biological enzymes, such as urease, have limitations in selective detection due to their lack of absolute specificity. By embedding urease and bovine hemoglobin in metal-organic frameworks, a bifunctional nanoreactor with outstanding enzymatic activity was constructed. This nanoreactor showed a wide linear range and low detection limit in urea detection, with excellent stability and selectivity.
SENSORS AND ACTUATORS B-CHEMICAL
(2022)
Article
Chemistry, Multidisciplinary
Francesco Ricci, Marc T. Cuairan, Andreas W. Schell, Erik Hebestreit, Raul A. Rica, Nadine Meyer, Romain Quidant
Summary: A single levitated nanoparticle is used as a nanoreactor to study surface chemistry at the nanoscale. The optical levitation technique provides precise control over the nanoparticle's dynamics, charge, and surface chemistry. By studying a single nanoparticle, the researchers were able to observe how the presence of silanol groups on its surface affects water adsorption and desorption from the surrounding gas. They demonstrated the potential of this versatile platform by studying the Zhuravlev model in silica particles, and observed an abrupt and irreversible change in scattering cross section, mass, and mechanical eigenfrequency during the dehydroxylation process.
Article
Chemistry, Multidisciplinary
Ruyue Wei, Yanhua Li, Peng Gao, Xia Zhang, Xiaoyu Li, Kaixian Wang, Wei Pan, Na Li, Bo Tang
Summary: We demonstrate a gold nanoparticle engineered metal-organic framework nanoreactor with photothermal, glucose oxidase-like, and GSH-consuming performance to achieve the accumulation of hydroxyl radicals and the enhancement of thermal sensitivity for combined ferroptosis and mild photothermal therapy.
CHEMICAL COMMUNICATIONS
(2023)
Article
Pharmacology & Pharmacy
Christina Haeuser, Pierre Goldbach, Joerg Huwyler, Wolfgang Friess, Andrea Allmendinger
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
(2020)
Article
Chemistry, Medicinal
Christoph Grapentin, Claudia Mueller, Ravuri S. K. Kishore, Michael Adler, Inas ElBialy, Wolfgang Friess, Jorg Huwyler, Tarik A. Khan
JOURNAL OF PHARMACEUTICAL SCIENCES
(2020)
Correction
Chemistry, Multidisciplinary
Joachim Schuster, Atanas Koulov, Hanns-Christian Mahler, Pascal Detampel, Joerg Huwyler, Satish Singh, Roman Mathaes
PHARMACEUTICAL RESEARCH
(2020)
Article
Chemistry, Physical
Deepika Sharma, Roderick Y. H. Lim, Thomas Pfohl, Yasin Ekinci
Summary: Utilizing geometry-induced electrostatic (GIE) potential trap in a nanofluidic device is an efficient and robust method for nanoparticle trapping, depending solely on device geometry and device-particle surface interaction. The study reveals crucial parameters affecting device efficiency, particle trapping stiffness, and particle residence time, providing guidelines for future developments in optimization of device geometry. Various simulations, including charged particle and point charge approximation, are presented to estimate particle trapping efficiency, with good agreement with experimental observations.
PARTICLE & PARTICLE SYSTEMS CHARACTERIZATION
(2021)
Article
Pediatrics
Leonie Wagner-Hattler, Klara Kiene, Julia Bielicki, Marc Pfister, Maxim Puchkov, Joerg Huwyler
Summary: The study evaluated the acceptability of a novel child-appropriate oral dispersible tablet formulation. The results showed high acceptability among parents and children, with smooth administration process and no distress observed in any of the children. The proposed child-friendly dosage form is expected to improve drug adherence in pediatric patients.
Article
Biochemistry & Molecular Biology
Laura Nicolle, Jens Casper, Melanie Willimann, Celine M. A. Journot, Pascal Detampel, Tomaz Einfalt, Hiu Man Grisch-Chan, Beat Thony, Sandrine Gerber-Lemaire, Jorg Huwyler
Summary: The study developed a novel chitosan-derivative, dCS-Suc-LPEI-14, showing promising biocompatibility, cytotoxicity, and transfection efficiency. Through in vitro and in vivo experiments, its potential for non-viral gene therapy was confirmed.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Multidisciplinary Sciences
Konstantinos Roumpos, Sarah Fontaine, Thomas Pfohl, Oswald Prucker, Juergen Ruehe, Guenter Reiter
Summary: The study demonstrated that periodic perturbations in a driving force field, caused by an array of elastic micro-pillars, can break the circular symmetry of expanding dewetting holes and establish a pattern of lower symmetry. The observed envelope of the dewetting holes reflected the symmetry of the underlying pattern, even at sizes much larger than the characteristic period of the pillar array. The researchers successfully managed to "square the circle" in the presented system.
SCIENTIFIC REPORTS
(2021)
Article
Polymer Science
Brahim Bessif, Thomas Pfohl, Guenter Reiter
Summary: The self-seeding procedure effectively controls the number and size of platelet-like crystals, independent of crystallization temperature; the crystal number increases linearly with polymer concentration and exponentially decays with self-seeding temperature. The study also demonstrates the control of stacked lamellae in crystals through the self-seeding procedure.
Article
Nanoscience & Nanotechnology
Deepika Sharma, Roderick Y. H. Lim, Thomas Pfohl, Yasin Ekinci
Summary: The focus of this work is on the development of simple and effective nanofluidic devices for trapping single charged nanoparticles in an aqueous environment. By modifying the surface of the device to change its charge properties and reducing the surface modification time, the study demonstrates the successful enhancement in device performance.
MICROSYSTEMS & NANOENGINEERING
(2021)
Article
Polymer Science
Cuong Minh Quoc Le, Gautier Schrodj, Ibrahima Ndao, Brahim Bessif, Barbara Heck, Thomas Pfohl, Guenter Reiter, Justine Elgoyhen, Radmila Tomovska, Abraham Chemtob
Summary: The photocatalytic thiol-ene aqueous emulsion polymerization under visible-light is a novel method to prepare linear semicrystalline latexes with specific properties. The reaction conditions are mild, the reaction time is short, and the resulting products exhibit a unique structure and characteristics.
MACROMOLECULAR RAPID COMMUNICATIONS
(2022)
Article
Polymer Science
Tianyu Wu, Sivasurender Chandran, Yao Zhang, Tianze Zheng, Thomas Pfohl, Jun Xu, Guenter Reiter
Summary: This study investigates the characteristics of the critical primary nucleus in polymer crystallization using a combination of experimental and simulation models. The results suggest that classical nucleation theory may not be applicable for weakly supersaturated solutions.
Article
Polymer Science
Brahim Bessif, Thomas Pfohl, Barbara Heck, Yaser Alshetwi, Emna Khechine, Jun Xu, Guenter Reiter
Summary: By using a hydrophobic-hydrophilic block copolymer, researchers created sandwich-like platelets in a solution through crystallization and observed changes in thickness and morphology when exposed to humid air.
Article
Biology
Nora Sauter, Matteo Sangermani, Isabelle Hug, Urs Jenal, Thomas Pfohl
Summary: A bacteria-on-a-bead system was developed to study the dynamics of flagellum and pili during cell separation and surface attachment. It was found that pili play a crucial role in cell attachment and cooperate with flagellum during the approaching and attaching process to surfaces.
COMMUNICATIONS BIOLOGY
(2022)
Article
Virology
Patrick Hauswirth, Philipp Graber, Katarzyna Buczak, Riccardo Vincenzo Mancuso, Susanne Heidi Schenk, Juerg P. F. Nueesch, Jorg Huwyler
Summary: Mutated NS1 variants, particularly the NS1-T585E single-amino acid mutant, showed potential oncotoxic effects in human hepatocellular carcinoma cell lines. Proteomics analysis revealed new interaction partners and signaling pathways of NS1, providing mechanistic explanations for its oncolytic effects.
Review
Pharmacology & Pharmacy
Klervi Golhen, Michael Buettcher, Jonas Kost, Joerg Huwyler, Marc Pfister
Summary: The majority of therapeutics currently available are not suitable for pediatric patients, thus there is a need to develop child-friendly dosage forms. This review discusses the challenges and opportunities in the development of such dosage forms, including taste masking, tablet size, dose flexibility, excipient safety, and acceptability. It also explores the example of orally dispersible tablets (ODTs) as a child-friendly drug delivery strategy, utilizing inorganic particulate drug carriers as multifunctional excipients to address unique medical needs in infants and children while maintaining a favorable excipient safety and acceptability profile in these vulnerable patient populations.
