Article
Engineering, Manufacturing
Frederik Wulle, Oliver Gorke, Sarah Schmidt, Maximilian Nistler, Gunter E. Tover, Oliver Riedel, Alexanser Verl, Achim Weber, Alexanser Southan
Summary: This paper introduces the potential and advantages of multi-axis 3D printing of hydrogels, and demonstrates through experiments the relative flexibility and water absorbency of 3D printed hydrogels compared to conventional molded hydrogels. The research also highlights related research questions, such as cross-linking chemistry and formulation of hydrogel inks.
ADDITIVE MANUFACTURING
(2022)
Article
Chemistry, Multidisciplinary
Ximin Yuan, Zhou Zhu, Pengcheng Xia, Zhenjia Wang, Xiao Zhao, Xiao Jiang, Tianming Wang, Qing Gao, Jie Xu, Debin Shan, Bin Guo, Qingqiang Yao, Yong He
Summary: Tough hydrogel is difficult to be used for tissue regeneration due to its poor biocompatibility, nondegradation, and compositional differences from natural tissues. This study proposes a gelatin-based tough hydrogel (GBTH) that overcomes these limitations. GBTH exhibits excellent tensile strength and can be sutured to ruptured tendons, promoting tendon differentiation and allowing quick return to the initial state within eight weeks. This strategy provides a new avenue for highly biocompatible tough hydrogel preparation for tissue regeneration.
Article
Engineering, Chemical
Vukasin Ugrinovic, Vesna Panic, Pavle Spasojevic, Sanja Seslija, Bojan Bozic, Rada Petrovic, Djordje Janackovic, Djordje Veljovic
Summary: This paper reports on the synthesis of PMAA/gelatin IPN hydrogels with adjustable properties through free-radical polymerization; it investigates the influence of different components in the precursor solution on the hydrogels' properties. The hydrogels exhibit pH sensitivity and promote cell proliferation.
POLYMER ENGINEERING AND SCIENCE
(2022)
Article
Multidisciplinary Sciences
Mingkun Wang, Shuofei Sun, Gening Dong, Feifei Long, Jonathan T. Butcher
Summary: We have successfully replicated the properties of load-bearing soft tissues using a thermomechanical approach. Our gelatin methacryloyl fiber hydrogel exhibits soft tissue-like mechanical properties, biochemical and architectural similarity to native extracellular matrix, and supports cell remodeling. This combination of mechanical properties and bioactivity is highly desirable for tissue engineering and regenerative medicine.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Chemistry, Multidisciplinary
Shahzad Hafeez, Monize Caiado Decarli, Agustina Aldana, Mahsa Ebrahimi, Floor A. A. Ruiter, Hans Duimel, Clemens van Blitterswijk, Louis M. Pitet, Lorenzo Moroni, Matthew B. Baker
Summary: This article investigates a synthetic supramolecular/covalent strategy for creating a tough hydrogel with the hierarchical fibrous architecture of the extracellular matrix (ECM). The hydrogelator self-assembles to form a viscoelastic hydrogel and is reinforced by covalent intra- and interfiber cross-links, resulting in enhanced mechanical properties. The hydrogels exhibit high tensile strain and compressive strain, are shear-thinning, and can be 3D bioprinted. Additionally, the hydrogels enable the bioprinting and differentiation of human mesenchymal stromal cell (hMSC) spheroids into chondrogenic tissue.
ADVANCED MATERIALS
(2023)
Article
Biotechnology & Applied Microbiology
Kai-Yang Wang, Xiang-Yun Jin, Yu-Hui Ma, Wei-Jie Cai, Wei-Yuan Xiao, Zhi-Wei Li, Xin Qi, Jian Ding
Summary: The injectable modified gelatin hydrogel developed in this study effectively adsorbed proteoglycans secreted by chondrocytes and introduced dynamic covalent bonds, promoting chondrocyte survival and cartilage differentiation of stem cells. The modified hydrogel showed efficient biocompatibility and enhanced tissue repair of cartilage defects.
JOURNAL OF NANOBIOTECHNOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Wenguang Wang, Yanbin Shi, Guimei Lin, Bingtao Tang, Xuelin Li, Jing Zhang, Xinbing Ding, Guangzhen Zhou
Summary: This paper discusses the application of hydrogels in cartilage repair, including their mechanical properties and materials used. The challenges faced by hydrogels and future research directions are also discussed.
MACROMOLECULAR BIOSCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Soroush Ahmadi, Ahmad Hivechi, S. Hajir Bahrami, Peiman B. Milan, Seyedeh Sara Ashraf
Summary: This study developed chitosan/gelatin nanofiber membranes with sustained release capacity to prevent infection by delivering cinnamon extract (CE) in the implanted site. The incorporation of CE enhanced the properties of the nanofibers, including degradation behavior, antibacterial activity, and biocompatibility. The extract release profile showed a burst release in the first 6 hours, followed by a controlled release in the next 138 hours.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Engineering, Biomedical
A. R. Chin, J. M. Taboas, A. J. Almarza
Summary: Research showed that mandibular condyle cartilage cells do have the potential for cartilage regeneration, but they are more sensitive to hydrogel materials compared to costal cartilage cells.
ANNALS OF BIOMEDICAL ENGINEERING
(2021)
Review
Engineering, Multidisciplinary
Liangbin Zhou, Peng Guo, Matteo D'Este, Wenxue Tong, Jiankun Xu, Hao Yao, Martin J. Stoddart, Gerjo J. V. M. van Osch, Kevin Ki-Wai Ho, Zhen Li, Ling Qin
Summary: Articular cartilage (AC) is a flexible connective tissue located on the bone surface in the joints. AC defects are common in physically active individuals. Functionalized hydrogels have emerged as promising substitutes for damaged cartilage in AC repair due to their favorable properties. This article introduces the composition, structure, and function of AC and its defects, and reviews the design and fabrication of functionalized hydrogels for AC repair.
Article
Biochemistry & Molecular Biology
Seung Bae Ryu, Kyung Min Park, Ki Dong Park
Summary: This study developed enzyme-mediated crosslinking gelatin-based hydrogels that mimic the structure of extracellular matrix (ECM) and effectively adhere to surrounding tissues. The addition of graphene oxide (GO) affects the physico-chemical properties of gelatin hydrogels, particularly tissue adhesion strength. The study also confirmed the biodegradability of the hydrogels and their promotion of cell proliferation.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Polymer Science
Parya Bahrami Miyanji, Dariush Semnani, Abdolkarim Hossein Ravandi, Saeed Karbasi, Aref Fakhrali, Sajjad Mohammadi
Summary: Chitosan-gelatin/single-walled carbon nanotubes functionalized by COOH (SWNTs-COOH) nanocomposite scaffolds were fabricated through electrospinning in this study. The addition of SWNTs-COOH improved the mechanical properties, stability, and cell viability of the scaffolds, making them suitable for cartilage tissue engineering applications.
POLYMERS FOR ADVANCED TECHNOLOGIES
(2022)
Article
Biochemistry & Molecular Biology
Ryoma Goto, Eisaku Nishida, Shuichiro Kobayashi, Makoto Aino, Tasuku Ohno, Yuki Iwamura, Takeshi Kikuchi, Jun-ichiro Hayashi, Genta Yamamoto, Masaki Asakura, Akio Mitani
Summary: The study found that visible-light-crosslinked GelMA hydrogels, along with encapsulated osteoblasts, exhibited good mechanical and biological properties, making them suitable for use as scaffolds for bone regeneration. Osteoblasts encapsulated in GelMA hydrogels photopolymerized with visible light showed higher cell viability. Additionally, GelMA-RF hydrogels promoted osteoblast differentiation and have the potential to treat bone-destructive diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biotechnology & Applied Microbiology
Yunong Ao, En Zhang, Yangxi Liu, Liu Yang, Jun Li, Fuyou Wang
Summary: Nanocomposite hydrogels show promise in cartilage tissue engineering for repair of cartilage defects. This review summarizes the different advanced nanoparticle hydrogels currently used and discusses their application scenarios and future prospects.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Engineering, Biomedical
Matthew L. Bedell, Angelica L. Torres, Katie J. Hogan, Ziwen Wang, Bonnie Wang, Anthony J. Melchiorri, K. Jane Grande-Allen, Antonios G. Mikos
Summary: The investigation of novel hydrogel systems in osteochondral tissue engineering is important for understanding the relationship between biomaterials, cells, and other factors. This study explored the use of 3D printing to fabricate hydrogel environments that mimic tissue-specific architectures. The researchers characterized a methacryloylated gelatin composite hydrogel system and investigated the effects of additives on bone and cartilage-like matrix deposition and genetic markers in human mesenchymal stem cells (hMSCs). New assays were developed to study the effects of different bioinks and printing techniques, and viable constructs with encapsulated hMSCs were successfully printed. The results demonstrate the potential of these novel hydrogel formulations for promoting osteochondral phenotypes and highlight the importance of bioink additives in printability.
Article
Nanoscience & Nanotechnology
Liufang Wang, Guorong Gao, Yang Zhou, Ting Xu, Jing Chen, Rong Wang, Rui Zhang, Jun Fu
ACS APPLIED MATERIALS & INTERFACES
(2019)
Article
Polymer Science
Dan Xu, Ting Xu, Guorong Gao, Ying Xiao, Zongbao Wang, Jing Chen, Yang Zhou, Rong Wang, Jingbo Yin, Jun Fu
JOURNAL OF POLYMER SCIENCE PART B-POLYMER PHYSICS
(2019)
Article
Engineering, Biomedical
Xiaoying Kong, Jun Fu, Kai Shao, Lili Wang, Xuefang Lan, Jinsheng Shi
ACTA BIOMATERIALIA
(2019)
Article
Chemistry, Multidisciplinary
Hua Zhang, Yang Cong, Amarachi Rosemary Osi, Yang Zhou, Fangcheng Huang, Remo P. Zaccaria, Jing Chen, Rong Wang, Jun Fu
ADVANCED FUNCTIONAL MATERIALS
(2020)
Article
Polymer Science
Linjie Zhou, Xinjie Pei, Kun Fang, Rui Zhang, Jun Fu
Article
Chemistry, Multidisciplinary
Shengnan Li, Hailong Yang, Nannan Zhu, Guoqi Chen, YueYue Miao, Jingxia Zheng, Yang Cong, Yousi Chen, Junpeng Gao, Xigao Jian, Jun Fu
Summary: Composite hydrogels with outstanding mechanical and electrical properties have been developed inspired by anisotropic biotissues. These hydrogels have high sensitivity and superior performance in conductivity, tensile strength, and modulus, making them suitable for self-sensing biomimetic actuators.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Article
Engineering, Environmental
Junyao Song, Haoyu Chen, Yaqian Lv, Wanqun Yang, Fenglang Zhang, Tianyi Wang, Danping Liu, Yingshan Qu, Lei Han, Jun Fu, Xiaoying Kong
Summary: This study developed a hybrid single atom nanozyme material composed of Zn single-atom catalysts and copper peroxide, which exhibited superior antibacterial properties and therapeutic effects for the treatment of biofilm-infected wounds.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Biochemistry & Molecular Biology
Yuanna Sun, Fenling Shi, Ruobing Tian, Xiaoliang Zhao, Qingshan Li, Chen Song, Ying Du, Xinhai He, Jun Fu
Summary: In this study, a biocompatible hydrogel with self-repairability, wide operating temperature, and precise sensing ability was successfully designed. The hydrogel exhibited unique heat-induced healing behavior, tunable stiffness and transparency, and favorable conductivity, anti-freezing and long-term stability. These advantages make it a promising material for wearable sensors.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Review
Materials Science, Biomaterials
Zhenwu Wang, Yang Cong, Jun Fu
JOURNAL OF MATERIALS CHEMISTRY B
(2020)
Article
Materials Science, Multidisciplinary
Yawen Xu, Jing Chen, Hua Zhang, Hua Wei, Linjie Zhou, Zhenwu Wang, Yuexiao Pan, Xinyan Su, Afang Zhang, Jun Fu
JOURNAL OF MATERIALS CHEMISTRY C
(2020)
Editorial Material
Engineering, Biomedical
Jun Fu
UHMWPE BIOMATERIALS FOR JOINT IMPLANTS: STRUCTURES, PROPERTIES AND CLINICAL PERFORMANCE
(2019)
Article
Materials Science, Biomaterials
Peng Sun, Hua Zhang, Dan Xu, Zhenwu Wang, Liufang Wang, Guorong Gao, Gaffar Hossain, Jiangyu Wu, Rong Wang, Jun Fu
JOURNAL OF MATERIALS CHEMISTRY B
(2019)
Article
Materials Science, Biomaterials
Penggang Ren, Hua Zhang, Zhong Dai, Fang Ren, Yidong Wu, Ruixia Hou, Yabin Zhu, Jun Fu
JOURNAL OF MATERIALS CHEMISTRY B
(2019)
Proceedings Paper
Polymer Science
Jun Fu
MACROMOLECULAR SYMPOSIA
(2019)
Article
Materials Science, Biomaterials
Zhenwu Wang, Jing Chen, Liufang Wang, Guorong Gao, Yang Zhou, Rong Wang, Ting Xu, Jingbo Yin, Jun Fu
JOURNAL OF MATERIALS CHEMISTRY B
(2019)