期刊
RUSSIAN CHEMICAL BULLETIN
卷 62, 期 4, 页码 1103-1110出版社
SPRINGER
DOI: 10.1007/s11172-013-0149-3
关键词
4-arylcoumarins; water-soluble anticancer agents; combretastatin A-4; ombrabulin; L-serine; cross-coupling; cytotoxicity
资金
- Russian Foundation for Basic Research [12-03-00214-a]
- Ministry of Education and Science [16.740.11.0476, 14.V37.21.0254, 14.V37.21.2039]
Novel 4-arylcoumarin derivatives were obtained. They are water-soluble analogs of the well-known anticancer drug combretastatin A-4. The key step of the synthesis involves the Suzuki-Miyaura cross-coupling. The water-soluble salts obtained exhibit considerable cytotoxic activity against the HBL-100 and HaCaT cell lines.
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