Article
Chemistry, Multidisciplinary
Arka Som, Meenakshi Pahwa, Sumit Bawari, Nilanjana Das Saha, Ranjan Sasmal, Monica Swetha Bosco, Jagannath Mondal, Sarit S. Agasti
Summary: Modern chemical and biological studies are focusing more on understanding the fate of individual cells within apparently homogeneous populations. This has led to a need for strategies that label individual cells with unique fluorescent signatures, and one promising approach involves using optically controlled host-guest recognition to generate distinct barcodes in cells. Multiple spectrally distinct CB[7]-conjugated fluorophores can be used to perform 10-color barcoding in fixed cells and 7-color barcoding in live cells, demonstrating the potential for multiplexed applications in cellular studies.
Article
Nanoscience & Nanotechnology
Han Wu, Hua Wang, Feilong Qi, Tian Xia, Yu Xia, Jiang-Fei Xu, Xi Zhang
Summary: A new strategy of activatable host-guest conjugate with self-inclusion property is proposed for supramolecular chemotherapy, which can achieve high-efficiency drug release triggered by intramolecular host-guest self-inclusion. The encapsulation of oxaliplatin in the conjugate leads to the formation of a stable supramolecular drug, and the release of oxaliplatin in the tumor microenvironment shows comparable anti-tumor bioactivity to naked oxaliplatin. This research may open new horizons for programmable and on-demand supramolecular chemotherapy with high anti-tumor efficiency.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Review
Agriculture, Multidisciplinary
Wenjie Li, Weiwei Xu, Siyun Zhang, Jia Li, Juan Zhou, Demei Tian, Jing Cheng, Haibing Li
Summary: Significant progress has been made in the research on drug encapsulation and release based on supramolecular macrocycles, laying a solid foundation for the development of novel nanopesticide preparations.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Xue Yang, Chunyang Li, Michel Giorgi, Didier Siri, Xavier Bugaut, Bastien Chatelet, Didier Gigmes, Mehdi Yemloul, Virginie Hornebecq, Anthony Kermagoret, Sophie Brasselet, Alexandre Martinez, David Bardelang
Summary: Porous organic crystals based on macrocycles have recently shown exceptional sorption and separation properties. In this study, the inclusion of trimethoxybenzyl-azaphosphatrane in the macrocycle cucurbit[8]uril (CB[8]) resulted in the formation of molecular porous host.guest crystals (PHGC-1) with radically new properties. The PHGC-1 crystals demonstrated spontaneous and selective adsorption of iodine at room temperature and atmospheric pressure, offering potential advantages in energy cost reduction.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Chemistry, Multidisciplinary
Xue Yang, Qian Cheng, Valerie Monnier, Laurence Charles, Hakim Karoui, Olivier Ouari, Didier Gigmes, Ruibing Wang, Anthony Kermagoret, David Bardelang
Summary: Chemists have successfully mimicked the function of natural molecular machines with synthetic systems in organic solvents and exchanged guest molecules in synthetic macrocycles for the production of pH-responsive hydrogels in water. Cucurbiturils may be excellent ring molecules for the construction of advanced molecular machines working in water.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Review
Chemistry, Inorganic & Nuclear
Xi Yang, Di Yuan, Jinhong Hou, Adam C. Sedgwick, Suying Xu, Tony D. James, Leyu Wang
Summary: The field of supramolecular chemistry has rapidly expanded and become highly influential in various areas like biomedicine, energy materials, catalysis, and sensing. The combination of host/guest chemistry with functional inorganic nanoparticles has led to many new applications in drug delivery, bioimaging, and sensing. Recent progress in the development of organic/inorganic supramolecular nano-systems incorporating host/guest chemistry has been summarized, highlighting their applications in drug delivery, biological imaging, and sensing.
COORDINATION CHEMISTRY REVIEWS
(2021)
Article
Chemistry, Multidisciplinary
Mingyang Zhang, Hao Zhang, Lunqiang Jin, Hao Li, Simin Liu, Shuai Chang, Feng Liang
Summary: Enhanced guest-pair interactions in the CB[8] cavity were quantitatively determined using SMFS, showing how dynamic conformational changes can affect the rupture force of CB[8]-mediated heteroternary complexation. SMFS was also utilized for detecting methyl viologen based on competitive host-guest interactions in CB[8] or CB[7.
CHEMICAL COMMUNICATIONS
(2022)
Article
Chemistry, Organic
Xiaodong Zhang, Tao Sun, Xin-Long Ni
Summary: This study explores the host-guest interactions of cucurbit[8]uril with pi-conjugated bispyridinium guests in aqueous solution, resulting in a series of dynamic assemblies distinguishable by naked-eye observation and quantitative fluorescence emissions. The dissociation and control of host-stabilized charge-transfer interactions by N-substituted alkyl chains on cationic guests led to the discovery of new possible binding modes for the cucurbit[8]uril host.
ORGANIC CHEMISTRY FRONTIERS
(2021)
Article
Chemistry, Applied
Meng-Qi Wang, Qian Wang, Meng Chen, Da-Hui Qu
Summary: The study successfully fabricated a supramolecular luminescence system with tunable fluorescence emissions ranging from yellow to green by assembling a simple fluorescent molecule, 4-(pyren-1-yl)-1-(4-vinylbenzyl)pyridin-1-ium chloride (PPD), and cucurbit[n]uril (CB[n], n = 7, 8) via host-guest interactions. This system exhibited enhanced emission efficiency and longer fluorescence lifetime, making it suitable for applications in fluorescent ink and potential for information encryption materials.
Review
Chemistry, Multidisciplinary
Takehiro Hirao, Takeharu Haino
Summary: This review introduces the research directions for the synthesis of supramolecular fullerene polymers, including the linear, networked, helical arrays directed by the use of calix[5]arene-fullerene interactions, and the investigation of the calix[5]arene-fullerene interaction for control over the chain structures of covalent polymers.
CHEMISTRY-AN ASIAN JOURNAL
(2022)
Article
Chemistry, Multidisciplinary
Suresh Moorthy, Alvaro Castillo Bonillo, Hugues Lambert, Elina Kalenius, Tung-Chun Lee
Summary: A new supramolecular approach has been reported to selectively deactivate the electrophilic alpha-carbon of phenyl diazonium ion through host-guest complexation, thus avoiding undesirable side reactions. This method holds great potential for the reactive chemistry of organic molecules in aqueous media.
CHEMICAL COMMUNICATIONS
(2022)
Article
Polymer Science
Amy C. Madl, David Myung
Summary: Over 6.2 million people worldwide suffer from moderate to severe vision loss due to corneal disease. While transplantation with allogenic donor tissue is sight-restoring for many patients with corneal blindness, this treatment modality is limited by long waiting lists and high rejection rates. Host-guest interactions have emerged as an important crosslinking strategy for cytocompatible, minimally invasive, injectable tissue substitutes.
Article
Chemistry, Multidisciplinary
Jie Gao, Ye Meng, Weiwei Zhao, Daofa Jiang, Yanmei Jin, Jun Zheng, Xinan Yang, Peihua Ma
Summary: The host-guest interactions between cyclopentanocucurbit-[6]uril and six alkyl imidazolium hydrochloride guests were studied, showing the formation of 1:1 inclusion complexes. The length of the alkyl chain was found to play a key role in determining the mode of host-guest interactions.
CHEMICAL RESEARCH IN CHINESE UNIVERSITIES
(2021)
Article
Chemistry, Multidisciplinary
Roelof Steeno, Andrea Minoia, Roberto Lazzaroni, Kunal S. Mali, Steven De Feyter
Summary: Nanoscopic lateral confinement on a graphite surface allows for the study of embryonic stages of molecular self-assembly on solid surfaces using scanning tunneling microscopy at the solution/solid interface.
CHEMICAL COMMUNICATIONS
(2022)
Article
Engineering, Chemical
Ying Wang, Song Zhao, Zhiyuan Zha, Zhi Wang, Jixiao Wang
Summary: A novel host-guest NF membrane based on CB-PEI was designed and fabricated, showing attractive separation performance for monovalent/divalent salts separation, purification and desalination of small molecule solutions.
Article
Chemistry, Organic
Atanas Kurutos, Stela Minkovska, Paraskev T. Nedialkov, Yury Fedorov
Summary: This study proposes an environmentally friendly method for the selective mono-halogenation of benzo[d]oxazol-2(3H)-ones. Simple operations and precise control over the oxidative halogenation make this method highly reproducible, with water being the main by-product.
JOURNAL OF HETEROCYCLIC CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Sergey D. Tokarev, Anatoly Botezatu, Andrey Khoroshutin, Yury Fedorov, Olga A. Fedorova
Summary: New polycyclic aromatic derivatives, crown naphthothiophenes, annulated both with thiophene and with 15-crown-5 ether moieties, were successfully synthesized via the Mallory photocyclization. Their complexation with Ba2+ and Mg2+ cations was investigated using optical and electrochemical methods, revealing the chemical stability of the compounds in the oxidized state depending on their structure.
MENDELEEV COMMUNICATIONS
(2022)
Article
Chemistry, Multidisciplinary
Alina E. Saifutiarova, Yury V. Fedorov, Elena E. Gulakova, Olga A. Fedorova
Summary: This study reports a new mechanism of hydride abstraction in the photochemical electrocyclic reaction of heterostilbene in aqueous solution. The investigation of electrocyclic transformations of heterostilbenes with different types of heterocyclic residues revealed that the estimated mechanism of hydride abstraction is common for the photochemical electrocyclization of heterostilbene through the formation of new C-N bond.
MENDELEEV COMMUNICATIONS
(2022)
Article
Biochemistry & Molecular Biology
Bayirta Egorova, Lyubov S. Zamurueva, Anastasia D. Zubenko, Anna Pashanova, Artem A. Mitrofanov, Anna B. Priselkova, Yuri Fedorov, Alexander L. Trigub, Olga A. Fedorova, Stepan N. Kalmykov
Summary: A synthetic procedure for the synthesis of azacrown ethers with pendant arms has been developed and studied for their applications in biomedical fields. The synthesized ligand showed strong binding affinity for copper and lead cations, effectively shielding them from transchelation and transmetallation in biologically relevant media.
Article
Spectroscopy
Maria A. Ustimova, Yuri V. Fedorov, Nelly S. Chmelyuk, Maxim A. Abakumov, Olga A. Fedorova
Summary: The study found that two bis(styryl) dyes have strong affinity for DNA and RNA, with their binding mode shifting between DNA groove binding and RNA intercalation. The fluorescence enhancement effect is more pronounced on DNA than on RNA, and the presence of energy transfer in the bis(styryl) system increases the Stokes shift of the dye.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2022)
Article
Chemistry, Inorganic & Nuclear
Sofia Khabirova, Gleb Aleshin, Evgeny Anokhin, Anna Shchukina, Anastasia Zubenko, Olga Fedorova, Aleksey Averin, Lev Trusov, Stepan Kalmykov
Summary: In this article, the first modification of nanoparticles with ligands for combined radiopharmaceuticals is reported. Nanoparticles with suitable magnetic properties can be used for both diagnostics and therapy, including magneto-mechanical therapy that is insufficiently studied. Strontium hexaferrite is a hard-magnetic material that can form stable biocompatible colloidal solutions. The nanoparticles were modified with a coupling agent and covalently linked to azacrown ether derivatives, and then radiolabeled with Bi-207. In vitro experiments showed that the complex is stable enough to be a potential theranostic radiopharmaceutical.
DALTON TRANSACTIONS
(2023)
Article
Chemistry, Applied
Dmitry O. Balakirev, Alexander N. Solodukhin, Svetlana M. Peregudova, Evgenia A. Svidchenko, Nikolay M. Surin, Yuriy V. Fedorov, Sergey A. Ponomarenko, Yuriy N. Luponosov
Summary: This study reports on the synthesis and comprehensive investigation of a series of novel luminescent push-pull molecules with different electron-withdrawing groups (EWGs). The results show that phenyl-substituted EWGs are more suitable for the design of thermally and electrochemically stable materials. The luminophores exhibited significant variability in terms of luminescence maxima and photoluminescence quantum yield depending on the EWG used. Compatibility with a polystyrene matrix resulted in higher PLQY values compared to solutions or polycrystalline films. The changes in spectral characteristics were well described using the semi-empirical theory of solvatochromism.
Article
Spectroscopy
Polina S. Perevozchikova, Ekaterina Y. Chernikova, Nikolai E. Shepel, Olga A. Fedorova, Yuri V. Fedorov
Summary: Novel conjugates consisting of 4-styrylpyridinium dye and 2,2-diphenyl-2H-chromene moiety were synthesized and their interaction with double stranded DNA and cucurbit[7]uril was investigated. The compounds were found to form supramolecular assemblies with the macromolecules through suitable binding sites, which were confirmed by various spectroscopic and mass spectrometric techniques.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2023)
Article
Chemistry, Physical
Ekaterina Y. Y. Chernikova, Polina S. S. Perevozchikova, Nikolai E. E. Shepel, Olga A. A. Fedorova, Yuri V. V. Fedorov
Summary: A series of 2,2-diphenyl-2H-chromene derivatives with electron-donating groups on the benzopyran ring have been synthesized. The study found the significant effect of bromoalkoxy chain length and chromene concentration on the conversion of closed form into open form under UV irradiation. The proposed scheme of the ring-opening reaction was confirmed by NMR analysis, providing insights into the nature of photochromic reactions.
Article
Chemistry, Physical
Anastasia S. Belova, Yuriy N. Kononevich, Dmitriy S. Ionov, Viacheslav A. Sazhnikov, Anton A. Anisimov, Andrey A. Safonov, Nikolay M. Surin, Evgeniya A. Svidchenko, Yury V. Fedorov, Olga I. Shchegolikhina, Aziz M. Muzafarov
Summary: A series of tetrachromophoric systems based on stereoregular tetracyclosiloxanes and dibenzoylmethanatoboron difluoride derivatives have been synthesized and characterized. The photophysical properties of these compounds were investigated using various spectroscopic methods. The synthesized compounds exhibited complex fluorescence behavior with different lifetimes, and showed promising potential for the development of single-emission materials for white illumination.
JOURNAL OF PHYSICAL CHEMISTRY B
(2023)
Article
Chemistry, Multidisciplinary
M. A. Pavlova, P. A. Panchenko, M. N. Vlasova, O. A. Fedorova
Summary: This article describes the synthesis and characterization of a previously unknown fluorescent sensor for zinc cations, which demonstrates fluorescence enhancement upon complexation with Zn2+ due to the formation of ligand-metal complexes with a composition of 1:1.
RUSSIAN CHEMICAL BULLETIN
(2023)
Review
Chemistry, Physical
Daria V. Berdnikova, Ekaterina Y. Chernikova
Summary: This review outlines the development of CB[n]-based systems for fluorescence and phosphorescence energy transfer and highlights the achievements, challenges, and future perspectives of this combination of classical photophysical process and supramolecular host. The review also focuses on the current and potential applications of these systems.
Article
Chemistry, Organic
Andrei V. Zaitsev, Sergey S. Kiselev, Alexander F. Smol'yakov, Yury V. Fedorov, Elena G. Kononova, Yurii A. Borisov, Valentina A. Ol'shevskaya
Summary: An efficient method for preparing 3,5-dicarborane-substituted BODIPY conjugates was developed by functionalizing 3,5-dibromo-8-pentafluorophenyl-BODIPY with carborane nucleophiles. The addition of a third carborane cluster to the BODIPYs was achieved by substituting the para-fluorine atom with the appropriate carborane nucleophile. The effects of carborane substitution on the absorption and fluorescence properties of the BODIPYs were analyzed, and the crystal structures of two BODIPY compounds were investigated.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Pavel A. Panchenko, Anna S. Polyakova, Yurii V. V. Fedorov, Olga A. Fedorova
Summary: In this study, a bis-chromophoric chemosensor BNI based on Azadithia-15-crown-5 ether was successfully synthesized via copper(I)-catalyzed azide-alkyne 1,3-dipolar cycloaddition click reaction. Excitation of BNI resulted in resonance energy transfer (RET) and the formation of a specific fluorescence band. Analysis of the spectra showed that the energy transfer efficiency in the free ligand was 65%. However, the experimental value was considerably lower than the theoretical value, which can be explained by the occurrence of competing photoinduced electron transfer (PET) process. Additionally, binding of silver cations to BNI inhibited PET and increased the efficiency of resonance energy transfer.
