Small molecule kinase inhibitors alleviate different molecular features of myotonic dystrophy type 1
出版年份 2014 全文链接
标题
Small molecule kinase inhibitors alleviate different molecular features of myotonic dystrophy type 1
作者
关键词
-
出版物
RNA Biology
Volume 11, Issue 6, Pages 742-754
出版商
Informa UK Limited
发表日期
2014-04-25
DOI
10.4161/rna.28799
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- A Novel CUGexp·MBNL1 Inhibitor with Therapeutic Potential for Myotonic Dystrophy Type 1
- (2013) Amin Haghighat Jahromi et al. ACS Chemical Biology
- High-content screening identifies small molecules that remove nuclear foci, affect MBNL distribution and CELF1 protein levels via a PKC-independent pathway in myotonic dystrophy cell lines
- (2013) Ami Ketley et al. HUMAN MOLECULAR GENETICS
- Single-molecule study of the CUG repeat–MBNL1 interaction and its inhibition by small molecules
- (2013) Amin Haghighat Jahromi et al. NUCLEIC ACIDS RESEARCH
- MBNL1 42 and MBNL1 43 gene isoforms, overexpressed in DM1-patient muscle, encode for nuclear proteins interacting with Src family kinases
- (2013) A Botta et al. Cell Death & Disease
- Design and Analysis of Effects of Triplet Repeat Oligonucleotides in Cell Models for Myotonic Dystrophy
- (2013) Anchel González-Barriga et al. Molecular Therapy-Nucleic Acids
- Rationally Designed Small Molecules Targeting the RNA That Causes Myotonic Dystrophy Type 1 Are Potently Bioactive
- (2012) Jessica L. Childs-Disney et al. ACS Chemical Biology
- Transcriptome-wide Regulation of Pre-mRNA Splicing and mRNA Localization by Muscleblind Proteins
- (2012) Eric T. Wang et al. CELL
- Ptbp2 represses adult-specific splicing to regulate the generation of neuronal precursors in the embryonic brain
- (2012) D. D. Licatalosi et al. GENES & DEVELOPMENT
- Expanded CTG repeats trigger miRNA alterations in Drosophila that are conserved in myotonic dystrophy type 1 patients
- (2012) Juan M. Fernandez-Costa et al. HUMAN MOLECULAR GENETICS
- GSK3β mediates muscle pathology in myotonic dystrophy
- (2012) Karlie Jones et al. JOURNAL OF CLINICAL INVESTIGATION
- RNA Interference Targeting CUG Repeats in a Mouse Model of Myotonic Dystrophy
- (2012) Krzysztof Sobczak et al. MOLECULAR THERAPY
- Targeting nuclear RNA for in vivo correction of myotonic dystrophy
- (2012) Thurman M. Wheeler et al. NATURE
- CUGBP1 and MBNL1 preferentially bind to 3′ UTRs and facilitate mRNA decay
- (2012) Akio Masuda et al. Scientific Reports
- Identification of new inhibitors of protein kinase R guided by statistical modeling
- (2011) Ruslana Bryk et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Suppression of PKR Promotes Network Excitability and Enhanced Cognition by Interferon-γ-Mediated Disinhibition
- (2011) Ping Jun Zhu et al. CELL
- GSK3β-cyclin D3-CUGBP1-eIF2 pathway in aging and in Myotonic Dystrophy
- (2011) Jingling Jin et al. CELL CYCLE
- Cellular toxicity of expanded RNA repeats: focus on RNA foci
- (2011) Marzena Wojciechowska et al. HUMAN MOLECULAR GENETICS
- Misregulation of miR-1 processing is associated with heart defects in myotonic dystrophy
- (2011) Frédérique Rau et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Triplet repeat RNA structure and its role as pathogenic agent and therapeutic target
- (2011) W. J. Krzyzosiak et al. NUCLEIC ACIDS RESEARCH
- Mutant CAG repeats of Huntingtin transcript fold into hairpins, form nuclear foci and are targets for RNA interference
- (2011) Mateusz de Mezer et al. NUCLEIC ACIDS RESEARCH
- Selective silencing of mutated mRNAs in DM1 by using modified hU7-snRNAs
- (2010) Virginie François et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- PKC inhibition ameliorates the cardiac phenotype in a mouse model of myotonic dystrophy type 1
- (2009) Guey-Shin Wang et al. JOURNAL OF CLINICAL INVESTIGATION
- Rational Design of Ligands Targeting Triplet Repeating Transcripts That Cause RNA Dominant Disease: Application to Myotonic Muscular Dystrophy Type 1 and Spinocerebellar Ataxia Type 3
- (2009) Alexei Pushechnikov et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- An RNA code for the FOX2 splicing regulator revealed by mapping RNA-protein interactions in stem cells
- (2009) Gene W Yeo et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Absence of a differentiation defect in muscle satellite cells from DM2 patients
- (2009) Richard Pelletier et al. NEUROBIOLOGY OF DISEASE
- A simple ligand that selectively targets CUG trinucleotide repeats and inhibits MBNL protein binding
- (2009) J. F. Arambula et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Pentamidine reverses the splicing defects associated with myotonic dystrophy
- (2009) M. B. Warf et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Triplet-repeat oligonucleotide-mediated reversal of RNA toxicity in myotonic dystrophy
- (2009) S. A. M. Mulders et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Reversal of RNA Dominance by Displacement of Protein Sequestered on Triplet Repeat RNA
- (2009) T. M. Wheeler et al. SCIENCE
- A chemical compound commonly used to inhibit PKR, {8-(imidazol-4-ylmethylene)-6H-azolidino[5,4-g] benzothiazol-7-one}, protects neurons by inhibiting cyclin-dependent kinase
- (2008) Hsin-Mei Chen et al. EUROPEAN JOURNAL OF NEUROSCIENCE
- Ectopic expression of cyclin D3 corrects differentiation of DM1 myoblasts through activation of RNA CUG-binding protein, CUGBP1
- (2008) Elizabeth Salisbury et al. EXPERIMENTAL CELL RESEARCH
- SRp20 and CUG-BP1 Modulate Insulin Receptor Exon 11 Alternative Splicing
- (2008) S. Sen et al. MOLECULAR AND CELLULAR BIOLOGY
- A postnatal switch of CELF and MBNL proteins reprograms alternative splicing in the developing heart
- (2008) A. Kalsotra et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Discover Peeref hubs
Discuss science. Find collaborators. Network.
Join a conversationAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started