期刊
RNA BIOLOGY
卷 10, 期 8, 页码 1356-1364出版社
TAYLOR & FRANCIS INC
DOI: 10.4161/rna.25481
关键词
microRNA; miR-8; Serpin 27; gloverin; insect immunity
资金
- UQ Research Higher Degree scholarship
- ARC Discovery grant [DP1094176]
- Australian Research Council [DP1094176] Funding Source: Australian Research Council
microRNAs (miRNAs) play significant regulatory roles in gene expression at the post-transcriptional level. This includes modulating processes such as development, immunity, cancer, and host-pathogen interactions. It was recently shown that the phylogenetically deeply conserved miRNA, miR-8, plays a role in maintaining the homeostasis of immunity by suppressing the production of anti-microbial peptides. In this study, we show that miR-8 from the insect Plutella xylostella positively regulates the transcript levels of the serine protease inhibitor Serpin 27, which has been shown to regulate activation of the Toll pathway and prophenoloxidase involved in the melanization response in insects. Interestingly, miR-8 is downregulated following parasitization by Diadegma semiclausum leading to significant declines in Serpin 27 transcript levels. This allows upregulation of antimicrobial peptides, such as gloverin, that are controlled by the Toll pathway and activation of proteolytic cascades essential for humoral immune responses to foreign invasion.
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