Article
Multidisciplinary Sciences
Edward J. Sanderlin, Melissa M. Keenan, Martin Mense, Alexey S. Revenko, Brett P. Monia, Shuling Guo, Lulu Huang
Summary: This study reveals that CFTR mRNAs with nonsense codons are predominantly degraded by the SMG6-mediated branch of the NMD pathway. This finding provides potential strategies for the treatment of cystic fibrosis.
NATURE COMMUNICATIONS
(2022)
Article
Biology
Hideyuki Nakanishi
Summary: Synthetic mRNAs produced by in vitro transcription can express any transgenes without the risk of insertional mutagenesis. Preclinical studies have developed translational regulation systems to ensure high efficacy and low adverse effects by producing the appropriate amount of therapeutic proteins.
Review
Medicine, General & Internal
I. Lisko, J. Kulmala, M. Annetorp, T. Ngandu, F. Mangialasche, M. Kivipelto
Summary: The aging population has led to a significant increase in older individuals living with dementia and disabilities, with dementia identified as the main cause of disability in old age. The World Health Organization's risk reduction guidelines highlight 12 modifiable risk factors that could contribute to approximately 40% of dementia cases worldwide. The FINGER trial has shown that multidomain lifestyle-based intervention can prevent cognitive and functional decline in at-risk older adults, supporting the need for integrated preventive interventions to address the shared risk factors between dementia and physical disability.
JOURNAL OF INTERNAL MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Timur N. Baymukhametov, Dmitry N. Lyabin, Yury M. Chesnokov, Ivan I. Sorokin, Evgeniya Pechnikova, Alexander L. Vasiliev, Zhanna A. Afonina
Summary: Polyribosomes, groups of ribosomes simultaneously translating a single mRNA molecule, are common in both prokaryotic and eukaryotic cells. Recent studies have shown that circular polyribosomes, although not abundant, have pseudo-regular structures and can enhance translation.
NUCLEIC ACIDS RESEARCH
(2023)
Review
Green & Sustainable Science & Technology
Xiaoxiao Xu, Hao Yu, Qiuwen Sun, Vivian W. Y. Tam
Summary: This research aims to review the evolution of occupant behavior research, investigate the knowledge base and domains, and identify current research gaps and future directions. The results show that the focus has shifted from individual behavior to complex behaviors. By using bibliometric approach and content analysis on 2791 relevant articles, this research provides potential researchers with sufficient knowledge and inspires them for future studies.
RENEWABLE & SUSTAINABLE ENERGY REVIEWS
(2023)
Article
Chemistry, Multidisciplinary
Afef Ladhari, Giorgia La Mura, Cinzia Di Marino, Giovanni Di Fabio, Armando Zarrelli
Summary: Sartans are a group of chemical compounds with antagonistic action towards AT1 receptors of angiotensin II, playing a role in regulating blood pressure. Their presence and fate in the environment, as well as their impact in wastewater treatment plants, are significant areas of concern.
SUSTAINABLE CHEMISTRY AND PHARMACY
(2021)
Article
Biochemistry & Molecular Biology
Hideyuki Nakanishi, Tatsuyuki Yoshii, Shunsuke Kawasaki, Karin Hayashi, Keita Tsutsui, Choji Oki, Shinya Tsukiji, Hirohide Saito
Summary: Two types of photo-controllable translational activation systems compatible with modRNAs have been developed, one consisting of a heterodimerization domain-fused split translational activator protein and a photocaged heterodimerizer, and the other consisting of a destabilizing domain-fused translational activator protein and a photocaged stabilizer. These systems not only enable translational activation but also translational repression of modRNAs, expanding the application of mammalian synthetic biology research.
CELL CHEMICAL BIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Melody D. D. Fulton, Wided Najahi-Missaoui
Summary: Since their discovery in the 1960s, liposomes have been effective drug delivery systems for treating various cancers. However, their translation into the clinic has been incremental due to potential toxicity and lack of specific targeting. This review summarizes the properties of liposomes, their current status in cancer therapy, and the challenges they face.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Multidisciplinary Sciences
Guangyong Ma, Jun-ichirou Yasunaga, Kazuya Shimura, Keiko Takemoto, Miho Watanabe, Masayuki Amano, Hirotomo Nakata, Benquan Liu, Xiaorui Zuo, Masao Matsuoka
Summary: Retroviral antisense mRNAs are predominantly localized in the nucleus, functioning as long noncoding RNAs rather than mRNAs, and contributing to viral persistence.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Multidisciplinary Sciences
Suki Albers, Elizabeth C. Allen, Nikhil Bharti, Marcos Davyt, Disha Joshi, Carlos G. Perez-Garcia, Leonardo Santos, Rajesh Mukthavaram, Miguel Angel Delgado-Toscano, Brandon Molina, Kristen Kuakini, Maher Alayyoubi, Kyoung-Joo Jenny Park, Grishma Acharya, Jose A. Gonzalez, Amit Sagi, Susan E. Birket, Guillermo J. Tearney, Steven M. Rowe, Candela Manfredi, Jeong S. Hong, Kiyoshi Tachikawa, Priya Karmali, Daiki Matsuda, Eric J. Sorscher, Pad Chivukula, Zoya Ignatova
Summary: Nonsense mutations, which account for about 11% of genetic diseases, can be suppressed by altering native tRNAs into suppressor tRNAs (sup-tRNAs) that match the physico-chemical properties of the carried amino acid. Administration of sup-tRNAs via lipid nanoparticles restored functional protein production in mice with nonsense mutations, without causing readthrough at endogenous stop codons. In cell and patient-derived systems, sup-tRNAs successfully re-established gene expression and function, providing a framework for the development of safe and effective tRNA-based therapies.
Article
Neurosciences
Marco Ghibaudi, Luca Bonfanti
Summary: Undifferentiated neurons may exist in the neural networks of the adult mammalian brain, not only in small stem cell niches from embryonic germinal layers but also in various parenchymal brain regions. However, our understanding of these young neurons is not yet clear, and further mapping and research are needed.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Business
Sher Jahan Khan, Puneet Kaur, Fauzia Jabeen, Amandeep Dhir
Summary: Environmental pollution has worsened in recent decades, putting pressure on firms to adopt green process innovations. However, existing literature on GPcIs is disjointed, lacking a comprehensive understanding. A systematic literature review identified seven themes and gaps in the literature, suggesting future research directions.
BUSINESS STRATEGY AND THE ENVIRONMENT
(2021)
Review
Biochemistry & Molecular Biology
Natthaphat Siri-Angkul, Behzad Dadfar, Riya Jaleel, Jazna Naushad, Jaseela Parambathazhath, Angelia Doye, Lai-Hua Xie, Judith Gwathmey
Summary: Heart failure remains a major issue globally, with efforts by clinicians and scientists to find effective treatments and cures not yet yielding major breakthroughs. The heart is not simply a pump, and treating heart failure requires consideration of its pathophysiological complexity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Cell Biology
Emanuele Scala, Sara Cacciapuoti, Natalie Garzorz-Stark, Matteo Megna, Claudio Marasca, Peter Seiringer, Thomas Volz, Kilian Eyerich, Gabriella Fabbrocini
Summary: Hidradenitis suppurativa is a chronic inflammatory skin disease primarily affecting apocrine gland-rich areas of the body. The pathogenesis involves follicular occlusion, immune responses, and results in an inflammatory vicious circle. Therapeutic approaches are limited, often requiring surgical interventions, presenting a challenge in treating this debilitating disease.
Article
Dentistry, Oral Surgery & Medicine
Wenbin Huang, Wenjie Zhong, Qing He, Yizhu Xu, Jiuxiang Lin, Yi Ding, Huaxiang Zhao, Xiaowen Zheng, Yunfei Zheng
Summary: This study provides a time-series expression landscape of mRNAs and lncRNAs during palatogenesis, highlighting the importance of processes such as cell adhesion and ossification.