Review
Medicine, General & Internal
Ryan Patel, Anthony H. Dickenson
Summary: Managing chronic pain is challenging due to its multifactorial nature and plasticity in sensory neuroaxis. Single agents often fail to provide adequate pain relief, leading to the importance of a multimodal or combination approach in pain control.
POSTGRADUATE MEDICINE
(2022)
Review
Rehabilitation
Daniela Bichsel, Fabian D. Liechti, Judith M. Schlapbach, Maria M. Wertli
Summary: This study compared guideline recommendations and level of evidence for the treatment of hip and knee osteoarthritis. The findings revealed variations in recommendations and evidence levels, particularly in terms of treatment timing and surgical referrals.
ARCHIVES OF PHYSICAL MEDICINE AND REHABILITATION
(2022)
Review
Pharmacology & Pharmacy
Vipin Arora, James N. Campbell, Man-Kyo Chung
Summary: Capsaicin, the pungent ingredient in chili peppers, can cause intense burning pain in humans, but it has also been used as an analgesic for chronic pain conditions. The analgesic effects of capsaicin depend on concentration, with low concentrations inducing short-term defunctionalization and high concentrations leading to long-term defunctionalization.
PHARMACOLOGY & THERAPEUTICS
(2021)
Article
Neurosciences
Jakub Mlost, Przemyslaw Kac, Marta Kedziora, Katarzyna Starowicz
Summary: This study demonstrates the anti-nociceptive and chondroprotective potential of beta-Caryophyllene (BCP) in an animal model of osteoarthritis (OA). BCP acts as a natural agonist of CB2 and does not produce tolerance for analgesic effects. These findings suggest that BCP could be a novel therapeutic strategy for treating OA.
Article
Surgery
Hyun-Chang Kim, Young Song, Jong Seok Lee, Myeong Eun Jeong, Yongmin Lee, Jin Hong Lim, Do-Hyeong Kim
Summary: This study aimed to evaluate the efficacy of combined operative analgesic techniques and pharmacologic analgesia in reducing pain in patients undergoing laparoscopic cholecystectomy (LC). The results showed that the combined approach decreased pain scores and improved sleep quality in these patients.
INTERNATIONAL JOURNAL OF SURGERY
(2022)
Article
Clinical Neurology
Gerardo A. Arwi, Penelope H. R. Tuffin, Stephan A. Schug
Summary: Compliance with discharge analgesia prescribing guidelines in a tertiary Australian hospital has increased but still needs improvement. The study reveals high rates of unused opioids and improper storage and disposal of pain medication.
JOURNAL OF PAIN RESEARCH
(2022)
Review
Clinical Neurology
Giovanni Iolascon, Sergio Gimenez, Dorottya Mogyorosi
Summary: Aceclofenac is an oral NSAID recommended for treating inflammation and pain in various conditions. Studies have shown that it is as effective as other NSAIDs in reducing pain and improving functional capacity in chronic pain conditions, with a more favorable gastrointestinal profile.
JOURNAL OF PAIN RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Patricia Dias, Isaura Tavares, Sara Fonseca, Daniel Humberto Pozza
Summary: The study proposes a new, reproducible, and less time-consuming thermal QST protocol to help characterize and monitor pain. The QST outcomes were compared between healthy and chronic pain subjects, revealing higher pain sensitivity and hyperalgesia in the chronic pain group.
Article
Health Care Sciences & Services
Feng-Hua Loh, Brigitte Azzi, Alexander Weingarten, Zvi G. Loewy
Summary: This study assessed the impact of CYP2D6 pharmacogenomic testing on physicians' choice in prescribing chronic pain medications and patient pain control. Results showed that over 50% of patients had their medications altered as a result of the pharmacogenomic testing, with patients with intense, moderate, and mild pain categories being more likely to receive changes in pain medications.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Article
Orthopedics
Eui Ho Park, Jinwon Seo, Yunsin Lee, Kiwon Park, Kyung-Ran Kim, Sujeong Kim, Ali Mobasheri, Heonsik Choi
Summary: The aim of the study was to investigate the analgesic mechanism of TissueGene-C (TG-C) in a pre-clinical animal model with monoiodoacetate (MIA)-induced pain. The results demonstrated that TG-C exerted potent analgesic effects by inhibiting the upregulation of pain mediators and modulating neuronal sensitization.
OSTEOARTHRITIS AND CARTILAGE
(2023)
Review
Medicine, General & Internal
Dmitriy Viderman, Karina Tapinova, Fatima Nabidollayeva, Ramil Tankacheev, Yerkin G. Abdildin
Summary: This study compares the use of intravenous and epidural routes for patient-controlled analgesia in abdominal surgery. The results show that there is no significant difference in pain control and side effects between the two methods. However, epidural analgesia is associated with a shorter length of hospital stay, while intravenous analgesia is associated with fewer episodes of hypotension.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Biochemistry & Molecular Biology
Jin Young Lee, Gil Ho Lee, Seung Hyun Yi, Woo Seog Sim, Bae Wook Kim, Hue Jung Park
Summary: Trigeminal neuralgia (TN) is a unilateral disorder characterized by sudden electric shock-like pain limited to the trigeminal nerve branches. Non-surgical treatments for TN were reviewed, including pharmacotherapies and interventional treatments. Carbamazepine and oxcarbazepine are recommended as first-line pharmacotherapies, and interventional treatments are suggested when pharmacotherapy is insufficient or withdrawn due to adverse effects.
Article
Agriculture, Dairy & Animal Science
Miriam S. Martin, Michael D. Kleinhenz, Abbie V. Viscardi, Andrew K. Curtis, Blaine T. Johnson, Shawnee R. Montgomery, Maria E. Lou, Johann F. Coetzee
Summary: This study evaluated the effectiveness of using bupivacaine liposome suspension as a cornual nerve block at the time of dehorning compared to current industry standard analgesic approaches. The results showed that administration of bupivacaine liposome suspension was as effective at controlling pain as a multimodal approach of lidocaine and meloxicam.
JOURNAL OF DAIRY SCIENCE
(2022)
Article
Agriculture, Dairy & Animal Science
Miriam S. Martin, Michael D. Kleinhenz, Abbie V. Viscardi, Andrew K. Curtis, Blaine T. Johnson, Shawnee R. Montgomery, Maria E. Lou, Johann F. Coetzee
Summary: Castration is a common procedure in the beef and dairy industry in the United States, but it causes pain. This study evaluated the effectiveness of bupivacaine liposome suspension as a nerve block during castration and found that it was as effective as a combination of lidocaine and meloxicam in controlling pain. A single injection that alleviates both perioperative and postoperative pain would be an attractive option for livestock producers to alleviate pain at the time of castration.
JOURNAL OF ANIMAL SCIENCE
(2022)
Article
Medicine, General & Internal
Nico Magni, Jill Collier, Peter McNair, David A. Rice
Summary: The study found that 42% of patients with symptomatic hand OA experienced neuropathic pain, which was associated with higher pain intensity. Pain intensity was correlated with the number of pain medications and body schema alterations, but not with psychological factors, hand function, and sleep.
JOURNAL OF CLINICAL MEDICINE
(2021)
