期刊
RHEUMATOLOGY INTERNATIONAL
卷 33, 期 12, 页码 3055-3057出版社
SPRINGER HEIDELBERG
DOI: 10.1007/s00296-012-2623-x
关键词
Interleukin-18; Systemic lupus erythematosus; Therapeutic
类别
资金
- National Natural Science Foundation of China [30830089, 81172764]
Interleukin-18 (IL-18), belongs to the IL-1 cytokine family, has a variety of effects on dendritic cell, T cell, natural killer cell. Previous studies have identified that IL-18 was associated with the pathogenesis of systemic lupus erythematosus (SLE), wherein elevated expression of IL-18 was found in the serum of patients, and IL-18 polymorphisms with susceptibility to SLE were reported, suggesting that IL-18 may be therapeutically relevant to SLE. In this article, we will discuss the role of IL-18 in the pathogenesis of and its therapeutic potential in SLE based on current understandings.
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