Article
Immunology
Stephany Bonin Godinho dos Santos, Janaina Carla da Silva, Hellen dos Santos Jaques, Marina Ferronato Dalla Vecchia, Mariane Okamoto Ferreira, Daniel Rech, Matheus Ryan Noah Sierota da Silva, Roberta Bonin Godinho dos Santos, Carolina Panis, Dalila Moter Benvegnu
Summary: Pesticide exposure has significant effects on the immune status and prognosis of breast cancer patients. Changes in cytokine levels, especially those related to tumor control, were observed in women occupationally exposed to pesticides, and these changes were associated with worse clinical outcomes.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Microbiology
Ekaterina Martynova, Albert Rizvanov, Richard A. Urbanowicz, Svetlana Khaiboullina
Summary: This review focuses on the mechanisms of inflammasome activation and their role in the development of Th1, Th2, and Th17 lymphocytes. The contribution of cytokines released from activated inflammasomes to the immune response is summarized, along with the discussion of the role of cytokines released from tissue cells in promoting lymphocyte differentiation.
FRONTIERS IN MICROBIOLOGY
(2022)
Review
Immunology
Weihang Luo, Jindong Hu, Weifang Xu, Jingcheng Dong
Summary: The immune response in the asthmatic respiratory tract is driven by CD4(+) T helper cells, especially Th2 cells. Asthma is a heterogeneous and progressive disease, with different stages of the disease course showing different immune responses. The complex immune networks in the inflammatory airway make it challenging to find a universal treatment for all asthmatics.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Xinjuan Liu, Yu Wu, Mengtao Li, Jianyu Hao, Qian Wang, Xiaofeng Zeng
Summary: FK506 has significant effects on Treg cells and subpopulations in SSc patients, reducing specific cell numbers and altering the immune imbalance between Tregs and Th17 cells.
INTERNATIONAL JOURNAL OF IMMUNOPATHOLOGY AND PHARMACOLOGY
(2021)
Article
Medicine, Research & Experimental
Kexiang Yan, Fuxin Zhang, Jie Ren, Qiong Huang, Nikhil Yawalkar, Ling Han
Summary: This study found that miR-125a-5p levels were decreased in peripheral blood CD4+ T cells of psoriatic patients, positively correlated with the proportion of Tregs, and negatively correlated with the PASI score. MiR-125a-5p mimics promoted the differentiation of Tregs and downregulated the mRNA levels of ETS-1, IFN-γ, and STAT3 in murine CD4+ T cells. Additionally, agomir-125a-5p alleviated psoriasis-like inflammation by downregulating the proportion of Th17 cells.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Review
Medicine, General & Internal
Kholoud Almaabdi, Zareen Ahmad, Sindhu R. Johnson
Summary: Systemic sclerosis is an autoimmune disease characterized by immune abnormalities, vasculopathy, and fibrosis. Autoantibody testing, including ANA, anti-Scl-70, and anticentromere antibodies, has become increasingly important for diagnosis and prognostication. This review examines the epidemiology, clinical associations, and prognostic value of advanced autoantibody testing in systemic sclerosis.
Review
Biochemistry & Molecular Biology
Stefano Piazza, Marco Fumagalli, Giulia Martinelli, Carola Pozzoli, Nicole Maranta, Marco Angarano, Enrico Sangiovanni, Mario Dell'Agli
Summary: Plants rich in hydrolyzable tannins have traditionally been used for the treatment of chronic inflammatory disorders. However, limited knowledge of their immunological targets hinders their rational use in phytotherapy. Recent advances in understanding the pathogenesis of inflammatory-based diseases provide an opportunity to elucidate the pharmacological mechanisms of these plant-derived metabolites with immunomodulatory activity. This review summarizes recent articles on the role of hydrolyzable tannins and their gut metabolites in various inflammatory responses.
Article
Immunology
Haiyan Bian, Lisheng Wang, Chengwen Gao, Zhihe Liu, Yang Sun, Minghui Hu, Yujing Xiao, Fengyun Hao, Yushuo Ma, Xia Zhao
Summary: This study explores the expression and clinical significance of Th1/Th2/Th17 cytokines and lymphocyte subsets in patients with Primary central nervous system lymphoma (PCNSL). The results show significant differences in cytokines and lymphocyte subsets between PCNSL patients, diffuse large B-cell lymphoma (DLBCL) patients, and healthy controls. These findings provide valuable information for the diagnosis, treatment, and prognosis of PCNSL.
JOURNAL OF INFLAMMATION RESEARCH
(2022)
Article
Immunology
Patrick Coit, Kaila L. Schollaert, Emily M. Mirizio, Kathryn S. Torok, Amr H. Sawalha
Summary: The study assessed DNA methylation differences between juvenile systemic sclerosis (jSSc) and juvenile localized scleroderma (jLS), revealing distinct epigenetic patterns and unique methylated genes in both diseases. Compared to healthy controls, differential methylation sites and genes were identified in jSSc and jLS, indicating potential novel diagnostic biomarkers for localized scleroderma. Pathway analysis showed enrichment of inflammatory pathways in jSSc and the HIPPO signaling pathway in jLS, highlighting different biological processes involved in each condition.
CLINICAL IMMUNOLOGY
(2021)
Article
Pharmacology & Pharmacy
Yumei Zhou, Linhan Hu, Honglei Zhang, Haiyun Zhang, Juntong Liu, Xiaoshan Zhao, Ji Wang, Qi Wang
Summary: The study found that GMK achieves a similar effect as dexamethasone in controlling symptoms of allergic asthma and inhibiting inflammation, reconstructs the immune balance of Th1/Th2 and Treg/Th17 cells, and impacts asthma treatment by altering gut microbiota. Metabolome results reveal specific substances associated with Th1/Th2 and Treg/Th17 cell balance.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Medicine, General & Internal
Mahmoud Nassar, Victoria Ghernautan, Nso Nso, Akwe Nyabera, Francisco Cuevas Castillo, Wan Tu, Luis Medina, Camelia Ciobanu, Mostafa Alfishawy, Vincent Rizzo, Saphwat Eskaros, Mamdouh Mahdi, Mohamed Khalifa, Mohamed El-Kassas
Summary: The gastrointestinal tract is frequently affected in individuals with systemic/localized scleroderma, leading to various GI manifestations and complications. Females are more susceptible to developing scleroderma, and esophageal and intestinal symptoms are common. Abnormal bowel movement and bacterial overgrowth contribute to malabsorption and increased mortality rate. Fecal incontinence is a common symptom that can lead to depression.
Article
Rheumatology
Robyn T. Domsic, Shiyao Gao, Maureen Laffoon, Steven Wisniewski, Yuqing Zhang, Virginia Steen, Robert Lafyatis, Thomas A. Medsger
Summary: Regardless of whether the first SSc manifestation or first non-Raynaud manifestation is used to define disease onset, a disease duration of less than 18 months at enrollment is preferable. A longer disease duration criterion more frequently results in regression to the mean of the mRSS score, which likely contributes to negative trial outcomes.
Article
Immunology
Xiao-Di Chen, Jing Xie, Yong Wei, Ji-Feng Yu, Ye Cao, Lu Xiao, Xue-Jing Wu, Cong-Jian Mao, Run-Min Kang, Yong-Gang Ye
Summary: Despite long-term control efforts, hepatic coccidiosis caused by Eimeria stiedai infection remains persistent in rabbits in China. This study provides the first evidence of changes in Th1/Th2/Treg/Th17/Th9/Th21 cells in rabbits infected with E. stiedai, offering insights into immune regulation mechanisms and potential vaccine development.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Review
Health Care Sciences & Services
Francesco Reggiani, Gabriella Moroni, Claudio Ponticelli
Summary: Systemic sclerosis is a chronic autoimmune disease that often involves the kidneys. Scleroderma renal crisis is the most serious renal event associated with this condition, and early and aggressive treatment is necessary to prevent irreversible organ damage and death.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Medicine, General & Internal
Andrea Itano, Douglas Maslin, Kritika Ramani, Golbarg Mehraei, Nancy Carpenter, Taylor Cormack, Mahdi Saghari, Matthijs Moerland, Erin Troy, Will Caffry, Leslie Wardwell-Scott, Stuart Abel, Duncan McHale, Mark Bodmer
Summary: This study introduces EDP1815, a non-colonizing pharmaceutical preparation derived from a single strain of Prevotella histicola. The research demonstrates that EDP1815 can regulate inflammatory responses throughout the body when taken orally and restricted to the gut.
FRONTIERS IN MEDICINE
(2023)
Article
Rehabilitation
Juan A. Pineda-Juarez, Mariel Lozada-Mellado, Andrea Hinojosa-Azaola, Jose M. Garcia-Morales, Midori Ogata-Medel, Luis Llorente, Jorge Alcocer-Varela, Arturo Orea-Tejeda, Eduardo Martin-Nares, Lilia Castillo-Martinez
Summary: In women with RA, DEP increases hand grip strength, MD decreases weight and waist circumferences, while the combination of DEP and MD improves disability.
PHYSIOTHERAPY THEORY AND PRACTICE
(2022)
Article
Immunology
Gabriela Fonseca-Camarillo, Janette Furuzawa-Carballeda, Braulio Martinez-Benitez, Rafael Barreto-Zuniga, Jesus K. Yamamoto-Furusho
Summary: In patients with active UC, EMMPRIN, MMP23 and MMP10 were upregulated, indicating their involvement in the inflammatory process.
SCANDINAVIAN JOURNAL OF IMMUNOLOGY
(2021)
Article
Surgery
Oscar Santes, Enrique Coss-Adame, Miguel A. Valdovinos, Janette Furuzawa-Carballeda, Angelica Rodriguez-Garces, Jose Peralta-Figueroa, Sofia Narvaez-Chavez, Hector Olvera-Prado, Uriel Clemente-Gutierrez, Gonzalo Torres-Villalobos
Summary: The study shows that the results achieved with laparoscopic Heller myotomy reoperation (LHM-R) are similar to those achieved with primary laparoscopic Heller myotomy (LHM-1), indicating that LHM-R is an effective and safe treatment option after a failed initial procedure.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2021)
Article
Immunology
Gabriela Fonseca-Camarillo, Janette Furuzawa-Carballeda, Angel A. Priego-Ranero, Braulio Martinez-Benitez, Rafael Barreto-Zuniga, Jesus K. Yamamoto-Furusho
Summary: This study is the first to characterize the gene and protein expression of the TOB/BTG family in rectal and ileum tissues of IBD patients. Results showed decreased expression of TOB1 and BTG1 genes in colonic mucosa of UC patients, while overexpression of TOB2 and BTG2 genes in patients with UC in remission. High TOB2 gene expression was associated with histological remission.
SCANDINAVIAN JOURNAL OF IMMUNOLOGY
(2021)
Article
Immunology
Gabriela Fonseca-Camarillo, Janette Furuzawa-Carballeda, Natalia Razo-Lopez, Rafael Barreto-Zuniga, Braulio Martinez-Benitez, Jesus K. Yamamoto-Furusho
Summary: The study showed an increase in gene and protein expression of SPARC in patients with active UC, with significant correlation to histological activity. The results suggest that SPARC could be a marker of intestinal inflammation in UC.
Editorial Material
Urology & Nephrology
Luis Gabriel Vazquez-Lavista, Jose Arturo Ramirez-Mucino, Perla Ximena Lopez-Almanza, Marcela Janka-Zires
Article
Ophthalmology
Gabriela Hernandez-Molina, Narlly Ruiz-Quintero, Guadalupe Lima, Diego Hernandez-Ramirez, Amaya Llorente-Chavez, Vanessa Saavedra-Gonzalez, Rodolfo Jimenez-Soto, Luis Llorente
Summary: Lower levels of CXCL10 and CCL2 were found in the tears of patients with PSS, with the former associated with more severe ocular symptoms and the latter correlated with positive ocular target tests.
INTERNATIONAL OPHTHALMOLOGY
(2022)
Article
Gastroenterology & Hepatology
Angel Priego-Ranero, Ghislain Opdenakker, Norma Uribe-Uribe, Diana Aguilar-Leon, Carlos A. Nunez-alvarez, Diego F. Hernandez-Ramirez, Elizabeth Olivares-Martinez, Enrique Coss-Adame, Miguel A. Valdovinos, Janette Furuzawa-Carballeda, Gonzalo Torres-Villalobos
Summary: Patients with achalasia show inflammation and fibrosis in their esophageal tissues, along with higher levels of active MMP-9 and specific autoantibodies. Abnormal expression of GAD65 and PNMA2 proteins may participate in the pathophysiology of achalasia, triggering and/or perpetuating autoimmune disease.
NEUROGASTROENTEROLOGY AND MOTILITY
(2022)
Article
Oncology
Silvia Mendez-Flores, Angel Priego-Ranero, Daniel Azamar-Llamas, Hector Olvera-Prado, Kenia Ilian Rivas-Redonda, Eric Ochoa-Hein, Andric Perez-Ortiz, Mario E. Rendon-Macias, Estefano Rojas-Castaneda, Said Urbina-Teran, Luis Septien-Stute, Thierry Hernandez-Gilsoul, Adrian Andres Aguilar-Morgan, Dheni A. Fernandez-Camargo, Elizabeth Olivares-Martinez, Diego F. Hernandez-Ramirez, Gonzalo Torres-Villalobos, Janette Furuzawa-Carballeda
CLINICAL AND TRANSLATIONAL MEDICINE
(2022)
Article
Nutrition & Dietetics
Mariel Lozada-Mellado, Luis Llorente, Andrea Hinojosa-Azaola, Jose M. Garcia-Morales, Midori Ogata-Medel, Jorge Alcocer-Varela, Juan A. Pineda-Juarez, Lilia Castillo-Martinez
Summary: This study compared the effects of a six-month dynamic exercise program (DEP) and the Mediterranean diet (MD) on the concentrations of pro- and anti-inflammatory cytokines in patients with rheumatoid arthritis (RA). The results showed that both DEP and MD had potential effects on pro-inflammatory cytokine concentrations compared to a control group. Only the MD group showed an increase in IL-Ra concentration.
FRONTIERS IN NUTRITION
(2022)
Meeting Abstract
Rheumatology
L. D. Fajardo Hermosillo
ANNALS OF THE RHEUMATIC DISEASES
(2022)
Meeting Abstract
Gastroenterology & Hepatology
Gonzalo Torres-Villalobos, Angel Priego-Ranero, Ghislain Opdenakker, Norma Uribe-Uribe, Diana E. Aguilar-Leon, Carlos Nunez-Alvarez, Diego F. Hernandez-Ramirez, Elizabeth Olivares-Martinez, Enrique Coss-Adame, Miguel A. Valdovinos, Janette Furuzawa-Carballeda
Meeting Abstract
Gastroenterology & Hepatology
Gonzalo Torres-Villalobos, Janette Furuzawa-Carballeda, Angel Priego-Ranero, Carlos Nunez-Alvarez, Elizabeth Olivares-Martinez, Diego F. Hernandez-Ramirez, Raymundo Valdez-Echeverria, Maria del Carmen Isabel Nunez Pompa, Alonso Trigos-Diaz, Rodrigo Arean-Sanz, Enrique Coss-Adame, Miguel A. Valdovinos
Meeting Abstract
Gastroenterology & Hepatology
Gabriela Fonseca-Camarillo, Janette Furuzawa-Carballeda, Jesus K. Yamamoto-Furusho
Article
Rheumatology
G. Hernandez-Molina, V Soto-Abraham, V Zamora-Legoff, J. Furuzawa-Carballeda
Summary: The study found different types of T follicular helper cells (Tfh) in patients with primary Sjögren's syndrome (pSS) and systemic lupus erythematosus (SLE) with associated SS. Tfh1, Tfh2, and Tfh17 were highly expressed in pSS patients, while Tfh17 predominated in SLE/SS patients. A positive correlation was observed between anti-Ro/SSA autoantibody and Tfh17 subset.
CLINICAL AND EXPERIMENTAL RHEUMATOLOGY
(2021)