Review
Immunology
Bo Zhang, Ming Zhao, Qianjin Lu
Summary: Extracellular vesicles (EVs) have attracted wide interest in basic and clinical research in the past two decades. They are small membrane vesicles released by almost all cells and play important roles in immunomodulation and the pathogenesis of autoimmune diseases, showing great potential in the diagnosis and treatment of autoimmune diseases.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Nutrition & Dietetics
Alessia Alunno, Francesco Carubbi, Elena Bartoloni, Davide Grassi, Claudio Ferri, Roberto Gerli
Summary: In recent years, there has been increasing interest in the influence of diet on rheumatic and musculoskeletal diseases (RMDs). Diet may play a role in the development and progression of these conditions through pro-inflammatory properties and effects on insulin resistance, obesity, and other co-morbidities. Research has been more extensive in rheumatoid arthritis (RA) compared to systemic lupus erythematosus (SLE), with most SLE studies conducted on experimental models.
Article
Engineering, Multidisciplinary
Hudan Pan, Jingrong Wang, Yong Liang, Canjian Wang, Ruimin Tian, Hua Ye, Xiao Zhang, Yuanhao Wu, Miao Shao, Ruijun Zhang, Yao Xiao, Zhi Li, Guangfeng Zhang, Hua Zhou, Yilin Wang, Xiaoshuang Wang, Zhanguo Li, Wei Liu, Liang Liu
Summary: Systemic lupus erythematosus (SLE) is an autoimmune disorder with unknown pathogenesis and heterogeneous clinical manifestations. By conducting glycomic analyses, we identified two N-glycans on serum immunoglobulin G (IgG) as excellent diagnostic biomarkers for SLE, with specificity and suitability for all stages of the disease. These findings are important for the early and precise diagnosis of SLE and provide insights into the pathogenic factors of the disease.
Review
Immunology
Han Wu, Shuxian Chen, Aifen Li, Kangyuan Shen, Shuting Wang, Sijie Wang, Ping Wu, Wenying Luo, Qingjun Pan
Summary: Long non-coding RNAs (lncRNAs) have emerged as potential novel biomarkers and therapeutic targets in systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA), playing key roles in the pathogenesis of these autoimmune diseases.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Marco Krasselt, Christoph Baerwald, Uwe G. Liebert, Olga Seifert
Summary: The study revealed that VZV IgG antibody concentrations in SLE patients were comparable to healthy controls but higher than in RA patients. Young SLE patients aged between 30 and 39 had the highest antibody levels, while RA patients had the lowest concentrations.
Review
Immunology
Michele Fresneda Alarcon, Zoe McLaren, Helen Louise Wright
Summary: Dysregulated neutrophil activation plays a significant role in the pathogenesis of rheumatoid arthritis and systemic lupus erythematosus, contributing to inflammation and autoantibody production in both autoimmune diseases.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Rheumatology
Hilde Julie T. Lien, Tina T. Pedersen, Bente Jakobsen, Arnar Flatberg, Konika Chawla, Pal Saetrom, Mona H. Fenstad
Summary: The study compared cellular composition and peripheral blood gene expression in Rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), and healthy pregnancies. The results showed distinct RA, SLE, and pregnancy signatures that were not attributed to medication or disease activity. The study supports the need for close postpartum follow-up of patients with SLE and highlights the importance of cell-type adjustment in gene expression analysis.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Article
Immunology
Chloe Bost, Marina I. Arleevskaya, Wesley H. Brooks, Samuel Plaza, Jean-Charles Guery, Yves Renaudineau
Summary: Growing evidence suggests that the long non-coding RNA Xist expressed in female cells plays a significant role in systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA). Xist controls transcription and sequesters miRNAs, leading to alterations in key inflammatory and proliferative pathways.
CLINICAL IMMUNOLOGY
(2022)
Article
Rheumatology
Latanya N. Coke, Hongxiu Wen, Mary Comeau, Mustafa H. Ghanem, Andrew Shih, Christine N. Metz, Wentian Li, Carl D. Langefeld, Peter K. Gregersen, Kim R. Simpfendorfer
Summary: The study revealed that the SLE risk association in the DNASE1L3 locus is related to the polymorphism rs35677470, which results in reduced secretion of DNASE1L3 protein but does not eliminate its DNase enzyme function. The association of the DNASE1L3/PXK gene locus with SLE risk is dependent on the missense SNP rs35677470, highlighting the importance of this polymorphism in SLE susceptibility.
ANNALS OF THE RHEUMATIC DISEASES
(2021)
Article
Immunology
Qi Huang, Wang-Dong Xu, Lin-Chong Su, Xiao-Yan Liu, An-Fang Huang
Summary: This study investigated CD40 gene polymorphisms in Chinese Han population with SLE and RA, finding associations between certain genotypes and alleles with susceptibility to the diseases. The findings suggest a potential role of CD40 gene polymorphisms in the pathogenesis of SLE and RA.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Medicine, General & Internal
Choong-Kyun Noh, Eunyoung Lee, Bumhee Park, Sung Soo Ahn
Summary: The presence of faecal haemoglobin, even in the absence of gastrointestinal bleeding, may indicate systemic inflammation and be linked to the development of immune-mediated inflammatory diseases (IMIDs). Positive faecal immunochemical test (FIT) is associated with an increased risk of rheumatoid arthritis (RA) in the general population.
Review
Medicine, General & Internal
Mrinalini Dey, Ioannis Parodis, Elena Nikiphorou
Summary: Fatigue is a common feature in systemic lupus erythematosus and rheumatoid arthritis, but the two diseases differ in their clinical manifestations and treatment approaches. Addressing fatigue in a holistic manner, along with pain, depression, and anxiety, is crucial for improving quality of life in these patients. Further research is needed to better understand and manage fatigue in these conditions.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Engineering, Environmental
Ting Liu, Xi Zhang, Lizhen He, Zehang Zhang, Yuhan Sun, Junmei Feng, Zhiming Lin, Tianfeng Chen
Summary: This study developed a selenium nanosystem with surface decoration of calf thymus DNA to specifically recognize and remove anti-dsDNA autoantibodies in SLE patients. The nanotherapeutics showed excellent biocompatibility and safety, and had higher clearance ratio compared to other clinical products. Furthermore, the nanotherapeutics could visualize the distribution of anti-dsDNA antibodies in kidney lesions and semi-quantify the antibody deposition.
CHEMICAL ENGINEERING JOURNAL
(2022)
Article
Biochemistry & Molecular Biology
Mansour Salesi, Milad Hayeri Dehabadi, Rasoul Salehi, Amirhossein Salehi, Bahram Pakzad
Summary: The methylation level of IFI44L promoter was found to be significantly lower in patients with SLE and RA compared to healthy controls, with no significant difference between the two disease groups. There was a negative correlation between IFI44L promoter methylation level and RA disease activity, but no significant association with clinical characteristics of SLE was observed.
MOLECULAR BIOLOGY REPORTS
(2022)
Article
Rheumatology
Yanli Zeng, Yan Zhang, Qinggui Chen, Qinghe Huang, Yiqiang Lin, Xuelian Wang, Jia Jia Wang, Longcan Jiang, Yun Xiao
Summary: The study found that levels of four ANA IgG subclasses were significantly higher in systemic lupus erythematosus (SLE) patients compared to patients with other autoimmune diseases (OAD) and healthy controls. High-avidity IgG ANAs may impact the distribution of ANA IgG3 and IgG4, with ANA IgG3 potentially playing a specific role in the activity and treatment of SLE.
Article
Immunology
Thiago Souza Onofre, Joao Paulo Ferreira Rodrigues, Marina Tiemi Shio, Silene Macedo, Maria Aparecida Juliano, Nobuko Yoshida
Summary: The interaction between MT surface molecule gp82 and host cell receptor LAMP2 leads to the activation of phospholipase C, which in turn promotes the activation of PKC and ERK1/2 in the host cell. This cascade of events results in disruption of actin cytoskeleton and lysosome spreading, facilitating the internalization of MT.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Article
Cell Biology
Rodrigo Saar Gomes, Muriel Vilela Teodoro Silva, Milton Adriano Pelli Oliveira, Leo A. B. Joosten, Fatima Ribeiro-Dias
Summary: Neutrophils play a crucial role in protecting against visceral leishmaniasis, and IL-32 gamma enhances their recruitment, phagocytosis, and killing of Leishmania parasites. The axis of IL-32 gamma -Th17-neutrophils is vital for controlling VL infection. These findings suggest a potential therapeutic target for enhancing immune response against visceral leishmaniasis.
CELLULAR IMMUNOLOGY
(2022)
Article
Cell Biology
Jose Rodrigues Neto, Arthur Wilson Florencio da Costa, Yarlla Loyane Lira Braga, Fernanda Helia Lucio, Ana Luisa Monteiro dos Santos Martins, Marlene Antonia dos Reis, Flavia Aparecida de Oliveira, Mara Rubia Nunes Celes, Marcos Vinicius da Silva, Milton Adriano Pelli Oliveira, Juliana Reis Machado
Summary: This study aimed to evaluate the histopathological changes caused by infection with the Colombian strain of Trypanosoma cruzi in acute and chronic phases. Results showed that the infection led to weight loss, intestinal inflammatory infiltrates, increased levels of interferon gamma and tumor necrosis factor-alpha, as well as elevated interleukin-10 in the early chronic phase.
MEDIATORS OF INFLAMMATION
(2022)
Article
Immunology
Yarlla L. L. Braga, Jose R. C. Neto, Arthur W. F. Costa, Muriel V. T. Silva, Marcos V. Silva, Mara R. N. Celes, Milton A. P. Oliveira, Leo A. B. Joosten, Fatima Ribeiro-Dias, Rodrigo S. Gomes, Juliana R. Machado
Summary: IL-32 gamma plays a crucial role in controlling acute phase Chagas disease by influencing immune response characteristics and myocarditis.
JOURNAL OF IMMUNOLOGY RESEARCH
(2022)
Article
Biology
Vivian Vasconcelos Costa, Michelle A. Sugimoto, Josy Hubner, Caio S. Bonilha, Celso Martins Queiroz-Junior, Marcela Helena Goncalves-Pereira, Jianmin Chen, Thomas Gobbetti, Gisele Olinto Libanio Rodrigues, Jordana L. Bambirra, Ingredy B. Passos, Carla Elizabeth Machado Lopes, Thaiane P. Moreira, Kennedy Bonjour, Rossana C. N. Melo, Milton A. P. Oliveira, Marcus Vinicius M. Andrade, Lirlandia Pires Sousa, Danielle Gloria Souza, Helton da Costa Santiago, Mauro Perretti, Mauro Martins Teixeira
Summary: This study suggests that altered levels of Annexin A1, a pro-resolving mediator, play a pathological role in dengue infection, and FPR2/ALX agonists may be a therapeutic target for dengue disease.
Article
Immunology
Aparecido Ferreira de Souza, Laurine Lacerda Pigosso, Lana O'Hara Souza Silva, Italo Dany Cavalcante Galo, Juliano Domiraci Paccez, Kleber Santiago Freitas e Silva, Milton Adriano Pelli de Oliveira, Maristela Pereira, Celia Maria de Almeida Soares
Summary: In this study, the exoproteome of Paracoccidioides brasiliensis (Pb18) under iron deprivation conditions was analyzed using nanoUPLC-MSE. One hundred forty-one proteins were identified, out of which 64 were predicted to be secreted. The regulation of several virulence factors was also identified, and Cyb5 was highlighted as a secreted molecule potentially involved in iron homeostasis in P. brasiliensis.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Immunology
Murilo Barros Silveira, Rodrigo Saar Gomes, Marina Tiemi Shio, Jeronimo Nunes Rugani, Larissa Ferreira Paranaiba, Rodrigo Pedro Soares, Fatima Ribeiro-Dias
Summary: Lipophosphoglycan (LPG) from Leishmania can induce the production of IL-32 and other pro-inflammatory cytokines through the TLR4 and NOD2 pathways. Additionally, IL-32 production is necessary for the production of IL-1 beta and IL-6.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Immunology
Camila Bernardo de Brito, Fernando Roque Ascencao, Raquel Duque Nascimento Arifa, Renata Lacerda Lima, Zelia Menezes Garcia, Micheli Fagundes, Brenda Goncalves Resende, Rafael Oliveira Bezerra, Celso Martins Queiroz-Junior, Anna Clara Paiva Menezes dos Santos, Milton Adriano Pelli Oliveira, Mauro Martins Teixeira, Caio Tavares Fagundes, Daniele Gloria Souza
Summary: Intestinal ischemia and reperfusion (I/R) result in severe tissue injury and death due to exacerbated inflammatory response. The deposition of IgG triggers Fc(gamma)RIIb activation, which controls the release of inflammatory mediators, reducing tissue damage and death.
Article
Parasitology
Mirian Vieira Teixeira, Santiago Aguiar Espellet Soares, Vagniton Amelio Souza, Andre Murilo de Souza Marques, Celia Maria de Almeida Soares, Lilian Cristiane Baeza, Milton Adriano Pelli de Oliveira
Summary: Leishmania (Viannia) braziliensis is the main cause of American tegumentary leishmaniasis in Brazil. However, there have been fewer studies using this parasite species to investigate Leishmania infection in mice compared to other Leishmania species. It has been found that the control of murine infection with Leishmania is associated with the production of nitric oxide by M1 macrophages, while the proliferation of Leishmania is related to the expression of arginase by M2 macrophages.
PARASITOLOGY RESEARCH
(2022)
Article
Immunology
Ariane Nardy, Camila Tussato Soares Camargo, Yasmim Faustina Castro de Oliveira, Fernanda Cristina da Silva, Millena Soares de Almeida, Fernanda Rodrigues Monteiro, Brenda Rodrigues Silva, Jonatas Bussador do Amaral, Danielle Bruna Leal Oliveira, Edison Luiz Durigon, Guilherme Pereira Scagion, Vanessa Nascimento Chalup, Erika Donizetti Candido, Andressa Simoes Aguiar, Neil Ferreira Novo, Marina Tiemi Shio, Carolina Nunes Franca, Luiz Henrique da Silva Nali, Andre Luis Lacerda Bachi
Summary: This study investigated the impact of IFN-lambda-3 polymorphism on specific IgG responses for COVID-19 in older adults seropositive for CMV. The results suggested that both CMV seropositivity and the homozygosis for allele 1 (C/C) in IFN-lambda-3 gene can negatively impact the antibody response to COVID-19 infection and vaccination in older adults.
Review
Microbiology
Moises Morais Inacio, Andre Luis Elias Moreira, Vanessa Rafaela Milhomem Cruz-Leite, Karine Mattos, Lana O'Hara Souza Silva, James Venturini, Orville Hernandez Ruiz, Fatima Ribeiro-Dias, Simone Schneider Weber, Celia Maria de Almeida Soares, Clayton Luiz Borges
Summary: Fungal infections pose a significant global health threat and have detrimental effects on health and the economy. Despite the lack of approved fungal vaccines for human use, the scientific community is actively striving to overcome this challenge through the development of fungal vaccines and experimental immunotherapies.
Article
Parasitology
Gabriela Martinez Moura Tavares, Hannar Angelica de Melo Alverga, Estela Moraes Felix, Giovana de Oliveira Dichman, Gabriel Monteiro Pinheiro, Yara Juliano, Priscila Paruci, Dennis Minoru Fujita, Lucas Melo Neves, Marina Tiemi Shio, Luiz Henrique da Silva Nali
Summary: This study investigated the frequency of N. gonorrhoeae infection in women in a poor area of São Paulo and found that most of the strains detected showed resistance to one or more antimicrobials.
Article
Geriatrics & Gerontology
Leandro Santos da Silva, Danielle Borges Germano, Francisco Antonio Helfenstein Fonseca, Marina Tiemi Shio, Luiz Henrique da Silva Nali, Izabela Dorota Tuleta, Yara Juliano, Maria Cristina de Oliveira Izar, Ana Paula Ribeiro, Juliana Tieko Kato, Jonatas Bussador do Amaral, Carolina Nunes Franca
Summary: The aim of this study was to evaluate the effects of combined lipid-lowering and antiplatelet strategies on the expression of CCR2, CCR5, and CX3CR1 receptors and the percentage of CCR2, CCR5, and CX3CR1 cells in monocyte subtypes after acute myocardial infarction. The results showed an increase in CCR2 expression and an increase in CCR2+ intermediate monocytes, as well as a reduction in CCR2+ non-classical monocytes after treatment. There was also a decrease in CCR5 expression and an increase in CCR5+ classical and non-classical monocytes. Finally, there were no significant changes in CX3CR1 expression, but a decrease in CX3CR1+ intermediate and non-classical monocytes was observed after treatment.
GERIATRICS & GERONTOLOGY INTERNATIONAL
(2023)
Article
Infectious Diseases
Graciela dos Santos Soares, Lucas Vinicius Morais, Kevin Cezar Nascimento Silva, Elaine Moura Ferreira, Marina Tiemi Shio, Camila Malta Romano, Carla Regiani Conde, Ester Cerdeira Sabino, Carolina Nunes Franca, Luiz Henrique Nali
Summary: This study investigated the prevalence of SARS-CoV2 in daycare centers after the resumption of educational activities. The results showed that there were few cases of COVID-19 transmission in daycare centers, indicating the effectiveness of preventive measures.
REVISTA DO INSTITUTO DE MEDICINA TROPICAL DE SAO PAULO
(2022)