Article
Cell Biology
Wenbo Dai, Yifu He, Kai Li
Summary: AS fibroblasts exhibited enhanced osteogenic differentiation potentials, with elevated expression of SPI1. Silencing of SPI1 inhibited osteogenic differentiation, while overexpression of TLR5 reversed this inhibition via NF-κB signaling. SPI1 regulated AS progression by modulating TLR5 through NF-κB signaling.
Article
Immunology
Hui-Chun Yu, Kuang-Yung Huang, Ming-Chi Lu, Hsien-Yu Huang Tseng, Su-Qin Liu, Ning-Sheng Lai, Hsien-Bin Huang
Summary: Ankylosing spondylitis (AS) is a chronic inflammatory disease associated with HLA-B27 expression, but other factors also play a role in its development. In AS patients, the levels of long non-coding RNA LOC645166 are reduced in T cells, impacting immune response regulation.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Kunihiko Moriya, Tomohiro Nakano, Yoshitaka Honda, Miyuki Tsumura, Masato Ogishi, Motoshi Sonoda, Masahiko Nishitani-Isa, Takashi Uchida, Mohamed Hbibi, Yoko Mizoguchi, Masataka Ishimura, Kazushi Izawa, Takaki Asano, Fumihiko Kakuta, Daiki Abukawa, Darawan Rinchai, Peng Zhang, Naotomo Kambe, Aziz Bousfiha, Takahiro Yasumi, Bertrand Boisson, Anne Puel, Jean-Laurent Casanova, Ryuta Nishikomori, Shouichi Ohga, Satoshi Okada, Yoji Sasahara, Shigeo Kure
Summary: This study reports six patients from five families with RELA mutations, leading to autoinflammatory and autoimmune manifestations. The mutations result in loss of function of RelA protein, leading to excessive IFN expression and autoimmune response. The DN RELA mutations are identified as a novel cause of chronic mucocutaneous ulcerations with autoinflammatory and autoimmune manifestations.
JOURNAL OF EXPERIMENTAL MEDICINE
(2023)
Article
Critical Care Medicine
Hu Qin, Tao Wu, Jun Liu, Gang Wang, Lei Fan, Boyao Wang, Yajun Shen
Summary: The study showed that inhibiting MALT-1 partially suppressed the inflammatory response in ankylosing spondylitis by regulating CYLD and NF-kappa B, leading to alleviation of arthritis symptoms.
INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED
(2021)
Article
Plant Sciences
Yanhua Wu, Junfeng Shen, Liyan Wang, Yinzhi Lin, Shiori Kojima, Shoshiro Okada, Kazuo Umezawa
Summary: Safe and effective nonsteroidal anti-inflammatory drugs are necessary, and adding amino acids to cultures of microorganisms may increase the likelihood of discovering new secondary metabolites. Two new compounds, myceliostatins A and B, with the myceliothermophin structure were isolated from a methionine-enriched culture of Myceliophthora thermophila. Both compounds exhibited inhibition of LPS-induced NO production and had anti-inflammatory and antioxidant effects by suppressing NF-KB activity and reactive oxygen species production.
JOURNAL OF NATURAL PRODUCTS
(2023)
Article
Cell Biology
Hongyun Liu, Bin Wang, Qiliang Zhang
Summary: This study found that the COX-2 polymorphism rs5275 may contribute to an increased risk of developing ankylosing spondylitis among Chinese Han people, while the polymorphisms rs20417 and rs2745557 may offer protection against disease incidence.
JOURNAL OF CELLULAR PHYSIOLOGY
(2023)
Article
Cell Biology
Mohamed Abu-Farha, Dhanya Madhu, Prashantha Hebbar, Anwar Mohammad, Arshad Channanath, Sina Kavalakatt, Nada Alam-Eldin, Fatima Alterki, Ibrahim Taher, Osama Alsmadi, Mohammad Shehab, Hossein Arefanian, Rasheed Ahmad, Thangavel Alphonse Thanaraj, Fahd Al-Mulla, Jehad Abubaker
Summary: The ANGPTL8 R59W variant is associated with increased levels of TNF alpha, IL7, and NF-kappa B p65 activity. The weak transient binding of the ANGPTL8 R59W variant explains its regulatory role on the NF-kappa B pathway and inflammation.
Article
Fisheries
Jianjun Feng, Yuankai Xu, Peng Lin, Xinwei Peng, Yilei Wang, Ziping Zhang
Summary: In this study, AjI kappa B alpha, a homologue of I kappa B alpha in Japanese eel, was cloned and studied for its regulation of immune responses. The results suggested that AjI kappa B alpha functions as an important negative regulator in the host's innate immunity against bacterial and viral infections by inhibiting the activation of NF-kappa B, AP1, and type I IFN signaling pathways.
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2021)
Article
Nutrition & Dietetics
Junquan Tian, Xuetai Bao, Fan Yang, Xiongzhuo Tang, Qian Jiang, Yuying Li, Kang Yao, Yulong Yin
Summary: Age-related osteoporosis is a common disease in the elderly, mainly caused by excessive activity of osteoclasts. Most approved drugs inhibit osteoclasts to treat osteoporosis. This study shows that supplementing dimethyl alpha-ketoglutarate (DM-AKG) can inhibit the differentiation of osteoclasts. The mechanism involves regulating NF-kappa B signaling pathway and oxidative phosphorylation through PHD1-dependent manner.
Article
Biochemistry & Molecular Biology
Maryam Abbasi, Mohammad Mahboubi-Rabbani, Khosrow Kashfi, Hojjat Sadeghi-Aliabadi
Summary: Multiple lines of evidence support the critical role of the NF-kappa B signaling pathway in carcinogenesis, with its activation promoting cell proliferation and inhibiting apoptosis in cancer. Inhibition of NF-kappa B through blocking IKK-alpha/beta enzymes and protecting p65 from acetylation and phosphorylation can lead to tumor suppression. This study utilized a virtual screening approach to identify potential inhibitors for both NF-kappa B and I kappa B proteins, resulting in the identification of three top-ranked compounds for each protein.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2023)
Article
Rheumatology
Zhixiu Li, Sjef M. van der Linden, Muhammad Asim Khan, Heinz Baumberger, Hermine van Zandwijk, Mohammad Kazim Khan, Peter M. Villiger, Matthew A. Brown
Summary: The objective of this study is to assess heterogeneity in axial spondyloarthritis (axSpA) and its sources. The results suggest that women clinically diagnosed with axSpA but without radiographic sacroiliitis have distinct characteristics compared to men with non-radiographic axSpA.
Article
Biochemistry & Molecular Biology
Marina Kolesnichenko, Nadine Mikuda, Uta E. Hoepken, Eva Kaergel, Bora Uyar, Ahmet Bugra Tufan, Maja Milanovic, Wei Sun, Inge Krahn, Kolja Schleich, Linda Hoff, Michael Hinz, Michael Willenbrock, Sabine Jungmann, Altuna Akalin, Soyoung Lee, Ruth Schmidt-Ullrich, Clemens A. Schmitt, Claus Scheidereit
Summary: The study reveals that DNA double-strand breaks elicit two subsequent phases of NF-kappa B activation, with the first phase controlling anti-apoptotic gene expression and the second phase driving expression of senescence-associated genes.
Article
Cell Biology
Chao Zhu, Wei Chen, Haiming Cui, Zhigang Huang, Ru Ding, Na Li, Qinqin Wang, Feng Wu, Yanmin Zhao, Xiaoliang Cong
Summary: Oxidized low-density lipoprotein (ox-LDL) promotes the expression of TRIM64, enhancing the activation of NLRP3 inflammasomes and the expression of downstream molecules. TRIM64 interacts with I kappa B alpha, promoting I kappa B alpha ubiquitination to activate the NF-kappa B signaling pathway. TRIM64 and NF-kappa B form a positive feedback mechanism in the development of atherosclerosis.
CELL BIOLOGY AND TOXICOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Lei Xu, Yangfan Ye, Zeqiang Tao, Tian Wang, Yutian Wei, Wanzhi Cai, Xin Wan, Pengzhan Zhao, Wei Gu, Bin Gu, Liuchao Zhang, Yufei Tian, Ning Liu, Yiming Tu, Jing Ji
Summary: This study elucidated the role of MLPH in GBM radiation resistance, showing that MLPH promotes radiotherapy resistance by regulating the NF-kappa B pathway. Additionally, O-GlcNAcylation of MLPH protects it from degradation and stabilizes its presence in cells. These findings provide insights into a potential mechanism of GBM radiation resistance and suggest a therapeutic strategy for GBM treatment.
Article
Medicine, Research & Experimental
Yan-yan Yu, Xiang-qian Li, Wen-peng Hu, Shi-chao Cu, Jia-jia Dai, Ya-nan Gao, Yi-ting Zhang, Xiao-yi Bai, Da-yong Shi
Summary: The NF-kappa B inhibitor 270 showed anti-inflammatory effects in LPS-induced AKI and ALI, improving pathological changes, reducing pro-inflammation gene expression, blocking NF-kappa B and JNK pathway activation, attenuating oxidative stress and autophagy inhibition, and reducing inflammation markers in plasma.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Medicine, General & Internal
Chia-Chun Tseng, Yuan-Zhao Lin, Chia-Hui Lin, Ruei-Nian Li, Wen-Chan Tsai, Tsan-Teng Ou, Cheng-Chin Wu, Wan-Yu Sung, Jeng-Hsien Yen
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
(2019)
Article
Medicine, General & Internal
Chia-Chun Tseng, Yuan-Zhao Lin, Chia-Hui Lin, Ruei-Nian Li, Chang-Yi Yen, Hua-Chen Chan, Wen-Chan Tsai, Tsan-Teng Ou, Cheng-Chin Wu, Wan-Yu Sung, Jeng-Hsien Yen
JOURNAL OF CLINICAL MEDICINE
(2019)
Article
Medicine, General & Internal
Chia-Chun Tseng, Ling-Yu Wu, Wen-Chan Tsai, Tsan-Teng Ou, Cheng-Chin Wu, Wan-Yu Sung, Po-Lin Kuo, Jeng-Hsien Yen
Review
Biochemistry & Molecular Biology
Chia-Chun Tseng, Yi-Jen Chen, Wei-An Chang, Wen-Chan Tsai, Tsan-Teng Ou, Cheng-Chin Wu, Wan-Yu Sung, Jeng-Hsien Yen, Po-Lin Kuo
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Article
Rheumatology
Hua-Chen Chan, Hsiu-Chuan Chan, Chan-Jung Liang, Hsiang-Chun Lee, Hung Su, An-Sheng Lee, Jentaie Shiea, Wen-Chan Tsai, Tsan-Teng Ou, Cheng-Chin Wu, Chih-Sheng Chu, Richard A. Dixon, Liang-Yin Ke, Jeng-Hsien Yen, Chu-Huang Chen
ARTHRITIS & RHEUMATOLOGY
(2020)
Article
Biochemistry & Molecular Biology
Chia-Chun Tseng, Man Chun Wong, Wei-Ting Liao, Chung-Jen Chen, Su-Chen Lee, Jeng-Hsien Yen, Shun-Jen Chang
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Review
Biochemistry & Molecular Biology
Chia-Chun Tseng, Man-Chun Wong, Wei-Ting Liao, Chung-Jen Chen, Su-Chen Lee, Jeng-Hsien Yen, Shun-Jen Chang
Summary: Variants of TFBS play a crucial role in regulating gene expression in the human genome, impacting human phenotypes through various mechanisms. However, challenges persist in studying such polymorphisms.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Rheumatology
Tzu-Jung Fang, Ruei-Nian Li, Yuan-Zhao Lin, Chia-Hui Lin, Chia-Chun Tseng, Wan-Yu Sung, Tsan-Teng Ou, Cheng-Chin Wu, Jeng-Hsien Yen
Summary: The study examined the relationship between F11R gene polymorphism and SS patients, showing that the -436A/G genotype is associated with susceptibility to SS in HLA-DR2 negative and HLA-DR3 negative individuals. Additionally, F11R mRNA expression was significantly lower in SS patients.
INTERNATIONAL JOURNAL OF RHEUMATIC DISEASES
(2021)
Article
Medical Laboratory Technology
Hua-Chen Chan, Shu-Chen Wang, Chia-Hui Lin, Yuan-Zhao Lin, Ruei-Nian Li, Jeng-Hsien Yen
Summary: The study aimed to investigate the association between CD209 promoter variants and RA development in a Taiwanese population. A novel variant -96C>A was identified, with significantly higher frequency in RA patients. Other known variants, such as -1180 T/T (rs7359874), were also found to be associated with RA. Additionally, certain haplotypes were increased in RA patients.
JOURNAL OF CLINICAL LABORATORY ANALYSIS
(2021)
Article
Rheumatology
Huai-Chia Chuang, Wei-Ting Hung, Yi-Ming Chen, Pu-Ming Hsu, Jeng-Hsien Yen, Joung-Liang Lan, Tse-Hua Tan
Summary: Multiple germline and somatic variants of the MAP4K3 (GLK) gene were found in patients with SLE, leading to increased GLK expression through mRNA or protein stability.
ANNALS OF THE RHEUMATIC DISEASES
(2022)
Article
Medicine, General & Internal
Chia-Chun Tseng, Yuan-Zhao Lin, Chia-Hui Lin, Daw-Yang Hwang, Ruei-Nian Li, Wen-Chan Tsai, Tsan-Teng Ou, Cheng-Chin Wu, Yu-Chih Lin, Wan-Yu Sung, Kuan-Yu Chen, Shun-Jen Chang, Jeng-Hsien Yen
Summary: This study found that CREM hypomethylation and upregulation occur in rheumatoid arthritis (RA), and CREM variants are associated with the development of serositis and lymphadenopathy in RA.
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
(2022)
Article
Biochemistry & Molecular Biology
Yi-Jing Chen, Wei-Chun Hung, Yu-Hsiang Chou, Chern-Hsiung Lai, Po Peng, Pei-Syuan Jhou, Min-Ru Tsai, Jim Jinn-Chyuan Sheu, Jeng-Hsien Yen
Summary: This study elucidates the important roles of A. butyrica and P. simiae as periodontal bacteria in the induction of ACPA production, leading to RA.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Medicine, General & Internal
Wan-Yu Sung, Yuan-Zhao Lin, Daw-Yang Hwang, Chia-Hui Lin, Ruei-Nian Li, Chia-Chun Tseng, Cheng-Chin Wu, Tsan-Teng Ou, Jeng-Hsien Yen
Summary: This study found that 5-methylcytosine and 5-hydroxymethylcytosine were decreased in SLE patients, while the mRNA expression of TET2 was significantly high and correlated with SLE disease activity biomarkers. Methylation rates in the TET2 promoter region were also found to differ significantly in SLE patients.
Article
Medicine, General & Internal
Chang-Yi Yen, Pin-Yi Wang, Kuan-Yu Chen, Chia-Chun Tseng, Cheng-Chin Wu, Tsan-Teng Ou, Jeng-Hsien Yen
Summary: In the Taiwanese population, HLA-DR2 was associated with susceptibility to SLE, leading to lower age of disease onset and more severe clinical manifestations.
JOURNAL OF THE CHINESE MEDICAL ASSOCIATION
(2023)
Article
Medical Laboratory Technology
Yu-Hung Hung, Yung-Hung Lee, Pei-Pei Chen, Yuan-Zhao Lin, Chia-Hui Lin, Jeng-Hsien Yen
ANNALS OF LABORATORY MEDICINE
(2019)