Review
Oncology
Barbora Kvokackova, Jan Remsik, Mohit Kumar Jolly, Karel Soucek
Summary: Epithelial-mesenchymal transition (EMT) and mesenchymal-epithelial transition (MET) play critical roles in the development of TNBC, shaping aggressive and heterogeneous biological features, but may also contribute to the progression of metastatic disease.
Article
Biochemistry & Molecular Biology
Stefano Zapperi, Caterina A. M. La Porta
Summary: Finding prognostic and predictive markers for TNBC is highly desirable, and the recently developed transcriptomic test ARIADNE shows promising capabilities in this regard.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Yang Liu, Yu Fang, Lili Bao, Feng Wu, Shilong Wang, Siyu Hao
Summary: This study analyzed cellular gene expression profiles from five TNBC patients and characterized the EMT process using scRNA-seq. The identification of dysregulated transcription factors and cell-cell communications shed light on potential treatment targets for TNBC, enhancing the understanding of EMT in the tumor microenvironment.
Article
Endocrinology & Metabolism
Xuezhang Chen, Xikang Chen, Zhixia Zhu, Yinsong Chen, Xiaoqi Pang, Xianxun Zhong, Shuang You, Yaoxu Chen, Huaqin Tian
Summary: This study aimed to identify a prognostic epithelial-mesenchymal transition (EMT)-correlated long noncoding RNA (lncRNA) signature in triple-negative breast cancer (TNBC). By analyzing gene expression data from TCGA and GEO databases, EMT-related genes were identified and differentially expressed lncRNAs were selected. A risk score (RS) model based on EMT-correlated lncRNAs was established, and the samples were divided into low- and high-risk groups. The study found that the RS model could predict the prognosis of TNBC and may serve as a treatment target for TNBC.
JOURNAL OF BIOLOGICAL REGULATORS AND HOMEOSTATIC AGENTS
(2023)
Article
Genetics & Heredity
Justine Marsolier, Pacome Prompsy, Adeline Durand, Anne-Marie Lyne, Camille Landragin, Amandine Trouchet, Sabrina Tenreira Bento, Almut Eisele, Sophie Foulon, Lea Baudre, Kevin Grosselin, Mylene Bohec, Sylvain Baulande, Ahmed Dahmani, Laura Sourd, Eric Letouze, Anne-Vincent Salomon, Elisabetta Marangoni, Leila Perie, Celine Vallot
Summary: The persistence of drug-resistant cancer cells is a major clinical challenge, particularly in triple-negative breast cancer. This study reveals that the repressive histone mark H3K27me3 plays a crucial role in regulating cell fate and chemotherapy tolerance in cancer cells. Manipulating H3K27me3 levels effectively enhances the potential of cancer cells to tolerate chemotherapy and delays tumor recurrence. These findings underscore the importance of understanding chromatin landscapes in shaping cancer cell response to initial therapy.
Article
Chemistry, Multidisciplinary
Charlene Waryah, Joseph Cursons, Momeneh Foroutan, Christian Pflueger, Edina Wang, Ramyar Molania, Anabel Sorolla, Christopher Wallis, Colette Moses, Irina Glas, Leandro Magalhaes, Erik W. Thompson, Liam G. Fearnley, Christine L. Chaffer, Melissa Davis, Anthony T. Papenfuss, Andrew Redfern, Ryan Lister, Manel Esteller, Pilar Blancafort
Summary: This work successfully silenced ZEB1 in triple negative breast cancer (TNBC) models through CRISPR/dCas9-mediated epigenetic editing, leading to significant tumor inhibition and the discovery of ZEB1-dependent-signature genes. Epigenetic changes, including reactivation and enhanced chromatin accessibility, were observed in cell adhesion loci, indicating a shift towards a more epithelial state. Silencing of ZEB1 also induced heterochromatin expansion, DNA methylation changes, and chromatin modifications in the ZEB1 promoter. This study demonstrated the potential of epigenome-engineering approaches and customizable precision molecular oncology for targeting poor outcome breast cancers.
Article
Pharmacology & Pharmacy
Jingnan Zhang, Ze Zhang, Zhenlin Huang, Manlin Li, Fan Yang, Zeqi Wu, Qian Guo, Xiyu Mei, Bin Lu, Changhong Wang, Zhengtao Wang, Lili Ji
Summary: This study reported that a natural compound isotoosendanin (ITSN) reduced TNBC metastasis by inhibiting TGF-P-induced EMT and the formation of invadopodia. ITSN can directly interact with TGF-P receptor type-1 (TGFPR1) and abrogated the kinase activity of TGFPR1, thereby blocking the TGF-P-initiated downstream signaling pathway. Moreover, ITSN also improved the inhibitory efficacy of programmed cell death 1 ligand 1 (PD-L1) antibody for TNBC in vivo via inhibiting the TGF-P-mediated EMT in the tumor microenvironment.
ACTA PHARMACEUTICA SINICA B
(2023)
Article
Multidisciplinary Sciences
Marketa Koleckova, Jiri Ehrmann, Jan Bouchal, Maria Janikova, Aneta Brisudova, Josef Srovnal, Katerina Staffova, Marek Svoboda, Ondrej Slaby, Lenka Radova, Katherine Vomackova, Bohuslav Melichar, Lucia Veverkova, Zdenek Kolar
Summary: Triple negative breast cancers (TNBC) are a morphologically and genetically heterogeneous group of breast cancers with uncertain prediction of biological behavior and response to therapy. Epithelial to mesenchymal transition (EMT) is a dynamic process characterized by loss of typical epithelial phenotype and acquisition of mesenchymal characteristics. The study aimed to analyze miRNA expression within areas of TNBCs with cellular morphology related to the EMT process, and found a specific miRNA expression profile of apocrine and spindle cell morphology which may be relevant for prognosis and therapy resistance of TNBC.
SCIENTIFIC REPORTS
(2021)
Article
Oncology
Yingzi Zhang, Jiao Tian, Chi Qu, Yang Peng, Jinwei Lei, Kang Li, Beige Zong, Lu Sun, Shengchun Liu
Summary: The study revealed that overexpression of SERPINA3 is associated with proliferation, migration, invasion, and EMT of breast cancer cells, as well as inducing cisplatin resistance. SERPINA3 could be a critical target for the clinical treatment of breast cancer progression.
Article
Multidisciplinary Sciences
Uyen Q. Le, Nanyue Chen, Seetharaman Balasenthil, Eugene Lurie, Fei Yang, Suyu Liu, Laura Rubin, Luisa Maren Solis Soto, Maria Gabriela Raso, Harsh Batra, Aysegul A. Sahin, Ignacio I. Wistuba, Ann McNeill Killary
Summary: This study demonstrates that the tumor suppressor DEAR1/TRIM62 is a critical regulator of luminal cell fate, maintaining luminal differentiation and inhibiting stem cell properties and generation of basal-like progenitor populations. DEAR1 loss leads to enhanced mammosphere formation and accelerated luminal-basal transition. Additionally, DEAR1 could serve as a biomarker for prognostic diagnosis and targeted stem cell therapies in early onset TNBCs.
SCIENTIFIC REPORTS
(2022)
Review
Oncology
Kah Keng Wong
Summary: Triple-negative breast cancer (TNBC) is the most aggressive subtype of breast cancer, with DNMT1 playing a crucial role in promoting tumorigenesis through multiple mechanisms. DNMT1 inhibitors show promise in targeting TNBC cells and sensitizing patients to immune checkpoint blockade therapy. This highlights the potential of DNMT1 as a therapeutic target for TNBC, aiming to disrupt its metastatic and aggressive phenotypes.
SEMINARS IN CANCER BIOLOGY
(2021)
Article
Oncology
Yuwei Ling, Qi Cao, Yihan Liu, Jing Zhao, Ye Zhao, Kaifu Li, Zhiqiang Chen, Xiaoyan Du, Xueyun Huo, Hua Kang, Zhenwen Chen
Summary: Higher expression of PFN2 is associated with worse prognosis in TNBC, promoting cell proliferation, migration, and invasion by regulating epithelial-to-mesenchymal transition.
Article
Chemistry, Multidisciplinary
Xi-yu Mei, Jing-nan Zhang, Wang-ya Jia, Bin Lu, Meng-na Wang, Tian-yu Zhang, Li-li Ji
Summary: In this study, researchers found that Scutellarin (SC), a natural flavonoid, can reduce the metastasis of triple-negative breast cancer (TNBC) by alleviating tumor-associated vascular endothelial barrier injury. SC regulates the TNF alpha-TNFR2-ERK1/2-EZH2 signaling pathway and restores the reduced expression of junctional proteins, thereby suppressing TNBC metastasis.
ACTA PHARMACOLOGICA SINICA
(2022)
Article
Surgery
Wei Jian, Xiao-Chong Deng, Amik Munankarmy, Oyungerel Borkhuu, Chang-Le Ji, Xue-Hui Wang, Wen-Fang Zheng, Yun-He Yu, Xi-Qian Zhou, Lin Fang
Summary: KIF23 is overexpressed in triple negative breast cancer, knockdown of KIF23 by siRNA inhibits proliferation and migration of TNBC cell lines, while miR-195-5p can combine with KIF23's 3'UTR to promote its degradation.
Article
Biochemistry & Molecular Biology
Natascha Skov, Carla L. Alves, Sidse Ehmsen, Henrik J. Ditzel
Summary: This study investigates the role of Aurora A and Bcl-xL in regulating basal B cell invasion in triple-negative breast cancer (TNBC). The results show that high levels of Aurora A and Bcl-xL promote metastasis, and inhibiting these proteins may suppress metastasis and improve patient survival in basal B TNBC.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell Biology
Na Yu, Min Xue, Weilong Wang, Dongxue Xia, Yajie Li, Xiaofeng Zhou, Dan Pang, Kui Lu, Jinghan Hou, Aijia Zhang, Ting Zhuang, Lidong Wang, Tingmin Chang, Xiumin Li
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2019)
Article
Oncology
Paul K. Paik, Rachel K. Kim, Linda Ahn, Andrew J. Plodkowski, Ai Ni, Mark T. A. Donoghue, Philip Jonsson, Miguel Villalona-Calero, Kenneth Ng, Daniel McFarland, John J. Fiore, Afsheen Iqbal, Juliana Eng, Mark G. Kris, Charles M. Rudin
CLINICAL CANCER RESEARCH
(2020)
Article
Oncology
Aijia Zhang, Weilong Wang, Zhijun Chen, Dan Pang, Xiaofeng Zhou, Kui Lu, Jinghan Hou, Sujie Wang, Can Gao, Benjie Lv, Ziyi Yan, Zhen Chen, Jian Zhu, Lidong Wang, Ting Zhuang, Xiumin Li
Article
Oncology
Zhonghao Wang, Qiong Kong, Peng Su, Miao Duan, Min Xue, Xin Li, Jianing Tang, Zhitao Gao, Beibei Wang, Zhongbo Li, Yun Liu, Xiao Yang, Ruilin Cao, Tingting Song, Ke Wang, Yuqing Cai, Danfeng Wu, Jinglei Li, Gaosong Wu, Asha M. Guled, Jian Zhu, Cheng Yan, Ting Zhuang
Article
Oncology
Laia Sadeghi, Gustav Arvidsson, Magali Merrien, Agata M. Wasik, Andre Gorgens, C. I. Edvard Smith, Birgitta Sander, Anthony P. Wright
Article
Oncology
Rui Zhou, Yinlu Ding, Min Xue, Bin Xiong, Ting Zhuang
CANCER CELL INTERNATIONAL
(2020)
Article
Oncology
Huijie Yang, Xulei Lv, Xin Li, Lanzhi Mao, Zhiguo Niu, Ting Wang, Ting Zhuang, Qingsong Huang
Summary: The study investigated the role of Zinc finger protein 213 in ER alpha protein stability and tamoxifen resistance, revealing its correlation with poor outcomes in endocrine treated patients. Depletion of ZNF213 inhibited ER alpha signaling and proliferation in breast cancer cells, suggesting it as a potential target for ER alpha positive breast cancer therapy.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Yun Liu, Peng Su, Wuchen Zhao, Xin Li, Xiao Yang, Jianing Fan, Huijie Yang, Cheng Yan, Lanzhi Mao, Yinlu Ding, Jian Zhu, Zhiguo Niu, Ting Zhuang
Summary: ZNF213 has been identified as a negative regulator of the Hippo/YAP axis in TNBC, promoting cell migration and invasion, and interacting with YAP to facilitate its K48-linked poly-ubiquitination at specific lysine sites, thus influencing TNBC progression and prognosis.
Review
Biochemistry & Molecular Biology
Laia Sadeghi, Anthony P. Wright
Summary: The migration and sequestration of lymphocytes in specific microenvironments are crucial for their differentiation and survival, being tightly regulated by various signaling pathways. The production of cytokines and chemokines is controlled by transcription factors in specific epigenetic landscapes, influencing the gene expression pattern in lymphocytes and promoting cell survival. Dysregulation of epigenetic mechanisms is increasingly recognized to contribute to cancer initiation, progression, and drug resistance.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Yaxuan Liu, Olga Axell, Tom van Leeuwen, Robert Konrat, Pedram Kharaziha, Catharina Larsson, Anthony P. H. Wright, Svetlana Bajalica-Lagercrantz
Summary: A logistic regression model was developed to predict outcomes of LFS and HBC based on the predicted effects of TP53 missense variants on protein conformation. The study found that LFS-variants were over-represented in residues buried in the core structure of TP53. The model described disease outcomes in terms of variables related to residues’ surface or buried status and their impact on protein compactness or interactions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Genetics & Heredity
Preethi Srinivasan, Chaitanya Bandlamudi, Philip Jonsson, Yelena Kemel, Shweta S. Chavan, Allison L. Richards, Alexander Penson, Craig M. Bielski, Christopher Fong, Aijazuddin Syed, Gowtham Jayakumaran, Meera Prasad, Jason Hwee, Selcuk Onur Sumer, Ino de Bruijn, Xiang Li, JianJiong Gao, Nikolaus Schultz, Roy Cambria, Jesse Galle, Semanti Mukherjee, Joseph Vijai, Karen A. Cadoo, Maria Carlo, Michael F. Walsh, Diana Mandelker, Ozge Ceyhan-Birsoy, Jinru Shia, Ahmet Zehir, Marc Ladanyi, David M. Hyman, Liying Zhang, Kenneth Offit, Mark E. Robson, David B. Solit, Zsofia K. Stadler, Michael F. Berger, Barry S. Taylor
Summary: The study identified pathogenic germline variants in cancer predisposition genes in 17,152 patients with cancer, revealing different mechanisms of tumorigenesis based on the penetrance and lineage of the gene variants.
Article
Oncology
Amir Mahani, Gustav Arvidsson, Laia Sadeghi, Alf Grandien, Anthony P. H. Wright
Summary: This study explores how mutations affecting MYC proteins can enhance oncogenic effects on normal MYC-target genes, particularly in the transition of B cells to lymphoma cells.
Article
Oncology
Evan Rosenbaum, Philip Jonsson, Kenneth Seier, Li-Xuan Qin, Ping Chi, Mark Dickson, Mrinal Gounder, Ciara Kelly, Mary L. Keohan, Benjamin Nacev, Mark T. A. Donoghue, Sarah Chiang, Samuel Singer, Marc Ladanyi, Cristina R. Antonescu, Martee L. Hensley, Sujana Movva, Sandra P. D'Angelo, William D. Tap
JCO PRECISION ONCOLOGY
(2020)
Article
Oncology
Zhiguo Niu, Xin Li, Suyin Feng, Qingsong Huang, Ting Zhuang, Cheng Yan, Hui Qian, Yinlu Ding, Jian Zhu, Wenrong Xu
Article
Medicine, Research & Experimental
Xiaofeng Zhou, Yajie Li, Weilong Wang, Sujie Wang, Jinghan Hou, Aijia Zhang, Benjie Lv, Can Gao, Ziyi Yan, Dan Pang, Kui Lu, Nor Hazwani Ahmad, Lidong Wang, Jian Zhu, Lichen Zhang, Ting Zhuang, Xiumin Li