Review
Health Care Sciences & Services
Mariangela Manfredi, Lieve Van Hoovels, Maurizio Benucci, Riccardo De Luca, Carmela Coccia, Pamela Bernardini, Edda Russo, Amedeo Amedei, Serena Guiducci, Valentina Grossi, Xavier Bossuyt, Carlo Perricone, Maria Infantino
Summary: uPAR is a membrane-bound glycoprotein, and its bioactive form, suPAR, is primarily expressed on the surface of immunologically active cells. Higher levels of suPAR have been associated with disease severity, relapse, and mortality in various inflammatory diseases. This review summarizes the current literature on the potential role of suPAR as a biomarker in autoimmune rheumatic and non-rheumatic diseases.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Review
Immunology
Yao-Chin Wang, Muh-Shi Lin, Abel Po-Hao Huang, Chieh-Chen Wu, Woon-Man Kung
Summary: This systematic review and meta-analysis demonstrate an increased risk of dementia among participants with systemic rheumatic diseases (SRDs), except for rheumatoid arthritis (RA).
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Nutrition & Dietetics
Sofia Charneca, Ana Hernando, Patricia Costa-Reis, Catarina Sousa Guerreiro
Summary: Despite advances in understanding the biological mechanisms of rheumatic diseases (RDs), a significant proportion of patients still do not achieve remission with current pharmacological treatments. Therefore, patients are increasingly seeking complementary dietary interventions, including the use of herbs and spices. These natural ingredients, which have been widely used for culinary and medicinal purposes across different cultures, are now gaining interest for their bioactive molecules and potential benefits in immune-mediated diseases, including RDs. This paper aims to provide an updated review of the mechanisms through which herbs and spices may be beneficial in RDs, including modulation of gut microbiota, and summarize human studies investigating their effects in Rheumatoid Arthritis, Osteoarthritis, and Fibromyalgia.
Article
Biochemistry & Molecular Biology
Kyung Rae Ko, Hyunil Lee, Soo-Hong Han, Wooyeol Ahn, Do Kyung Kim, Il-Su Kim, Bo Sung Jung, Soonchul Lee
Summary: This review provides an overview of the role of substance P and the neurokinin-1 receptor in musculoskeletal disorders and highlights their potential as therapeutic targets.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Medicine, General & Internal
Felix Rothe, Joern Berger, Pia Welker, Richard Fiebelkorn, Stefan Kupper, Denise Kiesel, Egbert Gedat, Sarah Ohrndorf
Summary: Fluorescence optical imaging (FOI) can help diagnose different rheumatic diseases by identifying specific image features. By analyzing FOI images of patients' hands, researchers were able to accurately diagnose rheumatoid arthritis (RA), osteoarthritis (OA), and connective tissue diseases (CTD) and determine the most important image features for each disease.
FRONTIERS IN MEDICINE
(2023)
Review
Endocrinology & Metabolism
Ruobing Zhao, Yan Chen, Dongxue Wang, Chunyu Zhang, Henan Song, Guoxin Ni
Summary: Bone diseases are common and detrimental to the daily activities and quality of life of middle-aged and elderly individuals. It is essential to identify key regulatory factors and potential therapeutic targets for bone diseases. Irisin, a newly discovered myokine, has been found to have beneficial effects on various diseases, especially bone-related disorders. Research has indicated that irisin plays a role in bone diseases such as osteoarthritis and osteoporosis, suggesting its potential as a molecule for the prevention and treatment of bone diseases. This review summarizes the specific regulatory mechanisms of irisin in different bone diseases and provides a theoretical basis for its application in the diagnosis and treatment of these conditions.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Medicine, General & Internal
Livia Roseti, Brunella Grigolo
Summary: Joint pain and arthralgia can be symptoms of COVID-19, and there is evidence suggesting a possible relationship between the virus and the development of inflammatory arthritis. Viral infections and rheumatic diseases have documented associations, and they share genetic and environmental risk factors. The interaction between viruses and the immune system plays a role in the development of rheumatic diseases, and infections may contribute to autoimmune rheumatic diseases and patient mortality. Therefore, understanding the interaction between viral infections and rheumatic diseases is crucial.
FRONTIERS IN MEDICINE
(2022)
Article
Biochemical Research Methods
Manuel Fuentes, Cristina Ruiz-Romero, Sara Misiego, Pablo Juanes-Velasco, Alicia Landeira-Vinuela, Adrian Torres-Roda, Hector Lorenzo-Gil, Maria Gonzalez-Gonzalez, Angela P. Hernandez, Lucia Lourido, Ronald Sjoberg, Elisa Pin, Javier de Las Rivas, Jose Manuel Sanchez-Santos, Peter Nilsson, Francisco J. Blanco
Summary: Rheumatic diseases are common and complex conditions with low sensitivity to clinical diagnosis. This study developed an early diagnosis method for personalized treatment based on the identification of relevant proteins associated with the specific pathologies. By utilizing functional proteomics screening, a panel of 30 serum proteins has been identified as potential biomarkers for rheumatic diseases such as osteoarthritis, rheumatoid arthritis, and psoriatic arthritis.
JOURNAL OF PROTEOME RESEARCH
(2023)
Review
Rheumatology
Amanda E. Nelson, Liubov Arbeeva
Summary: There has been rapid growth in the use of artificial intelligence (AI) analytics in medicine, including in rheumatic and musculoskeletal diseases (RMDs). However, the black box nature of most algorithms and the unfamiliarity of the terms pose challenges for clinicians, patients, and researchers. This review aims to provide relevant insights into the strengths and limitations of AI analytics in RMDs, as well as recent examples and future directions in diagnosis, phenotyping, prognosis, and precision medicine.
JOURNAL OF RHEUMATOLOGY
(2022)
Review
Immunology
Sara Assadiasl, Misagh Rajabinejad, Narjes Soleimanifar, Farideh Makiyan, Esfandiar Azizi, Alireza Rezaiemanesh, Mohammad Hossein Nicknam
Summary: Rheumatoid arthritis and ankylosing spondylitis are two common rheumatic disorders characterized by persistent inflammatory joint disease. This review provides an overview of the most important signaling pathways controlled by miRNAs in these diseases.
INFLAMMOPHARMACOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Nipith Charoenngam
Summary: Vitamin D plays a crucial role in maintaining skeletal and immune health, and research has shown an association between vitamin D levels and rheumatic diseases. However, the specific benefits of vitamin D supplements for treating and preventing rheumatic diseases are still debated.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Immunology
Andrea Favalli, Ennio Giulio Favalli, Andrea Gobbini, Elena Zagato, Mauro Bombaci, Gabriella Maioli, Elisa Pesce, Lorena Donnici, Paola Gruarin, Martina Biggioggero, Serena Curti, Lara Manganaro, Edoardo Marchisio, Valeria Bevilacqua, Martina Martinovic, Tanya Fabbris, Maria Lucia Sarnicola, Mariacristina Crosti, Laura Marongiu, Francesca Granucci, Samuele Notarbartolo, Alessandra Bandera, Andrea Gori, Raffaele De Francesco, Sergio Abrignani, Roberto Caporali, Renata Grifantini
Summary: COVID-19 is particularly severe for patients with pre-existing pathologies. Patients with rheumatic musculoskeletal disease (RMD) may have compromised immune responses to SARS-CoV-2 infection due to their impaired immune system and use of disease-modifying anti-rheumatic drugs (DMARDs). However, this study shows that RMD patients under most DMARD treatments can mount sustained antibody responses to the virus, as well as having a sizable population of effector T and B lymphocytes.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Public, Environmental & Occupational Health
Anand A. Bang, Shekhar Y. Bhojraj, Mahesh Deshmukh, Vinay R. Joshi, Tushar Yarmal, Sameer Kalkotwar, Abhay T. Bang
Summary: Pain in back and extremities is a significant public health concern in rural areas of India, with nearly five out of six adults experiencing this issue over a span of 12 months. Female gender, farming/labor occupation, and increasing age were identified as key risk factors associated with this pain.
JOURNAL OF GLOBAL HEALTH
(2021)
Review
Rheumatology
Mitsuhiro Akiyama, Waleed Alshehri, Keiko Yoshimoto, Yuko Kaneko
Summary: Recent technological progress has advanced our understanding of human immunology through the discovery of T follicular helper (Tfh) and T peripheral helper (Tph) cells. These cells play critical roles in B cell differentiation and maturation, with differences in their functional properties. In various rheumatic and musculoskeletal diseases, the contribution of Tfh and Tph cells varies, with Tph cells predominating in peripheral inflammatory lesions and Tfh cells predominating in affected lesions of IgG4-related disease. This review provides an overview of these novel T cell subsets and their involvement in these diseases.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Review
Rheumatology
Burhan Fatih Kocyigit, Zhaxybek Sagtaganov, Marlen Yessirkepov
Summary: Yoga, with its various physical poses and breathing techniques, has gained global popularity and is used as a complementary treatment for different diseases. It improves physical and mental health, including mood, anxiety, and stress management. In the treatment of rheumatic diseases, yoga is recognized as a significant component of non-pharmacological therapy.
RHEUMATOLOGY INTERNATIONAL
(2023)