Obesity and osteoarthritis, more than just wear and tear: pivotal roles for inflamed adipose tissue and dyslipidaemia in obesity-induced osteoarthritis

In Vivo Cyclic Compression Causes Cartilage Degeneration and Subchondral Bone Changes in Mouse Tibiae

(2013) Frank C. Ko et al.   ARTHRITIS AND RHEUMATISM

Adipose tissue hypoxia induces inflammatory M1 polarity of macrophages in an HIF-1α-dependent and HIF-1α-independent manner in obese mice

(2013) S. Fujisaka et al.   DIABETOLOGIA

Immune Regulation in Obesity-Associated Adipose Inflammation

(2013) J. M. Han et al.   JOURNAL OF IMMUNOLOGY

Initial Responses of Articular Tissues in a Murine High-Fat Diet-Induced Osteoarthritis Model: Pivotal Role of the IPFP as a Cytokine Fountain

(2013) Munetaka Iwata et al.   PLoS One

Leptin Induces IL-6 Expression through OBRl Receptor Signaling Pathway in Human Synovial Fibroblasts

(2013) Wei-Hung Yang et al.   PLoS One

Dyslipidemia in Obesity: Mechanisms and Potential Targets

(2013) Boudewijn Klop et al.   Nutrients

Cytokine production by infrapatellar fat pad can be stimulated by interleukin 1β and inhibited by peroxisome proliferator activated receptor α agonist

(2012) Stefan Clockaerts et al.   ANNALS OF THE RHEUMATIC DISEASES

Consensus statement on blocking the effects of interleukin-6 and in particular by interleukin-6 receptor inhibition in rheumatoid arthritis and other inflammatory conditions

(2012) Josef S Smolen et al.   ANNALS OF THE RHEUMATIC DISEASES

Osteoarthritis synovial fluid activates pro-inflammatory cytokines in primary human chondrocytes

(2012) Paula Hoff et al.   INTERNATIONAL ORTHOPAEDICS

Visfatin/Pre-B-cell Colony-enhancing Factor (PBEF), a Proinflammatory and Cell Motility-changing Factor in Rheumatoid Arthritis

(2012) Florian M. P. Meier et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Body mass index affects knee joint mechanics during gait differently with and without moderate knee osteoarthritis

(2012) Graeme T. Harding et al.   OSTEOARTHRITIS AND CARTILAGE

Chronic in vivo load alteration induces degenerative changes in the rat tibiofemoral joint

(2012) M.L. Roemhildt et al.   OSTEOARTHRITIS AND CARTILAGE

Perturbations in the HDL metabolic pathway predispose to the development of osteoarthritis in mice following long-term exposure to western-type diet

(2012) I.-E. Triantaphyllidou et al.   OSTEOARTHRITIS AND CARTILAGE

Characterization of synovial angiogenesis in osteoarthritis patients and its modulation by chondroitin sulfate

(2012) Cécile Lambert et al.   ARTHRITIS RESEARCH & THERAPY

Functional annotation of the human fat cell secretome

(2012) Ingrid Dahlman et al.   ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY

Leptin produced by joint white adipose tissue induces cartilage degradation via upregulation and activation of matrix metalloproteinases

(2011) Wang Hui et al.   ANNALS OF THE RHEUMATIC DISEASES

Association between leptin, adiponectin and resistin and long-term progression of hand osteoarthritis

(2011) E. Yusuf et al.   ANNALS OF THE RHEUMATIC DISEASES

Correlation of Plasma and Synovial Fluid Adiponectin with Knee Osteoarthritis Severity

(2011) Sittisak Honsawek et al.   ARCHIVES OF MEDICAL RESEARCH

Suppression of leukocyte infiltration and cartilage degradation by selective inhibition of pre-B cell colony-enhancing factor/visfatin/nicotinamide phosphoribosyltransferase: Apo866-mediated therapy in human fibroblasts and murine collagen-induced arthrit

(2011) Laura Evans et al.   ARTHRITIS AND RHEUMATISM

Interleukin-6 plays an essential role in hypoxia-inducible factor 2α-induced experimental osteoarthritic cartilage destruction in mice

(2011) Je-Hwang Ryu et al.   ARTHRITIS AND RHEUMATISM

Lectin-like oxidized low-density lipoprotein receptor 1 signal is a potent biomarker and therapeutic target for human rheumatoid arthritis

(2011) Masahiro Ishikawa et al.   ARTHRITIS AND RHEUMATISM

Regulation of subchondral bone osteoblast metabolism by cyclic compression

(2011) Christelle Sanchez et al.   ARTHRITIS AND RHEUMATISM

Association of chemerin levels in synovial fluid with the severity of knee osteoarthritis

(2011) Ke Huang et al.   BIOMARKERS

Chemerin induces CCL2 and TLR4 in synovial fibroblasts of patients with rheumatoid arthritis and osteoarthritis

(2011) Kristina Eisinger et al.   EXPERIMENTAL AND MOLECULAR PATHOLOGY

Serum resistin level is associated with radiographic changes in hand osteoarthritis: Cross-sectional study

(2011) Jung-Yoon Choe et al.   JOINT BONE SPINE

New insights into the mechanism of low high-density lipoprotein cholesterol in obesity

(2011) Hao Wang et al.   Lipids in Health and Disease

Increased synovial fluid visfatin is positively linked to cartilage degradation biomarkers in osteoarthritis

(2011) Yuanhui Duan et al.   RHEUMATOLOGY INTERNATIONAL

Human articular chondrocytes express ChemR23 and chemerin; ChemR23 promotes inflammatory signalling upon binding the ligand chemerin21-157

(2011) Vivian Berg et al.   ARTHRITIS RESEARCH & THERAPY

Serum Chemerin Levels Vary with Time of Day and Are Modified by Obesity and Tumor Necrosis Factor-α

(2010) Sebastian D. Parlee et al.   ENDOCRINOLOGY

The infrapatellar fat pad should be considered as an active osteoarthritic joint tissue: a narrative review

(2010) S. Clockaerts et al.   OSTEOARTHRITIS AND CARTILAGE

Circulating levels of IL-6 and TNF-α are associated with knee radiographic osteoarthritis and knee cartilage loss in older adults

(2010) O. Stannus et al.   OSTEOARTHRITIS AND CARTILAGE

Bone marrow lesions in people with knee osteoarthritis predict progression of disease and joint replacement: a longitudinal study

(2010) S. K. Tanamas et al.   RHEUMATOLOGY

Secreted proteins from adipose tissue and skeletal muscle – adipokines, myokines and adipose/muscle cross-talk

(2010) Paul Trayhurn et al.   ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY

Increased serum adiponectin levels in female patients with erosive compared with non-erosive osteoarthritis

(2009) M Filkova et al.   ANNALS OF THE RHEUMATIC DISEASES

Extreme obesity due to impaired leptin signaling in mice does not cause knee osteoarthritis

(2009) Timothy M. Griffin et al.   ARTHRITIS AND RHEUMATISM

The infrapatellar fat pad in knee osteoarthritis: An important source of interleukin-6 and its soluble receptor

(2009) Emilie Distel et al.   ARTHRITIS AND RHEUMATISM

Plasma Adiponectin in Patients with Active, Early, and Chronic Rheumatoid Arthritis Who Are Steroid- and Disease-Modifying Antirheumatic Drug-Naive Compared with Patients with Osteoarthritis and Controls

(2009) T. B. LAURBERG et al.   JOURNAL OF RHEUMATOLOGY

Leptin plays a catabolic role on articular cartilage

(2009) Jia-peng Bao et al.   MOLECULAR BIOLOGY REPORTS

Signalling cascades in mechanotransduction: cell-matrix interactions and mechanical loading

(2009) L. Ramage et al.   SCANDINAVIAN JOURNAL OF MEDICINE & SCIENCE IN SPORTS

Total cholesterol and triglycerides are associated with the development of new bone marrow lesions in asymptomatic middle-aged women - a prospective cohort study

(2009) Miranda L Davies-Tuck et al.   ARTHRITIS RESEARCH & THERAPY

Developments in the scientific understanding of osteoarthritis

(2009) Steven B Abramson et al.   ARTHRITIS RESEARCH & THERAPY

Phenotypic characterization of osteoblasts from the sclerotic zones of osteoarthritic subchondral bone

(2008) Christelle Sanchez et al.   ARTHRITIS AND RHEUMATISM

Crucial role of visfatin/pre–B cell colony-enhancing factor in matrix degradation and prostaglandin E2 synthesis in chondrocytes: Possible influence on osteoarthritis

(2008) Marjolaine Gosset et al.   ARTHRITIS AND RHEUMATISM

Obesity and osteoarthritis in knee, hip and/or hand: An epidemiological study in the general population with 10 years follow-up

(2008) Margreth Grotle et al.   BMC MUSCULOSKELETAL DISORDERS

Leptin induces IL-8 expression via leptin receptor, IRS-1, PI3K, Akt cascade and promotion of NF-κB/p300 binding in human synovial fibroblasts

(2008) Kwok-Man Tong et al.   CELLULAR SIGNALLING

A new player in cartilage homeostasis: adiponectin induces nitric oxide synthase type II and pro-inflammatory cytokines in chondrocytes

(2008) R. Lago et al.   OSTEOARTHRITIS AND CARTILAGE

Resistin is elevated following traumatic joint injury and causes matrix degradation and release of inflammatory cytokines from articular cartilage in vitro

(2008) J.H. Lee et al.   OSTEOARTHRITIS AND CARTILAGE

Assessment of paraoxonase activities in patients with knee osteoarthritis

(2008) Neslihan Soran et al.   REDOX REPORT

Early lymphocyte activation in the synovial microenvironment in patients with osteoarthritis: comparison with rheumatoid arthritis patients and healthy controls

(2008) R. Rollín et al.   RHEUMATOLOGY INTERNATIONAL

The potential role of vascular endothelial growth factor (VEGF) in cartilage

(2007) M. Murata et al.   OSTEOARTHRITIS AND CARTILAGE