Article
Rheumatology
Anella Saviano, Adel Abo Manosour, Federica Raucci, Francesco Merlino, Noemi Marigliano, Anna Schettino, Mussarat Wahid, Jenefa Begum, Andrew Filer, Julia E. Manning, Gian Marco Casillo, Marialuisa Piccolo, Maria Grazia Ferraro, Simona Marzano, Pasquale Russomanno, Rosa Bellavita, Carlo Irace, Jussara Amato, Mohammed Alfaifi, Peter Rimmer, Tariq Iqbal, Stefano Pieretti, Valentina Vellecco, Francesco Caso, Luisa Costa, Roberto Giacomelli, Raffaele Scarpa, Giuseppe Cirino, Mariarosaria Bucci, Helen M. McGettrick, Paolo Grieco, Asif Jilani Iqbal, Francesco Maione
Summary: This study identified a novel IL-17A/F-derived peptide and generated a new anti-IL-17 antibody that can effectively reverse the pro-inflammatory actions of IL-17A/F. The antibody showed less off-target effects compared to the current gold-standard biologic. Preclinical and clinical evidence demonstrated the high efficacy and therapeutic potency of the antibody in patients with IMIDs.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Article
Multidisciplinary Sciences
Anissa Fries, Fanny Saidoune, Francois Kuonen, Isabelle Dupanloup, Nadine Fournier, Ana Cristina Guerra de Souza, Muzlifah Haniffa, Feiyang Ma, Johann E. Gudjonsson, Lennart Roesner, Yang Li, Thomas Werfel, Curdin Conrad, Raphael Gottardo, Robert L. Modlin, Jeremy Di Domizio, Michel Gilliet
Summary: This study establishes the role of interleukin 26 (IL-26) in the generation of IL-17A producing Th17 CD4(+) T cells, indicating its involvement in the pathogenic response of psoriasis. IL-26-producing cells infiltrate psoriatic skin and promote their own differentiation into IL17A-producing T(H)17 cells through epithelial crosstalk involving paracrine production of TGF-& beta;1.
NATURE COMMUNICATIONS
(2023)
Review
Immunology
Claudia Schinocca, Chiara Rizzo, Serena Fasano, Giulia Grasso, Lidia La Barbera, Francesco Ciccia, Giuliana Guggino
Summary: IL-23 is a pro-inflammatory cytokine composed of two subunits and has a key role in protective immune response, but dysregulation can exacerbate chronic immune-mediated inflammation. Activation of the IL-23/IL-17 axis contributes to the development of various inflammatory diseases.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Andre Lopes Saraiva, Raphael Sanches Peres, Flavio Protasio Veras, Jhimmy Talbot, Kalil Alves de Lima, Joao Paulo Mesquita Luiz, Thiago Mattar Cunha, Paulo Louzada-Junior, Fernando Queiroz Cunha, Jose Carlos Alves-Filho
Summary: The experimental arthritis model established using citrullinated human plasma fibrinogen revealed the importance of IL-23/IL-17 immune axis-mediated inflammatory responses in the pathogenesis of rheumatoid arthritis.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Review
Medicine, General & Internal
Kamran Ghoreschi, Anna Balato, Charlotta Enerback, Robert Sabat
Summary: Psoriasis is a chronic inflammatory disease affecting 2-3% of the global population, characterized by sharply demarcated erythematous and scaly skin lesions. The disease results from hyperproliferation and disturbed differentiation of epidermal keratinocytes provoked by immune mediators of the IL-23 and IL-17 pathway. Therapeutics targeting IL-23, IL-17, and IL-17RA have shown excellent efficacy in treating psoriasis.
Review
Immunology
Jiajia Fu, Yan Huang, Ting Bao, Chengcheng Liu, Xi Liu, Xueping Chen
Summary: Neurodegenerative diseases are characterized by progressive loss of neurons, and immune pathway dysregulation is a common feature. Th 17 cells and IL-17A play important roles in the pathogenesis of these diseases. Targeting IL-17A may represent a potential therapeutic approach for neurodegenerative diseases.
JOURNAL OF NEUROINFLAMMATION
(2022)
Article
Rheumatology
Alessandra Nerviani, Marie-Astrid Boutet, Wang Sin Gina Tan, Katriona Goldmann, Nirupam Purkayastha, Tamas Ajtos Lajtos, Rebecca Hands, Myles Lewis, Stephen Kelly, Costantino Pitzalis
Summary: This study revealed distinct differences in gene expression between synovial and skin tissues in PsA patients, particularly in the heterogeneous expression of the IL-23 axis. IL-23 transcriptomic/protein expression was strongly linked to patients with high-grade synovitis, aiding in identifying those who may respond better to IL-23 inhibitors.
ANNALS OF THE RHEUMATIC DISEASES
(2021)
Review
Neurosciences
Jingjing Wang, Yuxiao Gao, Yujia Yuan, Huan Wang, Zhao Wang, Xiangjian Zhang
Summary: This paper reviews the mechanism of action of Th17 cells and IL-17A in ischemic stroke and the progress of research on targeted therapy.
MOLECULAR NEUROBIOLOGY
(2023)
Article
Multidisciplinary Sciences
Michael Crawford, Nicholas Borcherding, Nitin Karandikar
Summary: CD4(+) T-helper 17 (Th17) T cells play a crucial role in promoting inflammation through the secretion of IL-17 and are a major therapeutic target for autoimmune disorders. Recent studies have shown that IL-17 family cytokines can directly act on CD4(+) T cells, specifically naive cells, leading to functional changes. The differences in downstream signaling and functional consequences suggest that IL-17AF heterodimer is the most influential cytokine.
Article
Immunology
Chun-Wen Chan, Hung-Wen Chen, Yu-Wen Wang, Chia- Lin, Ya-Hui Chuang
Summary: This study found that the Th17 cell-derived cytokine IL-21 plays a role in the pathogenesis of PBC, exacerbating liver inflammation and fibrosis and increasing the numbers and effector activities of CD8+ T cells.
CLINICAL AND EXPERIMENTAL IMMUNOLOGY
(2023)
Article
Neurosciences
Xin Luo, Ouyang Chen, Zilong Wang, Sangsu Bang, Jasmine Ji, Sang Hoon Lee, Yul Huh, Kenta Furutani, Qianru He, Xueshu Tao, Mei-Chuan Ko, Andrey Bortsov, Christopher R. Donnelly, Yong Chen, Andrea Nackley, Temugin Berta, Ru-Rong Ji
Summary: The IL-23/IL-17A/TRPV1 axis regulates female-specific mechanical pain, with IL-23 inducing pain in females but impaired in mice lacking IL-23 or IL-23r. IL-23-induced pain is promoted by estrogen and suppressed by androgen.
Review
Immunology
Matteo Vecellio, Vivien Xanath Hake, Connor Davidson, Maria Cristina Carena, B. Paul Wordsworth, Carlo Selmi
Summary: Psoriatic arthritis (PsA) is a chronic inflammatory disease associated with psoriasis, with genetic predisposition playing a key role in its development. The IL-23/IL-17 axis is highlighted as important in the immunopathogenesis of PsA.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Dominique Baeten, Iannis E. Adamopoulos
Summary: This article discusses the pathobiology of axial spondyloarthritis, particularly the role of IL-23/IL-17 axis, and shares relevant lessons learned for translating emerging biological insights into clinical therapeutics.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Immunology
Victoria Navarro-Compan, Luis Puig, Silvia Vidal, Julio Ramirez, Mar Llamas-Velasco, Cristina Fernandez-Carballido, Raquel Almodovar, Jose Antonio Pinto, Eva Galindez-Aguirregoikoa, Pedro Zarco, Beatriz Joven, Jordi Gratacos, Xavier Juanola, Ricardo Blanco, Salvador Arias-Santiago, Jesus Sanz Sanz, Ruben Queiro, Juan D. Canete
Summary: The interleukin-17 family plays important roles in chronic inflammation and autoimmunity, controlling bacterial and fungal infections. IL-17A and IL-17F are involved in various immune-mediated inflammatory diseases and can be produced by different cell subtypes, including Th17 cells, gamma delta T cells, and innate lymphoid cells. IL-17A and IL-17F contribute independently to chronic tissue inflammation.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Immunology
Kingston H. G. Mills
Summary: IL-17 cytokines have both protective and pathological functions in the context of infection and autoimmunity. They promote protective immunity against pathogens but can also drive inflammatory pathology. Dysregulated IL-17 responses can contribute to immunopathology, and IL-17 is implicated in various inflammatory diseases.
NATURE REVIEWS IMMUNOLOGY
(2023)