Article
Medicine, General & Internal
Ted R. Mikuls
Summary: A 64-year-old man presents with pain, redness, and swelling in his left foot, and is unable to bear weight on it. He has a history of similar episodes in his right big toe and right elbow, which were relieved with naproxen. He also has hypertension, type 2 diabetes, and moderate chronic kidney disease. Physical examination reveals warmth, redness, and nodules in the left first metatarsophalangeal joint.
NEW ENGLAND JOURNAL OF MEDICINE
(2022)
Article
Rheumatology
Kanon Jatuworapruk, Rebecca Grainger, Nicola Dalbeth, Ratchaya Lertnawapan, Punchong Hanvivadhanakul, Patapong Towiwat, Lianjie Shi, William J. Taylor
Summary: This study developed and validated a risk stratification tool for predicting gout flare in hospitalized patients with comorbid gout. The GOUT-36 rule, which includes four items, showed good sensitivity and specificity for classifying high-risk patients. This tool can inform clinical decisions and future research on preventing inpatient gout flares.
Article
Immunology
Lei Pang, Xiaomei Xue, Yuwei He, Can Wang, Lin Han, Maichao Li, Han Qi, Changgui Li, Jie Lu
Summary: This study aimed to explore the relationship between the decrease in serum urate and the risk of gout flares during urate-lowering therapy (ULT) initiation. The results showed that the degree of decrease in serum urate is affected by baseline serum urate, and higher baseline serum urate and greater decrease in serum urate increase the risk of gout flares.
JOURNAL OF INFLAMMATION RESEARCH
(2023)
Review
Medicine, General & Internal
Nicola Dalbeth, Anna L. Gosling, Angelo Gaffo, Abhishek Abhishek
Summary: Gout is a common and treatable disease caused by the deposition of monosodium urate crystals in the body, leading to arthritis. Long-term urate lowering therapy is effective in preventing gout flares and improving quality of life.
Article
Rheumatology
Lisa K. Stamp, Hamish Farquhar
Summary: The purpose of gout treatment is to alleviate symptoms of flares, prevent flares from recurring by lowering serum urate, and minimize structural joint damage and functional impairment. Despite the availability of multiple effective therapies, suboptimal management and outcomes are often due to under-prescribing of urate-lowering therapy by physicians and poor adherence with prescribed therapy by patients.
BEST PRACTICE & RESEARCH IN CLINICAL RHEUMATOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Wei-Zheng Zhang
Summary: Gout is a multifactorial metabolic disease where the role of hyperuricemia in its development is not solely definitive. Understanding the intricate role of serum uric acid (SUA) in gout pathogenesis is crucial for advancing clinical and pharmaceutical approaches towards a cure for the disease.
Article
Rheumatology
Lisa K. Stamp, Hamish Farquhar, Huai Leng Pisaniello, Ana B. Vargas-Santos, Mark Fisher, David B. Mount, Hyon K. Choi, Robert Terkeltaub, Catherine L. Hill, Angelo L. Gaffo
Summary: The coexistence of gout and chronic kidney disease (CKD) is common, but there is a lack of quality evidence to guide gout management in CKD patients. This results in confusion among medical professionals about the appropriate management of gout and CKD patients.
NATURE REVIEWS RHEUMATOLOGY
(2021)
Article
Nutrition & Dietetics
Stephen P. Juraschek, Edgar R. Miller, Beiwen Wu, Karen White, Jeanne Charleston, Allan C. Gelber, Sharan K. Rai, Kathryn A. Carson, Lawrence J. Appel, Hyon K. Choi
Summary: The study investigated the effects of a dietitian-directed DASH-patterned groceries on serum urate levels in gout patients, showing potential benefits but also noting the vulnerability to strong carryover effects in crossover trials without a washout period. Further research with controlled feeding trials is needed to definitively evaluate the DASH diet as a treatment for gout.
Article
Rheumatology
T. Uhlig, L. F. Karoliussen, J. Sexton, T. K. Kvien, E. A. Haavardsholm, F. Perez-Ruiz, H. B. Hammer
Summary: This study investigates the relationship between fluctuation and change in serum urate (SU) levels and the occurrence of gout flares. The results show that fluctuations and changes in SU levels are related to gout flares, while changes between visits and reaching higher SU levels are not.
CLINICAL RHEUMATOLOGY
(2022)
Article
Multidisciplinary Sciences
Anya Topiwala, Kulveer Mankia, Steven Bell, Alastair Webb, Klaus P. Ebmeier, Isobel Howard, Chaoyue Wang, Fidel Alfaro-Almagro, Karla Miller, Stephen Burgess, Stephen Smith, Thomas E. Nichols
Summary: The potential association between neurodegenerative disease risk and gout is not fully understood. Here the authors showed that gout is causally related to several measures of brain structure which may explain their higher vulnerability to dementia. Studies of neurodegenerative disease risk in gout are contradictory. Relationships with neuroimaging markers of brain structure, which may offer insights, are uncertain. Here we investigated associations between gout, brain structure, and neurodegenerative disease incidence. Gout patients had smaller global and regional brain volumes and markers of higher brain iron, using both observational and genetic approaches. Participants with gout also had higher incidence of all-cause dementia, Parkinson's disease, and probable essential tremor. Risks were strongly time dependent, whereby associations with incident dementia were highest in the first 3 years after gout diagnosis. These findings suggest gout is causally related to several measures of brain structure. Lower brain reserve amongst gout patients may explain their higher vulnerability to multiple neurodegenerative diseases. Motor and cognitive impairments may affect gout patients, particularly in early years after diagnosis.
NATURE COMMUNICATIONS
(2023)
Article
Immunology
Wenji Liu, Jie Peng, Yixin Wu, Zuxiang Ye, Zhen Zong, Rui Wu, Hui Li
Summary: Gout is an autoimmune disease characterized by inflammation and damage to bone joints caused by the deposition of monosodium urate crystals. Research has uncovered the involvement of immune cells, inflammatory cytokines, and inflammasomes in gouty inflammation, providing insights into targeted therapy and further understanding the pathogenesis of gout.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Rheumatology
Till Uhlig, Tron Eskild, Lars F. Karoliussen, Joe Sexton, Tore K. Kvien, Espen A. Haavardsholm, Nicola Dalbeth, Hilde Berner Hammer
Summary: This study found that dual-energy CT measurements showed a decrease in urate depositions in ankles and feet in patients with gout during the first and second year of treat-to-target ULT strategy. This indicates the effectiveness of ULT in reducing urate deposition.
Article
Rheumatology
Xiaoli Li, Qin Shao, Jingfang Shen, Shaohui Ren, Lianju Li, Hua Lu, Shubo Chen
Summary: This observational study found that low-dose febuxostat and colchicine prophylaxis were equally effective in preventing gout flares, while high-dose febuxostat alone increased the risk of gout flares.
Article
Multidisciplinary Sciences
Amandine Chabernaud Negrier, Lokmane Taihi, Eric Vicaut, Pascal Richette, Thomas Bardin, Frederic Liote, Hang-Korng Ea, Valerie Bousson
Summary: DECT imaging reveals that foot erosions in patients with gout are not asymmetrically distributed and predominantly affect the first ray and midfoot. The erosion scores are significantly correlated with DECT urate volume, and there is an almost perfect correlation between the RAMRIS and Dalbeth-simplified scores.
Article
Medicine, General & Internal
Xiaomei Xue, Xuan Yuan, Lin Han, Xinde Li, Tony R. Merriman, Lingling Cui, Zhen Liu, Wenyan Sun, Can Wang, Fei Yan, Yuwei He, Aichang Ji, Jie Lu, Changgui Li
Summary: The study results demonstrate that a clinical hyperuricemia typing treatment strategy can help increase the proportion of gout patients achieving target serum urate levels.
FRONTIERS IN MEDICINE
(2022)
Letter
Rheumatology
Tuhina Neogi, Christine Peloquin, Priyanka Ballal, Cindy Germaine Boer
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Letter
Rheumatology
Priyanka Ballal, Christine Peloquin, Cindy Germaine Boer, Tuhina Neogi
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Article
Rheumatology
Joshua F. Baker, David R. Weber, Tuhina Neogi, Michael D. George, Jin Long, Lindsay N. Helget, Bryant R. England, Ted R. Mikuls
Summary: This study evaluated the relationship between low serum urate levels and sarcopenia, and found that low serum urate levels were associated with sarcopenia and weight loss. However, the association between low serum urate levels and mortality was attenuated and not significant after adjusting for differences in body composition and weight loss.
ARTHRITIS & RHEUMATOLOGY
(2023)
Article
Rheumatology
Kaitlin A. A. Quinn, Mark A. A. Ahlman, Hugh D. D. Alessi, Michael P. P. LaValley, Tuhina Neogi, Jamie Marko, Elaine Novakovich, Peter C. C. Grayson
Summary: The study aimed to investigate the association between vascular activity seen on FDG-PET scan and angiographic change in large vessel vasculitis. The results showed that FDG-PET activity was associated with angiographic change in LVV patients.
ARTHRITIS & RHEUMATOLOGY
(2023)
Article
Spectroscopy
Tom Niessink, Charline Kuipers, Brighton Z. de Jong, Aufried T. M. Lenferink, Matthijs Janssen, Tim L. Jansen, Cees Otto
Summary: The identification of synovial crystals is crucial for diagnosing rheumatic diseases. Currently, compensated polarized light microscopy (CPLM) is the commonly used method, but it has limitations. This study explores the potential use of Raman spectroscopy as an objective and accurate alternative. Through testing on synovial fluid samples from 28 patients with swollen joints, various crystals were identified, including traditional ones like monosodium urate and calcium pyrophosphate, as well as some previously undiscovered ones.
JOURNAL OF RAMAN SPECTROSCOPY
(2023)
Article
Rheumatology
Aleksandra M. Kostic, Valia P. Leifer, Faith Selzer, David J. Hunter, A. David Paltiel, Antonia F. Chen, Malcolm K. Robinson, Tuhina Neogi, Jamie E. Collins, Stephen P. Messier, Robert R. Edwards, Jeffrey N. Katz, Elena Losina
Summary: This study aimed to evaluate the cost-effectiveness of Roux-en-Y gastric bypass (RYGB), laparoscopic sleeve gastrectomy (LSG), and lifestyle nonsurgical weight loss (LNSWL) interventions in knee osteoarthritis patients with class III obesity considering total knee replacement (TKR). The results showed that LSG and RYGB were cost-effective interventions, while immediate TKR without weight loss was not economically efficient.
ARTHRITIS CARE & RESEARCH
(2023)
Article
Rheumatology
Patrick Corrigan, David T. Felson, Cara L. Lewis, Tuhina Neogi, Michael P. LaValley, K. Doug Gross, Michael C. Nevitt, Cora E. Lewis, James C. Torner, Joshua J. Stefanik
Summary: The study aimed to investigate the relationship between unilateral knee pain severity and temporal asymmetry during walking, as well as the associations of temporal asymmetry with changes in ipsilateral and contralateral knee pain over 2 years in individuals with mild-to-moderate unilateral knee pain. The study included participants with unilateral knee pain from the Multicenter Osteoarthritis Study, and gait and pain assessments were conducted at baseline and 2 years. The results showed that unilateral knee pain severity was not associated with temporal asymmetry during walking. However, certain measures of temporal asymmetry during self-selected and fast walking were related to longitudinal knee pain outcomes.
ARTHRITIS CARE & RESEARCH
(2023)
Editorial Material
Rheumatology
Tom Niessink, Cees Otto, Matthijs Janssen, Tim L. Jansen
CLINICAL RHEUMATOLOGY
(2023)
Article
Rheumatology
Alexander M. Gorzewski, Andrew C. Heisler, Tuhina Neogi, Lutfiyya N. Muhammad, Jing Song, Dorothy Dunlop, Clifton O. Bingham, Marcy B. Bolster, Daniel J. Clauw, Wendy Marder, Yvonne C. Lee
Summary: This study aimed to determine if the degree of baseline fibromyalgia symptoms in patients with rheumatoid arthritis (RA) predicts RA disease activity after initiation or change of a disease-modifying antirheumatic drug (DMARD). The results showed that the baseline FSQ score was independently associated with elevated DAS28-CRP scores 12 weeks after DMARD initiation. The primary factor that informed the FSQ's prediction of disease activity was the spatial extent of pain, as measured by the WPI.
JOURNAL OF RHEUMATOLOGY
(2023)
Article
Rheumatology
Alyssa Wohlfahrt, Lutfiyya N. Muhammad, Jing Song, Dorothy D. Dunlop, Tuhina Neogi, Clifton O. Bingham III, Marcy B. Bolster, Wendy Marder, Daniel J. Clauw, Yvonne C. Lee
Summary: This study used regression tree methodology to determine the mechanisms most predictive of disease activity after DMARD treatment. The results showed that lower knee pressure pain thresholds were the strongest predictor of higher posttreatment disease activity in patients with low/moderate disease activity. In patients with high baseline disease activity, less efficient descending pain modulation was the strongest predictor of higher posttreatment disease activity.
JOURNAL OF RHEUMATOLOGY
(2023)
Article
Rheumatology
Michael J. J. Rose, Tuhina Neogi, Brian Friscia, Kaveh A. A. Torabian, Michael P. P. LaValley, Mary Gheller, Lukas Adamowicz, Pirinka Georgiev, Lars Viktrup, Charmaine Demanuele, Paul W. W. Wacnik, Deepak Kumar
Summary: This study assessed the reliability of wearable sensors for at-home assessment of walking and chair stand activities in people with knee osteoarthritis. The results showed that the test-retest reliability during the at-home visit was good to excellent, and there was moderate to good agreement between at-home and laboratory visits. Systematic differences were noted, but participants reported a favorable experience during the at-home visit. Remote estimation of spatiotemporal gait measures and chair stand duration using wearable sensors is reliable, feasible, and acceptable in people with knee osteoarthritis.
ARTHRITIS CARE & RESEARCH
(2023)
Letter
Rheumatology
Yoon Y. Qiu, Tuhina Neogi, Lutfiyya N. Muhammad, Jing Song, Marcy B. Bolster, Wendy Marder, Andrew C. Heisler, Alyssa Wohlfahrt, Dorothy Dunlop, Yvonne C. Lee
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Article
Rheumatology
Abhishek Abhishek, Sara K. Tedeschi, Tristan Pascart, Augustin Latourte, Nicola Dalbeth, Tuhina Neogi, Amy Fuller, Ann Rosenthal, Fabio Becce, Thomas Bardin, Hang-Korng Ea, Georgios Filippou, John Fitzgerald, AnnaMaria Iagnocco, Frederic Liote, Geraldine M. McCarthy, Roberta Ramonda, Pascal Richette, Francisca Sivera, Mariano Andres, Edoardo Cipolletta, Michael Doherty, Eliseo Pascual, Fernando Perez-Ruiz, Alexander So, Tim L. Jansen, Minna J. Kohler, Lisa K. Stamp, Janeth Yinh, Antonella Adinolfi, Uri Arad, Thanda Aung, Eva Benillouche, Alessandra Bortoluzzi, Jonathan Dau, Ernest Maningding, Meika A. Fang, Fabiana A. Figus, Emilio Filippucci, Janine Haslett, Matthijs Janssen, Marian Kaldas, Maryann Kimoto, Kelly Leamy, Geraldine M. Navarro, Piercarlo Sarzi-Puttini, Carlo Scire, Ettore Silvagni, Silvia Sirotti, John R. Stack, Linh Truong, Chen Xie, Chio Yokose, Alison M. Hendry, Robert Terkeltaub, William J. Taylor, Hyon K. Choi
Summary: The ACR and EULAR have developed the first-ever validated classification criteria for symptomatic CPPD disease, which include the presence of calcium pyrophosphate crystals in synovial fluid and certain symptoms and laboratory findings. These criteria are of great importance for advancing research in CPPD disease.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Article
Rheumatology
Kelly Vogel, Lutfiyya N. Muhammad, Jing Song, Tuhina Neogi, Clifton O. Bingham, Marcy B. Bolster, Wendy Marder, Alyssa Wohlfahrt, Daniel J. Clauw, Dorothy Dunlop, Yvonne C. C. Lee
Summary: The objective of this study was to identify sex differences in pain intensity, pain interference, and quantitative sensory tests (QST) in patients with RA. Results showed that women reported higher pain intensity and lower pain sensitivity compared to men, but no significant differences were observed in pain interference, temporal summation, and conditioned pain modulation.
ARTHRITIS CARE & RESEARCH
(2023)
Article
Rheumatology
Abhishek Abhishek, Sara K. K. Tedeschi, Tristan Pascart, Augustin Latourte, Nicola Dalbeth, Tuhina Neogi, Amy Fuller, Ann Rosenthal, Fabio Becce, Thomas Bardin, Hang Korng Ea, Georgios Filippou, John FitzGerald, AnnaMaria Iagnocco, Frederic Liote, Geraldine M. M. McCarthy, Roberta Ramonda, Pascal Richette, Francisca Sivera, Mariano Andres, Edoardo Cipolletta, Michael Doherty, Eliseo Pascual, Fernando Perez-Ruiz, Alexander So, Tim L. L. Jansen, Minna J. J. Kohler, Lisa K. K. Stamp, Janeth Yinh, Antonella Adinolfi, Uri Arad, Thanda Aung, Eva Benillouche, Alessandra Bortoluzzi, Jonathan Dau, Ernest Maningding, Meika A. A. Fang, Fabiana A. A. Figus, Emilio Filippucci, Janine Haslett, Matthijs Janssen, Marian Kaldas, Maryann Kimoto, Kelly Leamy, Geraldine M. Navarro, Piercarlo Sarzi-Puttini, Carlo Scire, Ettore Silvagni, Silvia Sirotti, John R. R. Stack, Linh Truong, Chen Xie, Chio Yokose, Alison M. M. Hendry, Robert Terkeltaub, William J. J. Taylor, Hyon K. K. Choi
Summary: The 2023 ACR/EULAR CPPD disease classification criteria have been developed to facilitate research in the field of symptomatic CPPD disease, providing excellent performance characteristics with high sensitivity and specificity.
ARTHRITIS & RHEUMATOLOGY
(2023)
