Article
Cell & Tissue Engineering
Mayu Matsumura-Kawashima, Kenichi Ogata, Masafumi Moriyama, Yuka Murakami, Tatsuya Kawado, Seiji Nakamura
Summary: DPSC-CM contained more secreted factors with tissue-regenerating mechanisms, such as cell proliferation, anti-inflammatory effects, and immunomodulatory effects. DPSC-CM was more effective in suppressing the activated T cells than other groups. The stimulated salivary flow rate increased in SS mice with DPSC-CM compared with that in the other groups.
STEM CELL RESEARCH & THERAPY
(2021)
Review
Cell Biology
Varvara G. Blinova, Vladimir I. Vasilyev, Ekaterina B. Rodionova, Dmitry D. Zhdanov
Summary: Regulatory T cells (Tregs) play a key role in maintaining immune balance and regulating autoimmune diseases. In primary Sjogren's syndrome (pSS), Tregs are involved in the pathogenesis and development of ectopic lymphoid structures. The review emphasizes the need for further research on Tregs and highlights their potential use in cell-based therapy for pSS.
Review
Immunology
Qi An, Jingwen Zhao, Xueqing Zhu, Baoqi Yang, Zewen Wu, Yazhen Su, Liyun Zhang, Ke Xu, Dan Ma
Summary: This article explores the pathogenesis of Sjogrens syndrome caused by autoantibodies attacking salivary and lacrimal gland tissues, focusing on the role of T cells and therapeutic targeting of T cells for treatment of patients with SS.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Allergy
Yuan Yao, Jin-Fen Ma, Christopher Chang, Ting Xu, Cai-Yue Gao, M. Eric Gershwin, Zhe-Xiong Lian
Summary: Sjogren's syndrome is a systemic autoimmune disease characterized by dry mouth, eye dryness, and other systemic disorders. The pathogenesis involves lymphocytic infiltration, ectopic lymphoid tissue formation, and hyperactive B cells producing autoantibodies. The complexity is demonstrated by the involvement of multiple T cell subsets.
CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY
(2021)
Article
Rheumatology
Johannes Fessler, Patrizia Fasching, Andrea Raicht, Sabrina Hammerl, Jennifer Weber, Angelika Lackner, Josef Hermann, Christian Dejaco, Winfried B. Graninger, Wolfgang Schwinger, Martin H. Stradner
Summary: In primary Sjogren's syndrome (pSS), peripheral lymphopenia is associated with decreased proliferation and signs of immune cell aging in naive CD4(+) T cells. Shortened telomeres, reduced telomerase activity, and low levels of T-cell receptor excision circles (TRECs) suggest a history of extensive post-thymic cell division. This senescent phenotype in naive CD4(+) T cells may contribute to the inability to sustain cell numbers and ultimately leads to lymphopenia in pSS.
Article
Immunology
Anneline C. Hinrichs, Sofie L. M. Blokland, Aike A. Kruize, Floris P. J. Lafeber, Helen L. Leavis, Joel A. G. van Roon
Summary: The expression of CCL5 by CCR9+ CD8 T cells in primary Sjogren's syndrome (pSS) patients was studied in this research. The results showed an increased frequency of circulating CCR9+ CD8 T cells in pSS patients compared to healthy controls (HC). Antigen-experienced CD8 T cells, especially CCR9+ effector CD8 T cells, expressed the highest levels of CCL5 and released the highest levels of CCL5 upon activation. Furthermore, CCR9+ CD8 T cells rapidly released CCL5 and significantly more than CCR9+ CD4 T cells. These findings suggest that CCL5 release by CCR9+ CD8 T cells contributes to immunopathology in pSS.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Multidisciplinary Sciences
Jinkun Liu, Hongyan Gao, Chengyin Li, Fenglin Zhu, Miao Wang, Yanqiu Xu, Bin Wu
Summary: In this study, single-cell RNA sequencing was performed on PBMCs from pSS patients and healthy controls, revealing that CD14(+) monocytes in pSS patients express higher levels of the transcription factor CEBPD, which participates in regulating TNF-alpha signaling via NF-kappa B. Upregulation of FOLR3 and IL1B was observed in CD14(+) monocyte subsets from different pSS patients. Furthermore, a classification system based on FCER1G expression for CD56(-)CD16(+) NK cells was proposed, with pSS patients showing a higher ratio of CD56(-)CD16+FCER1G+ NK cells to CD56(-)CD16+FCER1G- NK cells.
Article
Cell & Tissue Engineering
Boya Li, Yixiao Xing, Yehua Gan, Jing He, Hong Hua
Summary: The study showed that LGMSCs or LGMSC-Exos have potential therapeutic effects against Sjogren's syndrome (SS), reducing inflammatory infiltration in salivary glands and restoring secretory function. They were also found to inhibit Th17 cell differentiation, promote Treg cell induction, decrease levels of IL-17, interferon gamma, and IL-6, and increase secretion of transforming growth factor beta and IL-10. These findings suggest that LGMSCs are promising for MSCs-based therapy and LGMSC-Exos could be used for a new cell-free therapy for SS.
STEM CELL RESEARCH & THERAPY
(2021)
Article
Biochemistry & Molecular Biology
Anneline C. Hinrichs, Aike A. Kruize, Floris P. J. G. Lafeber, Helen L. Leavis, Joel A. G. van Roon
Summary: Primary Sjogren's syndrome (pSS) is characterized by B cell hyperactivity. This study found limited overlap between CXCR5- Tph cells and CCR9+ Tfh-like cells in pSS patients and healthy controls. The highest expression of PD-1/ICOS was found in CXCR5/CCR9 co-expressing T cells, which are enriched in pSS patients and may contribute to ongoing immune responses.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Immunology
Mohammad Afzal Khan, Christine L. Lau, Alexander Sasha Krupnick
Summary: By studying the levels of Tregs/FOXP3 gene expression, it can serve as a crucial prognostic biomarker for the progression of chronic lung allograft dysfunction (CLAD) in lung transplant recipients, and provide potential therapeutic options to improve lung transplant survival rates.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Yanxiong Shao, Jiayao Fu, Tianle Zhan, Junhao Yin, Jiabao Xu, Yifan Lu, Qi Luo, Chuangqi Yu
Summary: This study found that fangchinoline inhibits the proliferation and infiltration of CD4+ T cells in the salivary gland tissues of NOD/ShiLtj mice with SS by upregulating miR-506-3p to inhibit NFATc1 expression. The results suggest that NFATc1 might be a potential therapeutic target for SS.
INFLAMMOPHARMACOLOGY
(2023)
Review
Immunology
Paola de Candia, Claudio Procaccini, Claudia Russo, Maria Teresa Lepore, Giuseppe Matarese
Summary: Regulatory T cells, as key metabolic sensors, play a crucial role in controlling immune state and have promising therapeutic potential for autoimmune and metabolic disorders.
Article
Multidisciplinary Sciences
Zohreh Amoozgar, Jonas Kloepper, Jun Ren, Rong En Tay, Samuel W. Kazer, Evgeny Kiner, Shanmugarajan Krishnan, Jessica M. Posada, Mitrajit Ghosh, Emilie Mamessier, Christina Wong, Gino B. Ferraro, Ana Batista, Nancy Wang, Mark Badeaux, Sylvie Roberge, Lei Xu, Peigen Huang, Alex K. Shalek, Dai Fukumura, Hye-Jung Kim, Rakesh K. Jain
Summary: In this study, researchers found that treatment with an agonistic anti-GITR antibody converts tumor infiltrating regulatory T cells to effector cells, overcoming resistance to PD1 blockade in preclinical models of GBM.
NATURE COMMUNICATIONS
(2021)
Article
Immunology
Huanhuan Yan, Baochen Li, Rui Su, Chong Gao, Xiaofeng Li, Caihong Wang
Summary: This study compared immune cell abnormalities in antiphospholipid syndrome (APS) patients and healthy controls, and analyzed the correlation between antiphospholipid antibody titres and T cell subsets, as well as the correlation between cytokine profiles and clinical characteristics. The results showed that APS patients have immune disturbances, characterized by an increase in the Th17/Treg ratio and a decrease in Treg cell numbers. Additionally, primary APS patients had higher levels of peripheral blood lymphocytes compared to secondary APS patients.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Cell Biology
Weiqian Chen, Fan Yang, Guanhua Xu, Jilin Ma, Jin Lin
Summary: Primary Sjogren's syndrome (pSS) is a chronic autoimmune disease characterized by lymphocytic infiltration into exocrine glands, leading to symptoms like dry eyes and mouth. Studies have shown an abundance of Tfh cells in pSS patients, while Tfr cells play a role in controlling the function of Tfh cells.
JOURNAL OF LEUKOCYTE BIOLOGY
(2021)
Letter
Rheumatology
Carlo Perricone, Elena Bartoloni, Giacomo Cafaro, Roberto Caporali, Roberto Gerli
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Article
Allergy
Christoph Bergmann, Aurelie Poli, Ioana Agache, Rodolfo Bianchini, Heather J. Bax, Mariana Castells, Silvia Crescioli, David Dombrowicz, Denisa Ferastraoaru, Edda Fiebiger, Hannah J. Gould, Karin Hartmann, Elena Izquierdo, Galateja Jordakieva, Debra H. Josephs, Marek Jutel, Francesca Levi-Schaffer, Leticia de las Vecillas, Michael T. Lotze, Gabriel Osborn, Mariona Pascal, Frank Redegeld, David Rosenstreich, Franziska Roth-Walter, Carsten Schmidt-Weber, Mohamed Shamji, Esther H. Steveling, Michelle C. Turner, Eva Untersmayr, Erika Jensen-Jarolim, Sophia N. Karagiannis
Summary: This paper discusses the interactions between the immune system and several 'danger' signals, such as DAMPs, PAMPs, and AAMPs, and their roles in allergy and cancer. It focuses on their interactions with different immune cells and their contrasting clinical outcomes in allergy and cancer.
Article
Allergy
Sheriene Moussa Afify, Andreas Regner, Luis F. Pacios, Bart R. Blokhuis, Sebastian A. Jensen, Frank A. Redegeld, Isabella Pali-Schoell, Karin Hufnagl, Rodolfo Bianchini, Sonja Guethoff, Matthias F. Kramer, Alessandro Fiocchi, Zdenek Dvorak, Erika Jensen-Jarolim, Franziska Roth-Walter
Summary: The lozenge formulated with catechin-iron complexes effectively masked IgE binding in milk-allergic children and reduced immune reactivity in mice and allergic subjects. By targeting antigen presenting cells, the lozenge dampened immune activation in a non-specific manner, providing immune resilience against allergic symptoms.
CLINICAL AND EXPERIMENTAL ALLERGY
(2022)
Article
Biochemistry & Molecular Biology
Luigi Cari, Lucrezia Rosati, Giuseppe Leoncini, Eleonora Lusenti, Marco Gentili, Giuseppe Nocentini, Carlo Riccardi, Graziella Migliorati, Simona Ronchetti
Summary: Ulcerative colitis (UC) and Crohn's Disease (CD) are chronic relapsing inflammatory diseases caused by genetic, environmental, and immune factors. The glucocorticoid-induced leucine zipper (GILZ) plays a role in inflammatory bowel disease (IBD) and is associated with genes MUC2, TLR2, and TLR4 in the mucosal barrier. Direct correlations between GILZ/TLR2 and GILZ/TLR4 were found in healthy subjects (HSs) and UC patients, while an inverse correlation was observed between GILZ and MUC2 in HS and IBD patients, particularly those with active disease.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Mahdieh Naghavi Alhosseini, Marianna Palazzo, Luigi Cari, Simona Ronchetti, Graziella Migliorati, Giuseppe Nocentini
Summary: B-acute lymphoblastic leukemia (B-ALL) is a common pediatric cancer. Treg and exhausted CD8(+) T cells play important roles in its development and maintenance. In this study, the expression of 20 Treg/CD8 exhaustion markers was evaluated and their correlation with other factors was analyzed. The results suggest that T cells expressing CD39, CTLA-4, TNFR2, TIGIT, and TIM-3 may promote B-ALL progression and targeted immunotherapy against these markers could be a promising approach for treating B-ALL.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, General & Internal
Fabio Cacciapaglia, Francesca Romana Spinelli, Elena Bartoloni, Serena Bugatti, Gian Luca Erre, Marco Fornaro, Andreina Manfredi, Matteo Piga, Garifallia Sakellariou, Ombretta Viapiana, Fabiola Atzeni, Elisa Gremese
Summary: Rheumatoid arthritis (RA) and diabetes mellitus (DM) are both influenced by inflammation and have a connection in their development and progression. This study compared the characteristics of RA patients with and without DM, and found that DM patients were older and more commonly male, with higher BMI and weight. They were also less likely to use glucocorticoids and had higher HAQ scores. The study also highlighted the association between DM and RA, suggesting systemic inflammation as an underlying condition for both diseases.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Health Care Sciences & Services
Margherita Zen, Mariele Gatto, Roberto Depascale, Francesca Regola, Micaela Fredi, Laura Andreoli, Franco Franceschini, Maria Letizia Urban, Giacomo Emmi, Fulvia Ceccarelli, Fabrizio Conti, Alessandra Bortoluzzi, Marcello Govoni, Chiara Tani, Marta Mosca, Tania Ubiali, Maria Gerosa, Enrica P. Bozzolo, Valentina Canti, Paolo Cardinaletti, Armando Gabrielli, Giacomo Tanti, Elisa Gremese, Ginevra De Marchi, Salvatore De Vita, Serena Fasano, Francesco Ciccia, Giulia Pazzola, Carlo Salvarani, Simone Negrini, Andrea Di Matteo, Rossella De Angelis, Giovanni Orsolini, Maurizio Rossini, Paola Faggioli, Antonella Laria, Matteo Piga, Alberto Cauli, Salvatore Scarpato, Francesca Wanda Rossi, Amato De Paulis, Enrico Brunetta, Angela Ceribelli, Carlo Selmi, Marcella Prete, Vito Racanelli, Angelo Vacca, Elena Bartoloni, Roberto Gerli, Elisabetta Zanatta, Maddalena Larosa, Francesca Saccon, Andrea Doria, Luca Iaccarino
Summary: This study assessed the efficacy of belimumab in treating joint and skin manifestations in a nationwide cohort of SLE patients. The results showed that belimumab significantly improved joint and skin symptoms and reduced the use of glucocorticoids. A significant proportion of patients who did not achieve complete remission initially achieved remission during follow-up.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Toxicology
Ambra Maddalon, Luigi Cari, Martina Iulini, Mahdieh Naghavi Alhosseini, Valentina Galbiati, Marina Marinovich, Giuseppe Nocentini, Emanuela Corsini
Summary: This study investigated the potential effects of endocrine disruptors (EDs) on immune cells, with a focus on gender differences. The results showed that exposure to different EDs resulted in alterations in RACK1 expression, pro-inflammatory activity, natural killer lytic ability, and lymphocyte differentiation, with gender-specific effects and magnitudes.
ARCHIVES OF TOXICOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Aila Fakhimahmadi, Ilir Hasanaj, Gerlinde Hofstetter, Clara Pogner, Markus Gorfer, Markus Wiederstein, Nathalie Szepannek, Rodolfo Bianchini, Zdenek Dvorak, Sebastian A. Jensen, Markus Berger, Erika Jensen-Jarolim, Karin Hufnagl, Franziska Roth-Walter
Summary: The major allergen Alt a 1 from Alternaria alternata is highly associated with severe allergic asthma. Alt a 1 can bind to micronutrients such as iron-quercetin complexes (FeQ2) and affect antigen presentation. It functions as an innate defense protein, binding strongly to FeQ2, and shows different enzymatic activity depending on its ligand-filled state. The uptake of Alt a 1 by cells alters cellular iron levels and can activate the Arylhydrocarbon receptor (AhR).
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Rheumatology
Giacomo Cafaro, Elena Bartoloni, Chiara Baldini, Franco Franceschini, Valeria Riccieri, Antonella Fioravanti, Marco Fornaro, Anna Ghirardello, Boaz Palterer, Maria Infantino, Amelia Rigon, Stefania Del Rosso, Roberto Gerli, Danilo Villalta, Nicola Bizzaro
Summary: This study evaluated the ability of a multiparametric assay to accurately classify patients with various connective tissue diseases (CTDs) and healthy controls (HC), regardless of clinical features. The study also found that the serological status can identify clusters of CTD patients with similar clinical features, independent of their final diagnosis.
Article
Rheumatology
A. Colangelo, F. Tromby, G. Cafaro, R. Gerli, E. Bartoloni, C. Perricone
Summary: Adenosine deaminase 2 deficiency is a rare monogenic vasculopathy with diverse clinical manifestations and challenging treatment.
Letter
Rheumatology
Mrinalini Dey, R. Naveen, Elena Nikiphorou, Parikshit Sen, Sreoshy Saha, James B. Lilleker, Vishwesh Agarwal, Sinan Kardes, Jessica Day, Marcin Milchert, Mrudula Joshi, Tamer Gheita, Babur Salim, Tsvetelina Velikova, Abraham Edgar Gracia-Ramos, Ioannis Parodis, Albert Selva O'Callaghan, Minchul Kim, Tulika Chatterjee, Ai Lyn Tan, Ashima Makol, Arvind Nune, Lorenzo Cavagna, Miguel A. Saavedra, Samuel Katsuyuki Shinjo, Nelly Ziade, Johannes Knitza, Masataka Kuwana, Oliver Distler, Bhupen Barman, Yogesh Preet Singh, Rajiv Ranjan, Avinash Jain, Sapan C. Pandya, Rakesh Kumar Pilania, Aman Sharma, Manesh M. Manoj, Vikas Gupta, Chengappa G. Kavadichanda, Pradeepta Sekhar Patro, Sajal Ajmani, Sanat Phatak, Rudra Prosad Goswami, Abhra Chandra Chowdhury, Ashish Jacob Mathew, Padnamabha Shenoy, Ajay Asranna, Keerthi Talari Bommakanti, Anuj Shukla, Arunkumar R. Pande, Kunal Chandwar, John D. Pauling, Chris Wincup, Dondu Uskudar Cansu, Erick Adrian Zamora Tehozol, Jorge Rojas Serrano, Ignacio Garcia-De La Torre, Nicoletta Del Papa, Gianluca Sambataro, Atzeni Fabiola, Marcello Govoni, Simone Parisi, Elena Bartoloni Bocci, Gian Domenico Sebastiani, Enrico Fusaro, Marco Sebastiani, Luca Quartuccio, Franco Franceschini, Pier Paolo Sainaghi, Giovanni Orsolini, Rossella De Angelis, Maria Giovanna Danielli, Vincenzo Venerito, Lisa S. Traboco, Leonardo Santos Hoff, Suryo Anggoro Kusumo Wibowo, Stylianos Tomaras, Daman Langguth, Vidya Limaye, Merrilee Needham, Nilesh Srivastav, Akira Yoshida, Ran Nakashima, Shinji Sato, Naoki Kimura, Yuko Kaneko, Jesus Loarce-Martos, Sergio Prieto-Gonzalez, Albert Gil-Vila, Raquel Aranega Gonzalez, Hector Chinoy, Vikas Agarwal, Rohit Aggarwal, Latika Gupta
Review
Rheumatology
Lorenza Bruno, Martina Mandarano, Guido Bellezza, Angelo Sidoni, Roberto Gerli, Elena Bartoloni, Carlo Perricone
Summary: Polyangiitis overlap syndrome is a rare clinical entity characterized by overlapping features of multiple vasculitis, typically eosinophilic granulomatosis with polyangiitis (EGPA) and granulomatosis with polyangiitis (GPA). We present a case of a 66-year-old woman with nasal obstruction, external nose deformity, sensorineural hearing loss, eosinophilia, high titer anti-PR3 antibodies and lung involvement, who was successfully treated with cyclophosphamide. Recognition of this entity is crucial due to its distinct clinical phenotype and response to therapy in the complex scenario of ANCA-associated vasculitides.
RHEUMATOLOGY INTERNATIONAL
(2023)
Article
Endocrinology & Metabolism
Shripa Amatya, Dylan Tietje-Mckinney, Schaefer Mueller, Maria G. Petrillo, Matthew D. Woolard, Sushma Bharrhan, Anthony Wayne Orr, Christopher G. Kevil, John A. Cidlowski, Diana Cruz-Topete
Summary: Adipocyte-specific glucocorticoid receptor signaling plays a crucial role in regulating immune homeostasis in adipose tissue.