T cells in systemic sclerosis: a reappraisal

Blockade of Interleukin-6 Receptor Alleviates Disease in Mouse Model of Scleroderma

(2011) Shun Kitaba et al.   AMERICAN JOURNAL OF PATHOLOGY

Fibrosis is regulated by Th2 and Th17 responses and by dynamic interactions between fibroblasts and macrophages

(2011) Luke Barron et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

GATA-3 up-regulation in CD8+ T cells as a biomarker of immune dysfunction in systemic sclerosis, resulting in excessive interleukin-13 production

(2011) Thomas A. Medsger et al.   ARTHRITIS AND RHEUMATISM

Immunization with DNA topoisomerase I and Freund's complete adjuvant induces skin and lung fibrosis and autoimmunity via interleukin-6 signaling

(2011) Ayumi Yoshizaki et al.   ARTHRITIS AND RHEUMATISM

TH1, TH2, and TH17 cells instruct monocytes to differentiate into specialized dendritic cell subsets

(2011) M. N. Alonso et al.   BLOOD

Treatment with imatinib results in reduced IL-4-producing T cells, but increased CD4+ T cells in the broncho-alveolar lavage of patients with systemic sclerosis

(2011) Anagha A. Divekar et al.   CLINICAL IMMUNOLOGY

Lebrikizumab Treatment in Adults with Asthma

(2011) Jonathan Corren et al.   NEW ENGLAND JOURNAL OF MEDICINE

Significantly increased CCL5/RANTES and CCR7 mRNA levels in localized scleroderma

(2011) Thilo Gambichler et al.   REGULATORY PEPTIDES

Altered T-cell and regulatory cell repertoire in patients with diffuse cutaneous systemic sclerosis

(2011) G Papp et al.   SCANDINAVIAN JOURNAL OF RHEUMATOLOGY

Endothelial activation and apoptosis mediated by neutrophil-dependent interleukin 6 trans-signalling: a novel target for systemic sclerosis?

(2010) T. C. Barnes et al.   ANNALS OF THE RHEUMATIC DISEASES

Reduction of regulatory T cells in skin lesions but not in peripheral blood of patients with systemic scleroderma

(2010) S. Klein et al.   ANNALS OF THE RHEUMATIC DISEASES

The monoclonal anti-CD25 antibody basiliximab for the treatment of progressive systemic sclerosis: an open-label study

(2010) M. O. Becker et al.   ANNALS OF THE RHEUMATIC DISEASES

Association of the CD226 Ser307 variant with systemic sclerosis: Evidence of a contribution of costimulation pathways in systemic sclerosis pathogenesis

(2010) P. Dieudé et al.   ARTHRITIS AND RHEUMATISM

Nonresolving Inflammation

(2010) Carl Nathan et al.   CELL

Regulatory T cells (CD4+CD25brightFoxP3+) expansion in systemic sclerosis correlates with disease activity and severity

(2010) Gleb Slobodin et al.   CELLULAR IMMUNOLOGY

Critical role of DNAX accessory molecule-1 (DNAM-1) in the development of acute graft-versus-host disease in mice

(2010) T. Nabekura et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Characterization of monocyte/macrophage subsets in the skin and peripheral blood derived from patients with systemic sclerosis

(2010) Nobuyo Higashi-Kuwata et al.   ARTHRITIS RESEARCH & THERAPY

Effector CD8+ T cells in systemic sclerosis patients produce abnormally high levels of interleukin-13 associated with increased skin fibrosis

(2009) Patrizia Fuschiotti et al.   ARTHRITIS AND RHEUMATISM

IL-17-producing human peripheral regulatory T cells retain suppressive function

(2009) G. Beriou et al.   BLOOD

Alternatively activated macrophages (M2 macrophages) in the skin of patient with localized scleroderma

(2009) Nobuyo Higashi-Kuwata et al.   EXPERIMENTAL DERMATOLOGY

IL-33 Induces IL-13-Dependent Cutaneous Fibrosis

(2009) A. L. Rankin et al.   JOURNAL OF IMMUNOLOGY

Increased Frequency and Compromised Function of T Regulatory Cells in Systemic Sclerosis (SSc) Is Related to a Diminished CD69 and TGFβ Expression

(2009) Timothy R. D. J. Radstake et al.   PLoS One

Th17 and regulatory T cells: rebalancing pro- and anti-inflammatory forces in autoimmune arthritis

(2009) K. Nistala et al.   RHEUMATOLOGY

Stem cell transplantation: a treatment option for severe systemic sclerosis?

(2008) J M van Laar et al.   ANNALS OF THE RHEUMATIC DISEASES

Efficient colonic mucosal wound repair requires Trem2 signaling

(2008) H. Seno et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Role of Interleukin-6 in Bleomycin-Induced Lung Inflammatory Changes in Mice

(2007) Fumitake Saito et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY