Article
Medicine, General & Internal
Vicky Duong, Sarah R. Robbins, Simone Dennis, Venkatesha Venkatesha, Manuela L. Ferreira, David J. Hunter
Summary: Digital technology shows potential for improving outcomes following total knee replacement (TKR). This study found that a digital technology package resulted in small but not clinically meaningful improvements in pain at 3 months after TKR.
Article
Acoustics
Win Min Oo, James M. Linklater, Kim L. Bennell, Matthew S. Daniel, Danielle Pryke, Xia Wang, Shirley P. Yu, Leticia Deveza, Vicky Duong, David J. Hunter
Summary: The study found excellent inter-rater reliability and strong correlations between ultrasound-detected synovitis, meniscal extrusion, and osteophytes and MRI outcomes in knee osteoarthritis. Absolute agreement was strong, particularly for medial tibiofemoral pathologies.
JOURNAL OF ULTRASOUND IN MEDICINE
(2022)
Review
Biochemistry & Molecular Biology
Francisco Javier Martin-Vega, David Lucena-Anton, Alejandro Galan-Mercant, Veronica Perez-Cabezas, Carlos Luque-Moreno, Maria Jesus Vinolo-Gil, Gloria Gonzalez-Medina
Summary: The application of NSAIDs by phonophoresis is effective in relieving symptoms and improving physical function in patients with knee osteoarthritis. Further long-term studies are recommended to validate the treatment effects.
Article
Rheumatology
Holly T. Philpott, Trevor B. Birmingham, Ryan Pinto, Codie A. Primeau, Dominique Arsenault, Brent A. Lanting, Yayuan Zhu, C. Thomas Appleton
Summary: This study found that moderate-to-severe synovitis is strongly associated with constant pain in patients with knee OA. Inflammation may play a specific role in pain experiences, especially in the early stages of knee OA.
JOURNAL OF RHEUMATOLOGY
(2022)
Article
Orthopedics
Noha Abdelhalim Elsawy, Aya Hanafy Ibrahiem, Gihan Abdellatif Younis, Marwa Ahmed Meheissen, Yousra Hisham Abdel-Fattah
Summary: This study evaluated the diagnostic performance of clinical examination and ultrasound assessment in detecting knee effusion in primary KOA patients. The results showed that ultrasound was superior to visual inspection in confirming the presence of effusion, suggesting that ultrasound should be used routinely for diagnosis. Long needles (spinal needles) may have a higher success rate in aspiration compared to shorter needles.
JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH
(2023)
Article
Medicine, General & Internal
Zongjie Liu, Xin Sui, Ran Hui, Ying Zhao, Hua Li, Xiaodan Huang
Summary: This study investigated the changes of the plantar fascia in patients with knee osteoarthritis. Using ultrasonic scanning, the thickness of the plantar fascia was measured and found to be significantly thicker in these patients. The degree of thickening was related to the duration of the disease and body mass index (BMI). Furthermore, the sonographic images of the plantar fascia in patients showed lower echogenicity compared to normal controls.
Article
Biotechnology & Applied Microbiology
Yi Wang, Zehua Chen, Zugui Wu, Junyi Li, Congcong Li, Jiaman Yang, Weijian Chen, Zixuan Ye, Xinxin Shen, Tao Jiang, Wengang Liu, Xuemeng Xu
Summary: The reliability of FPI-6 in foot posture assessment of patients with knee osteoarthritis (KOA) was examined. Thirty KOA patients (23 females, 7 males) were assessed by two raters and at three different moments. Inter-rater and test-retest reliability were found to be substantial, and there was good internal consistency between the items of FPI-6. These findings provide a reliable way for clinicians and researchers to assess foot posture in patients with KOA.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Orthopedics
Frank W. Roemer, Mylene Jansen, Anne C. A. Marijnissen, Ali Guermazi, Rafael Heiss, Susanne Maschek, Agnes Lalande, Francisco J. Blanco, Francis Berenbaum, Lotte A. van de Stadt, Margreet Kloppenburg, Ida K. Haugen, Christoph H. Ladel, Jaume Bacardit, Anna Wisser, Felix Eckstein, Floris P. J. G. Lafeber, Harrie H. Weinans, Wolfgang Wirth
Summary: The IMI-APPROACH cohort used MRI evaluation to study the characteristics of knee osteoarthritis, and found that the baseline prevalence and change of features were more common in knees with radiographic OA.
BMC MUSCULOSKELETAL DISORDERS
(2022)
Article
Rheumatology
Chien-Chih Wang, Chin-Tien Wang, Kun-Ling Tsai, Chen-Liang Chou, Jian-Kang Chao, Hsin-Yi Huang, Chung-Lan Kao
Summary: The study showed that increased suprapatellar effusion detected by ultrasound may predict reduced efficacy of HA injection in treating knee OA.
Review
Acoustics
Yi Liu, Yan Wang, Yang Wang, Xiaolin Jia
Summary: The study compared the efficacy of different types and intensities of ultrasound therapy in pain relief and functional recovery in knee osteoarthritis, finding that both pulsed and continuous ultrasound were effective with high intensity ultrasound having better results, and also improving joint function.
JOURNAL OF ULTRASOUND IN MEDICINE
(2022)
Review
Acoustics
Bo Liu, Hui-Ying Xu, Rui Zhang, Lu Han, Yang Li, Xiao-Feng Sun
Summary: In knee osteoarthritis (KOA), musculoskeletal ultrasonography (MSUS) can effectively detect various abnormalities and monitor responses to different therapies, guiding diagnostic and therapeutic procedures. The application of continuously evolving US tools in the future could enhance the clinical utility of MSUS in KOA.
JOURNAL OF ULTRASOUND IN MEDICINE
(2023)
Article
Rheumatology
Win Min Oo, James M. Linklater, Kim L. Bennell, Danielle Pryke, Shirley Yu, Kai Fu, Xia Wang, Vicky Duong, David J. Hunter
Summary: The OMERACT ultrasound scores were significantly associated with pain severity, KL grade, and MOAKS in knee osteoarthritis.
JOURNAL OF RHEUMATOLOGY
(2021)
Article
Medicine, General & Internal
Hui Jin, Hao Zuo, Rui Xu, Youbo Ji, Zhonghan Wang
Summary: Patients with knee osteoarthritis showed improved pain symptoms and better joint function after receiving treatment with pulsed radiofrequency and platelet-rich plasma injections. This treatment method has significant clinical efficacy and is worthy of further clinical application.
Article
Biophysics
Mustafa Fatih Yasar, Elif Yaksi, Ramazan Kurul, Muhammed Balci
Summary: This study aimed to compare the effectiveness of inpatient and outpatient physical therapy modalities combined with spa treatments for knee osteoarthritis. The results showed significant improvement in pain scores for the outpatient group, but no significant difference in functional status and mobility tests between the two groups. Further multicenter studies with larger sample sizes may provide more conclusive evidence.
INTERNATIONAL JOURNAL OF BIOMETEOROLOGY
(2021)
Article
Rehabilitation
Merve Karapinar, Veysel Atilla Ayyildiz, Meric Unal, Tuzun Firat
Summary: The study showed excellent reliability in assessing EI using ultrasonography in the QF muscle, with high consistency among evaluators. Although there was a slight bias in ROI calculations between FHT and RMT, the tools demonstrated validity in monitoring muscle changes due to KOA.
MUSCULOSKELETAL SCIENCE AND PRACTICE
(2021)
Review
Microbiology
Carlo Perricone, Paola Triggianese, Roberto Bursi, Giacomo Cafaro, Elena Bartoloni, Maria Sole Chimenti, Roberto Gerli, Roberto Perricone
Summary: IVIG, derived from plasma of donors, is used for prevention and treatment of various infections especially in immunocompromised patients, showing anti-viral and anti-inflammatory properties. Its evolution from passive immunity source to immunomodulatory agent has led to extensive applications in autoimmune diseases.
Letter
Rheumatology
Carlo Perricone, Elena Bartoloni, Giacomo Cafaro, Roberto Caporali, Roberto Gerli
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Article
Rheumatology
Andrea Latini, Lucia Novelli, Fulvia Ceccarelli, Cristiana Barbati, Carlo Perricone, Giada De Benedittis, Fabrizio Conti, Giuseppe Novelli, Cinzia Ciccacci, Paola Borgiani
Summary: In SLE patients, higher CD44v6 mRNA expression correlates with a higher level of this isoform, suggesting impaired CD44 splicing mechanism in the disease. The ratio of CD44v3/v6 mRNA is unbalanced, decreasing from healthy controls to SLE patients, and correlating with disease duration. The splicing regulator ESRP1 and CD44 polymorphism rs9666607 are potential factors influencing CD44 expression in SLE patients.
Editorial Material
Rheumatology
Elena Bartoloni, Carlo Perricone, Giacomo Cafaro, Alessia Alunno, Roberto Gerli
Article
Nutrition & Dietetics
Paola Triggianese, Carlo Perricone, Erica De Martino, Arianna D'Antonio, Maria Sole Chimenti, Paola Conigliaro, Sara Ferrigno, Ilio Giambini, Elisabetta Greco, Caterina De Carolis
Summary: The study found a higher proportion of DQ2 alleles in infertile and RSA women compared to controls, and predisposing DQ2 alleles are independent risk factors for AIDs and 25(OH)D deficiency. Patients with AIDs are more likely to have 25(OH)D deficiency.
Review
Rheumatology
Fulvia Ceccarelli, Francesco Natalucci, Giulio Olivieri, Carlo Perricone, Carmelo Pirone, Francesca Romana Spinelli, Cristiano Alessandri, Fabrizio Conti
Summary: Systemic lupus erythematosus (SLE)-related arthritis, traditionally defined as non-erosive, has been challenged by new imaging techniques showing up to 40% of patients with erosive damage. This more aggressive phenotype was considered in the 2012 classification criteria and 2019 treatment recommendations, with a focus on biomarkers associated with erosive damage in SLE patients.
Article
Immunology
Andrea Latini, Giada De Benedittis, Carlo Perricone, Serena Colafrancesco, Paola Conigliaro, Fulvia Ceccarelli, Maria Sole Chimenti, Lucia Novelli, Roberta Priori, Fabrizio Conti, Cinzia Ciccacci, Paola Borgiani
Summary: The study identified significant associations between three VDR gene polymorphisms and autoimmune connective tissue diseases in the Italian population, suggesting that specific genotypes may influence disease susceptibility and clinical phenotypes.
JOURNAL OF IMMUNOLOGY RESEARCH
(2021)
Article
Medicine, General & Internal
Antonio Marchesoni, Pierluigi Macchioni, Stefania Gasparini, Carlo Perricone, Fabio Massimo Perrotta, Rosa Daniela Grembiale, Ettore Silvagni, Roberta Ramonda, Luisa Costa, Alen Zabotti, Giacomo Curradi, Giuliana Gualberti, Francesca Marando, Carlo Salvarani
Summary: This study evaluated the use of ultrasound examination to distinguish pain from enthesitis in patients with psoriatic arthritis (PsA) and fibromyalgia syndrome (FMS). The results showed that PsA patients had a higher percentage of entheseal changes compared to FMS patients. The ultrasound evaluation can be helpful in differentiating the cause of pain in these patients.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Medicine, General & Internal
Fulvia Ceccarelli, Giulio Olivieri, Carmelo Pirone, Cinzia Ciccacci, Licia Picciariello, Francesco Natalucci, Carlo Perricone, Francesca Romana Spinelli, Cristiano Alessandri, Paola Borgiani, Fabrizio Conti
Summary: This study aimed to determine the distribution of organ damage in a cohort of systemic lupus erythematosus (SLE) patients and evaluate the roles of clinical and genetic factors in the development of chronic damage. The results showed that musculoskeletal, neuropsychiatric, and ocular domains were most frequently involved. The presence of damage was associated with age, disease duration, neuropsychiatric manifestations, anti-phospholipid syndrome, and anti-dsDNA positivity. Therapies such as cyclophosphamide, mycophenolate mofetil, and glucocorticoids were also associated with the development of damage. Genetic analysis revealed associations between specific genes (TNFSF4 and MIR1279) and renal and neuropsychiatric damage, respectively.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Rheumatology
Mauro Fatica, Arianna D'Antonio, Lucia Novelli, Paola Triggianese, Paola Conigliaro, Elisabetta Greco, Alberto Bergamini, Carlo Perricone, Maria Sole Chimenti
Summary: This review aims to investigate the pathophysiological mechanisms in spondyloarthritis (SpA). Genetic factors, immunological pathways, and abnormalities of bone metabolism are found to be closely related to the development of axial clinical manifestations in patients. Activation of immunological pathways leads to bone metabolism abnormalities, resulting in various bone anomalies in SpA patients. Treatment of SpA is challenging, but both biological and targeted synthetic drugs show promising efficacy and safety profile.
CURRENT RHEUMATOLOGY REPORTS
(2023)
Article
Biochemistry & Molecular Biology
Giada De Benedittis, Andrea Latini, Serena Colafrancesco, Roberta Priori, Carlo Perricone, Lucia Novelli, Paola Borgiani, Cinzia Ciccacci
Summary: This study found a significant decrease in mtDNA copies in the peripheral blood of Sjogren's syndrome (SS) patients, as well as expression variations in genes related to mitochondrial dynamics. These results provide further insight into the potential involvement of mitochondrial dysfunctions in SS disease.
Review
Health Care Sciences & Services
Mariangela Manfredi, Lieve Van Hoovels, Maurizio Benucci, Riccardo De Luca, Carmela Coccia, Pamela Bernardini, Edda Russo, Amedeo Amedei, Serena Guiducci, Valentina Grossi, Xavier Bossuyt, Carlo Perricone, Maria Infantino
Summary: uPAR is a membrane-bound glycoprotein, and its bioactive form, suPAR, is primarily expressed on the surface of immunologically active cells. Higher levels of suPAR have been associated with disease severity, relapse, and mortality in various inflammatory diseases. This review summarizes the current literature on the potential role of suPAR as a biomarker in autoimmune rheumatic and non-rheumatic diseases.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Rheumatology
A. Colangelo, F. Tromby, G. Cafaro, R. Gerli, E. Bartoloni, C. Perricone
Summary: Adenosine deaminase 2 deficiency is a rare monogenic vasculopathy with diverse clinical manifestations and challenging treatment.
Review
Rheumatology
Lorenza Bruno, Martina Mandarano, Guido Bellezza, Angelo Sidoni, Roberto Gerli, Elena Bartoloni, Carlo Perricone
Summary: Polyangiitis overlap syndrome is a rare clinical entity characterized by overlapping features of multiple vasculitis, typically eosinophilic granulomatosis with polyangiitis (EGPA) and granulomatosis with polyangiitis (GPA). We present a case of a 66-year-old woman with nasal obstruction, external nose deformity, sensorineural hearing loss, eosinophilia, high titer anti-PR3 antibodies and lung involvement, who was successfully treated with cyclophosphamide. Recognition of this entity is crucial due to its distinct clinical phenotype and response to therapy in the complex scenario of ANCA-associated vasculitides.
RHEUMATOLOGY INTERNATIONAL
(2023)
Article
Medicine, Research & Experimental
Carlo Perricone, Giacomo Cafaro, Elena Fiumicelli, Roberto Bursi, Dimitrios Bogdanos, Ilenia Riccucci, Roberto Gerli, Elena Bartoloni
Summary: This study retrospectively evaluated the predictive factors of sustained remission and flare in patients with polymyalgia rheumatica (PMR). The results showed that female patients and higher baseline prednisone dosage were negative predictors of complete remission at 24 months and were associated with a higher risk of flare.
CLINICAL AND EXPERIMENTAL MEDICINE
(2023)