Article
Rheumatology
Margherita Zen, Enrico Fuzzi, Marta Loredo Martinez, Roberto Depascale, Micaela Fredi, Mariele Gatto, Maddalena Larosa, Francesca Saccon, Luca Iaccarino, Andrea Doria
Summary: The safety of withdrawing immunosuppressive therapy in lupus nephritis (LN) patients is still unclear. This study assessed the rate and predictors of flare after immunosuppressive therapy withdrawal in LN patients in remission. The results showed that it is feasible to withdraw immunosuppressive therapy in LN patients who have been in remission for at least 3 years and are on antimalarial therapy.
Review
Medicine, General & Internal
Jackie Jia Lin Sim, Cynthia Ciwei Lim
Summary: Influenza increases morbidity and mortality in patients with systemic lupus erythematosus (SLE) and lupus nephritis, but vaccination is effective in preventing infection. Studies show that vaccination reduces influenza infection in SLE patients, with no significant changes in disease activity scores after vaccination. However, vaccination rates are relatively low, and barriers include lack of doctor recommendation and concerns over vaccine safety and efficacy.
AMERICAN JOURNAL OF MEDICINE
(2022)
Article
Biotechnology & Applied Microbiology
Gabriel Figueroa-Parra, Jorge Antonio Esquivel-Valerio, Leticia Santoyo-Fexas, Andrea Moreno-Salinas, Carmen Magdalena Gamboa-Alonso, Ana Laura De Leon-Ibarra, Dionicio Angel Galarza-Delgado
Summary: This study investigated the knowledge and attitudes about influenza vaccination among patients with rheumatic diseases and found that concerns about safety, efficacy, side effects, fear of the vaccine, and knowledge of cost can diminish vaccine uptake. These factors are related to confidence, complacency, and convenience as components of vaccine hesitancy in this population.
HUMAN VACCINES & IMMUNOTHERAPEUTICS
(2021)
Article
Rheumatology
Luca Quartuccio, Alen Zabotti, Tolinda Gallo, Salvatore De Vita, Francesca Valent
Summary: The study revealed that the adherence to the influenza vaccination program is low among patients with rheumatoid arthritis, psoriatic arthritis, or ankylosing spondylitis receiving immunosuppressive treatment, especially in elderly patients. Older age and diabetes were associated with higher vaccination rates, while treatment with a biologic agent alone or having a diagnosis of rheumatoid arthritis were linked to lower adherence.
Article
Public, Environmental & Occupational Health
Yanling Chen, Bo Chen, Xiaolin Shen, Aiping Zhou, Yan Liang, Ying Wang, Hong Chen
Summary: The vaccination rates for influenza and pneumococcal vaccines are low among SLE patients in Southwest China. The main concerns for non-vaccination are the fear of disease exacerbation or adverse events caused by vaccines and a lack of awareness of vaccine availability. However, a majority of patients are willing to be vaccinated, primarily influenced by concerns about infection and belief in the efficacy of vaccines.
FRONTIERS IN PUBLIC HEALTH
(2022)
Article
Immunology
Vasilis C. Pliasas, Peter J. Neasham, Maria C. Naskou, Rachel Neto, Philip G. Strate, J. Fletcher North, Stephen Pedroza, Strickland D. Chastain, Ian Padykula, S. Mark Tompkins, Constantinos S. Kyriakis
Summary: This study examined the immunogenicity and protective efficacy of different H1N1 influenza vaccine strategies against an H1N2 swine influenza virus. The results showed that heterologous prime-boost vaccination did not enhance cross-protection and worsened the clinical outcome and pathology.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Medicine, General & Internal
Xian-Bao Li, Nv-Wei Cao, Xiu-Jie Chu, Hao-Yue Zhou, Hua Wang, Si-Jie Yu, Dong-Qing Ye, Bao-Zhu Li
Summary: Antimalarials, especially hydroxychloroquine, may reduce the risk of cancer in patients with systemic lupus erythematosus (SLE), with significant risk reduction seen in Asian populations and SLE patients from multiple centers.
ANNALS OF MEDICINE
(2021)
Article
Immunology
Celeste J. Romano, Clinton Hall, Zeina G. Khodr, Anna T. Bukowinski, Gia R. Gumbs, Ava Marie S. Conlin
Summary: This study examined the association between receiving pandemic H1N1 (pH1N1) vaccines in consecutive influenza seasons and adverse pregnancy outcomes among vaccine-compliant pregnant military women. The results showed no significant association between receiving pH1N1-containing vaccine during pregnancy and spontaneous abortion or birth defects. Therefore, vaccination against pH1N1 in pregnancy is supported regardless of prior influenza season vaccination history.
Review
Rheumatology
Marcia A. Friedman, Jeffrey R. Curtis, Kevin L. Winthrop
Summary: Patients with rheumatic diseases are at increased risk of infectious complications, and disease-modifying antirheumatic drugs can reduce the immunogenicity of common vaccines. Different medications have varying impacts on vaccine immunogenicity, with rituximab having the most substantial effect and Janus kinase and tumour necrosis factor inhibitors decreasing antibody titres. Emerging data suggest that the effect of these medications on the SARS-CoV-2 vaccine immunogenicity is similar to other vaccines, but more research is needed.
ANNALS OF THE RHEUMATIC DISEASES
(2021)
Article
Immunology
Azam Safary, Kamal Esalatmanesh, Amir Taher Eftekharsadat, Mohammad -Reza Jafari Nakjavani, Alireza Khabbazi
Summary: Vaccination against COVID-19 is important for achieving herd immunity and controlling the pandemic. However, a small number of people may develop autoimmune rheumatic diseases (ARDs) as a rare adverse reaction to the vaccines. This study identifies individuals who developed de-novo ARDs after COVID-19 vaccination, with a higher prevalence among those who received the AstraZeneca vaccine. Prompt diagnosis and treatment can prevent irreversible organ damage.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Immunology
Anna Parys, Elien Vandoorn, Koen Chiers, Katharina Passvogel, Walter Fuchs, Thomas C. Mettenleiter, Kristien Van Reeth
Summary: The study showed that heterologous prime-boost vaccination induced stronger antibody responses and protection in pigs, especially against heterologous challenges. However, a pan-H1 antibody response was not achieved.
Article
Medicine, General & Internal
Ji-Won Kim, Ju-Yang Jung, Chang -Hee Suh, Young-Min Ye, Hyoun-Ah Kim
Summary: This study compared the occurrence of adverse events and disease flares after COVID-19 and influenza vaccination in patients with autoimmune rheumatic diseases (ARDs). The results showed that the rates of adverse events and disease flares were significantly higher after COVID-19 vaccination than after influenza vaccination. Previous allergic reactions to other vaccines were the only factor associated with the occurrence of adverse events. There was no difference in the post-vaccine response between mixed and matched vaccines.
JOURNAL OF KOREAN MEDICAL SCIENCE
(2023)
Article
Immunology
Tracy A. Becerra-Culqui, Darios Getahun, Vicki Chiu, Lina S. Sy, Hung Fu Tseng
Summary: This study investigated the association between prenatal influenza vaccination or infection and autism spectrum disorder (ASD) in offspring. The findings showed no association between prenatal influenza vaccination or infection and ASD risk in children.
CLINICAL INFECTIOUS DISEASES
(2022)
Article
Immunology
Zesheng An, Gabriel Figueroa-Parra, Xian Zhou, Yanfeng Li, Jane Jaquith, Kathleen McCarthy-Fruin, Jennifer Sletten, Kenneth J. J. Warrington, Cornelia Weyand, Cynthia S. S. Crowson, Saranya Chumsri, Keith L. L. Knutson, Alain Sanchez-Rodriguez, Uma Thanarajasingam, Ali Duarte-Garcia, Hu Zeng
Summary: This study evaluated the immune response, clinical manifestations, and disease biomarkers after 2 or 3 doses of COVID-19 mRNA vaccines in patients with rheumatic diseases. The results showed that most patients generated high levels of SARS-CoV-2 spike-specific neutralizing antibodies after 2 doses of the vaccine, and the antibody level recovered after the third dose. Patients with systemic lupus erythematosus or psoriatic arthritis did not experience significant flares post-vaccination. Overall, this study provides evidence for the efficacy and safety of repeated COVID-19 mRNA vaccination in rheumatic disease patients.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Rheumatology
Inigo Rua-Figueroa, David Rua-Figueroa, Natalia Perez-Veiga, Ana M. Anzola, Maria Galindo-Izquierdo, Jaime Calvo-Alen, Antonio Fernandez-Nebro, Clara Sanguesa, Raul Menor-Almagro, Eva Tomero, Natividad del Val, Esther Uriarte-Isazelaya, Ricardo Blanco, Jose L. Andreu, Alina Boteanu, Javier Narvaez, Tatiana Cobo, Cristina Bohorquez, Carlos Montilla, Esteban Salas, Francisco J. Toyos, Jose A. Bernal, Eva Salgado, Mercedes Freire, Antonio J. Mas, Lorena Exposito, Jose A. Hernandez-Beriain, Oihane Ibarguengoitia, Maria L. Velloso-Feijoo, Nuria Lozano-Rivas, Gemma Bonilla, Mireia Moreno, Inmaculada Jimenez, Victor Quevedo-Vila, Angela Pecondon, Elena Aurrecoechea, Elia Valls, Coral Mourino, Tomas Vazquez-Rodriguez, Jose M. Pego-Reigosa
Summary: Chronic heart failure is a common complication in patients with systemic lupus erythematosus (SLE), and treatment with antimalarials may have a cardioprotective effect.
SEMINARS IN ARTHRITIS AND RHEUMATISM
(2022)
Article
Medicine, General & Internal
Rosa M. R. Pereira, Marilia A. Dagostin, Valeria F. Caparbo, Lucas P. Sales, Sandra G. Pasoto, Clovis A. Silva, Emily F. N. Yuki, Carla G. S. Saad, Ana C. Medeiros-Ribeiro, Leonard V. K. Kupa, Solange R. G. Fusco, Victor A. O. Martins, Carolina C. M. F. Martins, Carmen Valente Barbas, Samuel K. Shinjo, Nadia E. Aikawa, Eloisa Bonfa
Summary: This study evaluates the immunogenicity, antibody decay, booster dose, and safety of inactivated CoronaVac vaccination in patients with ANCA-associated vasculitis. The results show that CoronaVac vaccine exhibits good safety and moderate immunogenicity in AAV patients, with a mild decline in antibodies after six months but a good response to the booster dose. Overall, the vaccine has minimal adverse effects.
Article
Rheumatology
Gabriela A. Munhoz, Nadia E. Aikawa, Clovis A. Silva, Sandra G. Pasoto, Tatiana N. Pedrosa, Luciana P. C. Seguro, Eloisa Bonfa, Eduardo F. Borba
Summary: This study aimed to determine the impact of lupus nephritis at disease onset on short-term accrual of 2019 European League Against Rheumatism (EULAR)/American College of Rheumatology (ACR) domains. The study found that patients with renal involvement had higher disease activity and required more treatment at disease onset, while patients without renal involvement also experienced damage in the early stages of the disease. Therefore, close monitoring and tailored treatment for lupus patients without renal involvement are important.
JCR-JOURNAL OF CLINICAL RHEUMATOLOGY
(2023)
Article
Rheumatology
Carla G. S. Saad, Matheus S. R. Silva, Percival D. Sampaio-Barros, Julio C. B. Moraes, Claudia G. Schainberg, Celio R. Goncalves, Andrea Y. Shimabuco, Nadia E. Aikawa, Emily F. N. Yuki, Sandra G. Pasoto, Leonard V. K. Kupa, Renato K. Aoyama, Carlo S. R. Araujo, Clovis A. Silva, Ana C. Medeiros-Ribeiro, Eloisa Bonfa
Summary: This study evaluated the humoral responses to the SARS-CoV-2 vaccine in patients with spondyloarthritis and found that therapy had an impact on the immune response. TNF inhibitors attenuated the immune response, while sulfasalazine had a positive impact on vaccine antibody production.
Article
Rheumatology
Epitacio D. S. Neto, Taurino S. R. Neto, Flavio Signorelli, Gustavo G. M. Balbi, Alex H. Higashi, Mario Luiz R. Monteiro, Eloisa Bonfa, Danieli C. O. Andrade, Leandro C. Zacharias
Summary: The objective of this study was to perform a multimodal ophthalmological evaluation, including OCTA, in asymptomatic APS secondary to SLE patients and compare them to SLE patients and a control group. Ophthalmologic abnormalities occurred in approximately one-third of APS/SLE patients and SLE patients, while none were found in the control group. The most common retinal finding was Drusen-like deposits (DLDs) in APS/SLE and SLE patients, with severe changes exclusively occurring in APS/SLE patients. There was a possible association between PAMM, aPL triple positivity, and high aGAPSS scores in APS/SLE patients.
CLINICAL RHEUMATOLOGY
(2023)
Article
Rheumatology
Sandra Gofinet Pasoto, Eduardo Ferreira Borba, Francisco Fellipe Claudino Formiga, Tatiana do Nascimento Pedrosa, Nadia Emi Aikawa, Marilda Agudo Mendonca Teixeira de Siqueira, Artur Silva Vidal Capao, Adriana Coracini Tonacio de Proenca, Ricardo Fuller, Emily Figueiredo Neves Yuki, Elaine Pires Leon, Victor Adriano de Oliveira Martins, Marta Heloisa Lopes, Alberto Jose da Silva Duarte, Clovis Artur Almeida da Silva, Eloisa Bonfa
Summary: This study investigated the safety and immunogenicity of influenza A (H3N2) vaccine in patients with primary Sjogren syndrome (pSS). The results showed that the vaccine induced a different pattern of immune response in pSS patients compared to other influenza A constituents. This finding is important for understanding the role of cellular immunity in pSS.
CLINICAL RHEUMATOLOGY
(2023)
Article
Rheumatology
Luis Alonso Gonzalez, Graciela S. Alarcon, Guillermina B. Harvey, Rosana Quintana, Guillermo J. Pons-Estel, Manuel F. Ugarte-Gil, Gloria Vasquez, Luis J. Catoggio, Mercedes A. Garcia, Eduardo F. Borba, Nilzio A. Da Silva, Joao C. Tavares Brenol, Marlene Guibert Toledano, Loreto Massardo, Oscar Neira, Virginia Pascual-Ramos, Mary-Carmen Amigo, Leonor A. Barile-Fabris, Ignacio Garcia De La Torre, Jose Alfaro-Lozano, Maria Segami, Rosa Chacon-Diaz, Maria H. Esteva-Spinetti, Antonio Iglesias-Gamarra, Bernardo A. Pons-Estel
Summary: This study aimed to determine the predictors of severe autoimmune hemolytic anemia (AIHA) occurrence and its impact on damage accrual and mortality in patients with systemic lupus erythematosus (SLE). The study found that male sex and higher disease activity at diagnosis were associated with a shorter time to severe AIHA occurrence. Although not statistically significant, hematological abnormalities at SLE diagnosis showed a certain trend toward predicting the occurrence of severe AIHA in a shorter time. Severe AIHA did not seem to impact damage and mortality.
Article
Rheumatology
Ana P. Sakamoto, Clovis A. Silva, Ana C. Pita, Vitor C. Trindade, Aline G. Islabao, Fernanda J. Fiorot, Sandra R. M. Lopes, Rosa M. R. Pereira, Claudia Saad-Magalhaes, Gleice C. S. Russo, Claudio A. Len, Rogerio do Prado, Lucia M. A. Campos, Nadia E. Aikawa, Simone Appenzeller, Virginia P. L. Ferriani, Marco F. Silva, Marta Felix, Adriana R. Fonseca, Ana P. L. Assad, Flavio R. Sztajnbok, Maria C. Santos, Blanca E. Bica, Evaldo G. Sena, Ana J. Moraes, Melissa M. Fraga, Teresa C. Robazzi, Paulo F. Spelling, Iloite M. Scheibel, Andre S. Cavalcanti, Erica N. Matos, Luciano J. Guimaraes, Flavia P. Santos, Licia M. H. Mota, Eloisa Bonfa, Maria T. Terreri
Summary: The objective of this study was to explore the associations between mortality in cSLE patients and their characteristics, as well as to evaluate the risk factors and determine the main causes of death. The results showed that the mortality rate in cSLE patients in Brazil was low, but neuropsychiatric lupus and chronic kidney disease were found to be significant risk factors for mortality.
Article
Nutrition & Dietetics
Bianca Depieri Balmant, Danielle Cristina Fonseca, Ana Paula Aguiar Prudencio, Ilanna Marques Rocha, Leticia Callado, Juliana Tepedino Martins Alves, Raquel Susana Matos de Miranda Torrinhas, Eduardo Ferreira Borba, Dan Linetzky Waitzberg
Summary: This study investigated the relationship between gut microbiota, intestinal permeability, food intake, and inflammatory markers in inactive SLE patients. The results showed that Megamonas genus was enriched in the inactive SLE group, with Megamonas funiformis associated with all evaluated laboratory tests. Plasma zonulin was associated with C3 levels, and sodium intake was negatively associated with C3 and C4 levels. These findings suggest that increased Megamonas funiformis abundance, elevated plasma zonulin, and higher sodium intake may contribute to reduced C3 complement levels in women with inactive SLE.
Article
Rheumatology
Clovis Artur Silva, Leonard de Vinci Kanda Kupa, Ana Cristina Medeiros-Ribeiro, Sandra Gofinet Pasoto, Carla Goncalves Schahin Saad, Emily Figueiredo Neves Yuki, Joaquim Ivo Vasques Dantas Landim, Victor Hugo Ferreira e Leda, Luisa Sacchi de Camargo Correia, Artur Fonseca Sartori, Carolina Campagnoli Machado Freire Martins, Carolina Torres Ribeiro, Filipe Waridel, Victor Adriano de Oliveira Martins, Samuel Katsuyuki Shinjo, Danieli Castro Oliveira Andrade, Percival Degrava Sampaio Barros, Eduardo Ferreira Borba Neto, Nadia Emi Aikawa, Eloisa Bonfa
Summary: The study aimed to evaluate the frequency and pattern of post-acute COVID-19 in vaccinated patients with autoimmune rheumatic diseases (ARD). The results showed that there was no significant difference in the frequency and symptoms of post-acute COVID-19 between ARD patients and non-ARD controls, suggesting that vaccination has a minimal impact on post-acute COVID-19 in ARD patients.
ADVANCES IN RHEUMATOLOGY
(2023)
Article
Immunology
Lucas Peixoto Sales, Bidossessi Wilfried Hounkpe, Mariana Ortega Perez, Valeria Falco Caparbo, Diogo Souza Domiciano, Eduardo Ferreira Borba, Georg Schett, Camille Pinto Figueiredo, Rosa Maria Rodrigues Pereira
Summary: This study analyzed the gene expression of classical monocytes in erosive and non-erosive rheumatoid arthritis (RA) patients and found that alterations in genes related to inflammation and bone formation might play an important role in the pathophysiology of bone erosions in RA patients.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Rheumatology
Karina Rossi Bonfiglioli, Ana Cristina de Medeiros Ribeiro, Ana Paula Carnieletto, Ivanio Pereira, Diogo Souza Domiciano, Henrique Carrico da Silva, Alisson Pugliesi, Leticia Rocha Pereira, Maria Fernanda Resende Guimaraes, Rina Dalva Neubarth Giorgi, Ana Paula Monteiro Gomides Reis, Claiton Viegas Brenol, Paulo Louzada-Junior, Maria de Fatima Lobato da Cunha Sauma, Sebastiao Cezar Radominski, Licia Maria Henrique da Mota, Geraldo da Rocha Castelar-Pinheiro
Summary: This study aimed to determine the prevalence of extra-articular manifestations (ExtRA) in rheumatoid arthritis (RA) patients and its association with demographic and clinical variables. The results showed that the overall prevalence of ExtRA in the cohort was 23.4%, and it was significantly associated with age, disease duration, serological markers, disease activity, and treatment options.
ADVANCES IN RHEUMATOLOGY
(2023)
Article
Public, Environmental & Occupational Health
Fabiana Infante Smaira, Bruna Caruso Mazzolani, italo Ribeiro Lemes, Rafael Pires da Silva, Ana J. Pinto, Sofia M. Sieczkowska, Nadia E. Aikawa, Sandra G. Pasoto, Ana C. Medeiros-Ribeiro, Carla G. S. Saad, Emily F. N. Yuk, Clovis A. Silva, Paul Swinton, Leonard de Vinci Kanda Kupa, Pedro C. Hallal, Hamilton Roschel, Bruno Gualano, Eloisa Bonfa
Summary: This study investigated the association between physical activity and immunogenicity in SARS-CoV-2 seropositive patients with autoimmune rheumatic diseases before and after receiving the Sinovac inactivated vaccine. The results showed no association between physical activity and immunogenicity before and after vaccination. These findings suggest that previous SARS-CoV-2 infection may override the positive association between physical activity and antibody responses seen in immunocompromised individuals following vaccination, and this association does not extend to natural immunity.
JOURNAL OF PHYSICAL ACTIVITY & HEALTH
(2023)
Review
Rheumatology
Jobson Lopes de Oliveira, Rafael Alves Cordeiro, Lissiane Karine Noronha Guedes, Sandra Gofinet Pasoto
Summary: Primary Sjogren's syndrome (pSS) is a systemic autoimmune disease that primarily affects the salivary and lacrimal glands, with potential lung involvement. Shrinking lung syndrome (SLS) is a rare respiratory complication associated with systemic lupus erythematosus, and its association with pSS is even rarer. This study describes a case of SLS in a patient with pSS and highlights the importance of considering SLS in patients with pSS and respiratory symptoms.
RHEUMATOLOGY INTERNATIONAL
(2023)