Article
Nutrition & Dietetics
Juan C. Pardo, Vicenc Ruiz de Porras, Joan Gil, Albert Font, Manel Puig-Domingo, Mireia Jorda
Summary: Prostate cancer is the most commonly diagnosed male malignancy in the Western world. Metabolic reprogramming and epigenetic remodeling play important roles in the progression and therapy resistance of prostate cancer, and there is crosstalk between metabolism and epigenetics. A high-fat diet has been associated with prostate cancer progression. Understanding these alterations and mechanisms can help identify prognostic and predictive biomarkers, as well as targetable vulnerabilities.
Article
Oncology
Massimo Lazzeri, Vittorio Fasulo, Giovanni Lughezzani, Alessio Benetti, Giulia Solda, Rosanna Asselta, Ilaria De Simone, Marco Paciotti, Pier Paolo Avolio, Roberto Contieri, Cesare Saitta, Alberto Saita, Rodolfo Hurle, Giorgio Guazzoni, Nicolo Maria Buffi, Paolo Casale
Summary: This study aimed to test the relationship between a specific genetic lesion and imaging scores, and to assess their effectiveness for the diagnosis of prostate cancer. The results showed that T2:ERG translocation and imaging results are independent of each other, but both are related to clinically significant prostate cancer. Using both T2:ERG detection and imaging techniques together can improve the accuracy of diagnosing prostate cancer and clinically significant prostate cancer.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Le Zhang, Sandrine Billet, Gabrielle Gonzales, Krizia Rohena-Rivera, Hayato Muranaka, Gina Chia-Yi Chu, Qian Yang, Hyung Kim, Neil A. Bhowmick, Bethany Smith
Summary: A high-fat diet is associated with prostate cancer progression, and cancer-associated fibroblasts (CAF) play an important role in this process. This study found that saturated fatty acids induce lineage plasticity reprogramming of prostate cancer through interaction with CAF via the Wnt5a and Hedgehog (Hh) signaling pathways. These findings provide relevant data to potentially improve the prognosis for patients with high fat intake.
Article
Oncology
Cheng Qian, Dan Li, Yu Chen
Summary: The ETS family of proteins plays critical roles in prostate cancer, and gene fusion and overexpression of certain members have been linked to the development of this cancer. This review provides an overview of the discovery, classification, and therapeutic targeting of ETS family members in prostate cancer.
Article
Biochemistry & Molecular Biology
Hiromi Sato, Shintaro Narita, Masanori Ishida, Yoshiko Takahashi, Huang Mingguo, Soki Kashima, Ryohei Yamamoto, Atsushi Koizumi, Taketoshi Nara, Kazuyuki Numakura, Mitsuru Saito, Toshiaki Yoshioka, Tomonori Habuchi
Summary: A diet rich in lard increases the risk of prostate cancer development and progression. Two mouse models fed with lard-enriched diets showed enhanced prostate cancer progression and weight gain compared to a fish oil diet. The composition of gut microbiota differed significantly between the two diets, with changes in bacterial species such as Clostridiales and Lactobacillales. The proportion of Lactobacillales in the gut was negatively associated with weight gain and prostate cancer progression. The study also identified genes involved in lipid metabolism and cholesterol biosynthesis that correlated with the abundance of Lactobacillales in the gut.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Oncology
Zhengliang Zhang, Weixi Wang, Piaoping Kong, Kangle Feng, Chunhua Liu, Tao Sun, Yiwen Sang, Xiuzhi Duan, Zhihua Tao, Weiwei Liu
Summary: Prostate cancer, the most common malignant tumor of the male urological system, poses a severe threat to the survival of middle-aged and elderly males worldwide. This review summarizes recent research advances in lipid metabolic pathways (fatty acids, cholesterol, and phospholipids) in prostate cancer. It discusses the metabolism of fatty acids, the role of cholesterol in pathogenesis and evolution, and the association of different types of phospholipids with cancer progression. Additionally, it highlights the clinical value of lipid metabolism proteins and lipids themselves as diagnostic and prognostic indicators, as well as therapeutic targets in prostate cancer.
INTERNATIONAL JOURNAL OF ONCOLOGY
(2023)
Article
Cell Biology
Giovana Rampazzo Teixeira, Luiz Gustavo Almeida Chuffa, Leonardo Oliveira Mendes, Allice Santos Cruz Veras, James McCabe, Wagner Jose Favaro, Patricia Fernanda Felipe Pinheiro, Joao Paulo Arruda Amorim, Otavio Augusto Martins, Wilson Mello-Junior, Francisco Eduardo Martinez
Summary: This study investigated the protective effects of strength training against ethanol-induced prostatic metabolism disorders in rats. Strength training reduced alcohol consumption, increased glucose and serum lipid levels, and decreased hormonal levels. Protein expression analysis showed significant differences in hormone receptors and cell regulation between ethanol-exposed and strength training groups, suggesting strength training as a potential therapeutic strategy for ethanol-induced prostate injuries.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Article
Pathology
Henrique J. Cardoso, Marilia I. Figueira, Tiago M. A. Carvalho, Catarina D. M. Serra, Catia V. Vaz, Patricia A. Madureira, Silvia Socorro
Summary: The study found that androgens can change the lipid metabolism of PCa cells and interact with LDL-cholesterol, increasing the viability, proliferation, and migration of PCa cells. These results support clinical data linking obesity with PCa and implicate androgens in this relationship for the first time. Therefore, pharmacological approaches targeting both cholesterol availability and androgens signaling simultaneously are of great significance.
PATHOLOGY RESEARCH AND PRACTICE
(2022)
Article
Oncology
Donald Poirier, Jenny Roy, Rene Maltais, Cindy Weidmann, Etienne Audet-Walsh
Summary: Prostate cancer ranks fourth among all new cancer cases worldwide, and metastatic PC is the leading cause of death with limited treatment options. The development of new innovative drugs is urgently needed, and the aminosteroid derivative RM-581 has shown promising antiproliferative activity on various cancer cell types. It effectively blocked tumor growth in mice at a low dose and demonstrated non-toxicity, suggesting its potential as a safe and effective treatment for prostate cancer.
Review
Immunology
Zhiyuan You, Hongbo Chi
Summary: Dendritic cells (DCs) are innate immune cells that link innate and adaptive immunity. Lipid metabolism plays a crucial role in regulating DC function, including de novo fatty acid synthesis, fatty acid beta oxidation, lipid storage, and cholesterol efflux. Dysregulation of lipid metabolism can impair DC function in the tumor microenvironment.
IMMUNOLOGICAL REVIEWS
(2023)
Article
Oncology
Huan Xu, Sangsang Li, Yi Sun, Lingfan Xu, Xin Hong, Zhong Wang, Hailiang Hu
Summary: This study reveals the impact of long-chain polyunsaturated fatty acid ELOVL5 on enzalutamide resistance and neuroendocrine differentiation in prostate cancer, providing a potential therapeutic target for treating enzalutamide-resistant NE-like prostate cancer.
Article
Biochemistry & Molecular Biology
Julia S. Scott, Lake-Ee Quek, Andrew J. Hoy, Johannes V. Swinnen, Zeyad D. Nassar, Lisa M. Butler
Summary: The fatty acid elongation enzyme ELOVL5 plays a critical role in promoting metastasis in prostate cancer. Knocking down ELOVL5 leads to the accumulation of malonyl-CoA, which inhibits fatty acid oxidation in mitochondria. This study highlights the importance of fatty acid elongation in regulating cell viability and provides a potential target for prostate cancer treatment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Oncology
Tiffany L. Weir, S. Raj J. Trikha, Henry J. Thompson
Summary: Cancer is a common disease, with complex interactions between diet, gut microbiota, and cancer risk. Lifestyle modifications, especially in diet, can prevent as much as 50% of cancer cases. Understanding the interplay between diet and gut microbiota helps clarify the impact of diet on cancer.
SEMINARS IN CANCER BIOLOGY
(2021)
Article
Pathology
Yuri Tolkach, Romina Zarbl, Simone Bauer, Manuel Ritter, Joerg Ellinger, Stephan Hauser, Laura Hueser, Sabine M. Klauck, Peter Altevogt, Holger Sultmann, Dimo Dietrich, Glen Kristiansen
Summary: CD24 is overexpressed in many human cancers, including prostate cancer, and its up-regulation can be influenced by DNA methylation of the CD24 promoter. Higher levels of CD24 expression are associated with poorer outcomes in prostate cancer patients, including shorter biochemical recurrence-free survival. Overexpression of ERG and PTEN deficiency are also correlated with increased CD24 expression levels in prostate cancer.
AMERICAN JOURNAL OF PATHOLOGY
(2021)
Article
Plant Sciences
Kang Ning, Cong Hou, Xiuye Wei, Yuxin Zhou, Shuanghua Zhang, Yongzhong Chen, Haibin Yu, Linlin Dong, Shilin Chen
Summary: Hemp seeds are rich in beneficial metabolites and can be used as a nutritional supplement. This study compared the metabolomes of seven hemp varieties using targeted metabolomics and identified a wide range of metabolites, including flavonoids, alkaloids, and phenolic acids. The research also determined the antioxidant activity of the varieties and identified the key metabolites responsible for the activity.
FRONTIERS IN PLANT SCIENCE
(2022)
Article
Oncology
Angelika Toelle, Klaus Jung, Frank Friedersdorff, Andreas Maxeiner, Michael Lein, Annika Fendler, Carsten Stephan
Summary: The combination of miR-222-3p with PHI can improve the diagnostic accuracy of prostate cancer, demonstrating potential clinical applications.
Article
Urology & Nephrology
Carsten Stephan, Klaus Jung, Michael Lein, Hannah Rochow, Frank Friedersdorff, Andreas Maxeiner
Summary: The Prostate Health Index density (PHID) showed a significant advantage over PHI in detecting any prostate cancer, but performed equally in detecting significant prostate cancer.
WORLD JOURNAL OF UROLOGY
(2021)
Article
Hematology
Andreas Maxeiner, Thomas Fischer, Carsten Stephan, Selda Treskatsch, Alexander Daniel Jacques Baur, Ernst-Michael Jung, Bernd Hamm, Markus Herbert Lerchbaumer
Summary: This study demonstrates that TDI parameters guided by MRI and ultrasound fusion can differentiate between cancerous and noncancerous lesions in prostate, aiding in determining the aggressiveness of prostate cancer.
CLINICAL HEMORHEOLOGY AND MICROCIRCULATION
(2021)
Article
Urology & Nephrology
Robert Peters, Carsten Stephan, Klaus Jung, Michael Lein, Frank Friedersdorff, Andreas Maxeiner
Summary: The study found that in a large Caucasian group, the Prostate Health Index (PHI) density (PHID) did not show a significant advantage over PHI alone, indicating that the increase in diagnostic accuracy is too small to justify its routine clinical use.
UROLOGIA INTERNATIONALIS
(2021)
Article
Oncology
Laura Kristin Esser, Vittorio Branchi, Farhad Shakeri, Adrian Georg Simon, Carsten Stephan, Glen Kristiansen, Andreas Buness, Hubert Schorle, Marieta Ioana Toma
Summary: This study investigated the effects of PARK2 overexpression in ccRCC cell lines and found that it can suppress tumor invasion and migration by regulating the expression of CKS2. It also revealed that high CKS2 levels are associated with high tumor grading and lower patient survival, suggesting CKS2 as a potential biomarker and therapeutic target for ccRCC.
INTERNATIONAL JOURNAL OF ONCOLOGY
(2022)
Article
Oncology
Christine Sanders, Almotasem Salah M. Hamad, Susanna Ng, Racha Hosni, Jorg Ellinger, Niklas Kluemper, Manuel Ritter, Carsten Stephan, Klaus Jung, Michael Holzel, Glen Kristiansen, Stefan Hauser, Marieta Toma
Summary: Clear cell renal cell carcinoma (ccRCC) is a highly immunogenic tumor with variable responses to immune checkpoint therapy. Analysis of immune cell infiltrate in primary tumors and distant metastases revealed correlations with metastasis, tumor differentiation, and overall survival in ccRCC. High levels of CD103+ cells and ITGAE/CD103 expression were associated with poor prognosis.
Article
Oncology
Carsten Stephan, Bernhard Ralla, Florian Bonn, Max Diesner, Michael Lein, Klaus Jung
Summary: Recent research on prostate cancer and vitamin D is controversial. This study investigated changes in three vitamin D-3 metabolites in prostate cancer patients over four years. While two metabolites showed higher values after the study's start, the concentration of 1,25(OH)(2)D-3 remained unchanged. Interestingly, this metabolite was higher in patients with bone metastasis. The potential prognostic value of this finding should be further explored.
Article
Computer Science, Software Engineering
K. U. Barthel, N. Hezel, K. Jung, K. Schall
Summary: Images sorted by similarity can be useful for stock photo agencies or e-commerce applications. We propose a new metric called distance preservation quality (DPQ) to evaluate the quality of image arrangement. Extensive user testing shows that DPQ has a strong correlation with user-perceived quality and performance in image retrieval tasks. We also introduce a new algorithm called Fast linear assignment sorting (FLAS) for creating visually sorted grid layouts, which achieves good sorting qualities while improving run time and computational resources.
COMPUTER GRAPHICS FORUM
(2023)
Letter
Medical Laboratory Technology
Carsten Stephan, Robert Peters, Klaus S. Jung, Andreas Maxeiner
JOURNAL OF CLINICAL LABORATORY ANALYSIS
(2023)
