Review
Immunology
Bo Zhang, Ming Zhao, Qianjin Lu
Summary: Extracellular vesicles (EVs) have attracted wide interest in basic and clinical research in the past two decades. They are small membrane vesicles released by almost all cells and play important roles in immunomodulation and the pathogenesis of autoimmune diseases, showing great potential in the diagnosis and treatment of autoimmune diseases.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Nutrition & Dietetics
Alessia Alunno, Francesco Carubbi, Elena Bartoloni, Davide Grassi, Claudio Ferri, Roberto Gerli
Summary: In recent years, there has been increasing interest in the influence of diet on rheumatic and musculoskeletal diseases (RMDs). Diet may play a role in the development and progression of these conditions through pro-inflammatory properties and effects on insulin resistance, obesity, and other co-morbidities. Research has been more extensive in rheumatoid arthritis (RA) compared to systemic lupus erythematosus (SLE), with most SLE studies conducted on experimental models.
Article
Rheumatology
Marco Sebastiani, Vincenzo Venerito, Serena Bugatti, Chiara Bazzani, Martina Biggioggero, Luca Petricca, Rosario Foti, Alessandra Bortoluzzi, Silvia Balduzzi, Elisa Visalli, Bruno Frediani, Andreina Manfredi, Elisa Gremese, Ennio Favalli, Florenzo Iannone, Gianfranco Ferraccioli, Giovanni Lapadula
Summary: After failure of biologic disease-modifying anti-rheumatic drugs (bDMARDs) such as TCZ or RTX, using tumor necrosis factor inhibitors (TNFi) or other mechanisms of action as a second-line treatment shows higher retention rates, which should be considered when treating rheumatoid arthritis (RA).
CLINICAL RHEUMATOLOGY
(2021)
Review
Immunology
Han Wu, Shuxian Chen, Aifen Li, Kangyuan Shen, Shuting Wang, Sijie Wang, Ping Wu, Wenying Luo, Qingjun Pan
Summary: Long non-coding RNAs (lncRNAs) have emerged as potential novel biomarkers and therapeutic targets in systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA), playing key roles in the pathogenesis of these autoimmune diseases.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Immunology
Esther F. Vicente-Rabaneda, Belen Atienza-Mateo, Ricardo Blanco, Lorenzo Cavagna, Julio Ancochea, Santos Castaneda, Miguel A. Gonzalez-Gay
Summary: Current evidence suggests that ABA may be a plausible alternative to treat RA patients with ILD. It would be highly desirable to develop prospective randomized controlled studies to confirm these findings.
AUTOIMMUNITY REVIEWS
(2021)
Review
Immunology
Michele Fresneda Alarcon, Zoe McLaren, Helen Louise Wright
Summary: Dysregulated neutrophil activation plays a significant role in the pathogenesis of rheumatoid arthritis and systemic lupus erythematosus, contributing to inflammation and autoantibody production in both autoimmune diseases.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Rheumatology
Hilde Julie T. Lien, Tina T. Pedersen, Bente Jakobsen, Arnar Flatberg, Konika Chawla, Pal Saetrom, Mona H. Fenstad
Summary: The study compared cellular composition and peripheral blood gene expression in Rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), and healthy pregnancies. The results showed distinct RA, SLE, and pregnancy signatures that were not attributed to medication or disease activity. The study supports the need for close postpartum follow-up of patients with SLE and highlights the importance of cell-type adjustment in gene expression analysis.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Review
Rheumatology
Resit Yildirim, Tatiana Oliveira, David Alan Isenberg
Summary: In recent years, there have been efforts to improve the prognosis and outcome in patients with autoimmune inflammatory rheumatic diseases by using treat-to-target strategy and early intervention strategies with immunosuppressive agents. However, infectious complications due to medication side effects remain a major concern. Vaccination programmes and vaccine immunity play a crucial role in patients with SLE in terms of morbidity and mortality. Although research on vaccines' efficacy and immune response in immunosuppressed patients has increased, there is still a lack of data investigating these parameters for those receiving biological agents, leading to a lack of consensus on a vaccination policy for patients with SLE.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Article
Immunology
Chloe Bost, Marina I. Arleevskaya, Wesley H. Brooks, Samuel Plaza, Jean-Charles Guery, Yves Renaudineau
Summary: Growing evidence suggests that the long non-coding RNA Xist expressed in female cells plays a significant role in systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA). Xist controls transcription and sequesters miRNAs, leading to alterations in key inflammatory and proliferative pathways.
CLINICAL IMMUNOLOGY
(2022)
Article
Rheumatology
Latanya N. Coke, Hongxiu Wen, Mary Comeau, Mustafa H. Ghanem, Andrew Shih, Christine N. Metz, Wentian Li, Carl D. Langefeld, Peter K. Gregersen, Kim R. Simpfendorfer
Summary: The study revealed that the SLE risk association in the DNASE1L3 locus is related to the polymorphism rs35677470, which results in reduced secretion of DNASE1L3 protein but does not eliminate its DNase enzyme function. The association of the DNASE1L3/PXK gene locus with SLE risk is dependent on the missense SNP rs35677470, highlighting the importance of this polymorphism in SLE susceptibility.
ANNALS OF THE RHEUMATIC DISEASES
(2021)
Review
Immunology
Ahmadreza Khoshroo, Keyvan Ramezani, Niusha Moghimi, Moein Bonakdar, Nazanin Ramezani
Summary: Rheumatoid arthritis (RA), an autoimmune disease, is associated with bone deterioration, particularly erosion of periarticular cortical bone. There is a complex interaction between inflammation and bone destruction in RA. Biological and targeted medicines have modified RA's bone metabolism. This article discusses the pathomechanisms of bone structure involved in biological and targeted treatments for RA, as well as the clinical implications of disease-modifying antirheumatic drugs (DMARDs).
INFLAMMOPHARMACOLOGY
(2023)
Article
Immunology
Qi Huang, Wang-Dong Xu, Lin-Chong Su, Xiao-Yan Liu, An-Fang Huang
Summary: This study investigated CD40 gene polymorphisms in Chinese Han population with SLE and RA, finding associations between certain genotypes and alleles with susceptibility to the diseases. The findings suggest a potential role of CD40 gene polymorphisms in the pathogenesis of SLE and RA.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Rheumatology
Xiaochan Chen, Xiaowei Shi, Han Xue, Honghua Lv, Lishi Yu, Xiudi Wu, Qiaohong Wang, Huaxiang Wu, Fei Han, Jing Xue
Summary: This multicentre prospective cohort study demonstrates that long-term RTX maintenance therapy has high efficacy and acceptable safety in relapsing or refractory SLE patients who had a clinical response to RTX induction therapy.
Article
Medicine, General & Internal
Choong-Kyun Noh, Eunyoung Lee, Bumhee Park, Sung Soo Ahn
Summary: The presence of faecal haemoglobin, even in the absence of gastrointestinal bleeding, may indicate systemic inflammation and be linked to the development of immune-mediated inflammatory diseases (IMIDs). Positive faecal immunochemical test (FIT) is associated with an increased risk of rheumatoid arthritis (RA) in the general population.
Review
Medicine, General & Internal
Mrinalini Dey, Ioannis Parodis, Elena Nikiphorou
Summary: Fatigue is a common feature in systemic lupus erythematosus and rheumatoid arthritis, but the two diseases differ in their clinical manifestations and treatment approaches. Addressing fatigue in a holistic manner, along with pain, depression, and anxiety, is crucial for improving quality of life in these patients. Further research is needed to better understand and manage fatigue in these conditions.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Medicine, General & Internal
Youri Yordanov, Agnes Dechartres, Ignacio Atal, Viet-Thi Tran, Isabelle Boutron, Perrine Crequit, Philippe Ravaud
Article
Pharmacology & Pharmacy
Jean-David Zeitoun, Joseph S. Ross, Ignacio Atal, Alexandre Vivot, Nicholas S. Downing, Gabriel Baron, Philippe Ravaud
CLINICAL PHARMACOLOGY & THERAPEUTICS
(2018)
Article
Health Care Sciences & Services
Arthur James, Amelie Yavchitz, Philippe Ravaud, Isabelle Boutron
JOURNAL OF CLINICAL EPIDEMIOLOGY
(2018)
Article
Rheumatology
Xavier Puechal, Michele Iudici, Ana Luisa Calich, Alexandre Vivot, Benjamin Terrier, Alexis Regent, Pascal Cohen, Claire Le Jeunne, Luc Mouthon, Philippe Ravaud, Loic Guillevin
Article
Health Care Sciences & Services
Viet-Thi Tran, Eugene Messou, Mariam Mama Djima, Philippe Ravaud, Didier K. Ekouevi
BMJ QUALITY & SAFETY
(2019)
Article
Health Care Sciences & Services
Van Thu Nguyen, Bridget Young, Philippe Ravaud, Nivantha Naidoo, Mehdi Benchoufi, Isabelle Boutron
JOURNAL OF MEDICAL INTERNET RESEARCH
(2019)
Article
Medicine, General & Internal
Antony J. Porcino, Larissa Shamseer, An-Wen Chan, Richard L. Kravitz, Aaron Orkin, Salima Punja, Philippe Ravaud, Christopher H. Schmid, Sunita Vohra
BMJ-BRITISH MEDICAL JOURNAL
(2020)
Editorial Material
Medicine, General & Internal
Isabelle Boutron, Anna Chaimani, Joerg J. Meerpohl, Asbjorn Hrobjartsson, Declan Devane, Gabriel Rada, David Tovey, Giacomo Grasselli, Philippe Ravaud
ANNALS OF INTERNAL MEDICINE
(2020)
Review
Health Care Sciences & Services
Alexander Perlmutter, Mehdi Benchoufi, Philippe Ravaud, Viet-Thi Tran
JOURNAL OF MEDICAL INTERNET RESEARCH
(2020)
Article
Health Care Sciences & Services
Astrid Chevance, Axel Fortel, Adeline Jouannin, Faustine Denis, Marie-France Mamzer, Philippe Ravaud, Stephanie Sidorkiewicz
Summary: Digital pills face limitations in prospective acceptability and willingness to use, primarily due to clinical and ethical concerns. Results indicate that willingness to take digital pills is associated with gender and the current use of connected devices to record health settings.
JOURNAL OF MEDICAL INTERNET RESEARCH
(2022)
Article
Health Care Sciences & Services
Van Thu Nguyen, Philippe Ravaud, Viet Thi Tran, Bridget Young, Isabelle Boutron
Summary: The study investigates patients' preferences for the organization of randomized controlled trials (RCTs) and finds that most patients prefer a hybrid model involving both on-site and remote visits. Patients are more likely to participate in a trial organized according to their preferences.
JOURNAL OF MEDICAL INTERNET RESEARCH
(2022)
Review
Health Care Sciences & Services
Gloria A. Aguayo, Catherine Goetzinger, Renza Scibilia, Aurelie Fischer, Till Seuring, Viet-Thi Tran, Philippe Ravaud, Tamas Bereczky, Laetitia Huiart, Guy Fagherazzi
Summary: Patient and public involvement (PPI) in research is important for improving the quality and relevance of studies. Various methods, including workshops, surveys, and focus groups, are commonly used for PPI in epidemiological research. Recommendations include early integration of PPI, combining methods for idea generation, and utilizing digital tools for e-cohorts.
JOURNAL OF MEDICAL INTERNET RESEARCH
(2021)
Article
Dermatology
Laura Fertitta, Kavita Y. Sarin, Christina Bergqvist, Ekshika Patel, Bastien Peiffer, Sabine Moryousef, Marie-Laure Armand, Arnaud Jannic, Salah Ferkal, Philippe Ravaud, Viet-Thi Tran, Jaishri O. Blakeley, Carlos G. Romo, Khaled Ezzedine, Pierre Wolkenstein
Summary: This study first defined severity strata for cutaneous neurofibromas using an anchoring approach. After validation in French and United States populations, the cNF-Skindex and the strata showed a strong correlation in interpreting cutaneous neurofibromas in daily practice and clinical trials.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2023)
Article
Obstetrics & Gynecology
M. Linard, B. Blondel, C. Estellat, C. Deneux-Tharaux, D. Luton, J. F. Oury, T. Schmitz, L. Mandelbrot, E. Azria
BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2018)
Review
Health Care Sciences & Services
Perrine Crequit, Ghizlene Mansouri, Mehdi Benchoufi, Alexandre Vivot, Philippe Ravaud
JOURNAL OF MEDICAL INTERNET RESEARCH
(2018)
