Review
Pharmacology & Pharmacy
Chu-Tian Mai, De-Chong Zheng, Xin-Zhi Li, Hua Zhou, Ying Xie
Summary: Rheumatoid arthritis is a chronic autoimmune disease with complex pathogenesis, where altered lipid metabolism can increase cardiovascular risks; LXR agonists play a key role in regulating lipid homeostasis and inflammatory responses, but both pro-inflammatory and anti-inflammatory effects have been observed in animal studies.
PHARMACOLOGICAL RESEARCH
(2021)
Article
Immunology
Qiong Wang, Qinbin Ye, Xiaoyu Xi, Xiaoxue Cao, Xing Wang, Mengxiao Zhang, Yuan Xu, Tingting Deng, Xiaobing Deng, Guoqiang Zhang, Cheng Xiao
Summary: This study explored the association between RIPK1-dependent necroptosis and the pathogenesis of rheumatoid arthritis (RA), and identified a potential new treatment option. The plasma levels of RIPK1 and MLKL were found to be higher in RA patients and positively correlated with disease severity. Treatment with KW2449, a small molecule inhibitor targeting RIPK1, reduced joint inflammation and tissue damage in an animal model of RA. These findings suggest that RIPK1-dependent necroptosis could be a therapeutic target for RA.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Chaitanya K. Gavini, Nadia Elshareif, Gregory Aubert, Anand Germanwala, Nigel A. Calcutt, Virginie Mansuy-Aubert
Summary: The study shows that activating LXR may delay peripheral nervous system aging in the elderly, thereby improving symptoms in aged mice with neuropathy.
JOURNAL OF NEUROINFLAMMATION
(2022)
Article
Biochemistry & Molecular Biology
Ju-Eun Hong, Chang-Gun Lee, Soonjae Hwang, Junyoung Kim, Minjeong Jo, Da-Hye Kang, Sang-Hyeon Yoo, Woo-Seung Kim, Yongheum Lee, Ki-Jong Rhee
Summary: This study found that pulsed electromagnetic field (PEMF) can alleviate inflammation in rheumatoid arthritis (RA), particularly at a frequency of 10 Hz. The treated mice had lower levels of joint inflammation and IL-1 beta. The results suggest that PEMF treatment can preserve joint morphology and delay the occurrence of RA.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Microbiology
Jiah Yeom, Dong Joon Yim, Seongho Ma, Young-Hee Lim
Summary: P. freudenreichii MJ2 inhibits osteoclast differentiation and improves rheumatoid arthritis in both in vitro and in vivo studies. Live and dead MJ2 showed similar therapeutic effects in the arthritis model.
Article
Immunology
Hongxing Wang, Nanyang Zhang, Kehua Fang, Xiaotian Chang
Summary: This study investigated the metabolic regulatory mechanism of glycolysis in collagen-induced arthritis (CIA) by treating rats with 2-deoxy-D-glucose (2-DG), an inhibitor of glycolysis. The analysis revealed significant changes in metabolic pathways in the plasma, liver, and spleen during the CIA process, with opposite changes following 2-DG treatment. The involvement of spleen and liver metabolism in CIA under the control of glycolysis was suggested.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Takashi Nawata, Hiroki Sakai, Takeshi Honda, Marina Otsuka, Hina Fujita, Hitoshi Uchinoumi, Shigeki Kobayashi, Takeshi Yamamoto, Masataka Asagiri, Masafumi Yano
Summary: Dantrolene inhibits Ca2+ leakage from destabilized ryanodine receptors and shows potential as a therapeutic agent against endoplasmic reticulum stress-associated diseases. In a mouse model of collagen-induced arthritis, oral administration of dantrolene significantly reduces arthritic scores, suppresses bone and chondral destruction, and inhibits the production of serum anti-type II collagen IgG. These findings suggest that dantrolene may be a potential anti-rheumatic drug.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Food Science & Technology
Yunhui Min, Yunji Heo, Fang Feng, Dahye Kim, Mangeun Kim, Jiwon Yang, Hyo Jin Kim, Youngheun Jee, Mrinmoy Ghosh, Inhae Kang, Young-Ok Son
Summary: Excessive consumption of sucrose leads to hepatic fibrosis and inflammation, increasing the risk of rheumatoid arthritis (RA) pathogenesis.
MOLECULAR NUTRITION & FOOD RESEARCH
(2023)
Article
Immunology
Yaling Tian, Ping Shi, Yan Zhou, Rui Yuan, Zhicheng Hu, Yan Tan, Guilan Ma, Lei Yang, Hongmei Jiang
Summary: The study successfully constructed tolDCs, and found that they had long-term tolerogenic potential in vivo, which could improve arthritis in CIA rats with different severity.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Instruments & Instrumentation
Abhirami Thumsi, Srivatsan J. J. Swaminathan, Joslyn L. L. Mangal, Abhirami P. P. Suresh, Abhinav P. P. Acharya
Summary: The reprogramming of immune cells' metabolism can improve their function and reduce the severity of autoimmune diseases. In this study, a rheumatoid arthritis (RA) mouse model was developed to mimic immune flare-ups. The use of immune metabolic modulator paKG(PFK15 + bc2) microparticles (MPs) effectively reduced clinical symptoms of RA in mice.
DRUG DELIVERY AND TRANSLATIONAL RESEARCH
(2023)
Article
Immunology
Lisheng Wu, Ran Wang, Yi Zhou, Di Zhao, Feilong Chen, Xianghui Wu, Xiaoguang Chen, Shixian Chen, Juan Li, Junqing Zhu
Summary: In rheumatoid arthritis, the infiltration of NK cells in the joints positively correlates with disease progression, inflammation, and bone destruction, but their pathogenic role may be independent of the NKp46 receptor.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Orthopedics
Jianhai Chen, Jian Li, Jinqing Chen, Wenxiang Cheng, Jietao Lin, Liqing Ke, Gang Liu, Xueling Bai, Peng Zhang
Summary: The study demonstrated that the Notch signaling pathway inhibitor LY411575 is effective in treating collagen-induced arthritis (CIA) by improving the joint destruction and bone loss in rats. It also reduced the severity of ankle joint inflammation and significantly decreased the expression of N1ICD and N3ICD.
JOURNAL OF ORTHOPAEDIC TRANSLATION
(2021)
Article
Immunology
Anqi Li, Zhanfeng Zhang, Xiaochen Ru, Yanfeng Yi, Xiaoyu Li, Jing Qian, Jue Wang, Xiaobing Yang, Yunliang Yao
Summary: Through gene expression analysis, a total of 1,885 up-regulated and 1,899 down-regulated DEGs were identified in RA samples. The analysis showed significant differences in the infiltration of 25 cells, and 603 immune-related genes were obtained through WGCNA, with 270 DEIRGs identified. Enrichment analysis indicated that DEIRGs were associated with immunity-related biological processes, and 4 candidate biomarkers were identified through the PPI network.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Multidisciplinary Sciences
Jing He, Yanan Chu, Jing Li, Qingren Meng, Yudong Liu, Jiayang Jin, Yifan Wang, Jian Wang, Bo Huang, Lianjie Shi, Xing Shi, Jiayi Tian, Yunzhi Zhufeng, Ruiling Feng, Wenjing Xiao, Yuzhou Gan, Jianping Guo, Changjun Shao, Yin Su, Fanlei Hu, Xiaolin Sun, Jun Yu, Yu Kang, Zhanguo Li
Summary: This study reveals the imbalance between butyrate-producing and butyrate-consuming species in rheumatoid arthritis patients. It shows that butyrate promotes the production of T-regs and reduces inflammation. Butyrate supplementation can alleviate inflammation by rebalancing immune cells and reducing antibody production.
Article
Biochemistry & Molecular Biology
Zhenzhen Zhang, Jin Zhao, Kuan Chen Lai, Laijun Lai
Summary: The study found that TAPBPL protein can significantly ameliorate CII-induced arthritis in mice and reduce the expression of inflammatory cytokines. The results suggest that TAPBPL protein has the potential to be used in the treatment of patients with RA.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Rheumatology
Oh Chan Kwon, Yong-Beom Park, Min-Chan Park
Summary: This study aimed to assess the effect of statins on the prevention of recurrent thrombosis in patients with thrombotic APS. The results showed that the use of statins was associated with a lower risk of recurrent thrombosis, suggesting that statins could be effective in reducing the risk of recurrent thrombosis in these patients.
Article
Rheumatology
Oh Chan Kwon, Min-Chan Park
Summary: This study determined the cut-off values of BASDAI for determining disease activity states in ankylosing spondylitis patients. The study found that BASDAI values of 1.9, 3.5, and 4.9 corresponded to ASDAS-CRP values of 1.3, 2.1, and 3.5, respectively. The agreement between disease activity states based on BASDAI and ASDAS-CRP cut-off values was good.
Article
Medicine, General & Internal
Hye Won Kim, Eun-Jeong Yoon, Seok Hoon Jeong, Min-Chan Park
Summary: This study reveals differences in microbiota composition between patients with asymptomatic hyperuricemia (asHU) and those with gout. The gut microbiota in asHU patients may have a protective effect against gout development, while in gout patients it may play a role in gout provocation. Uric acid-lowering therapy (ULT) alters the gut microbiota in gout patients, potentially alleviating gout pathology and mitigating gout progression.
YONSEI MEDICAL JOURNAL
(2022)
Article
Rheumatology
Oh Chan Kwon, Min-Chan Park
Summary: This study determines the cut-off values for age and symptom duration to differentiate radiographic axSpA from non-radiographic axSpA, aiming to select the preferred first-line imaging modality. Patients older than 33.5 years with a symptom duration longer than 4.1 years should undergo X-ray imaging as the first-line modality, while patients younger than 33.5 years with a symptom duration less than 4.1 years should undergo MRI as the first-line modality.
THERAPEUTIC ADVANCES IN MUSCULOSKELETAL DISEASE
(2022)
Article
Immunology
Donghyun Kim, Ye Jin Jeong, Yerin Lee, Jihoon Choi, Young Min Park, Oh Chan Kwon, Yong Woo Ji, Sung Jun Ahn, Hyung Keun Lee, Min-Chan Park, Jae-Yol Lim
Summary: Recent studies have shown that the oral microbiome in patients with Sjogren's syndrome (SS) differs significantly from that in healthy individuals. The composition and diversity of the oral microbiome are correlated with clinical features of SS, especially ductal structures and salivary flow, suggesting that the oral microbiome may serve as a potential diagnostic biomarker for SS.
FRONTIERS IN IMMUNOLOGY
(2022)
Meeting Abstract
Rheumatology
O. C. Kwon, M. C. Park
ANNALS OF THE RHEUMATIC DISEASES
(2022)
Article
Multidisciplinary Sciences
Oh Chan Kwon, Kyungdo Han, Jaeyoung Chun, Ryul Kim, Seung Wook Hong, Jie-Hyun Kim, Young Hoon Youn, Hyojin Park, Min-Chan Park
Summary: The presence of immune-mediated inflammatory diseases in patients with type 2 diabetes increases their risk of cardiovascular morbidity and mortality, including stroke, myocardial infarction, cardiovascular mortality, and all-cause mortality.
SCIENTIFIC REPORTS
(2022)
Article
Immunology
Oh Chan Kwon, Min-Chan Park
Summary: A new disease activity assessment tool comprising high ESR, NIH criteria 1 and 4, and carotidynia demonstrated higher accuracy in discriminating active and inactive disease compared to currently used clinical assessment tools.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Oh Chan Kwon, Min-Chan Park, Yong-Gil Kim
Summary: The study aimed to identify serologic parameters associated with the disease activity of IgG4-related disease. In patients with normal serum IgG4 concentrations, only IgG concentration was correlated with disease activity. However, in patients with elevated serum IgG4 concentrations, ESR, C3, C4, IgG4 concentration, IgG concentration, and IgG4/IgG ratio were correlated with disease activity. Among these parameters, the combination of C3 and IgG4 concentration had the strongest correlation coefficient in this group.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Multidisciplinary Sciences
Oh Chan Kwon, Min-Chan Park
Summary: This retrospective cohort study included 228 newly diagnosed SLE patients, and found that patients who were double-positive for anti-dsDNA and anti-Sm antibodies at the time of diagnosis had a higher risk of flare-ups, while single-positive patients had a relatively lower risk.
SCIENTIFIC REPORTS
(2023)
Review
Immunology
Oh Chan Kwon, Min-Chan Park, Yong-Gil Kim
Summary: Interleukin-32 (IL-32) is an important cytokine involved in innate and adaptive immune responses, and its role has been studied in various rheumatic diseases. IL-32 plays different roles in different types of rheumatic diseases and could serve as a biomarker for disease activity or specific manifestations. This narrative review summarizes the associations between IL-32 and various rheumatic diseases and discusses its putative role as a biomarker in each disease.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Medicine, General & Internal
Oh Chan Kwon, See Young Lee, Jaeyoung Chun, Kyungdo Han, Yuna Kim, Ryul Kim, Min-Chan Park, Jie-Hyun Kim, Young Hoon Youn, Hyojin Park
Summary: This population-based cohort study in Korea found that patients with immune-mediated inflammatory diseases (IMIDs) had a lower risk of all-cause mortality compared to individuals without IMIDs. The risks of cancer-specific and cardiovascular disease-specific mortalities were also lower in IMID patients.
FRONTIERS IN MEDICINE
(2023)
Article
Medicine, General & Internal
Oh Chan Kwon, Yuna Kim, Jaeyoung Chun, Kyungdo Han, Min-Chan Park, Ryul Kim, Jie-Hyun Kim, Young Hoon Youn, Hyojin Park
Summary: This study aimed to assess whether the presence of immune-mediated inflammatory diseases (IMIDs) confers a higher risk of depression and anxiety in patients with type 2 diabetes (T2DM). The results showed that the existence of gut, joint, and skin IMIDs was associated with a higher risk of depression and anxiety. Patients with multiple IMIDs had a higher risk than those with only one.
FRONTIERS IN MEDICINE
(2023)
Article
Rheumatology
Oh Chan Kwon, Kyungdo Han, Min-Chan Park
Summary: Patients with systemic sclerosis have a higher risk of kidney failure compared to the general population.
Article
Rheumatology
Oh Chan Kwon, Min-Chan Park
Summary: While controlling inflammation with TNFi may be beneficial in reducing cardiovascular risk, our data indicate no TNFi-specific reduction in cardiovascular risk in patients with axSpA.
ARTHRITIS RESEARCH & THERAPY
(2022)