期刊
RHEUMATOLOGY
卷 49, 期 9, 页码 1654-1664出版社
OXFORD UNIV PRESS
DOI: 10.1093/rheumatology/keq154
关键词
Cartilage thickness; Rat knee; Magnetic resonance imaging; Experimental osteoarthritis; Volume
类别
资金
- CNRS
- CEA
- ANR [*ANR-09-BLAN-0150-01]
- Conseil General de Meurthe et Moselle
- Communaute Urbaine du Grand Nancy
- Conseil Regional
- Agence Nationale de la Recherche (ANR) [ANR-09-BLAN-0150] Funding Source: Agence Nationale de la Recherche (ANR)
Objective. To assess OA-related changes in mean compartmental femorotibial cartilage thickness in rat knees by three-dimensional (3D) MRI (7T). Methods. MRI was performed in vivo at 7T on OA and untouched contralateral knee joints. Gradient Echo Fast Imaging 3D MR images were acquired sequentially in surgically induced OA (D0) in 40 Wistar rats (anterior cruciate ligament transection). Mean femoral (trochlear, lateral and medial) and tibial (lateral and medial) cartilage thicknesses were quantified from a 2D MRI slide in weight-bearing areas and from a 3D MRI data set. At each time-point [Day (D) 8, D14, D21, D40 and D60], eight animals (16 knees) were sacrificed for concomitant histomorphometry. Results. As body weight dramatically increased throughout the experiment (+150%, baseline vs endpoint), all compartmental mean cartilage thicknesses noticeably decreased (D8, D14) and then remained relatively stable. Femoral compartments in OA knees were thinner at the end of the experiment than in contralateral age-matched knees. Conversely, lateral and medial tibial cartilages were thicker than controls. Histological correlation was significant only in untouched healthy cartilages (3D better than 2D). Conclusions. 3D MRI (7T) enables in vivo monitoring of compartmental changes in OA-related femorotibial rat cartilage thickness vs contralateral age-matched knees.
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