Article
Biochemistry & Molecular Biology
So Rae Song, Seung Un Seo, Seon Min Woo, Ji Yun Yoon, Simmyung Yook, Taeg Kyu Kwon
Summary: In this study, the research focused on the effect of traditional Chinese medicinal herb, Tubeimoside-1 (TBMS-1), on the sensitization of cancer cells to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL). The results showed that combination therapy using TBMS-1 and TRAIL increased apoptotic cell death. Mechanistically, TBMS-1 destabilized c-FLIP expression by downregulating STAMBPL1, a deubiquitinase (DUB). Moreover, knockdown of STAMBPL1 enhanced TRAIL-mediated apoptosis via c-FLIP downregulation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Infectious Diseases
Alejandra Arguelles, Ruth Sanchez-Fresneda, Elisa Martinez-Marmol, Jose Antonio Lozano, Francisco Solano, Juan Carlos Arguelles
Summary: The study found that a certain propolis extract from China displayed cytotoxic activity against Cryptococcus neoformans, and when combined with carnosic acid, it exhibited a stronger fungicidal effect. Furthermore, this combination also showed inhibitory effects on the metabolic activity of sessile cells forming biofilms.
Article
Biochemistry & Molecular Biology
Huijuan Zheng, Jun Li, Fangjian Ning, Wahyu Wijaya, Yunjiao Chen, Jie Xiao, Yong Cao, Qingrong Huang
Summary: The study utilized CA-NE to enhance bioaccessibility and bioactivities of CA, showcasing high loading capacity, small particle size, and homogeneous particle distribution. Results demonstrated a 2.8-fold increase in bioaccessibility of CA-NE compared to CA in MCT oil, indicating promising application potential as a functional food.
Article
Biochemistry & Molecular Biology
Katren F. Khella, Ahmed I. Abd El Maksoud, Amr Hassan, Shaimaa E. Abdel-Ghany, Rafaat M. Elsanhoty, Mohammed Abdullah Aladhadh, Mohamed A. Abdel-Hakeem
Summary: This study introduces a promising formula, CA-BSA-NPs, for treating breast and colon cancer, which has good drug loading capacity and release rate, and exhibits high antitumor activity.
Article
Biochemistry & Molecular Biology
Tainara Cristina Michelotti, Erminio Trevisi, Johan S. Osorio
Summary: The study evaluated the effects of carnosic acid, an antioxidant and anti-inflammatory compound found in rosemary plants, on dairy cows during the transition period. Results showed that carnosic acid promoted positive responses on inflammation and oxidative stress biomarkers in dairy cows and may have beneficial effects on lactation performance.
Article
Agricultural Engineering
Chang-Jia Mo, Yu-Qing Xu, Yu Feng, Ai-Jing Chen, Cheng-Wei Yang, He Ni
Summary: This study developed a simple and efficient method for simultaneous preparation of water-soluble and lipid-soluble rosemary extracts. The extraction rates of carnosic acid and rosmarinic acid were high, and the prepared carnosic acid effectively suppressed bacterial growth. The study efficiently utilized rosemary resources, reducing extraction costs, and promoted the antibacterial application of carnosic acid.
INDUSTRIAL CROPS AND PRODUCTS
(2022)
Article
Engineering, Chemical
Jose Pedro Wojeicchowski, Caroline Marques, Luciana Igarashi-Mafra, Joao A. P. Coutinho, Marcos R. Mafra
Summary: In this study, deep eutectic solvents (DES) based on choline chloride were used to extract phenolics from rosemary leaves, resulting in a compound with good antioxidant and antimicrobial activities. The optimized extract showed high antioxidant activity and significant antimicrobial effects against tested bacteria.
SEPARATION AND PURIFICATION TECHNOLOGY
(2021)
Article
Cell Biology
Anna-Christina Rambow, Insa Aschenbach, Sofie Hagelund, Doaa Tawfik, Jan-Paul Gundlach, Sebastian Weisse, Nicolai Maass, Anna Trauzold
Summary: Binding of TRAIL to its death domain-containing receptors TRAIL-R1 and TRAIL-R2 can induce cell death and/or pro-inflammatory signaling. The importance of TRAIL and TRAIL-R1/R2 in tumor immune surveillance and cancer biology has meanwhile been well documented. TRAIL also binds to TRAIL-R3 and TRAIL-R4, which have regulatory functions in apoptotic and non-apoptotic signaling pathways. Knockdown of TRAIL-R4 affects the activation of apoptotic and non-apoptotic pathways in cancer cells, showing opposing effects on cell death and clonogenic survival. TRAIL-R4 also regulates the expression of anti-apoptotic proteins and affects the activity of AKT, ERK, p38 and NF-kappa B. This study provides evidence for the important role of endogenous TRAIL-R4 in cancer cells and improves the understanding of the complex TRAIL/TRAIL-R system in humans.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Food Science & Technology
Yuqi Wang, Yilei Zhang, Xinyue Sun, Xu Shi, Shiwen Xu
Summary: This study demonstrates that DEHP and MPs have a synergistic toxic effect on the mouse pancreas, inducing oxidative stress and activating the GRP78/CHOP/Bcl-2 pathway to promote pancreatic cell apoptosis.
FOOD AND CHEMICAL TOXICOLOGY
(2022)
Article
Agriculture, Dairy & Animal Science
Malgorzata Bialek, Marian Czauderna, Kamil Zaworski, Katarzyna Krajewska
Summary: The study showed that adding carnosic acid, selenised yeast, or selenate to animal diets can increase beneficial fatty acids and tocopherols in fat and heart, while reducing the concentration of harmful substance malondialdehyde.
Article
Chemistry, Organic
Lucas K. Johnson, Scott W. Niman, Darius Vrubliauskas, Christopher D. Vanderwal
Summary: In this study, we report a structural revision of the abietane diterpenoid plebeianiol A through synthesis, achieved by a short, convergent sequence featuring a cobalt-catalyzed hydrogen-atom-transfer-induced radical bicyclization. Additionally, we connected plebeianiol A as a likely biogenetic precursor to another previously reported ether-bridged abietane. Finally, we demonstrated the efficiency of the key cyclization event with the A ring diol protected in different cyclic acetals or unprotected forms.
Article
Cell Biology
Rosario Yerbes, Rocio Mora-Molina, F. Javier Fernandez-Farran, Laura Hiraldo, Abelardo Lopez-Rivas, Carmen Palacios
Summary: This study reveals a previously unknown cell death mechanism triggered in glutamine-addicted tumor cells in response to glutamine metabolism limitation. The mechanism is regulated by GCN2 activation induced by glutamine starvation and involves the activation of the extrinsic apoptotic pathway mediated by TRAIL-R2.
CELL DEATH & DISEASE
(2022)
Article
Plant Sciences
Danlu Han, Wenliang Li, Zhuangwei Hou, Chufang Lin, Yun Xie, Xiaofang Zhou, Yuan Gao, Junwen Huang, Jianbin Lai, Li Wang, Liangsheng Zhang, Chengwei Yang
Summary: Rosemary is a sacred plant commonly used in cooking and traditional medicine due to its special fragrance. The study provides insights into the genes and genetic traits involved in the synthesis and regulation of aromatic terpenoids in rosemary.
Article
Chemistry, Medicinal
Gunya Sittithumcharee, Ryusho Kariya, Teerapich Kasemsuk, Rungnapha Saeeng, Seiji Okada
Summary: Acanthoic acid (AA) extracted from the traditional plant Croton oblongifolius Roxb. in Thailand is found to effectively inhibit the proliferation of PEL cells, demonstrating potential as a new treatment option for PEL.
PHYTOTHERAPY RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Yeliz Demir, Hamid Ceylan, Cuneyt Turkes, Sukru Beydemir
Summary: The study demonstrates the inhibitory effects of VA, CA, and UA on AR and SDH enzymes, potentially useful in preventing diabetic complications.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2022)
