期刊
RHEUMATOLOGY
卷 48, 期 8, 页码 899-905出版社
OXFORD UNIV PRESS
DOI: 10.1093/rheumatology/kep125
关键词
Juvenile idiopathic arthritis; Cluster analysis; Inflammation; Cytokines; Biomarkers
类别
资金
- Dutch Government [BSIK 03012]
- Netherlands Organization for Scientific Research (NWO) [016.048.603]
- Dutch Arthritis Foundation (Reumafonds)
- Netherlands Organization for Scientific Research (NWO)
Methods. Cytokine measurements were performed using multiplex immunoassays. Using heuristic clustering methods, we set out to compare the pattern of 30 cytokines in plasma and SF of JIA, RA, OA, or diabetes type II patients and healthy controls. Results. Analysis shows that oligo- and polyarticular JIA have similar biomarker profiles, both in plasma and SF. Systemic onset JIA (SoJIA) has a profile distinct from other JIA subtypes, suggesting that they involve different inflammatory processes. SoJIA samples do, however, cluster together with RA in SF, suggesting that these two conditions have similar cytokine profiles. Furthermore, we identify several clusters of ILs and chemokines that are co-expressed, suggesting that they are co-regulated. Conclusions. We show that previously undetected clusters of cytokines and patients can be identified by applying cluster analysis to multiplex data. Cytokine clusters identified in plasma and SF samples were quite different, which underscore the differential cytokine signalling in these two compartments, and suggest that plasma samples may not be suitable for estimating joint biomarker profiles and inflammation.
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