Article
Pharmacology & Pharmacy
Francisco C. Ceballos, Eugenio Chamizo-Carmona, Carmen Mata-Martin, Carmen Carrasco-Cubero, Juan J. Aznar-Sanchez, Raul Veroz-Gonzalez, Sara Rojas-Herrera, Pedro Dorado, Adrian LLerena
Summary: Methotrexate (MTX) is commonly used for rheumatoid arthritis (RA), but its effectiveness varies among patients. Pharmacogenetics has the potential to improve personalized treatment of RA by identifying genetic markers for MTX response. This study aimed to identify markers associated with MTX efficacy and toxicity in RA patients, and found several genetic associations. However, clinical factors were more important for predictive models. These findings highlight the potential of pharmacogenetics for personalized RA treatment, but more research is needed.
Review
Gastroenterology & Hepatology
Virginia Solitano, Antonio Facciorusso, Dermot P. B. Mcgovern, Tran Nguyen, Ruben J. Colman, Lily Zou, Brigid S. Boland, Silje W. Syversen, Kristin Kaasen Jorgensen, Christopher Ma, Alessandro Armuzzi, Aze Wilson, Vipul Jairath, Siddharth Singh
Summary: This study evaluated the association between HLA-DQA1*05 genotype and the risk of immunogenicity with TNF-a antagonists in patients with IMIDs. The meta-analysis showed that patients with HLA-DQA1*05 variants had a 75% higher risk of immunogenicity compared to non-carriers. The study also found that patients with HLA-DQA1*05 variants had a higher risk of secondary loss of response.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Article
Immunology
Alison D. Petro, Joseph Dougherty, Bryant R. England, Harlan Sayles, Michael J. Duryee, Carlos D. Hunter, Joel M. Kremer, Dimitrios A. Pappas, William H. Robinson, Jeffrey R. Curtis, Geoffrey M. Thiele, Ted R. Mikuls
Summary: In rheumatoid arthritis patients, the number of positive autoantibodies is dose-dependently associated with treatment response to biologics, with anti-CCP antibody positivity having the strongest impact.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Rheumatology
Katriona Goldmann, Athina Spiliopoulou, Andrii Iakovliev, Darren Plant, Nisha Nair, Cankut Cubuk, Paul McKeigue, Michael R. Barnes, Anne Barton, Costantino Pitzalis, Myles J. Lewis
Summary: This study conducted expression quantitative trait locus (eQTL) analysis using RNA-Sequencing to explore the link between genetic variants and gene expression in rheumatoid arthritis (RA) patients. The analysis identified 898 eQTL genes in synovium and blood, with 232 genes in common. A specific eQTL at HLA-DPB2 was found to be associated with clinical severity and the lympho-myeloid pathotype.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Article
Medicine, General & Internal
Edyta Majorczyk, Malgorzata Mazurek-Mochol, Andrzej Pawlik, Piotr Kusnierczyk
Summary: In this study, we examined 312 patients with rheumatoid arthritis and found that older age at disease onset, low ESR, no erosive disease, and negative RF were independent factors associated with a good response to methotrexate treatment. However, younger age at disease onset, the presence of RF, erosive disease, and a high level of ESR were associated with a worse response to methotrexate therapy.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Medicine, General & Internal
Alejandro Escudero-Contreras, Clementina Lopez-Medina, Eduardo Collantes-Estevez, Rafaela Ortega-Castro, Jerusalem Calvo-Gutierrez, Natalia Mena-Vazquez, Blanca Panero-Lamothe, Barbara Manzanares-Martin, Rafael Caliz-Caliz, Alberto Jimenez-Morales, Mayte Ruiz-Jimenez, Pilar Font-Ugalde
Summary: This study identified significant associations between the GGH-T401C genotype and MTX intolerance, and the ABCC2-C24T genotype and MTX intolerance. These findings may contribute to the development of new biomarkers and personalized medicine for patients with RA.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Tomasz Wysocki, Agnieszka Paradowska-Gorycka
Summary: Rheumatoid arthritis is a common inflammatory arthritis in which tumor necrosis factor plays a key role. However, there is variation in response to TNF-targeting drugs, which may be influenced by genetic factors. The field of pharmacogenomics offers potential for developing novel prognostic tools.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Pharmacology & Pharmacy
Varvara Choida, Margaret Hall-Craggs, Bethany R. Jebson, Corinne Fisher, Maria Leandro, Lucy R. Wedderburn, Coziana Ciurtin
Summary: This study evaluated the role of biomarkers in predicting and assessing biologic treatment response and clinical remission in JIA, proposing new strategies for biomarker use. Various types of biomarkers were reviewed, identifying candidates with potential clinical utility and highlighting the need for new biomarker discovery and improved clinical applications.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Multidisciplinary Sciences
Helen R. Gosselt, Costanza L. Vallerga, Pooja R. Mandaviya, Erik Lubberts, Johanna M. W. Hazes, Robert de Jonge, Sandra G. Heil
Summary: The study did not identify genome-wide significant differences as biomarkers for Methotrexate (MTX) therapy response, necessitating meta-analyses.
Article
Biochemistry & Molecular Biology
Yezan M. Salamoun, Kishore Polireddy, Yu Kyoung Cho, Matthew R. Medcalf, Ryan S. Funk
Summary: This study found that treatment with MTX led to significant reductions in arthritis activity, affecting levels of 5mTHF, NMI, and quinolone in the blood, which may serve as potential biomarkers for therapeutic response and disease activity.
Article
Medicine, General & Internal
Borja Hernandez-Breijo, Ioannis Parodis, Marta Novella-Navarro, Ana Martinez-Feito, Victoria Navarro-Compan, Mariana Diaz-Almiron, Dora Pascual-Salcedo, Alejandro Balsa, Chamaida Plasencia-Rodriguez
Summary: This study found that serum BAFF concentrations are associated with response to TNF inhibitors in rheumatoid arthritis patients, highlighting the importance of B-cells in RA.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Rheumatology
Paul Studenic, Daniel Aletaha, Maarten de Wit, Tanja A. Stamm, Farideh Alasti, Diane Lacaille, Josef S. Smolen, David T. Felson
Summary: This study aimed to externally validate a revised Boolean remission criteria using a higher patient global assessment (PtGA) threshold and validate the provisionally endorsed index-based criteria. The results showed that using the higher PtGA threshold increased the proportion of patients classified as achieving remission under the "Boolean2.0" criteria, improved agreement with index-based criteria, and did not compromise predictive value for radiographic or functional outcomes. The study findings were endorsed by ACR and EULAR.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Article
Biochemistry & Molecular Biology
Matthew R. Medcalf, Pooja Bhadbhade, Ted R. Mikuls, James R. O'Dell, Rebekah L. Gundry, Ryan S. Funk
Summary: The study found that RA patients have altered plasma metabolome which is partially normalized following initiation of MTX therapy. Different metabolites were found to be impacted in responders and non-responders to MTX therapy.
Article
Rheumatology
Claire Daien, Marek Krogulec, Paul Gineste, Jean-Marc Steens, Laurence Desroys du Roure, Sophie Biguenet, Didier Scherrer, Julien Santo, Hartmut Ehrlich, Patrick Durez
Summary: This study evaluated the safety and efficacy of ABX464 in patients with moderate-to-severe active rheumatoid arthritis. The results showed that ABX464 at a 50 mg dose was safe, well tolerated, and showed promising efficacy. The 100 mg dose had a high dropout rate due to gastrointestinal adverse events.
ANNALS OF THE RHEUMATIC DISEASES
(2022)
Article
Rheumatology
Gerasimos Evangelatos, George E. Fragoulis, Kalliopi Klavdianou, Melina Moschopoulou, Dimitrios Vassilopoulos, Alexios Iliopoulos
Summary: The study found that 43% of rheumatoid arthritis patients treated with RTX developed HGG. Patients who developed low IgG or low IgM had lower baseline levels than those who did not, and the development of low IgM was associated with better disease outcomes.
Article
Neurosciences
Houssni Abid, Dorthe Cartier, Abdallah Hamieh, Anne-Marie Francois-Bellan, Christine Bucharles, Hugo Pothion, Destiny-Love Manecka, Jerome Leprince, Sahil Adriouch, Olivier Boyer, Youssef Anouar, Isabelle Lihrmann
MOLECULAR NEUROBIOLOGY
(2019)
Article
Rheumatology
Cecile Bergua, Helene Chiavelli, Yves Allenbach, Louiza Arouche-Delaperche, Christophe Arnoult, Gwladys Bourdenet, Laetitia Jean, Rachid Zoubairi, Nicolas Guerout, Michael Mahler, Olivier Benveniste, Laurent Drouot, Olivier Boyer
ANNALS OF THE RHEUMATIC DISEASES
(2019)
Review
Immunology
Celine Anquetil, Olivier Boyer, Nadege Wesner, Olivier Benveniste, Yves Allenbach
AUTOIMMUNITY REVIEWS
(2019)
Article
Rheumatology
Audrey Aussy, Manuel Freret, Laure Gallay, Didier Bessis, Thierry Vincent, Denis Jullien, Laurent Drouot, Fabienne Jouen, Pascal Joly, Isabelle Marie, Alain Meyer, Jean Sibilia, Brigitte Bader-Meunier, Eric Hachulla, Mohammed Hamidou, Sophie Hue, Jean-Luc Charuel, Nicole Fabien, Pierre-Julien Viailly, Yves Allenbach, Olivier Benveniste, Nadege Cordel, Olivier Boyer, Zahir Amoura, Jessie Aouizerate, Francois-Jerome Authier, Ygal Benhamou, Jacques Benichou, Bilade Cherqaoui, Olivier Chosidow, Sebastien Debarbieux, Laurence Fardet, Julie Graveleau, Jean-Emmanuel Kahn, Vincent Langlois, Herve Levesque, Jerome Martin, Nihal Martis, Agathe Masseau, Lucile Musset, Antoine Neel, Viviane Queyrel-Moranne, Benjamin Terrier, Stephan Vinzio
ARTHRITIS & RHEUMATOLOGY
(2019)
Review
Immunology
Alexandre Couture, Anthony Garnier, Fabian Docagne, Olivier Boyer, Denis Vivien, Brigitte Le-Mauff, Jean-Baptiste Latouche, Olivier Toutirais
FRONTIERS IN IMMUNOLOGY
(2019)
Article
Immunology
Vivien Hebert, Marie Petit, Maud Who-Valliant, Marie-Laure Golinski, Gaetan Riou, Celine Derambure, Olivier Boyer, Pascal Joly, Sebastien Calbo
FRONTIERS IN IMMUNOLOGY
(2019)
Article
Surgery
Sophie Candon, Dominique Guerrot, Laurent Drouot, Mathilde Lemoine, Ludivine Lebourg, Melanie Hanoy, Olivier Boyer, Dominique Bertrand
Summary: The study found that transplant patients were able to mount strong T cell and antibody responses to the SARS-CoV-2 virus after reducing immunosuppressive therapy, aiding in differential diagnosis and potentially playing a role in the development of severe forms of the disease.
AMERICAN JOURNAL OF TRANSPLANTATION
(2021)
Review
Rheumatology
Yves Allenbach, Olivier Benveniste, Werner Stenzel, Olivier Boyer
NATURE REVIEWS RHEUMATOLOGY
(2020)
Editorial Material
Allergy
Raphael Lukaszewicz, Guillaume Mahay, Olivier Boyer, Jeremie Martinet
Article
Biochemistry & Molecular Biology
Marie Petit, Marie-Laure Walet-Balieu, Damien Schapman, Marie-Laure Golinski, Carole Burel, Marion Barray, Laurent Drouot, Maud Maho-Vaillant, Vivien Hebert, Olivier Boyer, Muriel Bardor, Pascal Joly, Sebastien Calbo
Summary: The pathogenicity of serum IgG in pemphigus patients is correlated with disease activity, and alterations in N-glycan structure can affect the in vitro pathogenicity of autoantibodies. The pathogenic properties of pemphigus IgG do not seem to be related to variations in IgG N-glycans during the course of the disease.
Article
Biochemistry & Molecular Biology
Guillaume Font, Marie-Laure Walet-Balieu, Marie Petit, Carole Burel, Maud Maho-Vaillant, Vivien Hebert, Philippe Chan, Manuel Freret, Olivier Boyer, Pascal Joly, Sebastien Calbo, Muriel Bardor, Marie-Laure Golinski
Summary: This study found that patients with pemphigus have specific changes in their IgG N-glycome, but these changes may be more related to susceptibility to autoimmunity rather than signs of inflammation.
Letter
Allergy
Raphael Lukaszewicz, Guillaume Mahay, Olivier Boyer, Jeremie Martinet
Article
Biochemistry & Molecular Biology
Sarah Julien, Douangsone Vadysirisack, Camil Sayegh, Sharan Ragunathan, Yalan Tang, Emma Briand, Marion Carrette, Laetitia Jean, Rachid Zoubairi, Henri Gonde, Olivier Benveniste, Yves Allenbach, Laurent Drouot, Olivier Boyer
Summary: In a humanized mouse model of IMNM, early administration of zilucoplan was found to prevent the onset of myopathy and significantly inhibit complement activation.
Meeting Abstract
Immunology
C. Abad, A. Meyer, L. Drouot, G. Bourdenet, C. Boitard, O. Boyer
EUROPEAN JOURNAL OF IMMUNOLOGY
(2019)
Meeting Abstract
Rheumatology
Brigitte Bader-Meunier, Cyril Gitiaux, Jean-Luc Charuel, Nicole Fabien, Isabelle Melki, Pierre Quartier, Alexandre Belot, Nathalie Streichenberger, Christine Bodemer, Audrey Aussy, Olivier Boyer
ANNALS OF THE RHEUMATIC DISEASES
(2019)
