Article
Infectious Diseases
B. D. Curry, E. van't Wout, E. Maasdorp, A. Nortje, E. M. Irusen, D. Maree, C. F. N. Koegelenberg, B. W. Allwood
Summary: This study found weak correlations between lung function testing and exercise capacity in patients with post-TB lung disease (PTLD), with only forced vital capacity (FVC) showing a higher correlation with peak oxygen consumption (VO(2)peak).
INTERNATIONAL JOURNAL OF TUBERCULOSIS AND LUNG DISEASE
(2022)
Article
Cardiac & Cardiovascular Systems
Carolina M. S. Messina, Eloara V. M. Ferreira, Inderjit Singh, Angelo X. C. Fonseca, Roberta P. Ramos, Luiz E. Nery, David M. Systrom, Rudolf K. F. Oliveira, Jaquelina S. Ota-Arakaki
Summary: The study revealed that peak RV stroke work index and Delta PA compliance significantly influence pVO2 in patients with idiopathic pulmonary arterial hypertension, highlighting the crucial role of hemodynamic coupling to exercise capacity in IPAH.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2021)
Article
Critical Care Medicine
Katarina Zeder, Alexander Avian, Gerhard Bachmaier, Philipp Douschan, Vasile Foris, Teresa Sassmann, Florentine C. Moazedi-Fuerst, Winfried B. Graninger, Franz Hafner, Marianne Brodmann, Wolfgang Salmhofer, Horst Olschewski, Gabor Kovacs
Summary: The study found that exercise pulmonary resistances and mPAP/CO and TPG/CO slopes are predictors of mortality in patients with systemic sclerosis with no or mildly increased mean pulmonary arterial pressure.
Article
Cardiac & Cardiovascular Systems
Erik H. Van Iterson, Leslie Cho, Adriano Tonelli, J. Emanuel Finet, Luke J. Laffin
Summary: In patients with HFrEF, demonstrating a restrictive pattern on spirometry yields the severest mortality risk associated with (V) over dotO(2peak). Using spirometry to screen patients with HFrEF for ventilatory defects has a potential role in improving risk stratification based on (V) over dotO(2peak).
Article
Respiratory System
Apama Balasubramanian, Nirupama Putcha, Neil R. MacIntyre, Robert L. Jensen, Gregory Kinney, William W. Stlinger, Craig P. Hersh, Russell P. Bowler, Richard Casaburi, MeiLan K. Han, Janos Porszasz, R. Graham Barr, Elizabeth Regan, Barry J. Make, Nadia N. Hansel, Robert A. Wise, Meredith C. McCormack
Summary: DLCO is a potential predictor of mortality in COPD patients, independent of BODE index and CT evidence. For every 10% decrease in DLCO percent predicted, mortality increases by 28%. Adding DLCO to BODE improves the predictive accuracy of the model for COPD.
ANNALS OF THE AMERICAN THORACIC SOCIETY
(2023)
Article
Multidisciplinary Sciences
Oystein Rasch-Halvorsen, Erlend Hassel, Ben M. Brumpton, Haldor Jenssen, Martijn A. Spruit, Arnulf Langhammer, Sigurd Steinshamn
Summary: This study aimed to assess the association of FEV1Z-score with VO2peak in COPD and investigate whether this association differs between emphysema (E-COPD) and non-emphysema (NE-COPD) phenotypes. The results showed that FEV1Z-score is positively associated with VO2peak, with a stronger association seen in E-COPD but no statistically significant difference by phenotype.
Article
Multidisciplinary Sciences
Yosuke Wada, Norihiko Goto, Yoshiaki Kitaguchi, Masanori Yasuo, Masayuki Hanaoka
Summary: The objective of this study was to generate appropriate reference values for lung function parameters in the Japanese population and assess their applicability compared to existing values. The results showed that the reference values obtained in this study were more suitable for the Japanese population than those reported by the Global Lung Function Initiative in 2017. Differences in the equations were attributed to underestimation of the transfer coefficient and overestimation of alveolar volume in the GLI-2017 guidelines for the Japanese population.
Article
Surgery
Sidra N. Bonner, Kiran Lagisetty, Rishindra M. Reddy, Yadonay Engeda, Jennifer J. Griggs, Thomas S. Valley
Summary: The removal of race correction in pulmonary function tests is important because it wrongly assumes worse lung function in African Americans and may contribute to disparities in lung cancer treatment. This study found that the use of race correction in PFTs affected surgeon treatment recommendations for African American patients, highlighting the need for awareness and changes in testing.
Article
Respiratory System
Devin B. Phillips, Matthew D. James, Amany F. Elbehairy, Kathryn M. Milne, Sandra G. Vincent, Nicolle J. Domnik, Juan P. De-Torres, J. Alberto Neder, Denis E. O'Donnell
Summary: The study suggests that in COPD patients, a combination of low resting DLCO and high exercise ventilatory requirements may be associated with early dynamic mechanical constraints, dyspnea, and exercise limitation.
Article
Multidisciplinary Sciences
Antonella Lo Mauro, Gabriella Tringali, Franco Codecasa, Laura Abbruzzese, Alessandro Sartorio, Andrea Aliverti
Summary: Obesity is frequently associated with breathing disorders, especially restrictive lung defect. Otherwise healthy obesity might not be characterized by a systematic restrictive lung pattern. Obesity can lead to increased respiratory rate and poor thoracic expansion. Opto-electronic plethysmography provides valuable information for subjects with obesity and can help localize the restrictive effect of obesity.
SCIENTIFIC REPORTS
(2023)
Article
Medicine, General & Internal
Loukianos S. Rallidis, Konstantina Papangelopoulou, Anastasia Anthi, Iraklis Tsangaris, Christos Varounis, Georgios Makavos, Dimitrios Konstantonis, Panagiotis Vlachoyiannopoulos, Stylianos E. Orfanos, Efstathios K. Iliodromitis
Summary: This study investigated the diagnostic accuracy of exercise Doppler echocardiography for PAH in systemic sclerosis patients, revealing that post-exercise TR velocity >3.4 m/s had high sensitivity and accuracy in detecting PAH, and was positively correlated with RV contractile reserve.
Article
Respiratory System
Kathrin Kahnert, Lilli Maria Lempert, Juergen Behr, Laura Elsner, Toki Bolt, Amanda Tufman, Diego Kauffmann-Guerrero
Summary: This study found that lung function testing results are associated with prognosis in SCLC patients. Hyperinflation and reduced diffusing capacity were correlated with poorer outcomes. Therefore, body plethysmography and measurement of diffusing capacity should be included in the pre-therapeutic assessment of SCLC patients.
THERAPEUTIC ADVANCES IN RESPIRATORY DISEASE
(2023)
Article
Genetics & Heredity
Antonella LoMauro, Davide Lacca, Vittorio Landoni, Andrea Aliverti
Summary: Although Osteogenesis Imperfecta (OI) affects connective tissue, it can also result in compromised pulmonary function due to thoracic deformities. This study used opto-electronic plethysmography (OEP) to analyze trunk motion and respiratory kinematics in adult OI patients, particularly during maximal inspiratory and expiratory expansions. The results showed that Type III OI patients had lower lung volumes and sleep quality, as well as a more compressed thoracic configuration and reduced global expansion. The kinematics of the trunk changed to compensate for the structural deformities, and the restriction in OI patients was localized to the lateral part of the thorax. The 3D analysis proposed in this study provides a new method for studying the pathophysiology of chest wall restriction.
ORPHANET JOURNAL OF RARE DISEASES
(2022)
Article
Medicine, General & Internal
Barbara Wagner, Andrej Zdravkovic, Michael Pirchl, Milo A. Puhan, Ralf Harun Zwick, Vincent Grote, Richard Crevenna, Michael J. Fischer
Summary: The study introduced a new method, T2D, for classifying patient performance before and after rehabilitation, which takes into account the patient's current status and changes over time. Results showed that some patients, after reaching the MCID standard in absolute differences, were still classified as below average by T2D, and vice versa.
Article
Multidisciplinary Sciences
Timothy Howarth, Helmi Ben Saad, Ara J. Perez, Charmain B. Atos, Elisha White, Subash S. Heraganahally
Summary: This study identified significant differences in DLCO and TLC parameters between Indigenous Australians compared to Australian Caucasians, highlighting the need for establishing appropriate norms for Indigenous Australians.