Article
Biochemistry & Molecular Biology
Rakesh Mishra, Ramalingam Bethunaickan, Celine C. Berthier, Zhengzi Yi, Joshua J. Strohl, Patricio T. Huerta, Weijia Zhang, Anne Davidson
Summary: The study found significant disruption of renal circadian rhythms in mice with lupus nephritis, affecting multiple renal pathways including homeostasis, metabolism, and blood pressure regulation. Induction of remission therapy partially reversed this circadian dysregulation.
MOLECULAR MEDICINE
(2021)
Article
Urology & Nephrology
Changming Zhang, Xu Han, Ying Jin, Xiang Chen, Cheng Gong, Jiahui Peng, Yusha Wang, Xiaoxin Luo, Zhaohui Yang, Yangyang Zhang, Weiguo Wan, Xiaohui Liu, Jianhua Mao, Haiguo Yu, Jingyi Li, Li Liu, Li Sun, Sirui Yang, Yu An, Zhengzhao Liu, Erzhi Gao, Honghao Zhu, Yinghua Chen, Xiaomin Yu, Qing Zhou, Zhihong Liu
Summary: In this study, whole-exome sequencing was used to screen pathogenic gene variants in 1886 patients with lupus nephritis. 71 patients were confirmed to have Mendelian form of lupus nephritis, involving 63 variants in 39 pathogenic genes. In addition, it was found that patients with pathogenic gene variants had increased inflammatory manifestations and lower overall survival rate.
CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2023)
Review
Biochemistry & Molecular Biology
Rozita Mohd, Siok-Fong Chin, Syahrul Sazliyana Shaharir, Qin Shi Cham
Summary: Lupus nephritis is a severe manifestation of systemic lupus erythematosus (SLE) caused by immune dysregulation and kidney inflammation. Recent findings suggest that gut microbiota may play a key role in enhancing immune complex deposition and inflammation in the kidneys. In this review, we aim to explore the potential link between gut microbiota and the immune system, with a focus on renal inflammation, and discuss potential novel therapies to improve or complement current treatment of lupus nephritis.
Article
Rheumatology
Declan Webber, Jingjing Cao, Daniela Dominguez, Dafna D. Gladman, Andrea Knight, Deborah M. Levy, Fangming Liao, Lawrence Ng, Andrew D. Paterson, Zahi Touma, Joan Wither, Murray Urowitz, Earl D. Silverman, Linda T. Hiraki
Summary: This study identified a genetic variant in the WIPF1 gene that is associated with an increased risk of osteonecrosis (ON) in people with childhood-onset and adult-onset systemic lupus erythematosus (SLE). This finding provides valuable information for assessing the risk of ON in SLE patients.
Article
Medicine, General & Internal
Sung-Eun Choi, Dong-Jin Park, Ji-Hyoun Kang, Shin-Seok Lee
Summary: This study found that in Korean patients with biopsy-proven lupus nephritis, those who had simultaneous positivity for anti-dsDNA, nucleosome, and histone antibodies (3-pos) had higher disease activity and worse renal histopathology, and were more prone to experience a rapid decline in renal function.
ANNALS OF MEDICINE
(2023)
Review
Allergy
Katherine A. Owen, Amrie C. Grammer, Peter E. Lipsky
Summary: It has been found that patients of non-European ancestry experience more severe systemic lupus erythematosus (SLE) with different responses to standard medications. Despite extensive research, it remains unclear why ancestry remains a key determinant of poorer outcomes for non-European-ancestry patients. Novel bioinformatic and pathway-based approaches have shed light on the complex genetic architecture linking ancestry to SLE susceptibility.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Yves Renaudineau, Wesley Brooks, Julie Belliere
Summary: Lupus nephritis is the most severe organ manifestation of systemic lupus erythematosus. Efforts have been made to characterize the different steps of the disease and develop biomarkers for early diagnosis, disease monitoring, and preventing complications.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Urology & Nephrology
Dimas Abdirama, Sebastian Tesch, Anna-Sophie Griessbach, Caroline von Spee-Mayer, Jens Y. Humrich, Ulrik Stervbo, Nina Babel, Christian Meisel, Tobias Alexander, Robert Biesen, Petra Bacher, Alexander Scheffold, Kai-Uwe Eckardt, Falk Hiepe, Andreas Radbruch, Gerd-Rudiger Burmester, Gabriela Riemekasten, Philipp Enghard
Summary: Systemic lupus erythematosus is characterized by loss of tolerance towards nuclear antigens with autoreactive CD4(+) T cells implicated in disease pathogenesis. The frequencies of nuclear antigen specific CD4(+) T cells correlate with disease severity, and these cells produce multiple effector cytokines. These previously unrecognized characteristics support a role for nuclear antigen-specific CD4(+) T cells in systemic lupus erythematosus.
KIDNEY INTERNATIONAL
(2021)
Article
Immunology
Ch Lopez-Pedrera, A. M. Patino-Trives, T. Cerdo, R. Ortega-Castro, I. Sanchez-Pareja, A. Ibanez-Costa, L. Munoz-Barrera, M. C. Abalos-Aguilera, D. Ruiz-Vilchez, P. Segui Azpilcueta, M. Espinosa, N. Barbarroja, A. Escudero-Contreras, J. P. Castano, R. Luque, R. Ortega, M. A. Aguirre, C. Perez-Sanchez
Summary: This study characterized the splicing machinery (SM) of leukocytes from patients with primary antiphospholipid syndrome (APS), systemic lupus erythematosus (SLE), and antiphospholipid syndrome with lupus (APS + SLE), and assessed its clinical involvement. The results showed that leukocytes from APS, SLE, and APS + SLE patients displayed significant and specific alterations in SM-components (SMC), which were associated with clinical features. This study identified a specific alteration of SMC in leukocytes from APS, SLE, and APS + SLE patients, which may be responsible for the development of distinctive clinical profiles.
JOURNAL OF AUTOIMMUNITY
(2023)
Article
Cell Biology
Da-Cheng Wang, Wang-Dong Xu, Shen-Nan Wang, Xiang Wang, Wei Leng, Lu Fu, Xiao-Yan Liu, Zhen Qin, An-Fang Huang
Summary: The objective of this study was to establish a machine learning pipeline for the diagnosis of lupus nephritis (LN). A cohort of SLE patients was analyzed, and important features such as ASO, RBP, LA1, LA2, and proteinuria were identified using a collective feature selection method. The XGB model based on these features showed the best performance for LN diagnosis.
INFLAMMATION RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Maria Radanova, Vasil Vasilev, Galya Mihaylova, Mariya Kosturkova, Uday Kishore, Lubka Roumenina
Summary: Anti-C1q autoantibodies are important biomarkers in lupus nephritis and are associated with the severity of renal injury.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Immunology
Rahul Raiker, Haig Pakhchanian, Charles DeYoung, Latika Gupta, Sinan Kardes, Sakir Ahmed, Chengappa Kavadichanda
Summary: Individuals with lupus who contracted COVID-19 had comparable mortality but higher risks of hospitalization, ICU admission, mechanical ventilation, stroke, VTE, and sepsis compared to the general population. Factors such as gender, race, presence of nephritis, and use of immunomodulators were associated with COVID-19 outcomes.
JOURNAL OF AUTOIMMUNITY
(2021)
Article
Rheumatology
Andrea Fava, Paride Fenaroli, Avi Rosenberg, Serena Bagnasco, Jessica Li, Jose Monroy-Trujillo, Derek Fine, Mohamed G. Atta, Michelle Petri
Summary: This study aims to elucidate the prognostic value of a history of class switch in pure membranous lupus nephritis (LN). The findings suggest that the conversion from proliferative to membranous LN, and vice versa, is frequent in SLE patients, and can occur at any time during the course of the disease. Evidence of prior proliferative LN is associated with a higher risk of end stage kidney disease (ESKD) in non-proliferative LN.
Article
Hematology
Carl Petrus Linge, Andreas Jern, Helena Tyden, Birgitta Gullstrand, Hong Yan, Charlotte Welinder, Robin Kahn, Andreas Jonsen, John W. Semple, Anders A. Bengtsson
Summary: This study found that platelets in patients with SLE have a decreased size and a specific protein profile, including immunoglobulins, complement proteins, and autoantigens. The presence of these proteins may contribute to the pathogenesis of SLE.
THROMBOSIS AND HAEMOSTASIS
(2022)
Review
Immunology
Haeun Ko, Chan Johng Kim, Sin-Hyeog Im
Summary: Systemic Lupus Erythematosus (SLE) is a chronic autoimmune disease that mainly affects women in their reproductive years. Type 2 immune responses are involved during the pathology of SLE.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Rheumatology
S. Louis Bridges, Steffen Gay
RHEUMATIC DISEASE CLINICS OF NORTH AMERICA
(2024)
Article
Rheumatology
Joshua F. Baker, Daniel G. Baker
RHEUMATIC DISEASE CLINICS OF NORTH AMERICA
(2024)
Article
Rheumatology
William Neal Roberts Jr, Edward R. Lew, Matthew H. Liang
RHEUMATIC DISEASE CLINICS OF NORTH AMERICA
(2024)
Article
Rheumatology
Daniel A. Albert
RHEUMATIC DISEASE CLINICS OF NORTH AMERICA
(2024)
Article
Rheumatology
Virginia D. Steen, Thomas A. Medsger
RHEUMATIC DISEASE CLINICS OF NORTH AMERICA
(2024)
Article
Rheumatology
Patricia Woo, Ross E. Petty
RHEUMATIC DISEASE CLINICS OF NORTH AMERICA
(2024)
Article
Rheumatology
H. James Williams, Grant W. Cannon, Daniel O. Clegg
RHEUMATIC DISEASE CLINICS OF NORTH AMERICA
(2024)
Biographical-Item
Rheumatology
Daniel J. Wallace
RHEUMATIC DISEASE CLINICS OF NORTH AMERICA
(2024)
Article
Rheumatology
Ann K. Rosenthal, Mary E. Csuka, Paul Halverson
Summary: Dr. McCarty is a giant in the field of rheumatology. His clinical and scientific discoveries have had a major impact and benefited many patients. He has been an exceptional mentor and role model, influencing our clinical practice styles, the importance we place on clinical observation, and our approach to scientific questions.
RHEUMATIC DISEASE CLINICS OF NORTH AMERICA
(2024)
Article
Rheumatology
Arthur Weinstein
RHEUMATIC DISEASE CLINICS OF NORTH AMERICA
(2024)
Article
Rheumatology
Marc C. Hochberg
RHEUMATIC DISEASE CLINICS OF NORTH AMERICA
(2024)
Article
Rheumatology
Richard M. Silver
RHEUMATIC DISEASE CLINICS OF NORTH AMERICA
(2024)
Article
Rheumatology
Anthony M. Reginato, Michelle A. Petri, Jonathan Kay
Summary: Bauer and Ropes were influential figures in the field of rheumatology, making significant contributions through clinical observation and laboratory research. They were also exceptional mentors and leaders in the field.
RHEUMATIC DISEASE CLINICS OF NORTH AMERICA
(2024)
Article
Rheumatology
Mary K. Crow, Josef S. Smolen
RHEUMATIC DISEASE CLINICS OF NORTH AMERICA
(2024)
Article
Rheumatology
James S. Louie
RHEUMATIC DISEASE CLINICS OF NORTH AMERICA
(2024)