Article
Rheumatology
Zhixiu Li, Mohammad Kazim Khan, Sjef M. van der Linden, Bjorn Winkens, Peter M. Villiger, Heinz Baumberger, Hermine van Zandwijk, Muhammad Asim Khan, Matthew A. Brown
Summary: This study found that patients with ankylosing spondylitis (AS) have a higher mortality rate compared to the general population, and healthy individuals carrying the HLA-B27 gene also have a similar risk. Additionally, female patients have a lower life expectancy. However, in the overall European population, the presence of the HLA-B27 gene does not affect survival or the risk of death from cardiovascular disease.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Article
Rheumatology
Samantha S. R. Crossfield, Helena Marzo-Ortega, Sarah R. Kingsbury, Mar Pujades-Rodriguez, Philip G. Conaghan
Summary: This study found that the incidence of ankylosing spondylitis decreased between 1998 and 2007, then increased from 2007 to 2017. The rising prevalence may indicate improved patient survival. However, there is a persisting delay in rheumatology referral and diagnosis, particularly in women.
Article
Rheumatology
Adrian Ciurea, Andrea Gotschi, Seraphina Kissling, Alexander Bernatschek, Kristina Burki, Pascale Exer, Michael J. Nissen, Burkhard Moller, Almut Scherer, Raphael Micheroli
Summary: This study compared the characteristics of patients with axial spondyloarthritis (axSpA) and psoriatic arthritis (PsA), and found differences in demographic and clinical features between the two groups, but a similar disease burden.
Article
Rheumatology
Clementina Lopez-Medina, Anna Molto, Joachim Sieper, Tuncay Duruoz, Uta Kiltz, Bassel Elzorkany, Najia Hajjaj-Hassouni, Ruben Burgos-Vargas, Jose Maldonado-Cocco, Nelly Ziade, Meghna Gavali, Victoria Navarro-Compan, Shue-Fen Luo, Sara Monti, Kim Tae-Jong, Mitsumasa Kishimoto, F. M. Pimentel-Santos, Jieruo Gu, Ruxandra Schiotis, Floris A. van Gaalen, Pal Geher, Marina Magrey, Sebastian E. Ibanez Vodnizza, Wilson Bautista-Molano, Walter Maksymowych, Pedro M. Machado, Robert Landew, Desiree van der Heijde, Maxime Dougados
Summary: This study included 4465 patients with SpA from 24 countries around the world, showing quantitative differences in peripheral manifestations among different subtypes but no significant qualitative differences. It was found that a high proportion of patients with SpA had both axial and peripheral manifestations coinciding.
Article
Rheumatology
Carina Goetestam Skorpen, Stian Lydersen, Kjell Asmund Salvesen, Hege Suorza Svean Koksvik, Bente Jakobsen, Marianne Wallenius
Summary: This study analyzed the pregnancy outcomes of women with axial spondyloarthritis (axSpA) and psoriatic arthritis (PsA). The results showed that active inflammation increased the risk of cesarean section, which delayed recovery from inflammatory pain and stiffness.
Article
Rheumatology
Xabier Michelena, Clementina Lopez-Medina, Alba Erra, Xavier Juanola, Pilar Font-Ugalde, Eduardo Collantes, Helena Marzo-Ortega
Summary: This study compared the clinical and radiographical characteristics of axial psoriatic arthritis (PsA) with ankylosing spondylitis (AS) with psoriasis. It found that axial PsA is predominantly HLA-B27 negative and has different manifestations compared to AS with psoriasis. There is great heterogeneity in the definition of axial PsA from a clinical and imaging perspective.
Review
Rheumatology
Y. Alamanos, E. Pelechas, P. V. Voulgari, A. A. Drosos
Summary: This study systematically reviewed research on the incidence of SpA subtypes over the past 25 years, finding significant differences in methodology among studies leading to a wide range of incidence rates for all subtypes. More research from different populations using specific classification criteria is needed for a more accurate understanding of SpA epidemiology.
CLINICAL AND EXPERIMENTAL RHEUMATOLOGY
(2021)
Review
Rheumatology
Victoria Navarro-Compan, Alexandre Sepriano, Bassel El-Zorkany, Desiree van der Heijde
Summary: Axial spondyloarthritis is a chronic inflammatory disease primarily affecting the axial skeleton, leading to symptoms such as chronic back pain and spinal stiffness. Diagnosis relies on recognizing clinical patterns and utilizing clinical, laboratory, and imaging features. Treatment options include non-steroidal anti-inflammatory drugs as first-line therapy, with biologics as a second-line option, showing efficacy in improving disease symptoms.
ANNALS OF THE RHEUMATIC DISEASES
(2021)
Article
Rheumatology
Pedro M. Machado, Martin Schaefer, Satveer K. Mahil, Jean Liew, Laure Gossec, Nick Dand, Alexander Pfeil, Anja Strangfeld, Anne Constanze Regierer, Bruno Fautrel, Carla Gimena Alonso, Carla G. S. Saad, Christopher E. M. Griffiths, Claudia Lomater, Corinne Miceli-Richard, Daniel Wendling, Deshire Alpizar Rodriguez, Dieter Wiek, Elsa F. Mateus, Emily Sirotich, Enrique R. Soriano, Francinne Machado Ribeiro, Felipe Omura, Frederico Rajao Martins, Helena Santos, Jonathan Dau, Jonathan N. Barker, Jonathan Hausmann, Kimme L. Hyrich, Lianne Gensler, Ligia Silva, Lindsay Jacobsohn, Loreto Carmona, Marcelo M. Pinheiro, Marcos David Zelaya, Maria de los Angeles Severina, Mark Yates, Maureen Dubreuil, Monique Gore-Massy, Nicoletta Romeo, Nigil Haroon, Paul Sufka, Rebecca Grainger, Rebecca Hasseli, Saskia Lawson-Tovey, Suleman Bhana, Thao Pham, Tor Olofsson, Wilson Bautista-Molano, Zachary S. Wallace, Zenas Z. N. Yiu, Jinoos Yazdany, Philip C. Robinson, Catherine H. Smith
Summary: This study investigated factors associated with severe COVID-19 in patients with psoriasis, psoriatic arthritis, and axial spondyloarthritis. The study found that age, sex, comorbidities, disease activity, and glucocorticoid use were associated with the severity of COVID-19. Additionally, later pandemic time periods, psoriasis, and the use of TNFi, IL17i, and IL-23i/IL-12+23i were associated with a reduced risk of severe COVID-19.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Review
Rheumatology
Melanie Aureal, Milene Seauve, Soline Laplane, Jean-Christophe Lega, Natalia Cabrera, Fabienne Coury
Summary: This study aimed to estimate the incidence of infections among patients with psoriatic arthritis (PsA) or axial spondyloarthritis (axSpA) treated with different medications. Serious infections were rare in randomized controlled trials (RCTs) and real-life studies, while non-serious infections were more common in RCTs.
Article
Rheumatology
Robert D. Inman, Denis Choquette, Majed Khraishi, Dafna D. Gladman, Shamiza Hussein, Drew Neish, Patrick Leclerc
Summary: This study aimed to describe the real-world use of Secukinumab (SEC) in Canadian patients with axSpA. The results showed that SEC was effective in treating axSpA, with improvements in disease activity observed in patients after 12 months of treatment.
JOURNAL OF RHEUMATOLOGY
(2023)
Article
Rheumatology
Anton Jonatan Landgren, Mats Dehlin, Lennart Jacobsson, Ulrika Bergsten, Eva Klingberg
Summary: The study aimed to compare traditional cardiovascular risk factors among patients with different rheumatic diseases, and found that hypertension was the most common comorbidity, with patients with gout having the highest prevalence of traditional CVRFs. Significant differences in occurrence of CVRFs by sex were also observed among patients with PsA, RA and AS.
Article
Rheumatology
Victoria Navarro-Compan, Diego Benavent, Dafne Capelusnik, Desiree van der Heijde, Robert B. M. Landewe, Denis Poddubnyy, Astrid van Tubergen, Xenofon Baraliakos, Filip E. van den Bosch, Floris A. van Gaalen, Lianne Gensler, Clementina Lopez-Medina, Helena Marzo-Ortega, Anna Molto, Rodolfo Perez-Alamino, Martin Rudwaleit, Marleen van de Sande, Raj Sengupta, Ulrich Weber, Sofia Ramiro
Summary: This study developed a consensual definition for 'early axial spondyloarthritis-axSpA' and 'early peripheral spondyloarthritis-pSpA' through a systematic literature review and Delphi survey. The results indicated that early axSpA should be based on symptom duration only, without considering the presence of radiographic damage.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Editorial Material
Rheumatology
Juergen Braun, Dietmar Krause, Uta Kiltz
Summary: This editorial discusses the impact evaluation of a nurse-led program for patient self-assessment and self-management in axial spondyloarthritis, presented in a prospective, multicenter, randomized, controlled trial (COMEDSPA) conducted by Anna Molto et al.
Article
Rheumatology
Marta Arevalo Salaet, Clementina Lopez-Medina, Mireia Moreno, Victoria Navarro-Compan, Joan Calvet Fontova, Maria Llop, Maxime Dougados, Jordi Gratacos
Summary: This study analyzed the influence of HLA-B27 in the phenotypical expression of pSpA. The results showed that HLA-B27-positive patients had an earlier disease onset and higher axial involvement, tarsitis, and uveitis, but no association with other EMM, fibromyalgia, or peripheral structural damage was observed.
Article
Rheumatology
Jette A. van Lint, Naomi T. Jessurun, Sander W. Tas, Bart J. F. van den Bemt, Michael T. Nurmohamed, Martijn B. A. van Doorn, Phyllis Spuls, Astrid M. van Tubergen, Peter M. Ten Klooster, Eugene P. van Puijenbroek, Frank Hoentjen, Harald E. Vonkeman
Summary: The study aimed to describe the nature and frequency of gastrointestinal adverse drug reactions (GI-ADRs) of etanercept (ETN) in patients with inflammatory rheumatic diseases, and compare this with the GI-ADR frequency of adalimumab (ADA). The results showed that most GI-ADRs associated with ETN consisted of gastrointestinal symptoms, leading to dose adjustment or ETN discontinuation, with a frequency comparable to ADA-associated GI-ADRs. Knowledge of these ADRs can aid in early recognition and improve patient communication.
JOURNAL OF RHEUMATOLOGY
(2021)
Article
Rheumatology
Esther Beckers, Marin Been, Casper Webers, Annelies Boonen, Peter M. ten Klooster, Harald E. Vonkeman, Astrid van Tubergen
Summary: This study investigated the concurrent validity and discrimination of the DAPSA, PASDAS, and ASDAS scores in pSpA. The results showed that these scores had acceptable performance in pSpA and were independent of concomitant PsO.
JOURNAL OF RHEUMATOLOGY
(2022)
Article
Rheumatology
Esther Beckers, Annelies Boonen, Casper Webers, Peter Ten Klooster, Harald Vonkeman, Monique Efde, Astrid van Tubergen
Summary: The study found that internationally agreed treat-to-target recommendations were applied to a limited extent in clinical practice for patients with axial spondyloarthritis. Available disease activity scores did not seem to be utilized for determining the frequency of re-evaluation or treatment adaptation.
Article
Rehabilitation
Maria A. T. van Wissen, Max M. H. Teuwen, Cornelia H. M. van den Ende, Thea P. M. Vliet Vlieland, Alfons A. den Broeder, Wilbert B. van den Hout, Wilfred F. Peter, Dirkjan van Schaardenburg, Astrid M. van Tubergen, Maaike G. J. Gademan, Salima F. E. van Weely
Summary: This study aims to evaluate the effectiveness and cost-effectiveness of longstanding exercise therapy in patients with axSpA and RA who have severe functional limitations. The research will include two parallel randomized controlled trials with a total of 215 patients and will assess outcomes at 52 weeks. After the initial period, patients in the usual care group will also be offered active exercise therapy.
PHYSIOTHERAPY RESEARCH INTERNATIONAL
(2022)
Article
Rheumatology
Charlotte L. M. Krieckaert, Astrid van Tubergen, Johanna Elin Gehin, Borja Hernandez-Breijo, Guillaume Le Meledo, Alejandro Balsa, Peter Boehm, Sasa Cucnik, Ori Elkayam, Guro L. Goll, Femke Hooijberg, Meghna Jani, Patrick D. W. Kiely, Neil McCarthy, Denis Mulleman, Victoria Navarro-Compan, Katherine Payne, Martin E. Perry, Chamaida Plasencia-Rodriguez, Simon R. Stones, Silje Watterdal Syversen, Annick de Vries, Katherine M. Ward, Gertjan Wolbink, John D. Isaacs
Summary: This study develops EULAR points-to-consider for therapeutic drug monitoring (TDM) of biopharmaceuticals in inflammatory rheumatic and musculoskeletal diseases (RMDs). The points-to-consider are evidence-based and consensus-based statements that highlight the clinical utility of TDM. However, the lack of high quality trials addressing effectiveness and safety of TDM, as well as robust economic evaluation, limits its wider adoption.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Article
Rheumatology
Kasper Hermans, Annelies Boonen, Astrid van Tubergen
Summary: This study aimed to determine the necessity of routine follow-up visits in SpA outpatient clinics as perceived by rheumatologists and explore whether previsit remote health outcome assessments can identify the necessity of ensuing visits. The results showed that remote disease activity assessments can help identify patients for whom visits might be necessary from a rheumatologist's perspective.
JOURNAL OF RHEUMATOLOGY
(2022)
Editorial Material
Rheumatology
Astrid Van Tubergen, Kasper Hermans
JOURNAL OF RHEUMATOLOGY
(2022)
Article
Pharmacology & Pharmacy
Henrike J. Westerink, Leanne J. Kosse, Naomi T. Jessurun, Astrid Tubergen, Harald E. Vonkeman, Mike T. Nurmohamed, Bart J. F. van den Bemt, Marieke de Vries
Summary: This study explored the perceptions of inflammatory rheumatic disease patients and healthcare professionals on the burden of adverse drug reactions (ADRs). The findings revealed that both patients and healthcare professionals consider ADRs to have both physical and psychological impacts, with healthcare professionals placing more emphasis on the psychological consequences.
EXPERT OPINION ON DRUG SAFETY
(2023)
Review
Rheumatology
Dafne Capelusnik, Diego Benavent, Desiree van der Heijde, Robert Landewe, Denis Poddubnyy, Astrid van Tubergen, Louise Falzon, Victoria Navarro-Compan, Sofia Ramiro
Summary: This study conducted a systematic literature review to summarize the relationship between early treatment and treatment clinical response in patients with SpA. It found that early treatment was associated with better outcomes in patients with non-radiographic axSpA and symptom duration of less than 5 years, but no differences in response to treatment were found in radiographic axSpA or in patients with longer symptom duration.
Article
Rheumatology
Casper Webers, Astrid van Tubergen, Harald E. Vonkeman, Annelies Boonen
Summary: This study investigated the changes in work productivity in patients with spondyloarthritis (SpA) following the onset of the COVID-19 pandemic. The results showed that work productivity worsened in patients after the pandemic, especially in those with lower education. However, employment losses were limited and disease activity remained stable.
Article
Rheumatology
Victoria Navarro-Compan, Diego Benavent, Dafne Capelusnik, Desiree van der Heijde, Robert B. M. Landewe, Denis Poddubnyy, Astrid van Tubergen, Xenofon Baraliakos, Filip E. van den Bosch, Floris A. van Gaalen, Lianne Gensler, Clementina Lopez-Medina, Helena Marzo-Ortega, Anna Molto, Rodolfo Perez-Alamino, Martin Rudwaleit, Marleen van de Sande, Raj Sengupta, Ulrich Weber, Sofia Ramiro
Summary: This study developed a consensual definition for 'early axial spondyloarthritis-axSpA' and 'early peripheral spondyloarthritis-pSpA' through a systematic literature review and Delphi survey. The results indicated that early axSpA should be based on symptom duration only, without considering the presence of radiographic damage.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Article
Rheumatology
M. A. T. van Wissen, B. Straathof, T. P. M. Vliet Vlieland, C. H. M. van den Ende, M. M. H. Teuwen, W. F. Peter, A. A. den Broeder, W. B. van den Hout, D. van Schaardenburg, A. M. van Tubergen, M. G. J. Gademan, S. F. E. van Weely
Summary: The study aimed to assess the construct validity of PROMIS PF-10 in patients with severe limitations in physical functioning caused by RA or axSpA. By surveying and testing 316 patients, it was found that PROMIS PF-10 had strong correlations with measures of physical function and moderate to weak correlations with other outcome measures, supporting its construct validity.
SCANDINAVIAN JOURNAL OF RHEUMATOLOGY
(2023)
Article
Rheumatology
Esther Beckers, Annelies Boonen, Astrid van Tubergen
Summary: We developed a web-based evidence-based decision aid to support shared decision-making in patients with axial spondyloarthritis (axSpA) who face a treatment decision to initiate or switch a biological or targeted synthetic disease modifying antirheumatic drug (b/tsDMARDs). The decision aid was developed through an iterative process based on evidence from the literature, needs assessment interviews, and expert input. The decision aid was then introduced in clinical practice through a multifaceted strategy.
Review
Rheumatology
Esther Beckers, Kasper Hermans, Astrid Van Tubergen, Annelies Boonen
Summary: This study aims to summarize published reviews on fatigue in rheumatoid arthritis (RA), spondyloarthritis, osteoarthritis and fibromyalgia, focusing on the definition, measurement instruments and diagnosis, determinants, consequences, and effectiveness of interventions. A systematic literature search was conducted and data were extracted and synthesized. The results highlight the complexity of fatigue and provide evidence for tailored management plans in clinical practice and future research agendas.
Meeting Abstract
Rheumatology
E. Beckers, A. Boonen, C. Webers, P. M. Klooster, H. E. Vonkeman, M. Efde, A. van Tubergen
CLINICAL AND EXPERIMENTAL RHEUMATOLOGY
(2021)
Article
Rheumatology
S. Louis Bridges, Steffen Gay
RHEUMATIC DISEASE CLINICS OF NORTH AMERICA
(2024)
Article
Rheumatology
Joshua F. Baker, Daniel G. Baker
RHEUMATIC DISEASE CLINICS OF NORTH AMERICA
(2024)
Article
Rheumatology
William Neal Roberts Jr, Edward R. Lew, Matthew H. Liang
RHEUMATIC DISEASE CLINICS OF NORTH AMERICA
(2024)
Article
Rheumatology
Daniel A. Albert
RHEUMATIC DISEASE CLINICS OF NORTH AMERICA
(2024)
Article
Rheumatology
Virginia D. Steen, Thomas A. Medsger
RHEUMATIC DISEASE CLINICS OF NORTH AMERICA
(2024)
Article
Rheumatology
Patricia Woo, Ross E. Petty
RHEUMATIC DISEASE CLINICS OF NORTH AMERICA
(2024)
Article
Rheumatology
H. James Williams, Grant W. Cannon, Daniel O. Clegg
RHEUMATIC DISEASE CLINICS OF NORTH AMERICA
(2024)
Biographical-Item
Rheumatology
Daniel J. Wallace
RHEUMATIC DISEASE CLINICS OF NORTH AMERICA
(2024)
Article
Rheumatology
Ann K. Rosenthal, Mary E. Csuka, Paul Halverson
Summary: Dr. McCarty is a giant in the field of rheumatology. His clinical and scientific discoveries have had a major impact and benefited many patients. He has been an exceptional mentor and role model, influencing our clinical practice styles, the importance we place on clinical observation, and our approach to scientific questions.
RHEUMATIC DISEASE CLINICS OF NORTH AMERICA
(2024)
Article
Rheumatology
Arthur Weinstein
RHEUMATIC DISEASE CLINICS OF NORTH AMERICA
(2024)
Article
Rheumatology
Marc C. Hochberg
RHEUMATIC DISEASE CLINICS OF NORTH AMERICA
(2024)
Article
Rheumatology
Richard M. Silver
RHEUMATIC DISEASE CLINICS OF NORTH AMERICA
(2024)
Article
Rheumatology
Anthony M. Reginato, Michelle A. Petri, Jonathan Kay
Summary: Bauer and Ropes were influential figures in the field of rheumatology, making significant contributions through clinical observation and laboratory research. They were also exceptional mentors and leaders in the field.
RHEUMATIC DISEASE CLINICS OF NORTH AMERICA
(2024)
Article
Rheumatology
Mary K. Crow, Josef S. Smolen
RHEUMATIC DISEASE CLINICS OF NORTH AMERICA
(2024)
Article
Rheumatology
James S. Louie
RHEUMATIC DISEASE CLINICS OF NORTH AMERICA
(2024)